Ion channels in liver diseases and hepatocellular carcinoma: potential tools for diagnosis, prognosis, and therapy
作者机构：Department of PharmacologyCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360Mexico Escuela de Ciencias de la SaludUniversidad del Valle de MéxicoMexico City 04910Mexico Instituto Nacional de Medicina GenómicaMexico City 14610Mexico
出 版 物：《Hepatoma Research》 (肝癌研究（英文版）)
年 卷 期：2020年第6卷第4期
页 面：1-16页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Ion channels hepatocellular carcinoma hepatitis virus cirrhosis liver disease alcohol
摘 要：Cancer is a major cause of death *** carcinoma(HCC)is one of the malignancies with the highest mortality-to-incidence ratio(0.9),and in some countries this value is up to ***,many patients are diagnosed at advanced stages of the ***,HCC early markers,as well as novel therapeutic approaches,are urgently *** is the main type of liver cancer and it is associated with different factors including alcohol use,viral infections,and fatty liver disease.A significant percentage of HCC patients previously had liver *** ion channels have been proposed as novel potential markers and therapeutic targets for diverse cancers including ***,we review most of the findings associating ion channel expression with HCC and its etiological factors,as well as some possible pro-tumorigenic mechanisms of action for ion channels in *** therapies for HCC treatment and prevention are also *** channel targeting offers a plethora of opportunities for HCC prevention,early diagnosis,and therapy that may help to reduce the extremely high mortality-to-incidence ratio of this malignancy.
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