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Toward Carbon-Neutral Water s.s.ems.Ins.ghts.from Global Cities

Engineering 2022年第7期8卷 77-85页

作者： ka Leung Lam Gang Liu Anne Marieke Motelica-Wagenaar Jan Peter van der Hoek Divis.on of Natural and Applied s.iences Duke Kunshan UniversityKunshan 215316China Res.arch Center for Eco-Environmental s.iences Chinese Academy of SciencesBeijing 100085China Waternet Amsterdam 1096 ACNetherlands Department of Water Management Delft University of TechnologyDelft 2628 CNNetherlands

Many cities.have pledged to achieve carbon *** urban water indus.ry can als. contribute its.s.are to a carbon-neutral *** a multi-city time-s.ries.analys.s.approach,this.s.udy aims.to as.es. the progres. and les.ons.learned from the greenhous. gas.GHG)emis.ions.management of urban water s.s.ems.in four global cities.Ams.erdam,Melbourne,New york City,and *** cities.are advanced in s.tting GHG emis.ions.reduction targets.and reporting GHG emis.ions.in their water *** four cities.have reduced the GHG emis.ions.in their water indus.ries.compared with thos. from more than a decade ago(i.e.,the lates. three-year moving averages.are 13%–32%lower),although the emis.ions.have“rebounded”multiple times.over the *** emis.ions.reductions.were mainly due to various.engineering opportunities.s.ch as.s.lar and mini-hydro power generation,biogas.valorization,s.udge diges.ion and incineration optimization,and aeration s.s.em *** cities.have recognized the many challenges.in reaching carbon-neutrality goals.which include fluctuating water demand and rainfall,more carbon-intens.ve flood-prevention and water-s.pply s.rategies.meeting new air and water quality s.andards.and revis.ng GHG emis.ions.accounting *** s.udy has.als. s.own that it is.difficult for the water indus.ry to achieve carbon neutrality on its.own.A collaborative approach with other s.ctors.is.needed when aiming toward the city’s.carbon-neutrality *** an approach involves.expanding the us.al s.s.em boundary of the water indus.ry to externally tap into both engineering and non-engineering opportunities.

关键词： Urban water Greenhous. gas.emis.ions Cities Climate change mitigation Carbon neutrality

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Real-world performance analys.s.of a novel computational method in the precis.on oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodics.0} Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKis.éter Róbert Dóczi Dóra Lakatos.Anna Dirner Mátyás.Vidermann Péter Filotás.Réka s.alkai-Dénes.Is.ván s.egedi katalin Bartyik Kris.tina Míta Gábor Réka s.mon Péter Haus.r György Péter Cs.ngor Kis. Miklós.Garami Is.ván Peták Oncompas. Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Divis.on of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical s.iences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extens.ve molecular profiling of pediatric tumors.is.a matter of debate due to the high number of genetic alterations.of unknown s.gnificance or low evidence and the lack of s.andardized and pers.nalized decis.on s.pport *** drug as.ignment(DDA)is.a novel computational method to prioritize treatment options.by aggregating numerous.evidence-bas.d as.ociations.between multiple drivers.targets.and targeted *** has.been validated to improve pers.nalized treatment decis.ons.bas.d on the outcome data of adult patients.treated in the s.IVA01 clinical *** aim of this.s.udy was.to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-ris. pediatric cancer patients.years.were involved in our precis.on oncology program,and s.mples.from 100 patients.were eligible for further *** or blood s.mples.were analyzed by whole-exome(WEs.or targeted panel s.quencing and other molecular diagnos.ic modalities.and proces.ed by a s.ftware s.s.em us.ng the DDA algorithm for therapeutic decis.on ***,a molecular tumor board(MTB)evaluated the res.lts.to provide therapy *** Of the 100 cas.s.with comprehens.ve molecular diagnos.ic data,88 yielded WEs.and 12 panel s.quencing *** identified matching off-label targeted treatment options.actionability)in 72/100 cas.s.72%),while 57/100(57%)s.owed potential drug *** reached 88%(29/33)by 2020 due to the continuous.updates.of the evidence *** approved the clinical us. of a DDA-top-lis.ed treatment in 56 of 72 actionable cas.s.78%).The approved therapies.had s.gnificantly higher aggregated evidence levels.AELs.than dis.is.ed *** of WEs.res.lts.for targeted panels.mis.ed important mutations.affecting therapy *** DDA is.a promis.ng approach to overcome challenges.as.ociated with the interpretation of extens.ve molecular profiling in the routine car

关键词： Computational decis.on s.pport Pediatric tumors Precis.on oncology Tumor board

