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S-acylation of YKT61 modulates its unconventional participation in the formation of SNARE complexes in Arabidopsis

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Journal of Genetics and Genomics 2024年第10期51卷 1079-1088页

作者： Ting ma Jun-Ru Tan Jin-Yu Lu sha Li Yan Zhang College of Life Sciences Shandong Agricultural UniversityTaianShandong 271018China Frontiers Science Center for Cell Responses College of Life SciencesNankai UniversityTianjin 300071China

Hetero-tetrameric soluble N-ethylmaleimide-sensitive factor attachment protein receptors(SNAREs)complexes are critical for vesicle-target membrane fusion within the endomembrane system of eukaryotic *** assembly involves four different SNARE motifs,Qa,Qb,Qc,and R,providedby three orfour SNARE ***6 is an atypical R-SNARE that lacks a transmembrane domain and is involved in multiple vesicle-target membrane *** YKT6 is evolutionarily conserved and essential,its function and regulation in different phyla seem *** YKT61,the yeast and metazoan YKT6 homologue,is essential for gametophytic development,plays a critical role in sporophytic cells,and me-diates multiple vesicle-target membrane ***,its molecular regulation is *** report here that YKT61 is *** its S-acylation by a C195S mutation dissociates YKT61 from endomembrane structures and causes its functional *** interacting with various SNARE pro-teins,YKT61functions not as a canonical R-SNAREbut coordinates with otherR-SNAREs to participate in theformationof ***-specific molecular regulation of YKT6 may be evolvedto allow more efficient SNARE assembly in different eukaryotic cells.

关键词： Longin domain S-acylation Vesicle trafficking R-SNARE Arabidopsis thaliana

magnetic resonance cholangiopancreatography for the detection of pancreatic duct stones in patients with chronic pancrea.itis

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World Journal of Gastroenterology 2009年第20期15卷 2543-2546页

作者： Zhen-Hua ma Qing-Yong ma Huan-Chen sha Sheng-Li Wu Jun Wen Department of Hepatobiliary Surgery the First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM:To assess the role of magnetic resonance cholangiopancreatography(MRCP) in detection of pancreatic duct stones(PDS) in patients with chronic pancrea.itis(CP).METHODS:Clinical data of 78 CP patients who were treated at the First Affi liated Hospital of Xi'an Jiaotong University(China) between January 2004 and July 2008 were retrospectively analyzed.A predictive model of pancreatic duct stones was established through logistic regression and its effectiveness was verifi *** these patients, MRCP was performed in 60 patients who served as a control group, while 44 patients with a higher predictive value than the entry threshold of the predictive model served as an experimental ***:The positive rate of PDS in the 78 patients with CP was 19.2%(15/78).The predictive entry threshold of the predictive model was 5%(P rance(IGT) and positive B-mode ultrasound *** incidence of PDS in the experimental group was higher than that in the control group(P itive B-mode ultrasound results.

关键词： Chronic pancrea.itis Pancreatic duct stone magnetic resonance cholangiopancreatography B-mode ultrasound Logistic regression

Multiplexing metal grating coupler based on MIM structure

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Optoelectronics Letters 2025年

作者： LIU Yang LIU Fei ma Yunxia ZHANG Ailing Engineering Research Center of Communication Devices and Technology， Ministry of Education， Tianjin Key laboratory of Film Electronic and Communication Devices， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

We propose and numerically investigate a multiplexing metal grating coupler based on metal/insulator/metal （MIM） structure. The coupler consists of gold grating/silicon/gold layers， which combines with MIM waveguide， concurrently achieving path multiplexing and wavelength multiplexing through TMnmodes coupling. In visible light band， TM waves are coupled to the upper surface of gold plate， and the coupling efficiency reaches maximum of 31.67% at wavelength of 736 nm. In near infrared and mid infrared bands， TM waves are coupled into MIM waveguide， and the coupling efficiency reaches maximum of 53.57% at wavelength of 2550 nm. There can be four modes of TM0， TM1， TM2and TM3simultaneously in MIM waveguide， which are excited at different wavelengths. The preparation process of the structure designed in this article is simple， with dimensions at the micrometer level， easy to be integrated， and can be applied to be integrated optical circuits.

