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Lomatogonium rotatum extract alleviates diabetes mellitus induced by a high-fat,high-sugar diet and streptozotocin in rats

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World Journal of Diabetes 2023年第6期14卷 846-861页

作者： Li-Li dai Sung-Bo Cho Hui-Fang Li Li-Sha A Xiao-Ping ji Sirigunqiqige Pan Ming-Lan bao Laxinamujila bai Gen-Na ba Ming-Hai Fu NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsHainan Medical UniversityHaikou 571199Hainan ProvinceChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsSchool of PharmacyHainan Medical UniversityHaikou 571199Hainan ProvinceChina

baCKGROUND Lomatogonium rotatum(LR)is traditionally used in Mongolian folk medicine as a hypoglycemic agent,but its evidence-based pharmacological effects and mechanisms of action have not been fully *** To emphasize the hypoglycemic action mechanism of LR in a type 2 diabetic rat model and examine potential biomarkers to obtain mechanistic understanding regarding serum metabolite *** A high-fat,high-sugar diet and streptozotocin injection-induced type 2 diabetic rat model was *** chemical composition of the LR was identified by high performance liquid *** extract administrated as oral gavage at 0.5 g/kg,2.5 g/kg,and 5 g/kg for 4 ***-diabetic effects of LR extract were evaluated based on histopathological examination as well as the measurement of blood glucose,insulin,glucagon-like peptide 1(GLP-1),and lipid *** metabolites were analyzed using an untargeted metabolomics *** According to a chemical analysis,swertiamarin,sweroside,hesperetin,coumarin,1.7-dihydroxy-3,8-dimethoxyl xanthone,and 1-hydroxy-2,3,5 trimethoxanone are the principal active ingredients in *** anti-diabetic experiment revealed that the LR treatment significantly increased plasma insulin and GLP-1 levels while effectively lowering blood glucose,total cholesterol,triglycerides,low-density lipoprotein cholesterol,and oral glucose tolerance test compared to the model ***,untargeted metabolomic analysis of serum samples detected 236 metabolites,among which 86 were differentially expressed between the model and the LR *** was also found that LR considerably altered the levels of metabolites such as vitamin B6,mevalonate-5P,Dproline,L-lysine,and taurine,which are involved in the regulation of the vitamin B6 metabolic pathway,selenium amino acid metabolic pathway,pyrimidine metabolic pathway,and arginine and proline metabolic *** These findings indicated that LR may have a hypoglycemic im

关键词： Mongolian medicine Lomatogonium rotatum Type 2 diabetes Metabolomics Swertiamarin Streptozotocin

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准噶尔盆地北部晚白垩世至新近纪沉积介质环境演化特征及其对铀成矿的制约

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吉林大学学报（地球科学版） 2024年第3期54卷 800-810页

作者：何中波冀华丽胡宝群孙萧钟军杨喆陈虹东华理工大学核资源与环境国家重点实验室南昌330013 核工业北京地质研究院中核铀资源勘查与评价技术重点实验室北京100029 核工业216大队乌鲁木齐830011

沉积地层原生沉积介质的环境对砂岩型铀矿成矿作用及潜力分析具有重要意义。本文以准噶尔盆地北部铀矿地质探井N3006中上白垩统至新近系16件泥岩样品中的微量元素测试结果为基础,结合露头及钻孔岩心发育特征,选用对沉积介质环境反映比... 详细信息

沉积地层原生沉积介质的环境对砂岩型铀矿成矿作用及潜力分析具有重要意义。本文以准噶尔盆地北部铀矿地质探井N3006中上白垩统至新近系16件泥岩样品中的微量元素测试结果为基础,结合露头及钻孔岩心发育特征,选用对沉积介质环境反映比较敏感的锂(Li)、锶(Sr)、镓(Ga)、钡(ba)、铜(Cu)、铀(U)、钒(V)、镍(Ni)等微量元素指标,探讨了研究区晚白垩世至新近纪沉积介质环境演化特征及其对铀成矿作用的制约。研究结果表明:晚白垩世至新近纪古沉积环境总体表现为干旱炎热且富氧的淡水-微咸水沉积;据原生沉积环境判断,研究区内上白垩统至新近系各层组砂体总体上不利于传统的层间氧化和潜水氧化砂岩型铀矿化的发育;强氧化的古环境有利于铀元素的迁移,局部特殊环境形成的原生灰色层和后期遭受还原流体改造的灰色层是该区砂岩型铀矿找矿的重要突破方向。

关键词：晚白垩世新近纪泥岩微量元素古沉积环境演化铀成矿准噶尔盆地

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Outcome after Discharge from Hospital of Children with Complicated Severe Acute Malnutrition and Predictors Factors of Non-Response during Outpatient Treatment, in Senegal

