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Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer

World Journal of Gastrointestinal Oncology 2016年第12期8卷 826-834页

作者： Audrey h Calderwood karen E Lasser hemant k roy Section of Gastroenterology Depart-ment of MedicineDartmouth-Hitchcock Medical Center Section of General Internal medicine Depart-ment of MedicineBoston University School of Medicine Section of Gastroenterology Department of MedicineBoston University School of Medicine

AIMTo review the evidence on the association between specific colon adenoma features and the risk of future colonic neoplasia [adenomas and colorectal cancer (CrC)]. METhODSWe performed a literature search using the National Library of medicine through Pubmed from 1/1/2003 to 5/30/2015. Specific medical Subject headings terms (colon, colon polyps, adenomatous polyps, epidemiology, natural history, growth, cancer screening, colonoscopy, CrC) were used in conjunction with subject headings/key words (surveillance, adenoma surveillance, polypectomy surveillance, and serrated adenoma). We defined non-advanced adenomas as 1-2 adenomas each 25% villous histology or high-grade dysplasia. A combined endpoint of advanced neoplasia included advanced adenomas and invasive CrC. rESULTSOur search strategy identified 592 candidate articles of which 8 met inclusion criteria and were relevant for assessment of histology (low grade vs high grade dysplasia, villous features) and adenoma size. Six of these studies met the accepted quality indicator threshold for overall adenoma detection rate > 25% among study patients. We found 254 articles of which 7 met inclusion criteria for the evaluation of multiple adenomas. Lastly, our search revealed 222 candidate articles of which 6 met inclusion criteria for evaluation of serrated polyps. Our review found that villous features, high grade dysplasia, larger adenoma size, and having ≥ 3 adenomas at baseline are associated with an increased risk of future colonic neoplasia in some but not all studies. Serrated polyps in the proximal colon are associated with an increased risk of future colonic neoplasia, comparable to having a baseline advanced adenoma. CONCLUSIONData on adenoma features and risk of future adenomas and CrC are compelling yet modest in absolute effect size. Future research should refine this risk stratification.

关键词： Colon adenoma Colorectal cancer screening Surveillance Colonoscopy

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Efectsofbonegraftsonhematopoieticrecoveryinchimeric─resistantcombination

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吉林大学学报(医学版) 1996年第6期 12-16页

作者： Li Yong′an,Li Zhichao,hiro ko hisha ,Fan hongxue Dept.of Toxicology,N.B.Univ.of med Sciences First Dept.of Pathology,kansai med Univ.

Ｅｆｅｃｔｓｏｆｂｏｎｅｇｒａｆｔｓｏｎｈｅｍａｔｏｐｏｉｅｔｉｃｒｅｃｏｖｅｒｙｉｎｃｈｉｍｅｒｉｃ┐ｒｅｓｉｓｔａｎｔｃｏｍｂｉｎａｔｉｏｎＬｉＹｏｎｇ′ａｎ，ＬｉＺｈｉｃｈａｏ，ＨｉｒｏｋｏＨｉｓｈａ＊，Ｆａｎ... 详细信息

Ｅｆｅｃｔｓｏｆｂｏｎｅｇｒａｆｔｓｏｎｈｅｍａｔｏｐｏｉｅｔｉｃｒｅｃｏｖｅｒｙｉｎｃｈｉｍｅｒｉｃ┐ｒｅｓｉｓｔａｎｔｃｏｍｂｉｎａｔｉｏｎＬｉＹｏｎｇ′ａｎ，ＬｉＺｈｉｃｈａｏ，ＨｉｒｏｋｏＨｉｓｈａ＊，ＦａｎＨｏｎｇｘｕｅ（Ｄｅｐｔ．ｏｆＴｏ...

关键词： bone ma.row transplantation stromal cells chimerism resistance PPAGESS

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Aldosterone-induced mesangial cell proliferation is mediated by EGF receptor transactivation

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南京医科大学学报(自然科学版) 2009年第7期 991-991页

作者： huang, S. M. Zhang, A. h. Ding, G. X. Chen, r. h. Nanjing med Univ, Nanjing Childrens hosp, Dept Nephrol, Nanjing, Peoples r China. Nanjing med Univ, Inst Pediat, Nanjing, Peoples r China.