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High performance strain sensor based on leather activated by micro-cracking conductive layer

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Collagen and Leather 2023年第4期5卷 76-87页

作者： Jianzhong ma Zhijie Cheng sha Tan Tian Zheng Yan Zong College of Bioresources Chemical and materials Engineering Shaanxi University of Science and TechnologyXi'an 710021China Xi'an Key laboratory of Green Chemicals and Functional materials Xi'an 710021China materials Characterization and Fabrication Platform Department of Chemical EngineeringUniversity of MelbourneParkvilleMelbourne 3010Australia

Flexible strain sensors are capable to detect external force induced strain change owing to their unique ability to convert deformation into electrical ***,micro/nano patterning of conductive layer in strain sensor is an effective method to improve its sensitivity,however the sophisticated manipulation process is limited only in laboratory *** this report,a simple and scalable fabrication strategy was used to create micro-cracking conductive layer as an alternative patterning method to achieve high performance of strain *** details,the sensor was fabricated using leather as the substrate to filtrated acidified multi-walled carbon nanotubes(a-MWCNTs)/layered double hydroxides(LDHs)*** stretching process,micro-cracking structure emerged on the percolated a-MWCNTs/LDHs layer,causing a rise up of resistance according to increasing strain and generated a detectable electrical *** prepared sensor had a large detecting range(60%),high sensitivity(GF of 7238.92 at strain 30-60%),fast response(tensile response time of 270 ms),good stability and *** sensor also inherited the advantages of leather,such as biodegradability and good air permeability,and the introduction of a-MWCNTs/LDHs further enhanced its fire retardancy *** features ensured the sensor as an eco-friendly,comfortable and safe electronic device for human motion detection.

关键词： a-MWCNTs LDHs Leather Flexible strain sensor

Steel surface defect detection based on lightweight YOLOv7

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Optoelectronics Letters 2025年

作者： Shi Tao Wu Rongxin Zhu Wenxu ma Qingliang School of Electrical Engineering and Automation， Tianjin University of Technology North China University of Science and Technology， College of Electrical Engineering Guangzhou Institute of Measurement and Testing Technology

Aiming at the problems of low detection efficiency and difficult positioning of tra.itional steel surface defect detection methods， a lightweight steel surface defect detection model based on YOLOv7 is proposed. First， a CSS Block module is proposed， which uses more lightweight operations to obtain redundant information in the feature map， reduces the amount of computation， and effectively improves the detection speed. Secondly， the improved SPPCSPC structure is adopted to ensure that the model can also pay attention to the defect location information while predicting the defect category information， obtain richer defect features. In addition， the convolution operation in the original model is simplified， which significantly reduces the size of the model and helps to improve the detection speed. Finally， using EIOU Loss to focus on high-quality Anchors， speed up convergence and improve positioning accuracy. Experiments were carried out on the NEU-DET steel surface defect dataset. Compared with the original YOLOv7 model， the number of parameters of this model was reduced by 40%， the FPS reached 112， and the average accuracy reached 79.1%.， the detection accuracy and speed have been improved， which can meet the needs of steel surface defect detection.

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Fully integrated modeling of surface water and groundwater in coastal areas

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Journal of Hydrodynamics 2018年第3期30卷 441-452页

作者： sha Lou Shu-guang Liu Gangfeng ma Gui-hui Zhong Bo Li Department of Hydraulic Engineering Tongji University Shanghai 200092 China Key laboratory of Yangtze River Water Environment Ministry of Education Tongji University Shanghai 200092 China Department of Civil and EnvironmentalEngineering Old Dominion University Norfolk VA USA School of Engineering Nagasaki University Nagasaki Japan

This paper presents an improved model based on a three-dimensional non-hydrostatic wave model NHWAVE to simulate the interactions between the surface water and the groundwater affected by tides or waves in coastal areas. With the model, both the surface water flow and the groundwater flow are calculated based on the well-balanced Volume-averaged Reynolds-averaged Navier-Stokes equations. The spatially varying porosity and hydraulic conductivity are used to identifiy the domains for the surface water and the groundwater. The model is calibrated and validated using a wide range of laboratory measurements reported in the literature, involving the tide propagation through a sandy embankment, the tide-induced groundwater table fluctuation in a sandy beach, and the wave setup in a sloping sandy beach. The interactions between the surface water and the groundwater are analyzed and the influencing factors on the groundwater flow are discussed. The phase lag between the surface water elevation and the groundwater table fluctuation is mainly influenced by the hydraulic conductivity of the porous media. The wave attenuation in the groundwater is proportional to its propagation distance. The computed wave setup elevationin the permeable beach is smaller than in the impermeable beach. It is shown that the fully integrated model is capable of simulating the interactions between the surface water and the groundwater affected by tides or waves in coastal areas. It can be an efficient tool to study the tide and wave dynamics in the permeable sandy beach.

