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Glyphosa.e a. a.direct or indirect a.tiva.or of pro-infla.ma.ory signa.ing a.d cognitive impa.rment

Neura. Regenera.ion Resea.ch 2024年第10期19卷 2212-2218页

作者： Yukitoshi Izumi Ka.uko a.o'Dell Cha.les F.Zorumski Depa.tment of Psychia.ry Washington University School of MedicineSt.LouisMOUSA Ta.lor Fa.ily Institute for Innova.ive Psychia.ric Resea.ch Washington University School of MedicineSt.LouisMOUSA

Glyphosa.e-ba.ed herbicides a.e widely used a.ound the world, ma.ing it likely tha. most huma.s ha.e significa.t exposure. Beca.se of ha.itua. exposure, there a.e concerns a.out toxicity including neurotoxicity tha. could result in neurologica., psychia.ric, or cognitive impa.rment. We recently found tha. a.single injection of glyphosa.e inhibits long-term potentia.ion, a.cellula. model of lea.ning a.d memory, in ra. hippoca.pa. slices dissected 1 da. a.ter injection, indica.ing tha. glyphosa.e-ba.ed herbicides ca. a.ter cognitive function. Glyphosa.e-ba.ed herbicides could a.versely a.fect cognitive function either indirectly a.d/or directly. Indirectly, glyphosa.e could a.fect gut microbiota. a.d if dysbiosis results in endotoxemia.lea.y gut), infiltra.ed ba.teria. by-products such a. lipopolysa.cha.ides could a.tiva.e pro-infla.ma.ory ca.ca.es. Glyphosa.e ca. a.so directly trigger pro-infla.ma.ory ca.ca.es. Indeed, we observed tha. a.ute glyphosa.e exposure inhibits long-term potentia.ion in ra. hippoca.pa. slices. Interestingly, direct inhibition of long-term potentia.ion by glyphosa.e a.pea.s to be simila. to tha. of lipopolysa.cha.ides. There a.e severa. possible mea.ures to control dysbiosis a.d neuroinfla.ma.ion ca.sed by glyphosa.e. Dieta.y inta.e of polyphenols, such a. quercetin, which overcome the inhibitory effect of glyphosa.e on long-term potentia.ion, could be one effective stra.egy. The a.m of this na.ra.ive review is to discuss possible mecha.isms underlying neurotoxicity following glyphosa.e exposure a. a.mea.s to identify potentia. trea.ments.

关键词： cognitive impa.rment glyphosa.e microglia neuroinfla.ma.ion roundup toll-like receptor 4 zinc chela.ion

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Sta.ility a.a.ysis of a.time-dela.ed Va. der Pol–Helmholtz–Duffing oscilla.or in fra.ta. spa.e with a.non-perturba.ive a.proa.h

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Communica.ions in Theoretica. Physics 2024年第4期76卷 22-31页

作者： Yusry o El-Dib Depa.tment of Ma.hema.ics Faculty of EducationAin Shams UniversityRoxyCairoEgypt

The time-dela.ed fra.ta. Va. der Pol–Helmholtz–Duffing(VPHD)oscilla.or is the subject of this pa.er,which explores its mecha.isms a.d highlights its sta.ility *** time-dela.ed technologies a.e currently ga.nering significa.t a.tention,the focus of this resea.ch rema.ns crucia.ly releva.t.a.non-perturba.ive a.proa.h is employed to refine a.d set the sta.e for the system under *** innova.ive methodologies introduced yield a. equiva.ent linea. differentia. equa.ion,mirroring the inherent nonlinea.ities of the ***,the incorpora.ion of qua.ra.ic nonlinea.ity into the frequency formula.represents a.cutting-edge *** a.a.ytica. solution's va.idity is corrobora.ed using a.numerica. *** conditions a.e a.certa.ned through the residua. Ga.erkin ***,it is observed tha. the dela. pa.a.eter,in the context of the fra.ta. system,reverses its sta.ilizing influence,impa.ting both the a.plitude of dela.ed velocity a.d the *** a.a.ytica. solution's precision is underscored by its close a.ignment with numerica. ***,the study revea.s tha. fra.ta. cha.a.teristics emula.e da.ping *** its a.plica.ility a.ross diverse nonlinea. dyna.ica. systems,this non-perturba.ive a.proa.h emerges a. a.promising a.enue for future resea.ch.

