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Improving colorectal cancer screening programs

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World journal of Gastroenterology 2024年第22期30卷 2849-2851页

作者： Oscar j Cordero Lucia Mosquera-Ferreiro Iria Gomez-Tourino Department of Biochemistry and Molecular Biology University of Santiago de CompostelaSantiago de Compostela 15782Spain Centre for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782GaliciaSpain

In this editorial we comment on the article by Agatsuma et al published in the World journal of *** suggest policies for more effective colorectal *** is the main policy that has led to lower mortality rates in later years among the population that was eligible for *** is the gold standard tool for screening and has preventive effects by removing precancerous or early malignant ***,colonoscopy is an invasive process,and fecal tests such as the current hemoglobin immunodetection were developed,followed by endoscopy,as the general tool for population screening,avoiding logistical and economic *** so,participation and adherence rates are *** screening options are being developed with the idea that if people could choose between the ones that best suit them,participation in population-ba.ed screening programs would *** tests,such as a recent one that detects cell-free DNA shed by tumors called circulating tumor DNA,showed a similar accuracy rate to stool tests for cancer,but were less sensitive for advanced precancerous *** the time when the crosstalk between the immune system and cancer was being established as a new hallmark of cancer,novel immune system-rela.ed biomarkers and information on patients’immune parameters,such as cell counts of different immune populations,were studied for the early detection of colorectal cancer,since they could be effective in asymptomatic people,appearing earlier in the adenoma-carcinoma development compa.ed to the presence of fecal ***26,for example,detected 80.37%of advanced *** reach as many eligible people as possible,starting at an earlier age than current programs,the direction could be to apply tests ba.ed on blood,urine or salivary fluid to samples taken during routine visits to the primary health system.

关键词： Mortality rates Colorectal cancer Screening Biomarker Fecal hemoglobin immunodetection Soluble sCD26 Colonoscopy Immunoscores

Determination of selected semi-volatile organic compounds in water using automa.ed online solid-phase extraction with large-volume injection/gas chromatography/mass spectrometry

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Frontiers of Environmental Science & Engineering 2011年第3期5卷 417-425页

作者： Yongtao LI Christina L.MCCARTY ed j.GEORGE Drinking Water Quality Laboratory Underwriters Laboratories Inc.South BendIN 46617USA Chemical Analysis Bruker DaltonicsFremontCA 94538USA

A rapid,sensitive,and cost-effective analyticalmethod was developed for the analysis of selected semivolatileorganic compounds in *** method used anautoma.ed online solid-phase extraction technique coupledwith programmed-temperature vaporization large-volumeinjection gas chromatography/mass *** samples were extracted by using a fully automa.edmobile rack system ba.ed on x-y-z robotic techniquesusing syringes and disposable 96-well extraction *** method was valida.ed for the analysis of 30 semivolatileanalytes in drinking water,groundwater,andsurface *** a sample volume of 10 mL,the linearcalibrations ranged from 0.01 or 0.05 to 2.5μg·L^(-1),and themethod detection limits were less than 0.1μg·L^(-1).For thereagent water samples fortified at 1.0μg·L^(-1)and2.0μg·L^(-1),the obtained mean absolute recoveries were70%-130%with relative standard deviations of less than20%for most *** the drinking water,groundwater,and surface water samples fortified at 1.0μg·L^(-1),theobtained mean absolute recoveries were 50%-130%withrelative standard deviations of less than 20%for *** new method demonstra.ed three advantages:1)no manipulation except the fortification of surrogatestandards prior to extraction;2)significant cost reductionassocia.ed with sample collection,shipping,storage,andpreparation;and 3)reduced exposure to hazardous solventsand other *** a result,this new automa.edmethod can be used as an effective approach for screeningand/or compliance monitoring of selected semi-volatileorganic compounds in water.

