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Incidental right atrial mass in a patient with secondary pancreatic cancer: A case report and review of literature

World Journal of Clinical Cases 2023年第5期11卷 1206-1216页

作者： Agnese Maria fioretti Tiziana Leopizzi Daniele La Forgia Pietro Scicchitano Donato Oreste Annarita Fanizzi Raffaella Massafra Stefano Oliva Cardio-Oncology IRCCS Istituto Tumori“Giovanni Paolo Ⅱ”Bari 70124Italy Cardiology and Intensive Care Unit Ospedale SS.AnnunziataTaranto 74121Italy Department of Radiology IRCCS Istituto Tumori“Giovanni Paolo Ⅱ”Bari 70124Italy Cardiology and Intensive Care Unit Ospedale“Fabio Perinei”Altamura(Bari)70022Italy Department of Oncology IRCCS Istituto Tumori“Giovanni Paolo Ⅱ”Bari 70124Italy

BACKGROUND The incidental detection of a right atrial mass during routine cardioncological workup is a rare condition. The correct differential diagnosis between cancer and thrombi is challenging. A biopsy may not be feasible while diagnostic techniques and tools may not be *** SUMMARY We report the case of a 59-year-old female patient with a history of breast cancer and current secondary metastatic pancreatic cancer. She developed deep vein thrombosis and pulmonary embolism and was admitted to the Outpatient Clinic of our Cardio-Oncology Unit for follow-up. Transthoracic echocardiogram incidentally found a right atrial mass. Clinical management was difficult due to the abrupt worsening of the patient’s clinical condition and the progressive severe thrombocytopenia. We suspected a thrombus, according to its echocardiographic appearance, the patient’s cancer history and recent venous thromboembolism. The patient was unable to adhere to low molecular weight heparin treatment. Due to worsening prognosis, palliative care was recommended. We also highlighted the distinguishing features between thrombi and tumors. We proposed a diagnostic flowchart to aid diagnostic decision making in the case of an incidental atrial *** This case report highlights the importance of cardioncological surveillance during anticancer treatments to detect cardiac masses.

关键词： Atrial mass Cardiac tumor Venous thromboembolism Differential diagnosis Case report

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Broadband Vibrational Cooling of Cold Cesium Molecules： Theory and Experiments

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Chinese Journal of Chemical Physics 2009年第2期22卷 149-156页

作者： D. Sofikitis A. fioretti S. Weber M. Viteau A. Chotia R. Horchani M. Allegrini B. Chatel D. Comparat P. Pillet Laboratoire Aimé Cotton CNRS Université Paris-Sud Bat. 505 91405 Orsay France Laboratoire Collisions Agrégats Réactivité (UMR 5589 CNRS-Université Paul Sabatier Toulouse 3) IRSAMC Toulouse France CNISM Dipartimento di Fisica Universita di Pisa Largo Pontecorvo 356127 PISA Italy

The use of a broadband, frequency shaped femtosecond laser on translationally cold cesium molecules has recently demonstrated to be a very efficient method of cooling also the vibrational degree of freedom. A sample of cold molecules, initially distributed over several vibrational levels, has thus been transfered into a single selected vibrational level of the singlet X^1∑g ground electronic state. Our method is based on repeated optical pumping by laser light with a spectrum broad enough to excite all populated vibrational levels but limited in its frequency bandwidth with a spatial light modulator. In such a way we are able to eliminate transitions from the selected level, in which molecules accumulate. In this paper we briefly report the main experimental results and then address, in a detailed way by computer simulations, the perspectives for a ＂complete＂ cooling of the molecules, including also the rotational degree of freedom. Since the pumping process strongly depends on the relative shape of the ground and excited potential curves, ro-vibrational cooling through different excited states is theoretically compared.

关键词： Cold molecule Optical pumping Pulse .shaping Ultrashort pulse Laser cooling

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Temporomandibular joint damage in K/BxN arthritic mice

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International Journal of Oral Science 2020年第1期12卷 59-67页

作者： Sabine Kuchler-Bopp a.exa.dre Mariotte Marion Strub Chrystelle Po Aurore De Cauwer Georg Schulz Xavier Van Bellinghen Florence fioretti Francois Clauss Philippe Georgel Nadia Benkirane-Jessel Fabien Bornert INSERM(French National Institute of Health and Medical Research) UMR 1260Regenerative NanoMedicine(RNM)FMTSStrasbourgFrance INSERM UMR 1109Immuno Rhumatologie Moléculaire(IRM)FMTSStrasbourgFrance Fédération Hospitalo-Universitaire(FHU)OMICARE Universitéde StrasbourgStrasbourgFrance Facultéde Chirurgie Dentaire Universitéde Strasbourg(UDS)8 rue Ste ElisabethStrasbourgFrance Pole de Médecine et Chirurgie Bucco-Dentaires Hopitaux Universitaires de Strasbourg(HUS)1 place de l’HopitalStrasbourgFrance ICube UMR 7357 Universitéde StrasbourgCNRSFMTS4 rue KirschlegerStrasbourgFrance Department of Biomedical Engineering Core Facility Micro-and NanotomographyBiomaterials Science Center(BMC)University of BaselGewerbestrasse 144123AllschwilSwitzerland

Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FLSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood.

