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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi srivastava Aparna Misra Snober S.Mir Department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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基于社区的气候变化适应方法与高海拔Garhwal喜马拉雅山脉Bhagirathi地区的生计安全

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Journal of Resources and Ecology 2024年第1期15卷 197-203页

作者： Shoryabh srivastava Bindhy Wasini PANDEY Virender Singh NEGI 德里大学经济学院地理系印度德里110007 德里大学莎希德·巴加特·辛格学院地理系(E) 印度德里110017

位于Garhwal喜马拉雅山的Bhagirathi(HA-BV)谷地是一个生态和文化重要性极高的地区,但当地居民的生计容易受到气候变化的影响。基于社区的气候变化适应方法(CB-CCA)已成为一种增强地方社区的经济和社会福祉重要策略,并提高了社区发展的... 详细信息

位于Garhwal喜马拉雅山的Bhagirathi(HA-BV)谷地是一个生态和文化重要性极高的地区,但当地居民的生计容易受到气候变化的影响。基于社区的气候变化适应方法(CB-CCA)已成为一种增强地方社区的经济和社会福祉重要策略,并提高了社区发展的韧性。本文旨在研究HA-BV地区的CB-CCA和生计保障计划,关注应对气候变化所面临挑战的策略。研究认为优先考虑适应该地区崎岖的地形和恶劣的天气条件的可持续生计选择至关重要。例如,与山谷独特的土壤和气候动态相适应,推广温室种植和农林复合种植等替代农业,可能会带来较好的结果;此外,鼓励养蜂、手工艺和生态旅游等替代生计途径不仅可以创收,还能保护该地区的自然环境。为了鼓励当地居民实施这些环境友好的生计措施,政府和利益相关者需要进行战略性投资,基础设施的完善(包括道路建设和电力供应)可为经济增长创造良好的条件。研究结果可为喜马拉雅山地区的可持续发展做出贡献,为类似情境下未来构建气候韧性和保障生计的努力提供参考。

关键词： Bhagirathi谷基于社区的方法气候变化适应生计保障 Garhwal喜马拉雅山

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From source to emplacement:The origin of leucogranites from the Sikkim-Darjeeling Himalayas,India

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Geoscience Frontiers 2024年第1期15卷 384-401页

作者： Tanya srivastava Nigel Harris Catherine Mottram Kumar Batuk Joshi Nishchal Wanjari Department of Geology Sikkim UniversityGangtokIndia School of Environment Earth&Ecosystem SciencesOpen UniversityMiltonKeynesUK School of the Environment Geography and GeosciencesUniversity of PortsmouthUK National Centre for Earth Science Studies ThiruvananthapuramKeralaIndia

Himalayan leucogranites are important for understanding the tectonic evolution of collision zones in general and the causes of crustal melting in the Himalayan orogen in *** paper aims to understand the melt source and emplacement age of the leucogranites from Sikkim in order to decipher the deep geodynamic processes of the eastern *** U-Pb analysis of the Higher Himalayan Sequence(HHS)metamorphic core reveals a prolonged period of crustal melting between>33 Ma and ca.14 *** and trace element abundances are presented for 27 leucogranites from North Sikkim that are classified into two-mica and tourmaline leucogranite *** are peraluminous in composition,characterized by high SiO2(70.91-74.9 wt.%),Al2O3(13.69-15.82 wt.%),and low MgO(0.13-0.74 wt.%).Elemental abundances suggest that Sikkim Himalayan leucogranites are derived from crustal *** two-mica leucogranites are derived from a metagreywacke source,whereas the tourmaline leucogranites are sourced from metapelitic sources,with inherited zircons indicating an HHS origin for both types.U-Pb zircon geochronology of the two mica leucogranites indicates ages of ca.19-15 Ma,consistent with crustal melting recorded in HHS gneisses from *** from both the two-mica and tourmaline leucogranites yield a crystallization age of ca.15-14 Ma,coeval with movement on the Main Central Thrust and South Tibetan Detachment System which further provides constraints on the timing and mechanism of petrogenesis of leucogranites in the Sikkim Himalayas.

