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Lactate is a potentially harmful substitute for brain glucose fuel:consequences for metabolic restoration of neurotransmission

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Neural regeneration research 2025年第5期20卷 1403-1404页

作者： Oliver Kann Lennart Soder Babak Khodaie Institute of Physiology and Pathophysiology Heidelberg UniversityHeidelbergGermany Interdisciplinary Center for Neurosciences(IZN) Heidelberg UniversityHeidelbergGermany

The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;rae et al.,2024).

关键词： consequences Figure restoration

Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Analysing light pipe two-side aperture in dense population housing to improve the visual and thermal condition

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Energy and Built Environment 2024年第5期5卷 787-799页

作者： Tika Hanjani ova Candra Dewi Nandy Putra Department of Architecture Faculty of EngineeringUniversitas IndonesiaKampus UIDepok16424Indonesia Applied Heat Transfer research Group Department of Mechanical EngineeringUniversitas IndonesiaKampus UIDepok16424Indonesia

Daylight is one of the essential criteria for decent ***,in an urban kampung,access to daylight is limited due to the high-density population in urban Kampung *** study aims to improve the visual and thermal conditions by modifying the aperture of the light pipe based on visual daylight distribution,illuminance level,and thermal conditions in multi-storey houses in hot-humid *** pipe was developed experi-mentally through the simulation model to investigate the performance and impact on the visual and thermal conditions like operational temperature and rH in densely populated Kampung Kota without vertical *** to the results,the two-aperture light pipe residential space enhanced the current situation but did not fulfill the *** two aperture light pipe visually improved daylight distribution by 1.05%-31.36%and illumination level by 8.4%-14.8%.We also found that light pipe also impacts thermal conditions with a 10.92%rH reduction while at the same time increasing temperature up to 10.57%.Therefore,it can be concluded that a two-aperture light pipe has the potential to be applied to actual conditions in hot-humid climates.

关键词： Daylight Light pipe two aperture Densely populated urban kampung Housing Hot-humid climates

Finite Volume Evolution Galerkin Methods for the Shallow Water Equations with Dry Beds

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Communications in Computational Physics 2011年第7期10卷 371-404页

作者： Andreas Bollermann Sebastian Noelle Maria Lukacova-Medvid’ova IGPM RWTH AachenTemplergraben 5552062 AachenGermany Institut fur Mathematik Universitat MainzStaudingerweg 955099 MainzGermany.

We present a new Finite Volume Evolution Galerkin(FVEG)scheme for the solution of the shallow water equations(SWE)with the bottom topography as a source *** new scheme will be based on the FVEG methods presented in(Noelle and Kraft,***.,221(2007)),but adds the possibility to handle dry *** most important aspect is to preserve the positivity of the water *** present a general approach to ensure this for arbitrary finite volume *** main idea is to limit the outgoing fluxes of a cell whenever they would create negative water ***,this corresponds to the absence of fluxes in the presence of *** is then re-established by splitting gravitational and gravity driven parts of the ***,a new entropy fix is introduced that improves the reproduction of sonic rarefaction waves.

关键词： Well-balanced schemes dry boundaries shallow water equations evolution Galerkin schemes source terms

Suboptimal Auditory Dominance in Audiovisual Integration of Temporal Cues

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Tsinghua Science and Technology 2011年第2期16卷 121-132页

作者： M Maiworm B rder Biological Psychology and Neuropsychology University of Hamburg

The present study examined whether audiovisual integration of temporal stimulus features in humans can be predicted by the maximum likelihood estimation （MLE） model which is based on the weighting of unisensory cues by their relative reliabilities. In an audiovisual temporal order judgment paradigm, the reliability of the auditory signal was manipulated by Gaussian volume envelopes, introducing varying degrees of temporal uncertainty. While statistically optimal weighting according to the MLE rule was found in half of the participants, the other half consistently overweighted the auditory signal. The results are discussed in terms of a general auditory bias in time perception, interindividual differences, as well as in terms of the conditions and limits of statistically optimal multisensory integration.

关键词： audiovisual integration statistically optimal behavior temporal perception

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.saUrABH r.KIrAN D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Germination of Chenopodium Album in response to Microwave Plasma Treatment

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Plasma Science and Technology 2008年第4期10卷 506-511页

作者： Bo■ena Er Vitězslav STrA■K Michal Er■ Milan TICH■ Petr PATENKA Institute of Systems Biology and Ecology Academy of Sciences of the Czech RepublicNa Sádkách 7CZ-370 05eské BudějoviceCzech Republic University of South Bohemia in eské Budějovice Department of PhysicsJeronymova 10CZ-371 15 eské BudějoviceCzech Republic Charles University in Prague Faculty of Mathematics and PhysicsV Holeovikách 2CZ-180 00 Praha 8Czech Republic University of South Bohemia in eské Budějovice Department of PhysicsJeronymova 10 CZ-371 15 eské BudějoviceCzech Republic Technical University of LiberecDepartment of Material SciencesHáIkova 6CZ-461 17 Liberec iCzech Republic

The seeds of Lamb＇s Quarters （Chenopodium album agg.） were stimulated by low- pressure discharge. The tested seeds were exposed to plasma discharge for different time durations （from 6 minutes to 48 minutes）. Germination tests were performed under specified laboratory conditions during seven days in five identical and completely independent experiments. Significant differences between the control and plasma-treated seeds were observed. The treated seeds showed structural changes on the surface of the seat coat. They germinated faster and their sprout accretion on the first day of seed germination was longer. Germination rate for the untreated seeds was 15% while it increased approximately three times （max 55%） for seeds treated by plasma from 12 minutes to 48 minutes.

关键词： early growth germination Lamb's Quarters seed enhancement stimulation surfatron discharge

The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TrAIL in pancreatic cancer cell

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Hepatobiliary & Pancreatic Diseases International 2008年第2期7卷 201-209页

作者： Anna Trauzold Christian rder Holger Kalthoff Molecular Oncology research Laboratory Clinic for General and Thoracic Surgery Christian-Albrechts-University 24105 Kiel Germany

BACKGrOUND: TNF-related apoptosis-inducing ligand (TrAIL) is a death ligand of the TNF-superfamily that has been implicated in inducing apoptosis in some tumor cells. The purpose of this study was to find out if TrAIL could induce the expression of uPA, IL-8, MMP-7 and MMP-9. and to explore the corresponding potential signaling transduction pathway in pancreatic cancer cells. METHODS: Colo357wt, Panc89 and PancTu I cell lines were stimulated by TrAIL (100 ng/ml). Crystal violet cell vitality assay was used to check the sensitivity to TrAIL-induced apoptosis. real-time rT-PCr tested the expression of uPA, IL-8, MMP-7 and MMP-9. rESULTS: TrAIL can stimulate the expression of uPA, IL-8, MMP-7 and MMP-9 in pancreatic cancer cell lines, especially in Colo357wt. The members of caspases, MEK1/2, PKC, and NF-kappa B are involved in TrAIL-induced expression of uPA, IL-8, MMP-7 and MMP-9. Furthermore, caspases play a different role in Colo357wt, Panc89 and PancTu I. CONCLUSIONS: TrAIL-treatment may result in the enhancement of invasion involving the signaling pathways of caspases, MEK1/2, PKC and NF-kappa B, in pancreatic cancer cells. It points to the necessity to carefully evaluate in vivo side effects of TrAIL.

关键词： TrAIL molecular mechanism pancreatic neoplasms