关键词： damage alterations inflammation

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Adaptive Match-Filtering: A Biomedical Application to Identify T-Wave Alternans

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Natural Science 2014年第10期6卷 709-718页

作者： Laura Burattini Giovanni Ottaviano Francesco Di Nardo Sandro fioretti B.M.E.D. Bio-Medical Engineering Development SRL Università Politecnica delle Marche Ancona Italy Department of Information Engineering Università Politecnica delle Marche Ancona Italy

T-wave alternans (TWA), consisting in an alternation of the electrocardiographic (ECG) repolarization segment (T-wave), is a promising index of the risk of sudden cardiac death. By definition, it is characterized by a frequency component, termed fTWA, that matches half heart rate. The heart-rate adaptive match filter (AMF) based method is a technique for automatic TWA identification from the digital ECG. Aim of the present study was to provide a complete technical description of the filter able to explain its methodological principles. The AMF is usually realized as a 6th order Butterworth filter with a narrow (0.12 Hz) passing band centered in fTWA. It is applied in a bidirectional fashion, so that final filtering order is 12. While extracting the TWA component, the AMF simultaneously filters out every ECG component including noise and artefacts, and thus results are very robust. Goodness of the technique was tested using 8 synthetic ECG tracings corrupted by typical noisy factors, such as white random noise, baseline wanderings, heart-rate variability, and others. Six ECG tracings were affected by 100 μV TWA, whereas two were not. Results indicate that the AMF-based method is able to prevent false-positive and false-negative detections and, thus, represents a useful tool for a reliable TWA identification.

关键词： Adaptive Filtering Digital ECG T-Wave Alternans Sudden Cardiac Death

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Root proliferation in native perennial grasses of arid Patagonia,Argentina

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Journal of Arid Land 2014年第2期6卷 195-204页

作者： Yanina A TORRES Carlos A BUSSO Oscar A MONTENEGRO Leticia ITHURRART Hugo D GIORGETT Gustavo RODRíGUEZ Diego BENTIVEGNA Roberto E BREVEDAN Osvaldo A FERNáNDEZ María M MUJICA Sandra S BAIONI José ENTíO María N fioretti Guillermo TUCAT Agronomy Department National University of the South and CERZOS (CONICET) Experimental Farm EEA INTA Patagones Ministery of Agrarian Issues Faculty of Agrarian Sciences National University of La Plata

Pappophorum vaginatum is the most abundant C4 perennial grass desirable to livestock in rangelands of northeastern Patagonia, Argentina. We hypothesized that （1） defoliation reduce net primary productivity, and root length density and weight in the native species, and （2） root net primary productivity, and root length density and weight, are greater in P. vaginatum than in the other, less desirable, native species （i.e., Aristida spegazzinfi, A. subulata and Sporobolus cryptandrus）. Plants of all species were either exposed or not to a severe defoliation twice a year during two growing seasons. Root proliferation was measured using the cylinder method. Cylindrical, iron structures, wrapped up using nylon mesh, were buried diagonally from the periphery to the center on individual plants. These structures, initially filled with soil without any organic residue, were dug up from the soil on 25 April 2008, after two successive defoliations in mid-spring 2007. During the second growing season （2008-2009）, cylinders were destructively harvested on 4 April 2009, after one or two defoliations in mid- and/or late-spring, respectively. Roots grown into the cylinders were obtained after washing the soil manually. Defoliation during two successive years did reduce the study variables only after plants of all species were defoliated twice, which supported the first hypothesis. The greater root net primary productivity, root length den- sity and weight in P. vaginatum than in the other native species, in support of the second hypothesis, could help to explain its greater abundance in rangelands of Argentina.

关键词： Aristida species competitive ability Pappophorum vaginatum Sporobolus cryptandrus warm-season perennial grasses

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Bilateral Carotid Aneurysms Secondary to Catastrophic Antiphospholipid Syndrome in a Patient with Differential Diagnosis of Polyarteritis Nodosa

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World Journal of Cardiovascular Diseases 2022年第1期12卷 30-37页

作者： a.exa.dre Sacchetti Bezerra Fernanda Gonçalves Moya Idalecio Souto Fonseca Filho a.exa.dre cesa. fioretti Instituto de Infectologia Emilio Ribas S&atilde o Paulo Brazil Universidade de Sao Paulo S&atilde o Paulo Brazil Faculdade de Medicina do ABC S&atilde o Paulo Brazil

Background: Extracranial Carotid Artery Aneurysm is considered a therapeutic and diagnostic challenge. In an unprecedented way in the literature, we describe an aneurysm originating from the Catastrophic Antiphospholipid Syndrome. Case Presentation: A 25-year-old male patient came to the Emergency Room of the ABC University Hospital in Sao Bernardo do Campo referring to bilateral neck pain for 1 month, associated with carotid aneurysms. Due to the severity and urgency of the clinical condition, immediate surgical therapy was performed without a definitive etiological diagnosis. The initial morphological analysis of the carotid artery suggested a diagnosis of Polyarteritis Nodosa. After anamnesis, physical examination, the use of a specific primary vasculitis algorithm, and a review of the pathological anatomy was requested, which showed bilateral carotid aneurysms secondary to catastrophic antiphosp