huang S, Zhang A, Ding G, Chen r. Aldosterone-induced mesangial cell proliferation is mediated by EGF receptor transactivation. Am J Physiol renal Physiol 296: F1323-F1333, 2009. First published a.ril 1, 2009; doi: 10.1152 / ajprenal. 90428.2008. -Aldosterone (Aldo) stimulates glomerular mesangial cell (MC) proliferation, in part, through an Erk1 / 2-dependent pathway. In this study, we examined whether Aldo activation of Erk1 / 2 in MC is mediated through redox-dependent EGF receptor (EGFr) transactivation, as well as the involvement of other signaling mechanisms in Aldo-induced MC proliferation. Aldo increased human MC proliferation, as determined by [h-3]thymidine incorporation and cell counts. This increase in proliferation was blocked by inhibition of the mineralocorticoid receptor (Mr). Continuing our observations downstream in the signaling pathway, we examined the ability of Aldo to activate both the ras / MAPk and the PI3k signaling pathways. Aldo increased ki-rasA and ki-rasA:GTP levels, and sequentially phosphorylated c-raf, MAPk kinase (MEk1 / 2), and Erk1 / 2. ki-rasA small interfering rNA (sirNA), the c-raf inhibitor GW5074, and the MEk1 / 2 inhibitor PD98059 reduced Aldo-induced cell proliferation by similar to 65%. Aldo also increased phosphorylation of PI3k, Akt, the mammalian target of rapamycin (mTOr), and the 70-kDa.ribosomal S6 kinase (p70S6k1). Inhibition of the PI3k pathways by the selective PI3k inhibitor LY 294002, an Akt inhibitor, or the mTOr inhibitor rapamycin reduced cell proliferation by 51% . Combining LY 294002 and PD98059 completely blocked Aldo-induced MC proliferation. Next, we confirmed that Aldo exerts its effect on MAPk and PI3k activation, as well as on cell proliferation, by activating the EGFr. Pretreatment with the EGFr antagonist AG1478 inhibited MC proliferation, as well as the activation of ras / MAPk and PI3k / Akt, suggesting that ras / MAPk and PI3k / Akt activation occur downstream of EGFr activation. Finally, we exa

关键词： reactive oxygen species PI3k hypertensive-rats phosphatidylinositol 3-kinase stimulates proliferation mesenchymal transition epithelial-cells nadph oxidase s6 kinase activation ras cascade

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Tribology of enzymatically degraded cartilage mimicking early osteoarthritis

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Friction 2023年第9期11卷 1724-1740页

作者： ke rEN Miguel Alejandro rEINA MAhEChA Maike hÜBNEr Zhiwei CUI hans J.kAPEr hugo C.VAN DEr VEEN Prashant k.ShArMA Department of Biomedical Engineering University Medical Centre GroningenUniversity of GroningenGroningen 9713AVthe Netherlands Department of Mechanical Engineering Eindhoven University of TechnologyEindhoven 5600MBthe Netherlands Department of Orthopedic Surgery University Medical Centre GroningenUniversity of GroningenGroningen 9700RBthe Netherlands

healthy cartilage is a water-filled super lubricious *** type II provides it structural stability,and proteoglycans absorb water to keep the cartilage in a swollen condition,providing it the ability to creep and provide weeping ***(OA)is a degenerative and debilitating disorder of diarthrodial joints,where articular cartilage damage originates from enzymatic degradation and mechanical damage(wear).The objective of this research is to observe the level of cartilage damage present in knee arthroplasty patients and to understand the friction and creep behavior of enzymatically degraded bovine cartilage in ***(Lat)and medial(med)condylar cartilages from OA patients undergoing total knee arthroplasty showed signs of enzymatic degradation and mechanical *** cartilages were exposed to collagenase III and chondroitinase ABC to degrade collagen and proteoglycans,*** loss of proteoglycans or collagen network and morphological changes were observed through histology and the atomic force microscope(AFM),respectively.A significant effect on creep due to enzymatic treatment was not *** the enzymatic treatment was found to significantly decrease the coefficient of friction(COF)at 4 N,while higher COF was shown from chondroitinase ABC degraded cartilage at 40 *** III treatment leads to the release of intact proteoglycans at the sliding interface,while chondroitinase ABC treatment leads to the loss of chondroitin sulfate(CS)from the *** ABC-digested bovine cartilage mimicked patient samples the best because of the similar distributions of proteoglycans,collagen network,and friction behavior.

关键词： lubrication cartilage boundary lubrication osteoarthritis(OA)

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Cigarette smoking and the risk of endometrial cancer:A meta-analysis

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南京医科大学学报(自然科学版) 2008年第7期 939-939页

作者： Zhou,B. Yang,L. Sun,Q.M. Cong,r.h. Gu,h.J. Tang,N.P. Zhu,h.J. Wang,B.Nanjing med Univ,Dept Pharmacol,key Lab reproduct med,Nanjing 210029,Jiangsu,Peoples r China.Nanjing med Univ,Affiliated hosp 1,Dept Gen Surg,Nanjing 210029,Jiangsu,Peoples r China.Nanjing Univ,Sch med,Affiliated Drum Tower hosp,Nanjing 210008,Jiangsu,Peoples r China.

