检索结果-南通市图书馆

carcinosarcoma of the breast:Facing the challenge of a rare nosologic entity

World Journal of Clinical cases 2025年第2期13卷 14-20页

作者： Aikaterini Mastoraki Maria Tsamopoulou Foivos-Konstantinos Stamatis Alexios Strimpakos ero Mouchtouri Christiana Panagi Evgenia Mela Sotiria Mastoraki Aristotelis Kechagias Dimitrios Schizas Department of Surgery National and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece Department of Surgery National and Kapodistrian University of AthensAthens 11527Greece Department of Medical Oncology Hygeia HospitalAthens 15123Greece Department of Radiology Henry Dunant Hospital CenterAthens 11526Greece Department of Surgery Athens Metropolitan HospitalAthens 15562Greece

carcinosarcoma(CS),also known as metaplastic breast carcinoma with mesenchymal differentiation,is one of the five distinct subtypes of metaplastic breast *** is considered as a mixed,biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition *** cellular origin of this neoplasm remains controversial,most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic *** recent research on the therapeutic strategies against CS neoplastic disorders,surgical resection appears the only potentially curative *** CS metastasize by the lymphatic route,axillary assessment with sentinel lymph node biopsy and/or axillary lymph node dissection is always ***,the tumor also presents a hematogenous metastatic pattern including pleural,pulmonary,liver,brain and less commonly bone ***,surgical removal of breast CS does not necessarily ensure patient’s long-term ***,alternative therapies,such as radio-and chemotherapy proved insufficient and 5-year survival rate is ***,there is evidence that following surgery,the combination of radio and chemotherapy is associated with a better prognosis than either treatment *** aim of this review is to evaluate the results of surgical treatment for breast CS with special reference to the extent of its histological *** features,histogenesis,morphological and immunochemical findings are discussed,while the role of current diagnostic and therapeutic management of this aggressive neoplasm is emphasized.

关键词： carcinosarcoma Breast Diagnostic approach Therapeutic management Prognostic parameters

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Busting the myth: more good than harm in transgenic cells

引用

Neural Regeneration Research 2019年第6期14卷 967-968页

作者： Gonzalo Pi?ero Patricia Setton-Avruj Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicasy TécnicasInstituto de Químicay Fisicoquímica Biológicas (IQUIFIB)Facultad de Farmaciay Bioquímica

Peripheral neuropathy constitutes a highly incidental condition and a major public health concern worldwide(Hanewinckel et al.,2016).This pathology is triggered by peripheral nervous system damage as a consequence of systemic disease or ischemic-traumatic *** the latter case,nerve crush,partial or total transection and stretch injury interrupt nerve conduction and impair sensitivity and motility of the innervated area,which brings about partial or total functional loss in the affected limb and disabling neuropathic *** these reasons,digging into the molecular mechanisms underlying peripheral neuropathy becomes essential for the development of successful therapeutic strategies.

关键词： Busting the myth transgenic cells highly incidental

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trial eligibility in advanced hepatocellular carcinoma: Does it support clinical practice in underrepresented subgroups?

引用

World Journal of Gastroenterology 2021年第24期27卷 3429-3439页

作者： Federico Piñero Leonardo Gomes da Fonseca Hepatology and Liver Unit Hospital Universitario AustralSchool of MedicineAustral UniversityBuenos Aires B1629HJArgentina Clinical Oncology Insituto do Cancer do Estado de São PauloUniversity of São PauloSão Paulo 05403-000Brazil

Although hepatocellular carcinoma is considered a highly lethal malignancy,recent therapeutic advances have been achieved during the last 10 *** scenario resulted in an unprecedented improvement in survival for patients with advanced hepatocellular carcinoma,almost reaching 20-26 mo of overall survival after first-second line sequential *** advent of the combination of atezolizumab with bevacizumab showed,for the first time,superiority over sorafenib with improvement in overall ***,first and second-line trials were correctly based on the premise that a strict selection of patients enhances the power to capture the positive effect of treatment by excluding competing risks for mortality such as liver failure,decompensated cirrhosis or other underlying medical *** a result,the inclusion criteria used in clinical trials do not support the use of novel therapies in several real-world scenarios involving underrepresented subgroups,such as patients with unpreserved liver function,other comorbid conditions,a history of solid-organ transplantation,autoimmune disorders and those with a high risk of *** present text aims at discussing treatment strategies in these subgroups.