关键词： Aneurism Anticardiolipin Antibodies Antiphospholipid Syndrome Carotid Artery Thrombosis

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Nanostructured hybrid materials for bone-tooth unit regeneration

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Open Journal of Regenerative Medicine 2013年第3期2卷 47-52页

作者： Sabine Kuchler-Bopp Thibault Becavin Tunay Kokten Florence fioretti Etienne Deveaux Nadia Benkirane-Jessel Laetitia Keller Institut National de la Santeet de la Recherche Medicale(INSERM) UMR 1109Osteoarticular and Dental RegenerativeNanomedicineFacultede MedecineStrasbourgFrance Universitede Strasbourg Facultede Chirurgie Dentaire1 Place de l’HopitalStrasbourgFrance 3.UniversitéLille Nord de FranceFacultede Chirurgie DentaireLilleFrance

As a part of regenerative medicine, biomaterials are largely used in this field of nanotechnology and tissue engineering research. We have recently developed a new scaffold using electrospun nanofibers of Poly (ε-caprolactone), PCL which is able to mimic the collagen extracellular matrix of cells. The aim of this study was to engineer a biological and implantable structure leading the regeneration of the tooth-bone unit. For this aim, we have cultured mouse osteoblasts embedded in a collagen gel on the nanofibrous membrane and coupled this structure with an embryonic dental germ before implantation. To follow bone and tooth regeneration, we have performed RT-PCR, histology and immunofluorescence analysis. We showed here that this leaving implantable structure represents an accurate strategy for bone-tooth unit regeneration. We report here the first demonstration of bone-tooth unit regeneration by using a strategy based on a synthetic nanostructured membrane. This electrospun membrane is manufactured by using an FDA approved polymer, PCL and functionalized with osteoblasts before incorporation of the tooth germs at ED14 (the first lower molars) to generate bone-tooth unit in vivo after implantation in mice. Our technology represents an excellent platform on which other sophisticated products could be based.

关键词： Bone Nanostructured Material Osteoblast Tissue Engineering Tooth

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新复方避孕药(含20mcg炔雌醇和0.150mg地索高诺酮)的临床和代谢研究

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药学进展 1988年第4期 229-230页

作者： fioretti P 陈德珍

给17名健康妇女短期服用新复方避孕药[含0.150mg地索高诺酮和20m(?)g炔雌醇(EE)],用药1,3,6个月以后,将随访情况列表,评价其所有临床项目。在末次自然月经周期的第18和21天之间以及用药6个月时,收集所有人的血样,用于测定纤维蛋白A(FPA... 详细信息

给17名健康妇女短期服用新复方避孕药[含0.150mg地索高诺酮和20m(?)g炔雌醇(EE)],用药1,3,6个月以后,将随访情况列表,评价其所有临床项目。在末次自然月经周期的第18和21天之间以及用药6个月时,收集所有人的血样,用于测定纤维蛋白A(FPA)。为了评价脂代谢和碳水化合物代谢方面的作用,收集用药前和用药6个月的血样,测定血糖、胰岛素、糖基化血红蛋白

关键词：避孕药碳水化合物代谢脂代谢胰岛素 OGTT 多肽口服避孕药炔雌醇高诺酮

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Nanoscale Stiffness Distribution in Bone Metastasis

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World Journal of Nano Science and Engineering 2015年第4期5卷 219-228页

作者： Ludovic Richert Laetitia Keller Quentin Wagner Fabien Bornert Catherine Gros Sophie Bahi Francois Clauss William Bacon Philippe Clézardin Nadia Benkirane-Jessel Florence fioretti Centre National de la Recherche Scientifique(CNRS) UMRFacultéde Pharmacie de l’Universitéde Strasbourg(UdS)IllkirchFrance Institut National de la Santéet de la Recherche Médicale(INSERM) Osteoarticular and Dental Regenerative NanomedicineUMRFacultéde Médecine de l’Universitéde Strasbourg and FMTSStrasbourgFrance Facultéde Chirurgie Dentaire de l’Universitéde Strasbourg(UdS) StrasbourgFrance Hopitaux Universitaires de Strasbourg StrasbourgFrance Institut National de la Santéet de la Recherche Médicale(INSERM) UMRFacultéde Médecine Laennec de l’UniversitéClaude Bernard Lyon 1LyonFrance

Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.

关键词： Bone Metastasis Stiffness Risedronate

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威尼斯IUAV建筑学院工作坊主题设计

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百年建筑 2005年第9期 40-40页

作者： Donatella fioretti 柏林科技大学客座教授威尼斯建筑大学访问教授现任意大利Bruno fioretti Marquez建筑师事务所主设计师

2005年夏天，我们事务所应邀参加在威尼斯IUAV建筑学院举办的为期三周的工作坊。

关键词：建筑学院威尼斯主题设计作坊事务所

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