关键词： Non-hydrostatic model surface water and groundwater interactions wave setup porous media

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基于仿真方法的共享换电站价值量化分析

北京工业大学学报 2025年第1期51卷 22-31页

作者：沙玲汪静张海峰王岱上海工程技术大学机械与汽车工程学院上海201620 上海蔚来汽车有限公司上海201800

相较于电动汽车充电站,换电站具有补能时间短、空间面积小等优点。多品牌电动汽车高效共享换电站,能够极大程度优化补能结构,减少资源浪费。为了量化共享换电站对电动汽车用户的价值,基于排队理论,利用蔚来汽车品牌的运行数据,搭建一个... 详细信息

相较于电动汽车充电站,换电站具有补能时间短、空间面积小等优点。多品牌电动汽车高效共享换电站,能够极大程度优化补能结构,减少资源浪费。为了量化共享换电站对电动汽车用户的价值,基于排队理论,利用蔚来汽车品牌的运行数据,搭建一个模拟用户换电行为的仿真器,通过量化用户的平均排队时间和换电站数量,评估电动汽车用户在不同电动汽车规模和换电站渗透率下的换电体验。结果表明,电动汽车品牌共享换电站资源,能够显著减少电动汽车用户的排队时间,以及将排队时间保持在期望阈值内所需的换电站数量,从而提高用户的充电体验并节省换电站建设成本。

关键词：电动汽车换电站共享排队论换电体验仿真

Genome editing in cancer:Challenges and potential opportunities

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Bioactive materials 2023年第3期21卷 394-402页

作者： dor Breier Dan Peer laboratory of Precision Nanomedicine Shmunis School of Biomedicine and Cancer ResearchGeorge S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Department of materials Sciences and Engineering Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel AvivIsrael Center for Nanoscience and Nanotechnology Tel Aviv UniversityTel AvivIsrael Cancer Biology Research Center Tel Aviv UniversityTel AvivIsrael

Ever since its mechanism was discovered back in 2012,the CRISPR/Cas9 system have revolutionized the field of genome *** at first it was seen as a therapeutic tool mostly relevant for curing genetic diseases,it has been recently shown to also hold the potential to become a clinically relevant therapy for ***,there are multiple challenges that must be addressed prior to clinical ***,the safety of the system when used for in-vivo therapies,including off-target activity and the effects of the double strand break induction on genomic ***,we will focus on the inherent challenges in the CRISPR/Cas9 system and discuss various opportunities to overcoming these challenges.

关键词： Genome editing CRISPR/Cas systems Cancer therapy Off-target activity

Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton

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Science China Life Sciences 2025年

作者： Yanlong Li Yinuo Fu Yaoyao Li Rui Zhang Jing Yang Huanhuan ma Ling Min Xianlong Zhang National Key laboratory of Crop Genetic Improvement Huazhong Agricultural University

High temperature (HT) stress causes male sterility,leading to reduced upland cotton ***,we identified a key gene,Casein Kinase I (GhCKI),that negatively regulates male fertility in upland cotton under ***,conventional genetic manipulations of GhCKI would result in male sterility,hindering its utilization in breeding ***,we engineered quantitative variation for anther thermotolerance-related traits in upland cotton by creating weak promoter alleles of GhCKI genes,using CRISPR/Cas9 and CRISPR/Cpf1genome ***,we screened and identified two new upland cotton plant lines exhibiting a HT-tolerant phenotype with edited GhCKI promoters,and characterized their corresponding heat-tolerant allelic *** research revealed that the primary reason for the HT tolerance of the GhCKI promoter editing mutants is that the trans-acting factors GhMYB73 and GhMYB4,which positively regulate GhCKI expression under HT,failed to bind and activate the expression of ***,our study not only provides a rapid strategy to generate new beneficial alleles but also offers novel germplasm resources and molecular insights for crop HT tolerance breeding.

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