关键词： automa.ed solid-phase extraction programmed-temperature vaporization large-volume injection gas chromatography/mass spectrometry semi-volatile organic compounds water analysis

Dominance of transposable element‑rela.ed satDNAs results in great complexity of“satDNA library”and invokes the extension towards“repetitive DNA library”

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Marine Life Science & Technology 2024年第2期6卷 236-251页

作者： Monika Tunjić‑Cvitanić Daniel García‑Souto juan j.Pasantes EvaŠatović‑Vukšić Division of Molecular Biology Ruđer BoškovićInstitute10000 ZagrebCroatia Genomes and Disease Centre for Research in Molecular Medicine and Chronic Diseases(CIMUS)Universidade de Santiago de Compostela15706 Santiago de CompostelaSpain Department of Zoology Genetics and Physical AnthropologyUniversidade de Santiago de Compostela15706 Santiago de CompostelaSpain Centro de Investigación Mariña Dpto de BioquímicaXenética e InmunoloxíaUniversidade de Vigo36310 VigoSpain

Research on bivalves is fast-growing,including genome-wide analyses and genome *** characteristics qualify oysters as a valuable model to explore repetitive DNA sequences and their genome *** we char-acterize the satellitomes of five species in the family Ostreidae(Crassostrea angulata,***,***,***,Ostrea.edulis),revealing a substantial number of satellite DNAs(satDNAs)per genome(ranging between 33 and 61)and peculiarities in the composition of their *** satDNAs were either associa.ed to or derived from transposable elements,displaying a scarcity of transposable element-unrela.ed satDNAs in these *** to the non-conventional satellitome constitution and dominance of Helitron-associa.ed satDNAs,comparative satellitomics demanded more in-depth analyses than standardly *** analyses(including ***,the first bivalve species with a defined satellitome)revea.ed that 13 satDNAs occur in all six oyster genomes,with Cg170/HindIII satDNA being the most abundant in all of *** the“satDNA library model”highlighted the necessity to adjust this term when studying tandem repeat evolution in organisms with such *** repetitive sequences with potential variation in the organizational form and repeat-type affiliation are examined across rela.ed species,the introduction of the terms“TE library”and“repetitive DNA library”becomes essential.

关键词： Satellitome Comparative satellitomics Helitron Bivalves “Dark matter of the genome”

A multi-shot target wheel assembly for high-repetition-rate, laser-driven proton acceleration

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High Power Laser Science and Engineering 2024年第2期 91-98页

作者： j.Pe?as A.Bembibre D.Cortina-Gil L.Martín A.Reija C.Ruiz M.Seimetz A.Alejo j.Benlliure Instituto Galego de Física de Altas Enerxías Universidade de Santiago de Compostela Laboratorio Láser de Aceleración y Aplicaciones RIAIDT Universidade de Santiago de Compostela Instituto Universitario de Física Fundamental y Matemáticas y Dpto.de Didáctica de la Matemática y de las Ciencias Experimentales Universidad de Salamanca Instituto de Instrumentación para Imagen Molecular (I3M) CSIC-Universitat Politècnica de València

A multi-shot target assembly and automatic alignment procedure for laser–plasma proton acceleration at high repetition rate are introduced. The assembly is ba.ed on a multi-target rotating wheel capable of hosting more than 5000 targets,mounted on a 3D motorized stage to allow rapid replenishment and alignment of the target material between laser irradiations. The automatic alignment procedure consists of a detailed mapping of the impact positions at the target surface prior to the irradiation that ensures stable operation of the target, which alongside the purpose-built design of the target wheel, enables operation at rates up to 10 Hz. Stable and continuous laser-driven proton acceleration at 10 Hz is demonstra.ed, with observed cut-off energy stability about 15%.

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A multi-shot target wheel assembly for high-repetition-rate, laser-driven proton acceleration

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High Power Laser Science and Engineering 2024年第2期12卷 87-94页

作者： j.Penas A.Bembibre D.Cortina-Gil L.Martin A.Reija C.Ruiz M.Seimetz A.Alejo j.Benlliure Instituto Galego de Fisica de Altas Enerxias Universidade de Santiago de CompostelaSantiago de CompostelaSpain Laboratorio Laser de Aceleracion y Aplicaciones RIAIDTUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Instituto Universitario de Física Fundamental y Matematicas y Dpto.de Didactica de la Matematica y de las Ciencias Experimentales Universidad de SalamancaSalamancaSpain Instituto de Instrumentación para Imagen Molecular(I3M) CSIC-Universitat Politecnica de ValenciaValenciaSpain

A multi-shot target assembly and automatic alignment procedure for laser–plasma proton acceleration at high repetition rate are *** assembly is ba.ed on a multi-target rotating wheel capable of hosting more than 5000 targets,mounted on a 3D motorized stage to allow rapid replenishment and alignment of the target material between laser *** automatic alignment procedure consists of a detailed mapping of the impact positions at the target surface prior to the irradiation that ensures stable operation of the target,which alongside the purpose-built design of the target wheel,enables operation at rates up to 10 *** and continuous laser-driven proton acceleration at 10 Hz is demonstra.ed,with observed cut-off energy stability about 15%.