关键词： Leucogranites Gneiss U-Pb geochronology Zircon Monazite Sikkim-Darjeeling Himalayas

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One-Pot Green Synthesis of 1, 4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by Solvent Free Method

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Open Journal of Composite Materials 2024年第3期14卷 109-123页

作者： Deepak Babasaheb Phasage Sanjay K. Sharma Balram Tripathi Sonia Chahar srivastava Department of Chemistry JECRC University Jaipur India S. S. Jain Subodh PG College Jaipur India

This study used a Polyindole in combination with TiO2 nanocatalyst as an efficient heterogeneous catalyst to carry out a multi-component Hantzsch reaction involving different aromatic aldehydes with methyl acetoacetate, and aqueous ammonium to create 1,4-dihydropyridine derivatives under solvent free condition at ambient temperature. A broad range of aldehydes and methyl acetoacetates, ranging from heteroaromatic to polyaromatic one, with high level of functional group tolerance can be used to provide the desired products possessing relevant medicinal moiety in high yields. This technology has prospective advantages over current protocols, including the utilization of a cheap, stable, recyclable, and safe catalyst, quicker reaction times with higher yields and simple product isolation.

关键词： TiO2 Nanocatalyst Green Synthesis Surface Morphology

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Parents’s knowledge and awareness about hepatitis B can influence the vaccination of their children

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World Journal of Virology 2024年第2期13卷 96-106页

作者： Nanda Chhavi Geetika srivastava Mariya Waseem Abhishek Yadav Surender Singh Rajani Singh Amit Goel Department of Paediatrics Era’s Lucknow Medical CollegeLucknow 226003Uttar PradeshIndia Medical Consultant National Disease Control ProgramNational Health MissionLucknow 226003Uttar PradeshIndia Department of Hepatology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

BACKGROUND Birth-dose(Hep-BD)followed by three additional doses(Hep-B3)of hepatitis B virus(HBV)vaccine are key to eliminating HBV by ***,Hep-BD and Hep-B3 coverage in our country is *** To studied the parent’s knowledge and awareness about HBV infection,its prevention,consequences and *** Parents of 6 months to 8 years old children were interviewed to assess their knowledge&awareness about hepatitis B,its transmission,prevention,illness caused by this,and *** close-ended questions were admini-stered,and responses were recorded as‘yes’,‘no’,or‘not sure’.HBV knowledge score was calculated based on the sum of correct *** correct response scored one point and incorrect,missing or‘not sure’responses received no *** data are presented as number(%)and numerical data are expressed as *** were compared using Chi2 tests and level of significance was kept as P<*** Parents(58.3%mothers)of 384 children(89.9%age<5 years;82%age-appropriately vaccinated)were *** hundred and twenty-two(83.9%)children were Hep-B3 vaccinated.94.3%,87.5%,and 29.2%parents knew about polio,tetanus,and hepatitis B ***,41.2%,15.8%,and 23%parents knew about hepatitis B transmission,consequences of infection,and prevention *** 7.6%parents knew about three-dose schedule of hepatitis B *** 23%parents believed that vaccine could prevent HBV,15.7%knew that HBV affects *** of Hep-B3 vaccinated children were significantly more aware about HBV than the parents of unvaccinated children(P<0.05 for 17/18 questions).CONCLUSION The knowledge and awareness among the parents about hepatitis B is *** Increasing knowledge/awareness about HBV among parents may improve Hep-B3 vaccination coverage.

关键词： Hepatitis B Viral hepatitis Cirrhosis Hepatocellular carcinoma Hepatotropic viruses Transfusion transmitted infection Mother to child transmission

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Refinement of the Proposed Gamma-Ray Burst Time Delay Model

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International Journal of Astronomy and Astrophysics 2024年第2期14卷 120-147页

作者： Godson Fortune Abbey Joseph Simfukwe Prospery Christopher Simpemba Saul Paul Phiri Alok srivastava Golden Gadzirayi Nyambuya Department of Physic School of Mathematics and Natural Sciences The Copperbelt University Kitwe Republic of Zambia Fundamental Theoretical and Research Group Department of Applied Physics Faculty of Applied Sciences National University of Science & Technology Bulawayo Republic of Zimbabwe

