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Changes in the gut mycobiome in pediatric patients in relation to the clinical activity of Crohn's disease

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World Journal of Gastroenterology 2023年第14期29卷 2172-2187页

作者： Agnieszka Krawczyk Dominika Salamon Kinga Kowalska-Duplaga Barbara Zapała Teofila Książek Marta drażniuk-Warchoł Tomasz Gosiewski Department of Microbiology Division of Molecular Medical MicrobiologyJagiellonian University Medical CollegeCracow 31-121Poland Department of Pediatrics Gastroenterology and NutritionJagiellonian University Medical CollegeCracow 30-663Poland Department of Clinical Biochemistry Jagiellonian University Medical CollegeCracow 31-066Poland Department of Medical Genetics Jagiellonian University Medical CollegeCracow 30-663Poland Department of Pediatrics Gastroenterology and NutritionUniversity Children's HospitalCracow 30-663Poland

BACKGROUND Numerous studies have shown that in Crohn’s disease(CD),the gut microbiota is of great importance in the induction and maintenance of inflammation in the gastrointestinal *** recently,studies have focused almost exclusively on bacteria in the ***,more attention has been paid to the role of intestinal *** To study the gut mycobiome analysis of pediatric patients with CD(in different stages of disease activity)compared to healthy *** Fecal samples were collected from patients:With active,newly diagnosed CD(n=50);active but previously diagnosed and treated CD(n=16);non-active CD and who were in clinical remission(n=39)and from healthy volunteers(n=40).Fungal DNA was isolated from the ***,next generation sequencing(MiSeq,Illumina)was *** composition of mycobiota was correlated with clinical and blood *** Candida *** overrepresented in CD patients,while in the control group,the most abundant genus was *** CD patients,the percentage of Malassezia was almost twice that of the control(P<0.05).In active CD patients,we documented a higher abundance of Debaryomyces hansenii(***)compared to the non-active CD and control(P<0.05)***,statistically significant changes in the abundance of Mycosphaerella,Rhodotorula,and Microidium were *** analyses at the species level and linear discriminant analysis showed that in each group it was possible to distinguish a specific species characteristic of a given patient ***,we have documented statistically significant correlations between:*** and patient age(negative);*** and patient age(positive);*** and calprotectin(positive);*** and calprotectin(positive);and *** and pediatric CD activity index(PCDAI)(positive).CONCLUSION Mycobiome changes in CD patients,and the positive correlation of some species with calprotectin or PCDAI,give strong evidence that fungi may be

关键词： Intestinal mycobiome Fungi Crohn’s disease Inflammatory bowel disease Next generation sequencing Molecular microbiology

让P35更“听话” 微星MS-7345系列主板使用心得

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微型计算机 2008年第7期28卷 141-143页

作者： nova

拥有更高的性能，更低的发热量以及更强大的超频能力，P35主板成了多数玩家的不二选择，然而使用的人多了，各种各样的问题也随之而来，“网络断流”，“二次启动”的IDE芯片兼容等问题困扰着不少P35用户。

关键词： P35 主板微星超频能力二次启动发热量 IDE 兼容

WinLauncherXP管理多核心处理器

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微型计算机 2008年第6期28卷 146-147页

作者： nova

多核心日渐普及，单核心处理器渐渐退出了历史舞台。相比之下，多核心处理器有更强大的多任务处理能力，但很多情况下，几个程序争抢CPU资源，分配不均的情况仍有出现，虽然双核心可以保证程序运行，但流畅性上却打了折扣，有没有一种... 详细信息

多核心日渐普及，单核心处理器渐渐退出了历史舞台。相比之下，多核心处理器有更强大的多任务处理能力，但很多情况下，几个程序争抢CPU资源，分配不均的情况仍有出现，虽然双核心可以保证程序运行，但流畅性上却打了折扣，有没有一种方法可以让某个程序在CPU的指定核心中运行，而另外一个核心运行另外的程序呢？

关键词：多核心处理器程序运行 CPU资源管理多任务处理流畅性

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体验富士通笔记本电脑特色软件

微型计算机 2007年第12S期27卷 149-151页

作者： nova

特色软件也是笔记本电脑的一部分？当然了!笔记本电脑的差别除了外形、设计和配置外,厂商精心制作的特色软件也是它独有的“身份证”。这些特色软件不但使用方便，还带来了不少的乐趣、我们上两期介绍了ASUS；TNUS和ACER的笔记本电脑特... 详细信息

特色软件也是笔记本电脑的一部分？当然了!笔记本电脑的差别除了外形、设计和配置外,厂商精心制作的特色软件也是它独有的“身份证”。这些特色软件不但使用方便，还带来了不少的乐趣、我们上两期介绍了ASUS；TNUS和ACER的笔记本电脑特色软件-本期带给读者的是富土通笔记本电脑特色软件。

关键词：笔记本电脑软件富士通 ASUS ACER 身份证

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TRA LA MONDO

世界 2000年第Z1期 7-8页

作者： nova tragika mistifiko

nova tragika mistifikoLa jusesinta milito en Jugoslavio estaskroma,nova pruvo kiel la tutmondaj,"opin-iokanaligantoj"(Kiel ilin difinas Rejna deJong)ankoraǔfoje sukcesis perforti la veron,mistifiki kaj kretenigi la h... 详细信息