关键词： Eligibility Systemic therapies End-stage Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mineralization of pegmatites in parts of the Oban Massif,Southeastern Nigeria:A preliminary analysis

引用

Chinese Journal Of Geochemistry 2009年第2期28卷 146-153页

作者： Kingsley A.ero Ekwueme Barth N. Department of Geology University of CalabarP.O.Box 3651 Unical Post OfficeCalabarNigeria

The Oban Basement Massif of southeastern Nigeria is composed of metamorphosed rocks including phyllites, schists, gneisses and amphibolites cut by pegmatitic dykes of varying length and thickness, which intruded the metamorphic rocks. Preliminary geochemical study and analysis of these pegmatites from western Oban Massif at Uyanga, Akwa Ibami, Iwuru I, Iwuru Ⅱ and Igbofia showed that the pegmatites are highly albitized. This is incon-sistent with earlier postulations that the pegmatites in this part of Nigeria are barren. Indices of fractionation such as Ba/Rb, K/Rb, Na/K, K/Cs, K/Ba reveal that the pegmatites are mineralized and different discrimination plots show that they are enriched in Li, Be, Sn, Ba, ta, Ni, Cs, Sn and Zn. Rare metal indicative elements such as ta, Nb, Rb, Cs, and Sn are enriched in the pegmatites, confirming that the pegmatites are mineralized.

关键词：尼日利亚地块矿化化学研究稀有金属变质岩岩石包东南部

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation of the ^(121)Sb(α,γ)^(125)I reaction cross-section calculations at astrophysical energies

引用

Nuclear Science and Techniques 2023年第11期34卷 85-92页

作者： M.eroğlu C.Yalcın R.T.Güray Department of Physics Kocaeli UniversityUmuttepe41001 KocaeliTurkey Department of Electronics and Automation Piri Reis University34940 TuzlaIstanbulTurkey

Proton-rich nuclei are synthesized via photodisintegration and reverse *** examine this mechanism and reproduce the observed p-nucleus abundances,it is crucial to know the reaction rates and thereby the reaction cross sections of many *** that the number of experiments on the reactions in astrophysical energy regions is very rare,the reaction cross sections are determined by theoretical methods whose accuracy should be *** this study,given that ^(121)Sb is a stable seed isotope located in the region of medium-mass p-nuclei,we investigated the cross sections and reaction rates of the ^(121)Sb(α,γ)^(125)I reaction using the taLYS computer code with 432 different combinations of input parameters(OMP,LDM,and SFM).The optimal model combinations were determined using the threshold logic unit *** theoretical reaction cross-sectional results were compared with the experimental results reported in the *** reaction rates were determined using the two input parameter sets most compatible with the measurements,and they were compared with the reaction rate databases:StaRLIB and REACLIB.

关键词： Cross section Astrophysical S-factor Astrophysical reaction rate p-process nucleosynthesis Threshold logic unit method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Over-height truck collisions with railway bridges:attenuation of damage using crash beams

引用

Earthquake Engineering and Engineering Vibration 2022年第1期21卷 237-252页

作者： Dan Xu Xinxing Yuan Ali Irmak Ozdagli Marlon Agüero Roya Nasimi tao Wang Fernando Moreu Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina EarthquakeAdministrationSanhe 065201China Department of Civil Construction and Environmental EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA Courtesy Appointment Department of Electrical and Computer EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA Courtesy Appointment Department of Mechanical EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA

