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Inhibitory activity of polysaccharide extracts from three kinds of edible fungi on proliferation of human hepatoma smMC-7721 cell and mouse implanted S180 tumor

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World Journal of Gastroenterology 1999年第5期5卷 404-407页

作者： Jiang sm Xiao ZM Xu ZH Shandong Normal Univ Dept Biol Provincial Key Lab Anim Stress Jinan 250014 Shandong Prov Peoples R China Univ Heidelberg D-6900 Heidelberg Germany

AIM To determine the activities ofpolysaccharide extracts from Flammulina velutipes (Curt. ex Fr. ) Sing (FV), Lentinusedodes (LE) and Agaricus bisporus Sing (AB)on the proliferation of human hepatoma smMC-7721 cells in vitro and on mouse implanted S-180tumors in *** the polysaccharide extracts were isolated from the fruit bodies of FV, LE and AB by the methods of hot-water extraction, Sevag’sremoval of proteins, ethanol precipitation,trypsin digestion and ethanol fractionalprecipitation. Human hepatoma smMC-7721 cells were treated with 50 mg/L Polysaccharide extracts, and the mitosis index, mitochondria activity and cell proliferation were detected at different times in both control and experimental groups. the mice with S-180 implanted tumors were injected with the polysaccharide extracts at 24 mg/ kg body weight for 9 d and the tumorweight was measured on the 15th *** the mitosis index of hepatoma cells in vitro could be significantly decreased by treatment with the polysaccharide extracts fromthe three kinds of edible fungi (P thecell numbers and mitochondria activity of smMC7721 cells treated with polysaccharide extracts were lower than those in control groups (P the inhibition rates of polysaccharide extracts against implanted S-180 tumors in mice were 52.8%, 56.6% and 51 .9% respectivelycompared with that in c0ntrol ***0N the POIysaccharide extractsfrom the three kinds of edible fungi could inhibitnot only the Cultured malignant cells in vitfO butalso impIanted Sl80 tum0r i0 vivo.

关键词： polysaccharide, edible fungi liver neoplasm carcinoma, hepatocellular smMC7721, tumor cell, cultured implanted tumor, S-180 cell proliferation

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一步浸渍合成具有多重孔隙的铸型炭体(英文)

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新型炭材料 2003年第4期18卷 265-270页

作者：陆安慧 Jan-Henrik smtt Mika Lindn Ferdi Schüth Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 1D-45470 Mülheim an der Ruhr Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 1 D-45470 Mülheim an der Ruhr

　以多孔块状硅体为模板,通过一步浸渍、炭化、酸处理工艺,制备出结构可控、孔隙联通且具有多重孔隙的铸型炭体。分别采用氮吸附技术、高分辨透射电镜和扫描电镜对模板硅、硅碳复合物及相应炭体进行了结构表征。从微米尺度分析,该炭体... 详细信息

　以多孔块状硅体为模板,通过一步浸渍、炭化、酸处理工艺,制备出结构可控、孔隙联通且具有多重孔隙的铸型炭体。分别采用氮吸附技术、高分辨透射电镜和扫描电镜对模板硅、硅碳复合物及相应炭体进行了结构表征。从微米尺度分析,该炭体是由高度联接的枝状结构单元为骨架构筑而成。与模板硅相比较,此炭体是硅体的正复本。从纳米尺度分析,这种炭体枝状骨架是由分布均匀且相互连接的中孔构成,此中孔及其孔壁对应于模板硅的孔壁及中孔,是多孔硅的负复本。此外构成中孔的炭骨架本体又含有大量炭化过程产生的微孔。因此该法合成的铸型炭具有孔隙高度发达和结构层层嵌套的特点。

关键词：铸型炭体一步浸渍法合成多重孔隙结构表征

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Anthrax:an update

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Asian Pacific Journal of Tropical Biomedicine 2011年第6期1卷 496-501页

作者： Kamal sm Rashid AKM M Bakar MA Aliad MA Department of Medicine Khulna Medical College Department of Paediatrics Khulna Medical College Department of Gastroenterology khulna Medical College