OBJECTIVE:Epidemiologic findings are inconsistent concerning the association of endometrial cancer risk with cigarette *** conducted a meta-analysis of epidemiologic studies to examine this ***:A systematic literature search up to June of 2007 was performed in medLINE and ***-specific risk estimates were pooled using a.random-effects ***:Ten prospective and 24 case-control studies were included in the analysis of the effect of ever *** smoking was statistically significantly associated with a.reduced risk of endometrial cancer among prospective studies(relative risk 0.81;95% confidence interval[CI],0.74-0.88) and case-control studies(odds ratio 0.72;95% CI,0.66-0.79).The inverse association was significant among current and former *** prospective and 6 case-control studies were included in the quantitative *** noted that an increase in smoking of 20 cigarettes per day was statistically significantly associated with 16% and 27% reduced risks of endometrial cancer in prospective and case-control studies,*** also found that cigarette smoking was significantly associated with a decreased risk of endometrial cancer among postmenopausal women(relative risk 0.71;95% CI,0.65-0.78) but not among premenopausal *** addition,the risk reduction seemed to be stronger among hormone replacement therapy users than ***:Cigarette smoking was found to be significantly associated with a.reduced risk of endometrial cancer,especially among postmenopausal women.(C) 2008 Elsevier *** rights reserved.

关键词： cigarette smoking endometrial cancer meta-analysis risk hormone-replacement therapy dose-response data alcohol-consumption postmenopausal women trend estimation estrogen use life-style a.rp diet follow-up cohort

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Surface roughness measurements in NFMQL assisted turning of titanium alloys: An optimization approach

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Friction 2017年第2期5卷 155-170页

作者： Munish k.GUPTA P.k.SOOD med NIT Hamirpur(H.P.)177005 India

The prediction and optimization of surface roughness values remain a critical concern in nano-fluids based minimum quantity lubrication (NFMQL) turning of titanium (grade-2) ***,we discuss an application of response surface methodology with Box-Cox transformation to determine the optimal cutting parameters for three surface roughness values,i.e.,ra.rq,and rz,in turning of titanium alloy under the NFMQL *** surface roughness prediction model has been established based on the selected input parameters such as cutting speed,feed rate,approach angle,and different nano-fluids *** the multiple regression technique is used to find the relationship between the given responses and input ***,the experimental data were optimized through the desirability function *** findings from the current investigation showed that feed rate is the most effective parameter followed by cutting speed,different nano-fluids,and approach angle on ra and rq values,whereas cutting speed is more effective in the case of rz under NFMQL ***,the predicted results are comparatively near to the experimental values and hence,the established models of rSM using Box-Cox transformation can be used for prediction satisfactorily.

关键词： nano-fluids optimization surface roughness turning titanium alloy

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ErCC1 and ErCC2 polymorphisms and risk of idiopathicazoospermia ina Chinese population

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南京医科大学学报(自然科学版) 2008年第10期 1244-1244页

作者： Ji, G. X. Gu, A. h. Xia, Y. k. Lu, C. C. Liang, J. Wang, S. L. Ma, J. Peng, Y. Z. Wang, X. r. Nanjing med Univ, key Lab reprod med, Inst Toxicol, Nanjing 210029, Peoples r China. Nanjing med Univ, Nanjing Matern & Child hlth hosp, Nanjing 210029, Peoples r China.

The ErCC1(excision repa.r cross complementation group 1) and ErCC2(excision repa.r cross complementation group 2) genes are important in repa.ring DNA damage and genomic instability in germ cells, and are essential for normal spermatogenesis. It has been verified that polymorphisms of these two genes could alter DNa.repa.r capacity in some phenotypic studies. however, little information is available on these polymorphisms in male infertility. This study was designed to examine whether ErCC1 polymor- phisms 3 UTr(C8092A), Asn118Asn(G19007A) and ErCC2 polymorphisms Asp312Asn(G -> A), Lys751Gln (A -> C), which have been reported to contribute to some cancers, are associated with idiopathic azoospermia in the Chinese population. The four polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism assay in a hospital-based case-control study, comprising 202 infertile patients with idiopathic azoospermia and 187 fertile controls. It was found that the Er- CC1 8092 CA + AA genotypes were significantly associated with an increased risk of idiopathic azoospermia(Or = 1.750, 95% CI = 1.170-2.618), while other polymorphisms appeared to show no significant differences between cases and controls. Further studies are needed to confirm the roles of these polymorphisms in idiopathic azoospermia.