关键词： Va. der Pol-Helmholtz-Duffing oscilla.or fra.ta. spa.e time-dela. non-perturba.ive a.proa.h sta.ility a.a.ysis El-Dib's frequency formula

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Ma.ing topologica. protein links using enzyma.ic rea.tions

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Na.iona. Science Review 2024年第03期11卷 50-51页

作者： Roger Ca.tells-Gra.lls Todd o.Yea.es Depa.tment of Chemistry a.d Biochemistry University of California UCLa.DoE Institute for Genomics a.d Proteomics

Proteins a.e exceedingly complex molecules though, a. their hea.t, they a.e essentia.ly linea. polymers. Pull a. their ends a.d one obta.ns a. extended ba.kbone. While tha. is true in most ca.es, some na.ura. proteins... 详细信息

关键词： DESIGN

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a.synthetic microbia. community used a. a.bioinocula.t ca. overcome rice production constra.nts in a.id soils

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Science China.Life Sciences) 2024年第5期67卷 1085-1086页

作者： Ma.reen o’Ca.la.ha. Shengjing Shi Resilient a.riculture Group AgResearchLincolnChristcurch 8140New Zealand

a.customised synthetic microbia. community(SynCom)composed of ca.efully selected rhizosphere-competent ba.teria. stra.ns improved rice growth,yield a.d resista.ce to soil a.idity a.d a. toxicity.

关键词： soil soils rhizosphere

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Va.oriza.ion of Tree Ba.k-Derived Suberin in a.plica.ions for the Bio-Ba.ed Composites Industry–a.Recent Review

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Journa. of Renewa.le Ma.eria.s 2024年第6期12卷 1029-1042页

作者： a.eksa.dra.Jeżo Institute of Wood Sciences a.d Furniture SGGWNowoursynowska St.159Warsaw02-776Poland

Ba.k extra.ts a.e susta.na.le sources of biopolymers a.d hold grea. promise for repla.ing fossil fuel-ba.ed polymers,for exa.ple,in wood-ba.ed *** a.dition to prima.y a.d seconda.y meta.olites,tree ba.k a.so conta.ns suberin,which pla.s a.ma.or role in protecting the tree from environmenta. *** is a.na.ura. a.ipha.ic-a.oma.ic cross-linked polyester present in the cell wa.ls of both norma. a.d da.a.ed externa. tissues,the ma.n component of which a.e long-cha.n a.ipha.ic *** ma.n role a. a.pla.t ingredient is to protect a.a.nst microbiologica. fa.tors a.d wa.er *** of the most importa.t suberin monomers a.e suberin fa.ty a.ids,known for their hydrophobic a.d ba.rier ***,due to the diverse chemica. composition of suberin,it is a. a.tra.tive a.terna.ive to hydroca.bon-ba.ed *** its potentia. is recognized,it is not widely used in biocomposites technology,including wood-ba.ed composites a.d the polymer *** a.ticle will discuss the current knowledge a.out the potentia. of suberin a.d its components in biocomposites technology,which will include surfa.e finishes,composite a.hesives a.d polymer blends.

关键词： Suberin suberinic a.ids wood composites biocomposites biopolyester

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Investiga.ion of the effects of ra.ia. clea.a.ce on the screw conveyor performa.ces for different inclina.ions

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Pa.ticuology 2024年第9期92卷 72-80页

作者： Berna.Bola. Birgül a.çıoğlu Temizta. Enes Sezer Depa.tment of Mecha.ica. Engineering Yıldız Technical University34349BeşiktaşİstanbulTurkey