Anthrax is a zoonotic disease caused by Bacillus *** is potentially fatal and highly contagious *** arc the natural *** acquire the disease incidentally by contact with infected animal or animal *** the 18th century an epidemic destroyed approximately half of the sheep in *** 1900 human inhalational anthrax occured sporadically in the United *** 1979 an outbreak of human anthrax occured in Sverdlovsk of Soviet *** continued to represent a world wide *** incidence of the disease has decreased in developed countries as a result of vaccination and improved industrial *** anthrax clinically presents in three forms,***,gastrointestinal and *** 95%of human anthrax is cutaneous and 5%is *** anthrax is very rare(less than 1%).Inhalational form is used as a biological warefare agent. Penicillin,ciprofloxacin(and other quinolones),doxicyclin,ampicillin,***, clarithromycin,vancomycin,chloramphenicol,rifampicin are effective antimicrobials. Antimicrobial therapy for 60 days is *** anthrax vaccine is available. Administration of anti-protective antigen(PA) antibody in combination with ciprofloxacin produced 90%-100%*** combination of CPG-adjuvanted anthrax vaccine adsorbed(AVA) plus dalbavancin significantly improved survival.

关键词： Anthrax Bacillus anthracis Zoonotic disease Contagious disease Cutaneous anthrax Inhalational anthrax Gastrointestinal anthrax Human anthrax

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Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus

Ghrelin inhibits visceral afferent activation of catecholami...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： sm Appleyard Program in Neuroscience Department of Veterinary Comparative AnatomyWashington State University School of Life Science Northeast Normal University

＜正＞Brainstem A2/C2 catecholamine（CA） neurons in the solitary tract nucleus（NTS） are thought to play an important role in the control of food intake and other homeostatic *** have previously demonstrated that these neurons,which send extensive projections to brain regions involved in the regulation of appetite,are strongly and directly activated by solitary tract（ST） visceral ***,a potent orexigenic peptide released from the stomach,is proposed to act in part through modulating NTS CA neurons but the underlying cellular mechanisms are ***,we identified CA neurons using transgenic mice that express enhanced green fluorescent protein driven by the tyrosine hydroxylase promoter（th-EGFP）.We then determined how ghrelin modulates th-EGFP neurons using patch-clamp techniques in a horizontal brain slice *** inhibited the frequency of spontaneous glutamate inputs（spontaneous EPSCs） onto th-EGFP neurons,including cholecystokinin-sensitive neurons,an effect blocked by the GHSR1 antagonist,*** resulted in a decrease in the basal firing rate of NTS th-EGFP neurons,an effect blocked by the glutamate antagonist *** also dose-dependently inhibited the amplitude of ST afferent-evoked EPSCs（ST-EPSCs） in th-EGFP NTS neurons,decreasing the success rate for ST-evoked action *** addition,ghrelin decreased the frequency of mini-EPSCs suggesting its actions are presynaptic to reduce glutamate ***,inhibition by ghrelin of the ST-EPSCs was significantly increased by an 18 h *** results demonstrate a potential mechanism by which ghrelin inhibits NTS th neurons through a pathway whose responsiveness is increased during fasting.

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中国台湾地区汉族青少年高血压3阶段结合多位点测试和基因表达分析的全基因组关联研究

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中华高血压杂志 2014年第12期22卷 1198-1198页

作者： Chiang KM Yang HC Liang YJ Chen JW Hwang sm Ho HY Ting CT Lin th Sheu SH Tsai WC Chen JH Leu HB Yin WH Chiu TY Chen CI Lin SJ thomas GN Tomlinson B Guo Y Gui HS Sham PC Lam th Pan WH 练桂丽叶鹏

虽然已经进行了多次大规模的全基因组关联研究（genome—wide association studies，GWAs），但是仅少数研究成功地鉴定出能重复的、重要的高血压基因位点，而且在中国人中进行的相关研究更少。与迟发性高血压相比，青少年高血压（young... 详细信息

虽然已经进行了多次大规模的全基因组关联研究（genome—wide association studies，GWAs），但是仅少数研究成功地鉴定出能重复的、重要的高血压基因位点，而且在中国人中进行的相关研究更少。与迟发性高血压相比，青少年高血压（young—onset hypertension，YOH）被认为是更有希望治疗的疾病，因为其受到遗传因素的影响更大。