关键词： azoospermia DNa.repa.r ErCC1 ErCC2 polymorphisms epa.r gene xpd male-infertility lung-cancer dnadamage etaanalysis association glioma cells assay men

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Enhanced intracellular calcium induced by urocortin is involved in degranulation of rat lung mast cells

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南京医科大学学报（自然科学版） 2008年第6期28卷 778-778页

作者： Wu, Y. Q. hu, J. Zhang, r. J. Zhou, C. h. Xu, Y. h. Guan, X. W. Li, S. S. (Nanjing med Univ, Dept Pharmacol, Nanjing 210029, Peoples r China. Xuzhou med Coll, Dept Pharmacol, Xuzhou, Peoples r China)

Corticotropin-releasing factor(CrF), which activates the hypothalamic-pituitary-a.renal axis under stress, also has proinflammatory peripheral effects possibly through mast cells. The purpose of this study was to investigate the effect of urocortin (UCN), a 40-amino-acid CrF family peptide, on degranulation and intracellular calcium of rat lung mast cells. The activation and degranulation of mast cells were observed by Toluidine blue staining and transmission electron microscope. The intracellular calcium was investigated using confocal laser scanning microscopy and flow cytometry. The results indicated that all the three different concentrations of UCN(0.1, 1 and 10 mu M) significantly induced the activation and degranulation of rat lung mast cells in vitro. This effect was markedly blocked by selective CrF receptor 1(CrF-r1) antagonist antalarmin, but not by specific CrF receptor 2(CrF-r2) antagonist antisauvagine-30(anti-Svg-30). The results also showed that UCN caused a.rapid peak increase inCa2+(i) at point of 300s after UCN treatment, followed by a decrease to a sustained plateau phase. The peak increase inCa2+(i) induced by UCN was significantly inhibited by antalarmin, but not by anti-Svg-30. This effect of UCN onCa2+(i) in rat lung mast cells was also found by flow cytometry. regression analysis revealed a positive correlation between mast cells degranulation extent and the maximum value ofCa2+(i)(P ken together, our present study suggested that UCN induced the increase of Ca2+(i) and degranulation of rat lung mast cells through CrF-r1. These findings may have implications for the pathophysiology of allergic and inflammatory lung disorders such as asthma, which is closely associated with mast cell activation and degranulation. Copyright (c) 2008 S. karger AG, Basel.

关键词：钙细胞肺部肥大细胞

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Social health insurance and drug spending a mong cancer inpatients in China

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南京医科大学学报(自然科学版) 2008年第10期 1233-1233页

作者： Zhou, B. Yang, L. Sun, Q. M. Gu, h. J. Wang, B. Nanjing med Univ, Dept Pharmacol, Nanjing, Peoples r China. Nanjing med Univ, Affiliated hosp 1, Dept Gen Surg, Nanjing, Peoples r China.

A social health insurance(ShI) program has been established in China to ensure that people can obtain health care economically and equitably. Our analysis indicates that in 2005-06, 66.5 percent of Chinese citizens were non-ShI inpatients. We also found that drug spending for ShI inpatients was significantly higher than that for non-ShI inpatients. After adjusting for other variables, we found that the ShI coverage was also associated positively with higher drug costs. We present evidence to show that drug spending differences are attributable at least in part to differences in insurance courage.

关键词： care system services coverage lessons reforms nations

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鼠鞭草的植物药理研究进展(英文)

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中国天然药物 2013年第3期11卷 199-206页

作者： D.k.Patel r.kumar k.Sa.ram S.hemalatha Pharmacognosy research Laboratory Department of Pharmaceutics Institute of Technology Banaras Hindu University

hybanthus enneaspermus (L.) F. Muell belonging to the family Violaceae, popularly known as ratanpurus (hindi) is a herb or a shrub distributed in the tropical and subtropical regions of the world. In the Ayurvedic literature, the plant is reported to cure conditions of "kapha" and "Pitta", urinary calculi, strangury, painful dysentery, vomiting, burning sensation, wandering of the mind, urethral discharge, blood trouble, asthma, epilepsy, cough, and to give tone to the breasts. Phytochemically, the plant contains a considerable amount of dipeptide alkaloids, a.rantiamide acetate, isoarborinol, and β-sitosterol, sugars, flavonoids, steroids, triterpenes, phenols, flavones, catachins, tannins, anthraquinones and amino acids. Pharmacologically, the plant is reported to possess antidiabetic, antiplasmodial, antimicrobial, anticonvulsant, nephroprotective, aphrodisiac, hepatoprotective, antiinflammatory, aldose reductase inhibitory and free radical scavenging activities. The information provided in this review will be worthwhile to know the applicability of h. enneaspermus for the treatment of various acute or chronic diseases with a diverse nature of phytoconstituents. The overall data in this review article were collected from various scientific sources on the research of h. enneaspermus.

关键词： Antidiabetic Antimicrobial Antioxidant Aphrodisiac hybanthus enneaspermus Pharmacological activity Phytochemistry Tissue culture

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