关键词： Pro La

Lagrange’s Spectral Collocation Method for Numerical Approximations of Two-Dimensional Space Fractional Diffusion Equation

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American Journal of Computational Mathematics 2018年第2期8卷 121-136页

作者： Hasib Uddin Molla Mushfika Hossain nova Department of Mathematics University of Dhaka Dhaka Bangladesh Institute of Natural Sciences United International University Dhaka Bangladesh

Due to the ability to model various complex phenomena where classical calculus failed, fractional calculus is getting enormous attention recently. There are several approaches available for numerical approximations of various types of fractional differential equations. For fractional diffusion equations spectral collocation is one of the efficient and most popular ap-proximation techniques. In this research, we introduce spectral collocation method based on Lagrange’s basis polynomials for numerical approximations of two-dimensional (2D) space fractional diffusion equations where spatial fractional derivative is described in Riemann-Liouville sense. We consider four different types of nodes to generate Lagrange’s basis polynomials and as collocation points in the proposed spectral collocation technique. Spectral collocation method converts the diffusion equation into a system of ordinary differential equations (ODE) for time variable and we use 4th order Runge-Kutta method to solve the resulting system of ODE. Two examples are considered to verify the efficiency of different types of nodes in the proposed method. We compare approximated solution with exact solution and find that Lagrange’s spectral collocation method gives very high accuracy approximation. Among the four types of nodes, nodes from Jacobi polynomial give highest accuracy and nodes from Chebyshev polynomials of 1st kind give lowest accuracy in the proposed method.

关键词： Lagrange’s Spectral Method 2D Fractional Diffusion Equation Collocation Method

Nursing service quality,availability,accessibility and acceptability in communicable and chronic diseases prevention and treatment as well as in the primary health care

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International Journal of Nursing Sciences 2017年第4期4卷 349-349页

作者： dra.Mirna Frota COFEN Brazil

*** points·Based on the family health strategy(ESF)·Integrality of attention·Welcome(accessibility)·Family and community approach(link)·Health promotion·Risk and aggravation prevention(follow-up of chronic disea... 详细信息

关键词： prevention diseases service

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工程机械輪胎底盘

工程机械 1965年第7期 42-47页

作者： dra■AN

約十年前,工程机械采用履带与輪胎底盘的比例是60:40%,甚至达到70:30%。由于履带底盘的一些缺点及施工、維修費用高,故近来輪胎式工程机械愈来愈多。为了提高劳动生产和利潤率,势必提高机器的功率并应用較大的輪胎,这就要求相应地加大... 详细信息

約十年前,工程机械采用履带与輪胎底盘的比例是60:40%,甚至达到70:30%。由于履带底盘的一些缺点及施工、維修費用高,故近来輪胎式工程机械愈来愈多。为了提高劳动生产和利潤率,势必提高机器的功率并应用較大的輪胎,这就要求相应地加大机器其他参数,从而使机器售价提高。輪胎底盘的使用在逐步扩大,直至今天,同履带底盘相比,它已占了优势。据統計,目前輪胎与履带底盘的比例是70:30%,有的为80:20%,甚至达到90:10%。为了証实上述結論,本文拟将輪胎与履带底盘的优缺点作一对比,并談談輪胎底盘的应用情况,作为設計师选用底盘时的参考。

关键词：胎面附着系数牵引力外胎比压弹性变形行走力外力弹性形变接地面积滚动阻力拱形断面底盘

Fitting and evaluation of height-diameter models for Alnus japonica in La Trinidad, Benguet, Philippines

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Journal of Mountain Science 2018年第11期15卷 2422-2432页

作者： Kamae P.ANACIOCO Judy Ann L.GORIO Mary Relia S.PADSICO Roscinto Ian C.LUMBRES nova D.DOYOG Young Jin LEE College of Forestry Benguet State University Department of Forest Resources College of Industrial Science Kongju National University

The study was conducted to develop height-diameter at breast height(HT-DBH) models for Alnus japonica in La Trinidad, Benguet,Philippines and evaluate their predictive *** six widely used nonlinear growth models that were selected in this study were the ChapmanRichards, Schnute, Modified logistic, Korf/Lundqvist,Weibull and Exponential. A total of 208 Alnus japonica trees were measured using standard diameter tape for DBH(1.3 m above the ground) and Vertex and transponder was used for the total height measurement. The performance of the developed models were evaluated using the fit statistics including coefficient of determination(R^2), root mean square error(RMSE), mean bias(ē), absolute mean difference(AMD), and Akaike Information Criterion(AIC). The lack-of-fit statistics was also performed for further evaluation of the performance of the *** on the evaluation criteria, all six models were able to determine the DBH-height relationships and fitted the data well. Using the rank analysis, the Weibull HT-DBH model had the best performance among the six commonly used nonlinear growth models. The results of this study will help forest managers especially in La Trinidad, Benguet to easily predict the total height using the Weibull model for Alnus japonica utilizing the DBH as the predicting variable.

关键词： Height- DBH model Alnus japonica Rank analysis La Trinidad Benguet Philippines

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