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期刊生产率分布动态特性的定量研究

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国外情报科学 1994年第3期12卷 47-56页

作者： Ves.a,ov 俞培果

本文在一个扩展的时间区间上,考察分布曲线与数据内部结构特征之间的关系,发现分布曲残形态随时间变化,并且趋向为“s.形,是因为数据内部结构变化所致。在经验数据的分析中,使用了把收集数据的时域划分为若干子时域,从而把所取得的数... 详细信息

本文在一个扩展的时间区间上,考察分布曲线与数据内部结构特征之间的关系,发现分布曲残形态随时间变化,并且趋向为“s.形,是因为数据内部结构变化所致。在经验数据的分析中,使用了把收集数据的时域划分为若干子时域,从而把所取得的数据襄划分为若干子数据桌的方法。

关键词：期刊生产率分布曲线定量研究

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Formation of Edge Trans.ort Barriers.by L-H Trans.tion and Large Revers.d Plas.a Current on LHD

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Plas.a s.ience and Technology 2006年第1期8卷 5-9页

作者： K. TOI s. OHDACHI F. WATANABE K. NARIHARA T. MORIs.KI 高翔 M. GOTO K. IDA s. MAs.ZAKI K. MIyAZAWA s. MOR.ITA s. s.kaKIBARA K. TANAka T. TOKUZAWA K.W. WATANABE 严龙文 M. yOs.INUMA National Ins.itute for Fus.on s.ience Toki Japan Department of Energy s.ience and Engineering Nagoya University Nagoya Japan Ins.itute of Plas.a Phys.cs Chinese Academy of Science Hefei 230031 China s.uthwes.ern Ins.itute of Phys.cs Chengdu 610041 China

On the Large Helical Device （LHD） where nes.ed magnetic s.rfaces.are s.rrounded by the ergodic field layer, edge trans.ort barrier （ETB） was.produced in neutral-beam-injection （NBI） heated plas.as.through trans.tion and non-trans.tion proces.es. The former cas. is.the ETB formation by L-Htrans.tion, where characteris.ics.of L-H trans.tion obs.rved in a tokamak plas.a are clearly recognized. The confinement improvement is.the modes. （- 10%）, compared with the Is.95 international s.ellarator s.aling. The thres.old power for the trans.tion is.comparable or s.ightly lower than the ITER s.aling law es.ablis.ed by tokamaks.and compact tori. The ETB is.formed ins.de the ergodic field layer of the vacuum field. The ETB formation des.abilizes.edge coherent modes.s.ch as.m/n = 1/1, 2/3 and 1/2, of which rational s.rfaces.are in the magnetic hill. The formed ETB is.partially and trans.ently des.royed by thes. coherent edge MHD modes.and edge localized modes.（ELMs. typically obs.rved in Ha s.gnals. The latter ETB is.obs.rved in a plas.a with large revers.d NBI-driven current more than 100 ka at Bt = 1 T. In thes. plas.as. the edge magnetic s.ear is.enhanced by the current and the rotational trans.orm in the core region is.expected to be appreciably reduced. Thus.reduced rotational trans.orm in the plas.a central region will enhance outward heat and particle fluxes.toward ergodic edge layer. The ETB with s.eep electron temperature gradient up to - 5 keV/m is.formed by blocking enhanced outward heat flux.

关键词： edge trans.ort barrier ergodic field layer L-H trans.tion ELMs edge MHD modes

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s.LID s.ATE PROPERTIEs.AND LEACHING OF MECHANICALLy ACTIVATED TETRAHEDRITE

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Acta Metallurgica s.nica(Englis. Letters. 1994年第2期7卷 79-83页

作者： BAL■P ACHIMovI■ovM s.PLAKV BAs.LZ LIPAKJ

The mechanical activation of tetrahedrite Cu_(12)s._(4)s.(13) was.carried out in a planetary mill. The changes.in the s.rface and bulk properties.produced in mineral by mechanical activation were detected by infrared, photoelectron and Mos.bauer s.ectros.opy. The rate and s.lectivity of tetrahedrite acid leaching depends.on conditions.of mechanical activation.

关键词： mechanical activation leaching tetrahedrite

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Non-Diabetic Nephropathies.among Diabetic Patients.of the Nephrology Department of Dakar

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Open Journal of Nephrology 2019年第2期9卷 41-48页

作者： Mame s.lly Diawara M. M. Cis.e N. Keita y. kane s. Mahmoud A. T. Lemrabott M. A. Faye s. Diagne F. ka A. Niang B. Diouf Nephrology Department of Regional Hos.ital of Thies Thies Senegal Nephrology Department of Teaching Hos.ital Le Dantec Dakar Senegal Nephrology Department of Regional Hos.ital of Zinguinchor Zinguinchor Senegal

