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中华医学杂志 1933年第1期19卷 81-87页

作者： W. Trotter, British med. Journ, March 19, 1932　齐大

咽部之癌紧急而不易治疗,并非罕见之病,其天然经过为疼痛,烦苦,且必致命,故可视为中年人最恶之病之一种。处理咽病,有三种障碍:(1)不易达及其处。(2)位置险而官能重要;(3)所含脓毒性物质,周围组织无从抵抗。

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应用树脂粘结全瓷修复体进行全面的美观与功能重建——随访4．5年的病例报告

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中国口腔医学继续教育杂志 2008年第1期11卷 45-52页

作者： Martin Groten Dr med dent 刘云松（译）冯海兰（校）不详北京大学口腔医学院修复科北京海淀区中关村南大街22号100081

应用单冠进行全面的修复重建在某些病例中已被证实是成功的，但这种方法是一个有创的治疗方案。牙体预备深度相对较少的树脂粘结玻璃陶瓷修复体可以作为一个微创的替代方法。在本文中所介绍的病例是一个40岁的女性患者，口内多颗牙齿存... 详细信息

应用单冠进行全面的修复重建在某些病例中已被证实是成功的，但这种方法是一个有创的治疗方案。牙体预备深度相对较少的树脂粘结玻璃陶瓷修复体可以作为一个微创的替代方法。在本文中所介绍的病例是一个40岁的女性患者，口内多颗牙齿存在水门汀充填体、腐蚀、异常功能磨耗，上颌前牙区域散在间隙等问题。为解决这些问题．她接受了功能与美观重建的治疗，并且应用了微创的树脂粘结玻璃陶瓷全冠、部分冠和贴面。功能重建包括抬高咬合2mm。这个患者每年复查．经过了4.5年的临床随诊，资料包括牙齿、牙周状况评估和以改良加利福尼亚牙科协会（CDA）标准为准的修复体临床质量评价。观察发现，只有较小的有临床意义的修复体边缘变色和牙龈退缩发生，没有出现其他不利的情况，患者没有不适主诉，对修复体的美观效果非常满意。

关键词：酸蚀树脂粘结全瓷修复体 Celay 美学功能重建玻璃陶瓷长期的成功微创预备

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互联网即时搜索项目一年回顾

中国继续医学教育 2010年第A1期2卷 36-37页

作者： Jerrald Roberts-Jaack Dolcourt med-Brad Halvorsen 张英楠曾诚美国犹他州大学继续医学教育部

1前言从2005年开始,通过互联网搜索回答患者相关的问题,可获得美国医学会医师认可系统1类学分(AMAPRA1类学分)。对于医师在何种情形下使用互联网搜索和学习还知之甚少,然而,根据全国范围内的基于反馈的调查显示,86%的医师通过互联网获... 详细信息

1前言从2005年开始,通过互联网搜索回答患者相关的问题,可获得美国医学会医师认可系统1类学分(AMAPRA1类学分)。对于医师在何种情形下使用互联网搜索和学习还知之甚少,然而,根据全国范围内的基于反馈的调查显示,86%的医师通过互联网获得有关健康、医学及处方的信息；

关键词：用互联网搜索引擎医师学分美国医学会网络搜索数据采集学习患者获得

Highly Magnetic,Monodisperse Microspheres with Hierarchically Mesoporous Silica Shell:Synthesis and Characterization

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Highly Magnetic,Monodisperse Microspheres with Hierarchicall...

新发现的清代噶伦索康·斯觉次旦传记写本考述

加速功能材料自主创新，促进西部战略性新兴产业发展——2011中国功能材料科技与产业高层论坛

作者： Jixi ZHANG,Hongchen GU Nano Biomedical Research Center,School of Biomedical Engineering and med-X Research Institute,Shanghai Jiaotong University,Shanghai,China,200030

Hierarchically mesoporous silica coated superparamagnetic microspheres with an uniform particle diameter of 750-800 nm and shell thickness of 65-100 nm were synthesized utilizing the surfactant-templated coating process using ethanol as cosolvent and CTAB as *** obtained materials were highly magnetic with large saturation *** mesoporous silica shell structures were obtained with the aid of organic swelling agent TMB at the TMB/CTAB molar ratios above *** kinds of porosities with peak pore sizes of 3.3 nm,5.3 nm,and that larger than 10 nm coexisted in the mesoporous shell due to the inhomogeneous distribution of TMB in CTAB micelles and disordered packing of mesophase by the influence of *** surface area gradually decreased and the total pore volume first decreased then increased with the increase of TMB/CTAB molar *** hierarchically mesoporous silica coated superparamagnetic microspheres are believed to be highly potential in magnetic targeted delivery of multiple biomolecules with different molecular sizes.

关键词： magnetic microspheres hierarchical mesoporous pore swelling

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藏学学刊 2021年第1期 190-204,360页

作者：永中久美西藏拉萨市柳梧新区管委会

近年来,一部关于清代西藏地方噶伦索康·斯觉次旦的传记写本发现于青海贵德县,记载了西藏历史上贵族索康家族的发展历程和噶伦本人的生平事迹。传记分为上下集,上集由噶伦本人撰写,占据主要篇幅;下集为噶伦去世后由家族后人整理而成。... 详细信息

近年来,一部关于清代西藏地方噶伦索康·斯觉次旦的传记写本发现于青海贵德县,记载了西藏历史上贵族索康家族的发展历程和噶伦本人的生平事迹。传记分为上下集,上集由噶伦本人撰写,占据主要篇幅;下集为噶伦去世后由家族后人整理而成。内容涉及索康·斯觉次旦在18世纪末到19世纪初在噶厦担任官职、赴边履任、升迁噶伦、辞官出家到最后圆寂的全部人生过程。入世到出世之间,看似蝶变,却始终贯穿着一名俗官在政教合一社会中的修行生活。本文重点梳理了写本中记载的索康家族历史和噶伦生平,同时对其中反映的重大历史事件和相关政教人物、宗教修学、跨文化互动以及文学特点等方面做了考述。