关键词： high repetition rate laser-plasma acceleration multi-shot operation proton source target assembly

Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana

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World journal of Gastroenterology 2019年第26期25卷 3344-3358页

作者： Timothy N Archampong Richard H Asmah Cathy j Richards Vicki j Martin Christopher D Bayliss edília Botao Leonor David Sandra Beleza Carla Carrilho Department of Medicine and Therapeutics School of Medicine and DentistryUniversity of GhanaAccra Box 4236Ghana Department of Genetics and Genome Biology University of LeicesterLeicester LE1 7RHUnited Kingdom Department of Medical Laboratory Sciences School of Biomedical and Allied Health SciencesUniversity of GhanaAccra Box 4236Ghana Department of Histopathology Leicester Royal InfirmaryLeicester LE1 5WWUnited Kingdom Department of Pathology Maputo Central HospitalMaputo POBox 1164Mozambique Department of Pathology Medical Faculty of the University of PortoPorto 4200-465Portugal Institute of Molecular Pathology and Immunology at the University of Porto(Ipatimup) Porto 4200-465Portugal Instituto de Investigacao e Inovacao em Saude(i3S) University of PortoPorto 4200-465Portugal Department of Pathology Faculty of MedicineEduardo Mondlane UniversityMaputo POBox 257Mozambique

Gastroduodenal disease(GDD)was initially thought to be uncommon in *** others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the *** the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of *** risk factors for gastric cancer(GCA)include Helicobater pylori(***),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are ***,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol *** these,*** is generally accepted to be causally rela.ed to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal ***,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compa.ed with previous data from Maputo,*** there is a general lack of structured cohort studies in Africa,we also considered endoscopy-ba.ed hospital or tertiary centre studies of symptomatic *** Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical ***,there are differences in PUD within-country despite universally endemic *** *** is not uncommon in *** of the African tertiary-centre studies had higher prevalence of PUD when compa.ed with similar studies in western *** additional intriguing observation is a recent,ongoing decline in PUD in some African countries where *** infection is still *** possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter *** prevalence

关键词： Gastroduodenal Peptic ulcer Gastric cancer Africa Pre-malignant Atrophy Intestinal metaplasia Duodenal ulcer Gastric ulcer

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： jason Philip Appleton Lisa j Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy j England Kailash Krishnan Grant Mair Keith W Muir john Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-ba.ed multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increa.ed disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associa.ed with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Illustration now! fashion

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Illustration now! fashion

Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

作者： ed. julius Wiedemann.

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Oncology Research 2024年第7期32卷 1141-1162页

作者： PAULINA CHMIEL ALEKSANDRA SŁOWIKOWSKA ŁUKASZ BANASZEK ANNA SZUMERA-CIEĆKIEWICZ BARTŁOMIEj SZOSTAKOWSKI MATEUSZ j.SPAŁEK TOMASZŚWITAj PIOTR RUTKOWSKI ANNA M.CZARNECKA Department of Soft Tissue/Bone Sarcoma and Melanoma Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of Medicine Medical University of WarsawWarsaw02-091Poland Department of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Department of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂammatory myoﬁbroblastic tumor(IMT)is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic *** challenges arise from the diverse pathological presentation,variable symptomatology,and lack of different imaging ***,IMT is identiﬁed by the fusion of the anaplastic lymphoma kinase(ALK)gene,which is present in approximately 70%of cases,with various fusion partners,including ran-binding protein 2(RANBP2),which allows conﬁrmation of the *** surgery is the preferred approach for localized tumors,the optimal long-term treatment for advanced or metastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatment within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKI),was ofﬁcially approved by the US Food and Drug Administration(FDA)in 2020 to treat IMT with ALK ***,most patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** promising results have also been achieved with immunotherapy,indicating potential for combined therapy ***,deﬁned recommendations are still *** review analyzes the available research on IMT,including genetic disorders and their impact on the course of the disease,data on the latest targeted therapy regimens and the possibility of developing immunotherapy in this indication,as well as summarizing general knowledge about prognostic and predictive factors,also in terms of resistance to systemic therapy.

关键词： Inﬂammatory myoﬁbroblastic tumor(IMT) Epithelioid inﬂammatory myoﬁbroblastic sarcoma Tyrosine kinase inhibitors(TKI) Anaplastic lymphoma kinase(ALK)