Introduction: Diabetic nephropathy is.the mos. common caus. of kidney dis.as. in diabetics. However, in s.me cas.s.the clinical s.mptoms.is.not typical and nephropathy may be different from diabetic and require the us. of renal biops. (RB) which is.not us.ally indicated unles. non-diabetic nephropathy (NND) is.s.s.ected. The objective of this.s.udy was.to evaluate the prevalence of non-diabetic nephropathy (NDN) among the diabetic patients.and to analys. the different predictive factors.of its.occurrence. Patients.and methods. It was.a retros.ective, des.riptive and analytical s.udy which is.carried out at the nephrology department of Aris.ide Le DANTEC hos.ital of Dakar over a period of 60 months. Diabetics.with s.s.ected NDN diagnos.s.bas.d on renal anomalie that is.as.ociated with a recent diabetes. Acute renal failure with rapid progres., Diabetic retinopathy’s.abs.nce, and Extrarenal s.gns.(cutaneous. diges.ive and articular) as.ociated with an acute renal failure. Micros.opic haematuria was.included. The epidemiological, clinical, biological and his.ological parameters.were collected and analys.d us.ng the s.s., 3.5 vers.on s.ftware. Res.lts. Out of 34 biops.ed diabetic patients. 12 had NDN that is.a prevalence of 35, 3%. The average age was.49.88 ± 4.15 years. 0.78 for the s.x-ratio and the mean duration of diabetes.is.12.53 ± 4.7 years. Glomerular s.ndrome was.found in 30 patients.(88.23%), vas.ular nephropathy s.ndrome in 3 patients.(8.82%) and tubule-inters.itial nephropathy s.ndrome in only one patient (2.94%). Diabetic retinopathy (DR) and micros.opic haematuria (HU) res.ectively exis.ed in 10 patients.(34%) and 15 patients.(44. 12%). The Kidney biops. (KB) indications.were renal abnormalities.as.ociated with recent diabetes. acute renal failure with rapid progres., abs.nce of DR, extrarenal s.gns.as.ociated with acute renal failure and micros.opic haematuria. Twenty-two patients.(64.7%) had diabetic nephropathy (DN) and 12 patients.(38.2%) pres.nted a N

关键词： Diabetes Diabetic Nephropathy Non-Diabetic Nephropathy Dakar

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Health Emergency and Dis.s.er Ris. Management (Health-EDRM) in Remote Ethnic Minority Areas.of Rural China:The Cas. of a Flood-Prone Village in s.chuan

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International Journal of Dis.s.er Ris. s.ience 2017年第2期8卷 156-163页

作者： Emily ying yang Chan Chunlan Guo Poyi Lee s.da Liu Carman ka Man Mark Collaborating Centre for Oxford Univers.ty and CUHK for Dis.s.er and Medical Humanitarian Res.ons. (CCOUC) The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford FXB Centre of Health and Human Rights Harvard University

Remote,rural ethnic-minority communities.face greater dis.s.er-related public health ris.s.due to their lack of res.urces.and limited acces. to health *** Ethnic Minority Health Project(EMHP) was.initiated in 2009 to work with remote,dis.s.er-prone ethnic-minority villages.that live in extreme *** of the project's.aims.is.to develop and evaluate bottom-up health ris. reduction efforts.in emergency and dis.s.er ris. management(HealthEDRM).This.article s.ares.project updates.and des.ribes.field intervention res.lts.from the yi ethnic community of Hongyan village in China's.s.chuan Province,an area that experiences.recurrent *** was.found that 64% of the village res.ondents.had never cons.dered any form of dis.s.er preparation,even with the recurrent flood *** intervention participants.s.owed s.s.ained knowledge retention and were nine times.more likely to know the correct compos.tion of oral rehydration s.lution(ORs. after the *** als. retained the improved knowledge on ORs.and dis.s.er preparednes. kit owners.ip12 months.after the intervention.

关键词： Dis.s.er preparednes. kit Dis.s.er ris. reduction Ethnic minority Health emergency and dis.s.er ris. management (Health-EDRM) Oral rehydration s.lution Recurrent floods Rural China

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Voltage-gated K^+channels.promote BT-474 breas. cancer cell migration

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Chines. Journal of Cancer Res.arch 2018年第6期30卷 613-622页

作者： Louis.WC Chow ka-s.un Cheng kar-Lok Wong yuk-Man Leung s.ate Key Laboratory of Quality Res.arch in Chines. Medicines Macao University of Science and TechnologyTaipaMacao 999078China UNIMED Medical Ins.itute Hong Kong 999077China Organis.tion for Oncology and Trans.ational Res.arch Hong Kong 999077China Department of Anes.hes.ology China Medical University HospitalTaiehung 40447TaiwanChina Department of Anes.hes.ology the Qingdao University Yuhuangding HospitalYantai 264000China Department of Phys.ology China Medical UniversityTaichung 40402TaiwanChina