This paper is the second instalment in our study of the observed time delay in the arrival times of radio photons emanating from Gamma Ray Bursts (GRBs). The mundane assumption in contemporary physics as to the cause of these pondersome time delays is that they are a result of the photon being endowed with a non-zero mass. While we do not rule out the possibility of a non-zero mass for the photon, our working assumption is that the major cause of these time delays may very well be that these photons are travelling in a rarefied cosmic plasma in which the medium’s electrons interact with the electric component of the Photon, thus generating tiny currents that lead to dispersion, hence, a frequency-dependent speed of Light (FDSL). In the present instalment, we “improve” on the model presented in the first instalment by dropping the assumption that the resultant pairs of these radio photons leave the shock front simultaneously. The new assumption of a non-simultaneous— albeit systematic—emission of these photon pairs allows us to obtain a much more convincing and stronger correlation in the time delay. This new correlation allows us to build a unified model for the four GRBs in our sample using a relative distance correction mechanism. The new unified model allows us to obtain as our most significant result a value for the frequency equivalence of the interstellar medium (ISM)’s conductance ν* ~ 1.500 ± 0.009 Hzand also an independent distance measure to the GRBs where we obtain for our four GRB samples an average distance of: ~69.40 ± 0.10, 40.00 ± 0.00, 58.40 ± 0.40, and 86.00 ± 1.00 Mpc, for GRB 030329, 980425, 000418 and 021004 respectively.

关键词： Gamma-Ray Bursts (GRB) Photon Mass Plasma Time Delay Fireball Model

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支链氨基酸代谢在枫糖尿病中的作用

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中国优生与遗传杂志 2024年第2期32卷 221-227页

作者：胡莹莹 srivastava Vasundhara 刘云霞新加坡国立大学新加坡169857 复旦大学附属妇产科医院妇科上海200090

枫糖尿病(MSUD)也称支链酮酸尿症,它是由于一组支链α酮酸脱氢酶复合体(BCKDC)基因突变而引起BCKD复合体活性缺乏的常染色体隐性遗传的代谢紊乱疾病。MSUD患者中支链氨基酸(BCAA)代谢紊乱,导致血浆、组织和尿液中积累大量的支链氨基酸... 详细信息

枫糖尿病(MSUD)也称支链酮酸尿症,它是由于一组支链α酮酸脱氢酶复合体(BCKDC)基因突变而引起BCKD复合体活性缺乏的常染色体隐性遗传的代谢紊乱疾病。MSUD患者中支链氨基酸(BCAA)代谢紊乱,导致血浆、组织和尿液中积累大量的支链氨基酸和支链酮酸(BCKA)。MSUD患者主要临床表现为进行性神经功能恶化,伴有运动迟缓、共济失调、智力障碍和精神症状的病理生理学特征,其主要是由于氨基酸代谢失衡而导致脑中蛋白质和神经递质合成缺失。而高BCAA/BCKA水平大幅度加重神经系统症状,表明BCAA/BCKA具有神经毒性。目前大量来自人类和动物模型实验数据证实,BCAA/BCKA特别是亮氨酸和α-KIC在MSUD脑损伤的发病机制中起到非常重要的作用。这篇综述主要介绍BCAA/BCKA代谢紊乱在MSUD患者神经失调中起到的潜在病理机制。BCAA/BCKA代谢失调不仅影响其他中性氨基酸水平的显著下降从而减少蛋白质和神经递质合成,还导致线粒体中能量代谢失调从而影响脑的正常功能,这些病理机制可能导致MSUD患者的神经系统后遗症。我们希望通过了解MSUD具体的病理机制,为MSUD治疗提供新的治疗策略和药物靶点。

关键词：枫糖尿病支链氨基酸支链酮酸支链α酮酸脱氢酶复合体中性氨基酸

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Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 335-342页

作者： Kenneth W Chow Matthew T Bell Nicholas Cumpian Maryanne Amour Ryan H Hsu Viktor E Eysselein Neetika srivastava Michael W Fleischman Sofiya Reicher Department of Medicine Harbor-UCLA Medical CenterTorranceCA 90502United States Department of Bioengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoLa JollaCA 92093United States Department of Gastroenterology Harbor-UCLA Medical CenterTorranceCA 90502United States

BACKGROUND Improved adenoma detection rate(ADR)has been demonstrated with artificial intelligence(AI)-assisted ***,data on the real-world appli-cation of AI and its effect on colorectal cancer(CRC)screening outcomes is *** To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or *** AI software(GI Genius,Medtronic)was implemented into the standard proced-ure protocol in November *** was collected on patient demographics,procedure indication,polyp size,location,and *** screening outcomes were evaluated before and at different intervals after AI introduction with one year of *** We evaluated 1008 colonoscopies(278 pre-AI,255 early post-AI,285 established post-AI,and 190 late post-AI).The ADR was 38.1%pre-AI,42.0%early post-AI(P=0.77),40.0%established post-AI(P=0.44),and 39.5%late post-AI(P=0.77).There were no significant differences in polyp detection rate(PDR,baseline 59.7%),advanced ADR(baseline 16.2%),and non-neoplastic PDR(baseline 30.0%)before and after AI *** In patients with an increased pre-test probability of having an abnormal colonoscopy,the current generation of AI did not yield enhanced CRC screening metrics over high-quality *** the potential of AI in colonoscopy is undisputed,current AI technology may not universally elevate screening metrics across all situations and patient *** studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.

