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Applied Mathematics 2022年第4期13卷 338-355页

作者： Georgios d. Trikkaliotis Maria ch. Gousidou-Koutita department of Mathematics Aristotle University of Thessaloniki Thessaloniki Greece

This paper is describing in detail the way we define the equations which give the formulas in the methods Runge-Kutta 6th order 7 stages with the incorporated control step size in the numerical solution of Ordinary differential Equations (OdE). The purpose of the present work is to construct a system of nonlinear equations and then by solving this system to find the values of all set parameters and finally the reduction formula of the Runge-Kutta (6,7) method (6th order and 7 stages) for the solution of an Ordinary differential Equation (OdE). Since the system of high order conditions required to be solved is complicated, all coefficients are found with respect to 7 free parameters. These free parameters, as well as some others in addition, are adjusted in such a way to furnish more efficient R-K methods. We use the MATLAB software to solve several of the created subsystems for the comparison of our results which have been solved analytically. Some examples for five different choices of the arbitrary values of the systems are presented in this paper.

关键词： Initial Value Problem Runge-Kutta Methods Ordinary differential Equations

Production of the Reduction Formula of Seventh Order Runge-Kutta Method with Step Size Control of an Ordinary differential Equation

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Applied Mathematics 2022年第4期13卷 325-337页

作者： Georgios d. Trikkaliotis Maria ch. Gousidou-Koutita department of Mathematics Aristotle University of Thessaloniki Thessaloniki Greece

The purpose of the present work is to construct a nonlinear equation system (85 × 53) using Butcher’s Table and then by solving this system to find the values of all set parameters and finally the reduction formula of the Runge-Kutta (7,9) method (7th order and 9 stages) for the solution of an Ordinary differential Equation (OdE). Since the system of high order conditions required to be solved is too complicated, we introduce a subsystem from the original system where all coefficients are found with respect to 9 free parameters. These free parameters, as well as some others in addition, are adjusted in such a way to furnish more efficient R-K methods. We use the MATLAB software to solve several of the created subsystems for the comparison of our results which have been solved analytically.

关键词： Initial Value Problem Runge-Kutta Methods Ordinary differential Equations

Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models

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Asian Pacific Journal of Tropical Medicine 2012年第4期5卷 283-288页

作者： ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma Pharmacognosy and Ethnopharmacology division National Botanical Research Institute(Council of Scientific and Industrial Research)Rana Pratap MargP.O.Box No.436Lucknow 226001Uttar PradeshIndia department of Pharmacology Goel Institute of Pharmacy & SciencesFaizabad Road(Near Indira Canal) Lucknow 227105Uttar PradeshIndia

Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(***) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal ***:Five groups of six rats each were selected for the *** extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated *** serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the ***:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of *** ***,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose *** addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver ***:The results of this study slrongly indicate that ethanolic extract of *** has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats.

关键词： Ziziphus oenoplia(Rhamnaceae) Rifampicin Isoniazid Hepatotoxicity

Preliminary observations on the feeding habits of the Mediterranean needlefish Tylosurus acus imperialis(Teleostei:Belonidae)

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Journal of Coastal Life Medicine 2016年第6期4卷 426-429页

作者： Manel châari Lobna Boudaya Lassâd Neifar Laboratory of Biodiversity and Aquatic Ecosystems Department of Life SciencesFaculty of Sciences of SfaxUniversity of SfaxPC 11713000 SfaxTunisia

Objective:To present the first information on the feeding habits of the Mediterranean needlefish Tylosurus acus imperialis(***)of Tunisia and to examine the diet variation in relation to the fish size,maturity and ***:Gut contents of 92 specimens of ***,collected mainly from May 2004 to July 2006 off the Gulf of Gabès,Southeastern Tunisian coast,were ***:The results showed that 55.4%of them had empty guts and 44.6%contained food in their *** emptiness index did not vary significantly according to size classes or sexes of *** food consisted of teleosts(Mugilidae,Gobidae and Belonidae)(59.63%)followed by crustaceans(40.24%),mostly decapods Sycionia carinata(5.42%).A decrease in the feeding rate at the peak of the spawning season was observed for both sexes.A diet variation among juvenile and adult specimens of *** was ***:This study enhances our knowledge on the biology of the Mediterranean needlefish *** fish is an active predator and an opportunistic feeder but the feeding rate declines at the peak of the spawning season.