Objective: A variety of ion channels.have been implicated in breas. cancer proliferation and *** K+(Kv) channels.not only caus. repolarization in excitable cells.but are als. involved in multiple cellular functions.in non-excitable *** this.s.udy we inves.igated the role of Kv channels.in migration of BT474 breas. cancer ***: Trans.ell technique was.us.d to s.parate migratory cells.from non-migratory ones.and thes. two groups.of cells.were s.bject to electrophys.ological examinations.and microfluorimetric meas.rements.for cytos.lic *** migration was.examined in the abs.nce or pres.nce of Kv channel ***: When compared with non-migratory cells.migratory cells.had much higher Kv current dens.ties.but rather unexpectedly,more depolarized membrane potential and reduced *** trans.riptas.polymeras. chain reaction(RT-PCR) analys.s.revealed the pres.nce of Kv1.1,Kv1.3,Kv1.5,Kv2.1,Kv3.3,Kv3.4 and Kv4.3 *** migration was.markedly inhibited by tetraethylammonium(TEA),a delayed rectifier Kv channel blocker,but not by 4-aminopyridine,an A-type Kv channel ***: Taken together,our res.lts.s.ow that increas.d Kv channel expres.ion played a role in BT474 cell migration,and Kv channels.could be cons.dered as.biomarkers.or potential therapeutic targets.for breas. cancer *** mechanis.(s. by which Kv channels.enhanced migration appeared unrelated to membrane hyperpolarization and Cainflux.

关键词： Breas. cancer Kv channels migration biomarkers

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中医药在干燥综合征治疗中的应用

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中草药 2024年第10期55卷 3516-3528页

作者：刘维岳青云陈常青王爱华吴沅皞高晶月卫博文王怡文王文卡玉秀天津中医药大学第一附属医院天津300193 国家中医针灸临床医学研究中心天津300193 天津中医药大学天津301617 天津药物研究院天津300462

干燥综合征是一种慢性炎症性自身免疫病,多见于中老年女性,中医药对于该病的治疗有其独特的优势,且相关研究逐年增多,内治法涉及中药单体、中药提取物、中药复方,外治法涉及针刀、针刺、外敷等。通过从中医药基础和临床研究方面,对近年... 详细信息

干燥综合征是一种慢性炎症性自身免疫病,多见于中老年女性,中医药对于该病的治疗有其独特的优势,且相关研究逐年增多,内治法涉及中药单体、中药提取物、中药复方,外治法涉及针刀、针刺、外敷等。通过从中医药基础和临床研究方面,对近年来中医药治疗原发性干燥综合征的研究进展进行综述,为探索更加全面有效的中医药治疗方案提供依据。

关键词：干燥综合征中药单体中药提取物中药复方外治法中医药治疗基础研究临床研究

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The effect of downs.ream res.s.ance on flow diverter treatment of a cerebral aneurys. at a bifurcation: A joint computational-experimental s.udy

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Journal of Hydrodynamics 2018年第5期30卷 803-814页

作者： ANDers.n C.O.Ts.ng Billy y.s.yiu Abraham y.s.Tang W.C.Chung Gilberto K.K.Leung AlexANDer K.K.Poon Alfred C.H.yu s.mon s.M.Lai K.W.Chow Department of s.rgery Li Ka Shing Faculty of Medicine University of Hong Kong Department of Electrical and Computer Engineering University of Waterloo Department of Mechanical Engineering University of Hong Kong Department of Electrical and Electronic Engineering University of Hong Kong

Intracranial aneurys. can lead to hemorrhagic s.roke upon rupture. Deployment of flow diverters.can res.rict the blood flow into aneurys. and mitigate the rupture ris.. Computational fluid dynamics.CFD） and ultras.nography with puls.-wave and color Doppler ultras.und meas.rements.were employed jointly to inves.igate the complex flow pattern in cerebral aneurys.s. both before and after the deployment of flow diverters. Patient-s.ecific configurations.of both bifurcation and s.de-wall aneurys.s.were s.lected. The effect of downs.ream flow res.s.ance was.inves.igated by adjus.ing the volume flow rate and pres.ure at the outlet ves.els.computationally and experimentally. Velocity profiles.in the aneurys. meas.red from ultras.nography s.owed good agreement with thos. from computer s.mulations. The dis.repancy in velocity between the computational and experimental s.ts.of data is.les. than 10%. The downs.ream res.s.ance can alter the volume flux into a bifurcation aneurys. with a flow diverter deployed by 236%, while the corres.onding value of a s.de-wall aneurys. is.negligible. The vorticity of the aneurys.al flow was.reduced by more than 80% in both cas.s.after s.enting. This.s.udy demons.rated that careful inves.igation of downs.ream flow res.s.ance of a bifurcation aneurys. is.es.ential to provide an accurate as.es.ment of the aneurys.al flow dynamics.after flow diverter deployment.

关键词： Intracranial aneurys.s computational fluid dynamics.(CFD) doppler ultras.und

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