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Open Journal of Pediatrics 2023年第4期13卷 473-483页

作者： Abou ba Aliou Thiongane babacar Niang Younoussa Keïta Fatou Ly Aliou Abdoulaye Ndongo Ousmane Ndiaye Pediatric Department of dalal Jamm National Hospital Center Dakar Senegal Institute of Social Pediatrics of Cheikh Anta DIOP University Dakar Senegal Albert Royer Children’s National Hospital Center Dakar Senegal Abass Ndao Hospital Center Dakar Senegal Pikine National Hospital Center Dakar Senegal

Introduction: Malnutrition is a public health problem. It is responsible for high morbidity and mortality in children aged 6 - 59 months. The aim of this study was to determine the outcome of children with complicated severe acute malnutrition after hospital discharge. Methods: This is a descriptive and analytical cross-sectional study conducted from March 1 to November 31, 2021 at the Albert Royer Children’s Hospital. Children discharged from hospital for complicated severe acute malnutrition were included. Results: A total of 103 children were included. The mean age of children at hospitalization was 16.41 ± 10.11 months and mean duration of follow-up after hospital discharge was 29.63 ± 8.59 months. Three children (2.91%) died after hospital discharge. The mean z-score of the weight-for-current height was -1.34 ± 1.08. Almost a quarter (24.27%) of the children remain acute malnourished with 3.88% of severe acute malnutrition (SAM). The predictors’ factors associated with non-response were weaning before 2 years of age (ORaj: 12.21;95% CI [6.82 - 18.44];p = 0.04) and tuberculosis (ORaj: 21.06;95% CI [12.54 - 41.09];p = 0.03). Conclusion: The rate of recovery of nutritional status in children with complicated severe acute malnutrition is satisfactory. Ablactation before the age of two and the existence of tuberculosis are significantly associated with non-recovery of nutritional status.

关键词： Children Severe Acute Malnutrition Recovery Non-Response

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经皮穴位电刺激治疗老年认知功能障碍的效果

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中国医学创新 2024年第26期21卷 45-48页

作者：季韧张柳柳启东市人民医院(南通大学附属启东医院)老年医学科江苏启东226200 启东市第六人民医院全科江苏启东226200

目的:探讨经皮穴位电刺激治疗老年认知功能障碍的效果及对其血清β分泌酶1(baCE1)、超氧化物歧化酶1(SOD1)水平的影响。方法:选择2020年7月—2023年7月启东市人民医院收治的115例老年认知功能障碍患者,按照乱数表法分为对照组(n=57)和... 详细信息

目的:探讨经皮穴位电刺激治疗老年认知功能障碍的效果及对其血清β分泌酶1(baCE1)、超氧化物歧化酶1(SOD1)水平的影响。方法:选择2020年7月—2023年7月启东市人民医院收治的115例老年认知功能障碍患者,按照乱数表法分为对照组(n=57)和观察组(n=58),对照组给予常规药物治疗,观察组在对照组基础上给予经皮穴位电刺激治疗。观察两组认知功能、血清因子(baCE1、SOD1)水平、颅内动脉血流速度[大脑中动脉(MCA)、基底动脉(ba)、椎动脉(VA)血流速度]及日常生活能力。结果:治疗前,两组蒙特利尔认知评估量表(MoCA)评分、日常生活活动能力(ADL)评分及MCA、ba、VA血流速度及SOD1、baCE1水平比较,差异均无统计学意义(P>0.05);治疗后,观察组MoCA评分、MCA、ba、VA血流速度及SOD1、baCE1水平均明显高于对照组,ADL评分明显低于对照组,差异均有统计学意义(PbaCE1水平,还能改善血流动力学,提高日常生活能力。

关键词：认知功能障碍老年患者低频电刺激仪血清因子颅内动脉血流速度

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Theoretical Calculation of Energy Spectrum of YGG:Cr^(3+)and Thermal Shifts of Its R-Lines

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Communications in Theoretical Physics 2009年第5期51卷 914-918页

作者： YANG Kuo ZHANG ji-Ping College of Physical Science and Technology Sichuan University Chengdu 610065 China Physical Department of A＇ba Teachers College Wenchuan 623000 China

With the strong-field scheme and trigonal bases, the complete d3 energy matrix in a trigonally distorted cubic-field has been constructed. By diagonalizing this matrix, the energy spectrum of YGG：Cr^3＋ at normal pressure and low temperature has been calculated. The g factor of the ground-state has been evaluated in terms of the energy spectrum. At the same time, by using the wavefunctions obtained from diagonalizing the complete d^3 energy matrix and Thermal Shifts theory, we calculate the thermal shifts of the sharp lines of YGG：Cr^3＋ and determine the relevant parameters. The calculated results are all in good agreement with the optical-spectrum and EPR experimental data. It is demonstrated that the obtained wavefunctions and the values of parameters are reasonable.

