检索结果-南通市图书馆

Genome-wide gene expression analysis for target genes to differentiate patients with intestinal tuberculosis and Crohn’s disease and discriminative value of FOXP3 mRNA expression

引用

Gastroenterology Report 2016年第1期4卷 59-67,I0003页

作者： Vineet Ahuja Swati Subodh Amit Tuteja Veena Mishra Sushil Kumar garg Neha Gupta Govind Makharia SK Acharya Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew DelhiIndia The Centre for Genomic Application(An IGIB–IMM collaboration) New DelhiIndia

Background and aims:Crohn’s disease(CD)and intestinal tuberculosis(ITB)are both chronic granulomatous conditions with similar phenotypic ***,there is need for a biomarker to differentiate between both these two *** study aimed at genome-wide gene expression analysis of colonic biopsies from confirmed cases of ITB and CD in comparison with *** evaluate the role of T regulatory cells,forkhead box P3(FOXP3)mRNA expression was quantified in serum as well as in colonic biopsies from patients with ITB and with the ***:Paired samples,including serum and colonic biopsies,were taken from 33 study subjects(CD,ITB and controls),and total RNA was *** whole genome gene expression microarray analysis was performed using the Illumina HumanWG-6 BeadChip kit with six total RNA samples of the three groups in ***-time PCR for FOXP3 mRNA expression was analyzed in serum samples and colonic biopsy samples(4-CD,5-ITB,4-controls).Results:In CD and ITB there was 1.5-fold upregulation of 92 and 382 genes and 1.5-fold downregulation of 91 and 256 genes,*** proliferators via the PPARc pathway were most significantly downregulated(P2-fold *** ITB,the complement activation pathway,specifically the classical pathway,was the most significantly ***3 mRNA expression was significantly elevated in colonic biopsies obtained from ITB patients as compared with CD cases(4.7062.21 vs 1.4860.31,P=0.016).Conclusions:FOXP3 mRNA expression in colonic mucosa could be a discriminatory marker between ITB and *** of the complement activation pathway in ITB suggests that pathogenetic mechanisms for ITB are similar to those of pulmonary *** CD,downregulation of PPARc was seen in colonic tissue,suggesting that restoratio

关键词： Crohn’s disease intestinal tuberculosis microarray gene expression profiling signaling pathway FOXP3 mRNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeted therapy of gastrointestinal stromal tumours

引用

World Journal of Gastrointestinal Surgery 2016年第5期8卷 345-352页

作者： Ashish Jakhetiya Pankaj Kumar garg Gaurav Prakash Jyoti Sharma Rambha Pandey Durgatosh Pandey Department of Surgical Oncology Dr BRA Institute Rotary Cancer HospitalAll India Institute of Medical Sciences Department of Surgery University College of Medical Sciences and Guru Teg Bahadur HospitalUniversity of Delhi Clinical Hematology and Bone Marrow Transplant Unit Department of Internal MedicinePost-Graduate Institute of Medical Education and Research Department of Radiation Oncology Dr BRA Institute Rotary Cancer HospitalAll India Institute of Medical Sciences

Gastrointestinal stromal tumours(GISTs) are mesen-chymal neoplasms originating in the gastrointestinal tract, usually in the stomach or the small intestine, and rarely elsewhere in the abdomen. The malignant potential of GISTs is variable ranging from small lesions with a benign behaviour to fatal sarcomas. The majo-rity of the tumours stain positively for the CD-117(kit) and discovered on GIST-1(DOG-1 or anoctamin 1) expression, and they are characterized by the presence of a driver kinase-activating mutation in either kit or platelet-derived growth factor receptor α. Although surgery is the primary modality of treatment, almost half of the patients have disease recurrence following surgery, which highlights the need for an effective adjuvant therapy. Traditionally, GISTs are considered chemotherapy and radiotherapy resistant. With the advent of targeted therapy(tyrosine kinase inhibitors), there has been a paradigm shift in the management of GISTs in the last decade. We present a comprehensive review of targeted therapy in the management of GISTs.

关键词： Gastrointestinal tumors Molecular targeted therapy Protein kinase inhibitors Imatinib Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：