Railway bridges are susceptible to over-height truck collisions and to address this issue,it is necessary to attenuate the effect of these impacts to ensure the safety of transportation *** study experimentally investigates the effectiveness of crash beams as a cushioning mechanism for railway bridges against ***-height truck and railway bridge impact events were simulated in a 1:5 scale *** design parameters such as the stiffness of the crash beam and the bridge supports were scaled to evaluate different levels of *** experiments were conducted with five configurations consisting of four different types of crash beams and one no-crash beam *** results show that crash beams attenuate bridge total peak dynamic displacement responses between 14.5%and 35.7%,depending on the intensity of the impact and crash beam *** addition,the results show that the average effectiveness in attenuating residual deformation for all four crash beams ranges from 43.03%to 83.40%.Finally,various designs and their effectiveness against lateral impacts with different speeds are *** overall scope of this research is to provide objective information about the design of crash beams for railway bridges based on their response to over-height truck collisions at various speeds.

关键词： railway bridge over-height truck impact attenuation crash beam dynamic displacement scaled model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ni-based catalysts obtained from perovskites oxides for ethanol steam reforming

引用

燃料化学学报 2018年第11期46卷 1332-1341页

作者： Fabiola Nerina Agüero Jose Antonio Alonso Maria Teresa Fernández-Díaz Luis Eduardo cadus Instituto de Investigaciones en Tecnología Química(INTEQUI) UNSL-CONICETAlmirante Brown 14555700 San LuisArgentina Instituto de Ciencia de Materiales de Madrid Consejo Superior de Investigaciones CientíficasCantoblanco28049 MadridSpain Institut Laue-Langevin B.P.156F-38042 Grenoble Cedex 9France

Perovskites as host structures of cations were used in order to generate in situ active and stable catalysts for ethanol steam reforming. For this purpose,La_(1-x)Mg_xAl_(1-y)Ni_yO_3(x = 0.1; y = 0,0.1,0.2,0.3) perovskites were synthetized by the citrate *** segregation is evident for a substitution level higher than 0. 2. The segregation of Ni as NiO generated species interacts with different metal-support after the reduction step. The y = 0.1 catalyst presents the highest H_2 yield value about 85% during reaction time,with low mean values of CH_4 and CO selectivities of 3.4% and 11%,respectively and a low carbon formation. The better performance of y = 0.1 catalyst could be attributed to the minor proportion of segregated phases,thus a controlled expulsion of Ni is successfully reached.

关键词： perovskites catalyst design ethanol steam reforming

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Seamount chains and hotspot tracks:Superficially similar,deeply different

引用

Geoscience Frontiers 2023年第6期14卷 307-326页

作者： Edgardo cañón-tapia División de Ciencias de la Tierra CICESE.Carretera Ensenada-Tijuana#3985Ensenada Baja CaliforniaCP 22860Mexico

Nearly 80%of the seafloor extension has not been covered by high-resolution bathymetry,impeding direct observation of ***,lists of seamount location and height at a global scale have been produced using different *** this work four of such databases(publicly available)are compared with each other to assess their *** identify large differences among databases that could have exerted strong influences on models of seamount production and associated geodynamic *** those differences,it is shown that all databases allow the identification of seamount lines both along the present-day Mid Ocean Ridge(MOR)system and on intraplate ***,those seamount lines do not coincide with the so-called hotspot tracks that commonly were defined by selectively focusing attention on the larger *** of all the databases also shows that distinction based only on seamount size between seamounts produced at Mid-Ocean Ridge(MOR)environments from those associated with mantle-plum fed-hotspot activity has been ***,combined with the fact that most seamount lines defined by the available databases can be traced back to past locations of MOR indicates that most of the present-day intraplate linear arrays of seamounts,which include some large seamounts,were not produced by the action of underlying mantle anomalies envisaged in the form of mantle *** evidence presented here calls for a reassessment of the form in which volcanic and tectonic activities are conceptually related to each other.