关键词： optical propenty electron-phonon interaction electronic structure thermal shift g factor

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Prevalence and Clinical Characteristics of Chronic Constipation in Senegalese Children

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Open Journal of Pediatrics 2023年第6期13卷 921-928页

作者： Abou ba Aliou Thiongane Ndeye Fatou Sow babacar Niang Younoussa Keïta Fatou Ly Ousmane N’diaye Service de pédiatrie centre hospitalier national Dalal Jamm Dakar Senegal Centre hospitalier national d’enfants Albert Royer Dakar Senegal Service de pédiatrie centre hospitalier Abass Ndao Dakar Senegal Service de pédiatrie centre hospitalier national de Pikine Dakar Senegal

Introduction: Constipation is the infrequent emission of hard stools. It is common, most often of functional origin, with a prevalence ranging from 0.7% to 29.6%. The aim of our study was to investigate the prevalence of constipation in children undergoing paediatric gastroenterology. Methodology: This was a bi-centric retrospective study carried out at the Albert Royer Children’s Hospital and the dalal Jamm Hospital Pediatrics Department. Children followed in the pediatric gastroenterology consultation during the period from January 1, 2013 to February 29, 2020 were included. Results: A total of 337 children (205 boys;60.83%) were included, representing a prevalence of 25%. The median age was 3 years 6 months. The 13 - 24 months age group was the most frequent (27.6%). Rare stools were the main reason for consultation (92.8%). Rare stools were noted in 92.88% of cases. Bristol types 1 and 2 accounted for 6.53% and 54.60% respectively. The main associated signs were abdominal pain (29.4%), followed by abdominal bloating (20.96%). Abdominal pain was functional in 73.58% of cases. Under treatment, 90.19% of children had a favorable outcome. Conclusion: Constipation is common in Senegalese children with a prevalence close to that reported in Western countries. In most case, it is functional with good prognostic.

关键词： Children Chronic Constipation Bristol Scale dakar Hirschsprung Disease

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High responsivity and flexible deep-UV phototransistor based on ta-doped β-Ga_(2)O_(3)

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npj Flexible Electronics 2022年第1期6卷 457-465页

作者： Xiao-Xi Li Guang Zeng Yu-Chun Li Hao Zhang Zhi-Gang ji Ying-Guo Yang Man Luo Wei-da Hu david Wei Zhang Hong-Liang Lu State Key Laboratory of ASIC and System Shanghai Institute of Intelligent Electronics&SystemsSchool of MicroelectronicsFudan University200433 ShanghaiChina National Key Laboratory of Science and Technology on Micro/Nano Fabrication Shanghai Jiao Tong University200240 ShanghaiChina Shanghai Synchrotron Radiation Facility(SSRF) Zhangjiang LabShanghai Advanced Research Institute&Shanghai Institute of Applied PhysicsChinese Academy of Sciences201204 ShanghaiChina State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of Sciences200083 ShanghaiChina

Deep-ultraviolet(DUV)phototransistors have shown great potential applications in UV imaging,artificial intelligence,and wearable *** a large number of wide bandgap semiconductors,the quasi-two-dimensionalβ-Ga_(2)O_(3) is considered as an ideal candidate for DUV photodetector ***,we report a high responsivity(R)and fully flexible ta-dopedβ-Ga_(2)O_(3) DUV phototransistor which exhibits outstanding optoelectrical properties with a high R of 1.32×10^(6) A/W,a large detectivity of 5.68×10^(14) Jones,a great photo-to-dark current ratio of 1.10×10^(10)%,a high external quantum efficiency of 6.60×10^(8)%,and an ultra-fast response time of~3.50 ***,the flexible ta-dopedβ-Ga_(2)O_(3) device also displays high reliability and mechanical flexibility that can sustain well after over 1×10^(4) bending ***,high-contrast imaging of UV light was obtained on the flexible DUV detector arrays,which can be efficiently trained and recognized by an artificial neural *** findings offer a perspective to develop wearable optoelectronics and UV imaging based on high-performance flexibleβ-Ga_(2)O_(3) DUV phototransistors,providing an inspiration for the future work in artificial intelligence and bionic robot fields.