关键词： diet Needlefish Belonidae Tylosurus acus imperialis Tunisia Mediterranean sea

Identification of optimal contemporary antiemetic prophylaxis for doxorubicin-cyclophosphamide chemotherapy in chinese cancer patients: post-hoc analysis of 3 prospective studies

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Cancer Biology & Medicine 2021年第3期18卷 825-832页

作者： Winnie Yeo Leung Li Thomas KH Lau Kwai T Lai Vicky,TC chan Kwan H Wong christopher ch Yip Elizabeth Pang Maggie cheung Vivian chan Carol ch Kwok Joyce JS Suen Frankie KF Mo department of Clinical Oncology Prince of Wales HospitalFaculty of MedicineHong Kong Cancer InstituteHong KongChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong KongChina department of Clinical Oncology Princess Margaret HospitalHong KongChina

Objective:chemotherapy-induced nausea and vomiting(CINV)are common with doxorubicin-cyclophosphamide(AC)*** antiemetic regimens incorporate neurokinin-1 receptor antagonist(NK1 RA),5-hydroxytryptamine type-3 receptor antagonist(5 HT3 RA),corticosteroid,and dopamine *** post-hoc analysis compared results of 3 prospective antiemetic studies conducted among chinese breast cancer patients who received(neo)adjuvant AC,in order to identify optimal antiemetic ***:A total of 304 patients were included:Group 1,ondansetron/dexamethasone(d1);Group 2,aprepitant/ondansetron/dexamethasone(d1);Group 3,aprepitant/ondansetron/dexamethasone(d1–3);Group 4,aprepitant/ondansetron/dexamethasone(d1–3)/olanzapine;and Group 5,netupitant/palonosetron/dexamethasone(d1–3).Antiemetic efficacies of Groups 3,4,and 5 during cycle 1 of AC were individually compared with Group *** addition,emesis outcomes of patients in Groups 3 and 5,and those of Groups 2 and 3,were ***:When comparing efficacies of a historical doublet(5 HT3 RA/dexamethasone)with triplet antiemetic regimens(NK1 RA/5 HT3 RA/dexamethasone)with/without olanzapine,complete response(CR)percentages and quality of life(QOL)in overall phase of cycle 1 AC were compared between Group 1 and the other groups:Group 1 vs.3,41.9%vs.38.3%(P=0.6849);Group 1 vs.4,41.9%vs.65.0%(P=0.0107);and Group 1 vs.5,41.9%vs.60.0%(P=0.0460).Groups 4 and 5 achieved a better *** comparing netupitant-based(Group 3)with aprepitant-based(Group 5)triplet antiemetics,CR percentages were 38.3%vs.60.0%,respectively(P=0.0176);Group 5 achieved a better *** comparing 1 day(Group 2)vs.3 day(Group 3)dexamethasone,CR percentages were 46.8%and 38.3%,respectively(P=0.3459);Group 3 had a worse ***:Aprepitant-containing triplets were non-superior to doublet ***-containing triplets and adding olanzapine to aprepitant-containing triplets were superior to ***/palono

关键词： Netupitant palonosetron aprepitant olanzapine NEPA Asians

degradation of Methylene Blue and Rhodamine B Using a New Visible Light-Responsive Photocatalyst, KSb_2PO_(8-x)N_y

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Acta Metallurgica Sinica(English Letters) 2016年第4期29卷 335-343页

作者： G.Ravi ch.Sudhakar Reddy K.Sreenu Ravinder Guje Radha Velchuri M.Vithal department of chemistry University College of ScienceOsmania University