关键词： Seamount origin Chains of seamounts Spatial distribution of volcanism Intraplate volcanism Mid Ocean Ridge volcanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of chosen force fields and applied load on thin film lubrication

引用

Friction 2021年第5期9卷 1259-1274页

作者： Thi D.ta Hien D.ta Kiet A.TIEU Bach H.TRAN School of Mechanical MaterialsMechatronicsand Biomedical EngineeringUniversity of WollongongNSW 2522Australia Ho Chi Minh City University of Technology and Education Ho Chi Minh City 800010Vietnam

The rapid development of molecular dynamics(MD)simulations,as well as classical and reactive atomic potentials,has enabled tribologists to gain new insights into lubrication performance at the fundamental ***,the impact of adopted potentials on the rheological properties and tribological performance of hydrocarbons has not been researched *** extensive study analyzed the effects of surface structure,applied load,and force field(FF)on the thin film lubrication of *** lubricant film became more solid‐like as the applied load *** particular,with increasing applied load,there was an increase in the velocity slip,shear viscosity,and *** degree of ordering structure also changed with the applied load but rather *** was also significantly dependent on the surface *** chosen FFs significantly influenced the lubrication performance,rheological properties,and molecular *** adaptive intermolecular reactive empirical bond order(AIREBO)potential resulted in more significant liquid‐like behaviors,and the smallest velocity slip,degree of ordering structure,and shear stress were compared using the optimized potential for liquid simulations of united atoms(OPLS‐UAs),condensed‐phase optimized molecular potential for atomic simulation studies(COMPASS),and ***,classical potentials,such as OPLS‐UA and COMPASS,exhibit more solid‐like behavior than reactive potentials ***,owing to the solid‐like behavior,the lubricant temperatures obtained from OPLS‐UA and COMPASS were much lower than those obtained from AIREBO and *** increase in shear stress,as well as the decrease in velocity slip with an increase in the surface potential parameterζ,remained conserved for all chosen FFs,thus indicating that the proposed surface potential parameterζfor the COMPASS FF can be verified for a wide range of atomic models.

关键词： molecular dynamics simulation force fields applied load tribofilm hydrocarbon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unit-cell design for two-dimensional phase-field simulation of microstructure evolution in single-crystal Ni-based superalloys during solidification

引用

Progress in Natural Science:Materials International 2017年第6期27卷 678-686页

作者： Dongjia cao Na ta Lijun Zhang State Key Lab of Powder Metallurgy Central South University Interdisciplinary Centre for Advanced Materials Simulation (IcaMS) Ruhr-University Bochum

Phase-field simulation serves as an effective tool for quantitative characterization of microstructure evolution in single-crystal Ni-based superalloys during solidification nowadays. The classic unit cell is either limited to γdendrites along crystal orientation or too ideal to cover complex morphologies for γ dendrites. An attempt to design the unit cell for two-dimensional(2-D) phase-field simulations of microstructure evolution in single-crystal Ni-based superalloys during solidification was thus performed by using the MICRESS(MICRostructure Evolution Simulation Software) in the framework of the multi-phase-field(MPF) model,and demonstrated in a commercial TMS-113 superalloy. The coupling to caLPHAD(caLculation of PHAse Diagram) thermodynamic database was realized via the TQ interface and the experimental diffusion coefficients were utilized in the simulation. Firstly, the classic unit cell with a single γ dendrite along crystal orientation was employed for the phase-field simulation in order to reproduce the microstructure ***, such simple unit cell was extended into the cases with two other different crystal orientations, i.e., and . Thirdly, for crystal orientations, the effect of γ dendritic orientations and unit cell sizes on microstructure and microsegregation was comprehensively studied, from which a new unit cell with multiple γdendrites was proposed. The phase-field simulation with the newly proposed unit cell was further performed in the TMS-113 superalloy, and the microstructure features including the competitive growth of γ dendrites,microsegregation of different solutes and distribution of γ′ grains, can be nicely reproduced.

关键词： Ni-based superalloys Solidification Microstructure Phase-field simulation Unit cell

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：