关键词： transistor responsivity artificial

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Generation of human neutralizing monoclonal antibodies against the 2009 pandemic H 1N 1 virus from peripheral blood memory B lymphocytes

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Cellular & Molecular Immunology 2013年第5期10卷 403-412页

作者： Hao Wang Chi Ma Yanlai Lu Xu ji Yongsheng Pang Fang Hua Lianxian Cui Denian ba Wei He Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic Medicine Peking UnionMedical College State Key Laboratory of Medical Molecular Biology Beijing China

The 2009 H 1N 1 influenza pandemic demonstrated the significance of a global health threat to human beings. Although pandemic H 1N 1 vaccines have been rapidly developed, passive serotherapy may offer superior immediate protection against infections in children, the elderly and immune-compromised patients during an influenza pandemic. Here, we applied a novel strategy based on Epstein-barr virus （EBV）-immortalized peripheral blood memory B cells to screen high viral neutralizing monoclonal antibodies （MAbs） from individuals vaccinated with the 2009 pandemic H1N1 vaccine PANFLU.1. Through a massive screen of 13 090 immortalized memory B-cell clones from three selected vaccinees, seven MAbs were identified with both high viral neutralizing capacities and hemagglutination inhibition （HAl） activities against the 2009 pandemic H 1N 1 viruses. These MAbs may have important clinical implications for passive serotherapy treatments of infected patients with severe respiratory syndrome, especially children, the elderly and immunodeficient individuals. Our successful strategy for generating high-affinity MAbs from EBV-immortalized peripheral blood memory B ceils may also be applicable to other infectious or autoimmune diseases.

关键词： Epstein-barr virus hemagglutinin memory B cells neutralizing monoclonal antibody 2009 pandemicinfluenza HIN1 virus

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碳纳米管异质结构的ECR-CVD法制备

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无机材料学报 2006年第5期21卷 1244-1248页

作者：王志巴德纯于春宏梁吉清华大学机械工程系北京100084 沈阳航空工业学院东北大学机械工程与自动化学院沈阳110004

使用电子回旋共振微波等离子体化学气相沉积方法(ECR·CVD),以Fe3O4纳米粒子为催化剂,多孔硅为基底,采用CH4／H2和CH4／B2H6／H2两种气源在连续的CVD过程中大量合成了一种新型的纳米管异质结构．扫描电镜(SEM)和透射电镜(TEM)观察表明:... 详细信息

使用电子回旋共振微波等离子体化学气相沉积方法(ECR·CVD),以Fe3O4纳米粒子为催化剂,多孔硅为基底,采用CH4／H2和CH4／B2H6／H2两种气源在连续的CVD过程中大量合成了一种新型的纳米管异质结构．扫描电镜(SEM)和透射电镜(TEM)观察表明:合成的异质结构一端是类竹节状的掺硼碳纳米管,另一端是光滑中空的纯碳纳米管．异质结构采用底端生长模式,先行生长的掺硼纳米管处于纳米管结构的顶端．

关键词： ECR-CVD 异质结构碳纳米管硼掺杂

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基于蓝莓花青素的新鲜度指示膜制备及性能研究

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食品与发酵工业 2024年第15期50卷 97-103页

作者：陈赛艳刘红林汤俊炀赵正禾冀俊杰四川农业大学食品学院四川雅安625014 山东技师学院文化创意学院山东济南250200

为提升pH指示膜的综合性能,以微晶纤维素(micro-crystalline cellulose,MCC)、马铃薯淀粉(potato starch,PS)、聚乙烯醇(polyvinyl alcohol,PVA)为原料,蓝莓花青素(blueberry anthocyanins,ba)为指示剂,采用流延法制备指示膜,对指示膜的性能进行分析。结果表明,当ba、MCC、PS和PVA的质量比为0.3:0.2:3:0.3时,微晶纤维素提高了薄膜的拉伸强度(1.59 MPa至2.16 MPa)、断裂伸长率(35.83%至38.24%)、杨氏模量(8.25 GPa至25.65 GPa),降低了薄膜的含水率(34.85%至33.23%)和吸水率(122.97%至110.36%)。蓝莓花青素提高了薄膜的机械性能、阻隔性能,降低了耐水性,且与膜中各基质融合良好,指示膜结构均匀、致密。拉伸强度和杨氏模量分别升至2.19 MPa和37.12 GPa;透水率、含水率和吸水率分别降至1.45×10^(-12) g·cm/(cm^(2)·s·Pa)、30.7%和87.52%。蓝莓花青素还赋予薄膜pH敏感性。在不同pH环境中,指示膜与花青素的颜色变化趋势一致,色差可视;同时环境稳定性佳,在不同温度和光照条件下,指示膜的颜色稳定超过14 d(ΔE≤2)。研究结果可为蓝莓花青素指示膜的制备提供参考。

关键词：指示膜蓝莓花青素微晶纤维素马铃薯淀粉聚乙烯醇

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