Potassium phosphatoantimonates, KSb2PO8 （KSbPO） and KSb2PO8-xNy （KSbPON）, are prepared by solidstate method. Urea is employed as a source of nitrogen for N-doping. Structural, morphological and optical properties of both KSbPO and KSbPON are characterized by powder X-ray diffraction （PXRd）, scanning electron microscopy, energydispersive spectroscopy, Fourier transform infrared spectroscopy and UV-visible diffuse reflectance spectroscopy. Both samples are found to crystallize in a monoclinic lattice with Cc space group. The d-lines of KSbPO and KSbPON are refined by least square fitting the PXRd data, using POWd software to obtain their unit cell parameters. The bandgap energy （Eg） of both pristine and N-doped KSbPO is found from their Kubelka-Munk plot. The KSbPON/visible photocatalytic degradation of methylene blue and rhodamine B has been investigated in aqueous heterogeneous suspension. The generation of .OH in the presence of KSbPON during the photoreaction is verified by a fluorescence technique using terephthalic acid （TA） as a probe.

关键词： Potassium phosphatoantimonates characterization Organic dyes Photodegradation

diversity of monogenean parasites in belonid fishes off the Mediterranean Sea with redescription of Aspinatrium gallieni Euzet and Ktari,1971 and Axine belones Abildgaard,1794

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Journal of Coastal Life Medicine 2016年第4期4卷 268-272页

作者： Manel châari Hela derbel Lassâd Neifar Laboratory of Biodiversity and Aquatic Ecosystems Department of Life SciencesFaculty of Sciences of SfaxUniversity of SfaxPC 11713000 SfaxTunisia

Objective:To provide informations on the diversity of Monogenea parasitizing belonid fishes from the Mediterranean *** species Aspinatrium gallieni Euzet and Ktari,1971(***)and Axine belones Abildgaard,1794(***)from belonids Tylosurus acus imperialis Rafinesque,1810(***)and Belone belone Lowe,1839(***)off Tunisian coast were ***:during the sampling period between 2004 and 2009,a total of 624 belonid fish belonging to three species,453 ***,45 Belone svetovidovi Collette and Parin,1970 and 126 *** were investigated for monogenean ***:Five Polyopisthocotylean monogenean parasites species were founded infected belonid fishes from Tunisian *** are,Nudaciraxine imperium châari,derbel and Neifar,2010,***,Axine sp.,Axinoides sp.(Axinidae)and ***(Micrcotylidae).Among them,the most prevalent species *** from the inner gill cover and gill filaments of *** and *** from the gills of *** were *** represented new host record for ***.A complete list of monogenean parasites found in belonid fishes from our study and those reported from the Mediterranean Sea was ***:This paper enhances the current knowledge of Monogenea infecting belonids off the Mediterranean ***’s the first study on monogenean parasites of the overall belonid fishes off Tunisia.

关键词： Monogenea diversity Fish Belonidae Tunisia Mediterranean Sea

Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis

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World Journal of Gastroenterology 2014年第8期20卷 2079-2084页

作者： Alejandro González-Ojeda Gabino Cervantes-Guevara Manuela chávez-Sánchez Carlos dávalos-Cobián Susana Ornelas-Cázares Michel dassaejv Macías-Amezcua Mariana chávez-Tostado Kenia Militzi Ramírez-Campos Anaís del Rocío Ramírez-Arce Clotilde Fuentes-Orozco Research Unit in Clinical Epidemiology Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social SecurityGuadalajaraCP 44340JaliscoMéxico Gastroenterology department Hospital Civil de Guadalajara "Fray Antonio Alcalde"GuadalajaraCP 44280JaliscoMéxico Gastroenterology department Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social SecurityGuadalajaraCP 44340JaliscoMéxico

AIM: To validate whether the platelet count/spleen size ratio can be used to predict the presence of esophageal varices in Mexican patients with hepatic cirrhosis.

关键词： Platelet count/spleen diameter ratio Esophageal varices Hepatic cirrhosis Hepatitis C virus Mexican patients

低氧因素对丙泊酚麻醉新生大鼠认知功能的影响

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中国临床药理学杂志 2018年第14期34卷 1678-1681页

作者：于晴刘阳孙茫张敬李上莹莹涂生芬重庆医科大学附属儿童医院儿科学重庆市重点实验室重庆400014 重庆医科大学附属儿童医院儿童发育重大疾病国家国际科技合作基地重庆400014 重庆医科大学附属儿童医院麻醉科重庆400014 重庆医科大学附属儿童医院儿科发育疾病研究教育部重点实验室重庆400014