Screw conveyors a.e widely used for bulk ma.eria. *** study investiga.es the critica. role of ra.ia. clea.a.ce,the ga. between the screw a.d the conveyor body,on performa.ce a.ross va.ious inclina.ion *** Discrete Element Method(DEM)is employed to a.a.yze the effects of different ra.ia. clea.a.ces on conveyor performa.ce for concrete a.grega.e a.d sa.d a. bulk *** efficiencies a.d ca.a.ity losses serve a. key performa.ce indica.ors,qua.tita.ively a.sessed for ea.h ra.ia. clea.a.ce a.d inclina.ion *** va.ida.ion is conducted to corrobora.e the *** the study,the optima. ra.ia. clea.a.ce wa. identified a. 1.5 to 3 times of the pa.ticle *** optima. clea.a.ce minimizes the ma.eria. ja.ming a.d increa.es the performa.ce for screw conveyors with different inclina.ions a.d bulk ma.eria. types a. a.result.

关键词： Screw conveyors Ra.ia. clea.a.ce Discrete element method(DEM) Volumetric efficiency Conveyor performa.ce

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Rota.ing effects on the photoioniza.ion cross-section of a.2D qua.tum ring

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Communica.ions in Theoretica. Physics 2024年第10期76卷 153-159页

作者： Ca.los Ma.no o Pereira.Fra.kbelson dos S a.evedo Luís Ferna.do C Pereira.Edilberto o Silva Depa.ta.ento de Física Universidade Federal do Maranh?o

In this a.ticle, we investiga.e the nonrela.ivistic qua.tum motion of a.cha.ged pa.ticle within a.rota.ing fra.e, ta.ing into a.count the a.a.onov–Bohm(a.) effect a.d a.uniform ma.netic field. our a.a.ysis enta.ls the deriva.ion of the equa.ion of motion a.d the corresponding ra.ia. equa.ion to describe the system. Solving the resulting ra.ia. equa.ion ena.les us to determine the eigenva.ues a.d eigenfunctions, providing a.clea. expression for the energy levels. Furthermore,our numerica. a.a.ysis highlights the substa.tia. influence of rota.ion on both energy levels a.d optica. properties. Specifica.ly, we eva.ua.e the photoioniza.ion cross-section with a.d without the effects of rota.ion. To elucida.e the impa.t of rota.ion on the photoioniza.ion process of the system, we present gra.hics tha. offer a. a.pea.ing visua.iza.ion of the intrinsic na.ure of the physics involved.

关键词： a.a.onov-Bohm effect photoioniza.ion cross-section qua.tum ring rota.ing effect

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Ha.nessing the power of pericytes a.d hypoxia.inducible fa.tor-1 to modula.e stroke outcome

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Neura. Regenera.ion Resea.ch 2024年第3期19卷 473-474页

作者： omola.a.o.ogunshola.Chih-Chieh Tsa. Institute of Veterina.y Physiology Vetsuisse FacultyUniversity of ZurichZurichSwitzerland

The huma. bra.n ha. exceedingly high meta.olic *** cerebra. va.cula.ure ha. the critica. ta.k of providing sufficient blood supply to meet this *** sudden interruption of blood flow to the bra.n,a. observed during ischemic stroke,results in a.ute neurologica. injury with deva.ta.ing consequences-a.high ra.e of a.ult disa.ility a.d *** stroke is thus a.va.cula. disorder with a.dra.a.ic neurologica. *** is a. urgent need for more effective disea.e ma.a.ement to comba. stroke a. current trea.ment pa.a.igms,focusing on va.cula. reca.a.iza.ion a.d neuroprotection,ha.e only limited clinica. *** a.cumula.ing da.a.suggests successful long-term neuroprotection is unlikely to be a.hieva.le without a.functiona. microva.cula. network,stra.egies tha. reduce endothelia. dysfunction could be ***,very recent evidence highlighted herein suggests protecting the humble pericyte ma. be a.new a.proa.h to rea.hing this goa..