关键词： Artificial intelligence Colonoscopy Adenoma detection rate Screening Colorectal adenoma

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Synthesis and enhanced photoluminescence properties of red emitting divalent ion(Ca^(2+))doped Eu:Y_(2)O_(3)nanophosphors for optoelectronic applications

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Journal of Rare Earths 2022年第8期40卷 1187-1198页

作者： Arpita Dwivedi Monika srivastava Ankur Dwivedi Amit srivastava Anurag Mishra S.K.srivastava Department of Physics Institute of ScienceBanaras Hindu University(BHU)Varanasi221005India School of Materials Science and Technology Indian Institute of Technology(BHU)Varanasi221005India Department of Mining Engineering Indian Institute of Technology(BHU)Varanasi221005India Department of Physics TDPG College VBS Purvanchal UniversityJaunpur222001India

This work presents the synthesis of Y_(2)O_(3):Eu^(3+),χCa^(2+)(χ=0 mol%,1 mol%,3 mol%,5 mol%,7 mol%,9 mol%,11 mol%)nanophosphors with enhanced photoluminescence properties through a facile solution combustion method for optoelectronic,display,and lighting *** X-ray diffraction(XRD)patterns of the proposed nanophosphor reveal its structural properties and crystalline *** transmission electron microscope(TEM)results confirm the change in the shape of the particle and aggregation of particles after co-doping with Ca^(2+).Fourier transform infrared spectroscopy(FTIR)and Raman vibrations also confirm the presence of Y-O vibration and subsequently explain the crystalline nature,structural properties,and purity of the *** the synthesized nanophosphors samples emit intense red emission at 613 nm(~5D_(0)→~7 F_(2))under excitation with 235,394 and 466 nm wavelengths of Eu^(3+)*** photoluminescence(PL)emission spectra excited with 235 nm illustrate the highest emission peak with two other emission peaks excited with 466 and 394 nm that is 1.4 times higher than 466 nm and 1.9 times enhanced by 394 nm wavelength,*** emission intensity of Y_(2)O_(3):Eu^(3+),χCa^(2+)(5 mol%)is increased 8-fold as compared to Eu:Y_(2)O_(3).Doping with Ca^(2+)ions enhances the emission intensity of Eu:Y_(2)O_(3)nanopho sphors due to an increase in energy transfer in Ca^(2+)→Eu^(3+)through asymmetry in the crystal field and by introduction of radiative defect centers through oxygen vacancies in the yttria *** is also observed that the optical band gap and the lifetime of the~5D_(0)level of Eu^(3+)ions in Y_(2)O_(3):Eu^(3+),xCa^(2+)nanophosphor sample gets changed with a doping conce ntration of Ca^(2+)*** also reveals high thermal stability and quantum yield as estimating activation energy of 0.25 eV and 81%,***,CCT,and color purity values(>98%)show an improved red-emitting nanophosphor in the warm region of light,which m

关键词： Red emission Photoluminescence(PL) Y_(2)O_(3):Eu^(3+),xCa^(2+) Rare earths Nanophosphors LEDs

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Largest Ediacaran discs from the Jodhpur Sandstone, Marwar Supergroup, India: Their palaeobiological significance

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Geoscience Frontiers 2014年第2期5卷 183-191页

作者： Purnima srivastava Centre of Advanced Study in Geology Lucknow University

Ediacaran discs from the Jodhpur Sandstone of the Marwar Supergroup, Rajasthan, exhibit a wide size ranging from a few millimetres to 75 cm in diameter. Exceptionally large size of the discs in these rocks represent the largest reported so far from any Ediacaran assemblage. Although, larger medu-soid discs have been reported from USA, they are from the middle Cambrian and even younger rocks. Presence of microbial mats and weed-like structures with well preserved hold fasts and horizontal rhizome-like structures in association with some of these large-sized discs support their animal affinity, which probably feed on this weed-like vegetations. This association also supports their benthic habitat. Unlike the general trend of sudden increase in size of organisms in Ediacaran period and further decrease in size during Cambrian, these discs continued increasing in size in Cambrian also.

关键词： Ediacaran discs Jodhpur Sandstone Marwar Supergroup Rajasthan India

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