关键词：文学特点辞官政教合一次旦生平事迹传记青海贵德写本

Urocortin ameliorates diabetic nephropathy in obese db /db mice

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南京医科大学学报(自然科学版) 2008年第10期 1311-1311页

作者： Li, X. Hu, J. Zhang, R. Sun, X. Zhang, Q. Guan, X. Chen, J. Zhu, Q. Li, S. Nanjing med Univ, Dept Pharmacol, Nanjing 210029, Peoples R China. Nanjing Univ Chinese med, Natl Standard Lab Pharmacol Chinese Mat med, Nanjing, Peoples R China.

Background and purpose: Hyperglycaemia induces overproduction of mitochondrial reactive oxygen species (ROS) in endothelial cells, which is believed to be a major molecular mechanism underlying complications of diabetes, including diabetic nephropathy. Impairment of endothelium-dependent vasodilatation is found in type 2 diabetes. Urocortin is a 40 amino-acid peptide related to the corticotrophin-releasing factor (CRF) family, which suppresses production of ROS in endothelial cells and sustains endothelium-dependent relaxations of rat coronary artery. However, it is not clear if urocortin has any effect on diabetic nephropathy. Experimental approach: Possible mechanisms underlying the effects of urocortin on diabetic nephropathy were investigated in db/db mice and cultured rat mesangial cells. Key results: Urocortin decreased body weight, plasma levels of advanced glycation end-prod ucts, blood urea nitrogen and creatinine levels. However, food intake, plasma insulin and glucose levels remained unaffected. Superoxide dismutase activity was increased markedly, whereas malonaldehyde levels in kidney homogenate and sorbitol concentrations in red blood cells were decreased significantly in urocortin-treated mice. Urocortin significantly decreased glomerular extracellular matrix expansion and accumulation in kidney. Moreover, urocortin inhibited the overexpression of transforming growth factor-beta 1 and connective tissue growth factor in rat mesangial cells induced by 25 mM glucose. All the effects of urocortin, except sorbitol accumulation, were abolished by the non-selective CRF receptor blocker, astressin. Conclusion and implications: Urocortin could significantly ameliorate diabetic nephropathy and this effect was mediated via the

关键词： urocortin diabetic nephropathy extra cellular matrix glycation end-products tissue growth-factor mesangial cells polyol pathway iv collagen in-vivo rat expression insulin complications

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脓胸

中华医学杂志 1933年第1期19卷 94-98页

作者： compiled chiefly from Trasers article, med. Annual, 1932 齐大

治疗脓胸时,首要在断定为一侧胸膜之全腔受累,抑或为腔之某处受累,致有局部脓肿。按病理论之,胸膜发炎时即渗出若干液体,其液体先为浆液性或纤维蛋白浆液性,而后因有细菌累及之,乃有甚多之白血球渗出成肿液。其脓液渐增,致

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Mechanisms for progression of cervical squamous premalignant lesions:Implications in cervical cancer screening

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Mechanisms for progression of cervical squamous premalignant...

Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome

第八次全国妇产科学学术会议

作者： Jian Yu Rao, M. D., Associate Professor Dept. of Pathology and Lab med Jonsson Comprehensive Cancer Center University of California at Los Angeles

Morphological changes of cervical squamous premalignant lesions have been well defined in the past. These changes include the gradual progression from HPV - associated koilocytie atypia,, to low grade dysplasia, to high grade dysplasia, to carcinoma in situ, and eventually invasive carcinoma. Cytological and histological monitoring by Papsmear and cervical biopsy, coupled with colposcopic examination as well as cone/leep biopsy,have been a successful strategy in reducing the incidence of cervical squamous cell carcinoma. While the latency from HPV infection to cancer is long (around 15 to 20 years), and only a small group of women with HPV infection eventually develop

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南京医科大学学报（自然科学版） 2010年第5期30卷 730-730页

作者： Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China

Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains *** quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were *** high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate *** data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma *** combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma.

关键词：肿痛临床治疗疗效

宣传工作在农村乙肝疫苗接种中地位和作用的研究

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疾病监测 1996年第5期11卷 170-173页

作者： (Dept Diseases Control,Chinese Acad emy of Preventive med icine,Beijing 100050) 中国预防医学科学院疾病控制处

为探讨农村地区推广新生儿乙肝疫苗免疫接种可行性及具体措施，我们于１９９３年７月至１９９４年２月在四川省崇庆县、吉林省安图县及宁夏回族自治区中卫县进行了试点工作。本次试点工作显示，在经济条件中下等的农村地区，利用各种形... 详细信息

为探讨农村地区推广新生儿乙肝疫苗免疫接种可行性及具体措施，我们于１９９３年７月至１９９４年２月在四川省崇庆县、吉林省安图县及宁夏回族自治区中卫县进行了试点工作。本次试点工作显示，在经济条件中下等的农村地区，利用各种形式、各种渠道地广泛宣传乙肝疫苗接种意义及知识，新生儿乙肝疫苗免疫接种率有明显的提高，由宣传前３３．４％增至宣传后的８４．９％（Ｐ＜０．０１）。同时，我们也感到经济困难在未接种原因分析中仍占有很大比例，提示经济状况在中下水平农村地区推广乙肝疫苗免疫接种工作也是一个不可忽视的因素。

关键词：乙型肝炎疫苗接种宣传工作