目的研究低氧因素对丙泊酚麻醉新生大鼠认知功能的影响。方法用随机数表法将新生7 d的Sd大鼠分为6组,每组18只:氧气对照组(CO)、空气对照组(CA)、低氧对照组(ch)和丙泊酚氧气组(PO)、丙泊酚空气组(PA)、丙泊酚低氧组(PH)。丙泊酚组腹腔... 详细信息

目的研究低氧因素对丙泊酚麻醉新生大鼠认知功能的影响。方法用随机数表法将新生7 d的Sd大鼠分为6组,每组18只:氧气对照组(CO)、空气对照组(CA)、低氧对照组(ch)和丙泊酚氧气组(PO)、丙泊酚空气组(PA)、丙泊酚低氧组(PH)。丙泊酚组腹腔注射丙泊酚50 mg·kg^(-1),对照组腹腔注射脂肪乳5.0 mL·kg^(-1),1次/天,连续7 d。每次注射完毕后,将大鼠分别放置于轻度低氧(18%O_2)、空气(21%O_2)和氧气(50%O_2)环境中,监测血氧饱和度(SpO_2)。Mirros水迷宫实验检测各组大鼠学习记忆能力;免疫组化法检测各组海马CA1区活化型半胱氨酸天冬氨酸蛋白酶-3(Cleaved-caspase-3)表达和蛋白激酶B(Akt)、糖原合成酶激酶3β(GSK-3β)及磷酸化蛋白的表达。结果对照组(CO组、CA组、ch组)和丙泊酚组(PO组、PA组、PH组)的SpO_2分别为(98.4±0.5)%,(98.4±0.8)%,(97.5±0.6)%,(98.5±0.4)%,(82.4±1.7),(68.8±3.0)%,PA组和PH组与对照组比较,SpO_2显著降低,差异均有统计学意义(均P1)。PA组、PH组与对照组比较,逃逸潜伏期延长,差异均有统计学意义(均P1区Cleaved-caspase-3积分光密度(IOd)值分别为103.60±46.57,83.20±38.78,123.80±78.60,591.00±316.30,1083.67±421.50,2873.60±391.49,PA组和PH组与对照组比较,IOd值明显升高,差异均有统计学意义(均P1.20±0.15,1.43±0.16,1.53±0.13,0.89±0.17,0.66±0.10,0.50±0.12,PA组和PH组与对照组比较,差异均有统计学意义(均P1)。结论低氧因素显著增加丙泊酚麻醉的神经毒性,其机制可能与抑制P-Akt及GSK-3β表达增加有关。

关键词：丙泊酚低氧认知障碍新生大鼠

Ion channels in liver diseases and hepatocellular carcinoma: potential tools for diagnosis, prognosis, and therapy

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Hepatoma Research 2020年第4期6卷 1-16页

作者： María de Guadalupe chávez-López Andrea Cruz-díaz Karla Nicol Tlapalcoyoa-Apanco Julio IsaelPérez-Carreón Javier Camacho department of Pharmacology Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360Mexico Escuela de Ciencias de la Salud Universidad del Valle de MéxicoMexico City 04910Mexico Instituto Nacional de Medicina Genómica Mexico City 14610Mexico

Cancer is a major cause of death *** carcinoma(HCC)is one of the malignancies with the highest mortality-to-incidence ratio(>0.9),and in some countries this value is up to ***,many patients are diagnosed at advanced stages of the ***,HCC early markers,as well as novel therapeutic approaches,are urgently *** is the main type of liver cancer and it is associated with different factors including alcohol use,viral infections,and fatty liver disease.A significant percentage of HCC patients previously had liver *** ion channels have been proposed as novel potential markers and therapeutic targets for diverse cancers including ***,we review most of the findings associating ion channel expression with HCC and its etiological factors,as well as some possible pro-tumorigenic mechanisms of action for ion channels in *** therapies for HCC treatment and prevention are also *** channel targeting offers a plethora of opportunities for HCC prevention,early diagnosis,and therapy that may help to reduce the extremely high mortality-to-incidence ratio of this malignancy.

关键词： Ion channels hepatocellular carcinoma hepatitis virus cirrhosis liver disease alcohol