关键词： consequences exceeding herein

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Muta.ions of volta.e-ga.ed sodium cha.nel contribute to pyrethroid resista.ce in Pa.onychus citri

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Insect Science 2024年第3期31卷 803-816页

作者： Deng Pa. Qiu-Jua. Luo a.dria. o.o'Reilly Guo-Rui Yua. Jin-Jun Wa.g Wei Dou Key La.ora.ory of Entomology a.d Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwest UniversityChongqingChina Key La.ora.ory of a.ricultura. Biosa.ety a.d Green Production of Upper Ya.gtze River(Ministry of Educa.ion) Academy of Agricultural SciencesSouthwest UniversityChongqingChina School of Biologica. a.d Environmenta. Sciences Liverpool John Moores UniversityLiverpoolUK

Insecticide resista.ce in Pa.onychus citri is a.ma.or obsta.le to mite control in citrus *** insecticides a.e continua.ly used to control mites in China.a.though resista.ce to pyrethroids ha. evolved in some ***,the resista.ce to the pyrethroid fenpropa.hrin wa. investiga.ed a.d 7 out of 8 field-collected popula.ions of P citri exhibited a.high level of resista.ce,ra.ging from 171-fold to 15391-fold higher tha. the susceptible(SS)compa.ison *** volta.e-ga.ed sodium cha.nel(VGSC)muta.ions were identified in the tested popula.ions:L1031V,F1747L,a.d *** sequencing wa. used to eva.ua.e the frequency of these muta.ions in the 19 field popula.ions.L1031V a.d F1751I were present in a.l popula.ions a. frequencies of 11.6%-82.1%a.d 0.5%-31.8%,respectively,wherea. the F1747L muta.ion wa. only present in 12 popula.ions from Chongqing,Sichua.,Gua.gxi,a.d Yunna. *** of these muta.ions singly or in combina.ion into tra.sgenic flies significa.tly increa.ed their resista.ce to fenpropa.hrin a.d these flies a.so exhibited reduced morta.ity a.ter exposure to the pyrethroids permethrin a.dβ-*** citri VGSC homology modeling a.d liga.d docking indica.e tha. F1747 a.d F1751 form direct binding conta.ts with pyrethroids,which a.e lost with muta.ion,wherea. L1031 muta.ion ma. diminish pyrethroid effects through a. a.losteric ***,the results provide molecula. ma.kers for monitoring pest resista.ce to pyrethroids a.d offer new insights into the ba.is of pyrethroid a.tions on sodium cha.nels.

关键词： a.plicon sequencing kdr muta.ion molecula. docking Pa.onychus citri pyrethroid resista.ce tra.sgenic flies

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a.plica.ion of Ba.in Morphometry La.s in ca.chments of the south-western qua.ra.gle of south-ea.tern Nigeria

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Frontiers of Ea.th Science 2013年第3期7卷 361-374页

作者： a.o a.SUEBEoGUN I.C EZEKWE Depa.tment of Geogra.hy a.d Environmenta. Ma.a.ement Niger Delta University Wilberforce Island 560001 Nigeria Depa.tment of Geogra.hy a.d Environmenta. Ma.a.ement University of Port Harcourt Port Harcourt 500001 Nigeria

The rela.ionship between process a.d form ha. been a. the core of resea.ch in fluvia. geomorphology. Form-process rela.ionships of a.na.ura. river ba.in a.e strongly influenced by its hydrologic a.d sedimentologic processes a. ba.in morphometric properties of length, sha.e, a.d relief, cha.ge in response to va.ious hydrologic stimuli from the environment, but usua.ly in line with well esta.lished la.s. In the four fiver ba.ins （ora.hi, ota.iri, Sombreiro, New Ca.a.a.） exa.ined in this study, however, empirica. evidence does not conform nea.ly with theoretica. postula.es. Rema.ka.le va.ia.ions a.e noted in the molphometric properties of the ca.chments, when compa.ed with esta.lished morphometric la.s. The most va.ied in conformity a.e the ora.hi a.d New Ca.a.a. ba.ins, a.though the Sombreiro a.d ota.iri ca.chments a.so show some level of va.ia.ion. Prime expla.a.ion for the morphometric a.d topogra.hic non-conformity is ca.sed by the na.ure of surficia. ma.eria. a.d the profoundly sha.low relief of much of the study a.ea. especia.ly the a.luvia. flood a.d delta.c pla.ns to the south a.d south-west of the study a.ea.

关键词： ca.chments wa.ershed morphology morpho- metric a.a.ysis Nigeria a.rica

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