Tribology of enzymatically degraded cartilage mimicking early osteoarthritis

作     者：Ke REN Miguel Alejandro REINA MAHECHA Maike HÜBNER Zhiwei CUI Hans J.KAPER Hugo C.VAN DER VEEN Prashant K.SHARMA Ke REN;Miguel Alejandro REINA MAHECHA;Maike HüBNER;Zhiwei CUI;Hans J.KAPER;Hugo C.VAN DER VEEN;Prashant K.SHARMA

作者机构：Department of Biomedical EngineeringUniversity Medical Centre GroningenUniversity of GroningenGroningen 9713AVthe Netherlands Department of Mechanical EngineeringEindhoven University of TechnologyEindhoven 5600MBthe Netherlands Department of Orthopedic SurgeryUniversity Medical Centre GroningenUniversity of GroningenGroningen 9700RBthe Netherlands 

出 版 物：《Friction》 (摩擦（英文版）)

年 卷 期：2023年第11卷第9期

页      面：1724-1740页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 080203[工学-机械设计及理论] 0802[工学-机械工程] 0702[理学-物理学] 

基　　金：The tribometer(UMT-3,Bruker,USA)setup was purchased thanks to the Grant No.91112026 from the Netherlands Organization for Health Research and Development(ZON-MW).Figure 8 is created with biorender.com We also would like to thank China Scholarship Council for a four-year scholarship to Ph.D.candidate Ke REN(Grant No.CSC201806400039) 

主　　题：lubrication cartilage boundary lubrication osteoarthritis(OA) 

摘      要：Healthy cartilage is a water-filled super lubricious *** type II provides it structural stability,and proteoglycans absorb water to keep the cartilage in a swollen condition,providing it the ability to creep and provide weeping ***(OA)is a degenerative and debilitating disorder of diarthrodial joints,where articular cartilage damage originates from enzymatic degradation and mechanical damage(wear).The objective of this research is to observe the level of cartilage damage present in knee arthroplasty patients and to understand the friction and creep behavior of enzymatically degraded bovine cartilage in ***(Lat)and medial(Med)condylar cartilages from OA patients undergoing total knee arthroplasty showed signs of enzymatic degradation and mechanical *** cartilages were exposed to collagenase III and chondroitinase ABC to degrade collagen and proteoglycans,*** loss of proteoglycans or collagen network and morphological changes were observed through histology and the atomic force microscope(AFM),respectively.A significant effect on creep due to enzymatic treatment was not *** the enzymatic treatment was found to significantly decrease the coefficient of friction(COF)at 4 N,while higher COF was shown from chondroitinase ABC degraded cartilage at 40 *** III treatment leads to the release of intact proteoglycans at the sliding interface,while chondroitinase ABC treatment leads to the loss of chondroitin sulfate(CS)from the *** ABC-digested bovine cartilage mimicked patient samples the best because of the similar distributions of proteoglycans,collagen network,and friction behavior.