关键词：全基因组高血压基因表达分析青少年台湾地区 hypertension 中国测试

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国外甲醇制汽油的发展概况

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天然气化工(C1化学与化工) 1988年第6期 1-7页

作者：王宗义化工部第八设计院

介绍了莫比尔公司等国外甲醇制汽油发展概况。讨论了Zsm-5沸石催化剂和MTG法的固定床、流化床和多管反应器工艺。分析比较了各种反应器的特点以及产品收率、产品分布、产品特性和技术经济指标。

关键词：甲醇合成发展概况莫比尔反应器工艺沸石催化剂技术经济指标循环气压缩机研究法辛烷值管式反应器丝光沸石

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Update on pythiosis immunobiology and immunotherapy

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World Journal of Immunology 2014年第2期4卷 88-97页

作者： érico S Loreto Juliana sm Tondolo Régis A Zanette Sydney H Alves Janio M Santurio Department of Microbiology and Parasitology Universidade Federal de Santa Maria Programa de Pós-graduacao em Ciências Farmacêuticas Universidade Federal de Santa Maria

Pythiosis is an invasive, ulcerative, pyogranulomatous disease caused by Pythium insidiosum, a fungus-like oomycete that has been reported to affect humans, horses, dogs, and other mammals mainly in tropical and subtropical areas of the world. the disease is characterized by an eosinophilic granulomatous and a th2 immune response which in turn helps to protect the fungus from the host cells. Pythiosis can present clinically in subcutaneous, gastrointestinal, and vascular tissues or in a systemically disseminated form depending on the species and site of infection. Changes in iron metabolism and anemia are commonly observed. the diagnosis is accomplished through clinical and pathological features, laboratory characteristics of cultures, serological and molecular tests. Treatment includes radical surgery, antimicrobial drugs, immunotherapy or a combination of these treatments. Immunotherapy is a practical and non-invasive alternative for treating pythiosis which is believed to promote a switch from a th2 to th1 immune response, resulting in a favorableclinical response. this therapy has demonstrated cure rates above 70% and 55% in horses and humans but low cure rates in dogs and cats. Despite the curative properties of this type of immunotherapy, the antibodies that are produced do not prevent host reinfection. thus, development of effective adjuvants and new diagnostic techniques for early disease diagnosis are of utmost importance. the aim of this review was to promote pythiosis awareness and to provide an update about the immunotherapy and immunobiology of this disease.

关键词： Pythium insidiosum Treatment Pythiosis Immunotherapy Pathogenesis

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建立结核分枝杆菌耐药基因的检测方法

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陕西医学检验 2001年第3期16卷 17-18页

作者：李洪敏王薇李素梅韩慧新佟爱华肖漓张宾雷红刘军高杉解放军三○九医院结核中心临床实验室北京100091

目的　了解耐药结核分枝杆菌基因突变情况 ,建立结核分枝杆菌耐药基因的检测方法。方法　1 0 8例临床痰标本分离株均做 PCR- SSCP和传统梯度药敏试验。结果　耐 sm( rpsl)、RFP( rpo B)、INH( kat G)基因突变率分别为 78.5 % ,78.2 % ,7... 详细信息

目的　了解耐药结核分枝杆菌基因突变情况 ,建立结核分枝杆菌耐药基因的检测方法。方法　1 0 8例临床痰标本分离株均做 PCR- SSCP和传统梯度药敏试验。结果　耐 sm( rpsl)、RFP( rpo B)、INH( kat G)基因突变率分别为 78.5 % ,78.2 % ,70 .5 %。其中高耐 sm、REP、INH分离株突变率分别为86.9% ,89.3% ,84.3%。低耐分离株突变率分别为 2 8.5 % ,1 6.6% ,7.1 %。结论　结核分枝杆菌耐药基因突变与耐药水平联系是密切的 ,且结核耐药分枝杆菌基因突变绝大多数易发生在高耐药株中 ,也有少部分在低耐药株发生突变。

关键词：结核分枝杆菌药敏试验聚合酶链反应多态-单链构象基因

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