检索结果-南通市图书馆

Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease:A crosssectional study

引用

World Journal of Gastroenterology 2025年第7期31卷 63-73页

作者： Yolanda Real Martinez carlos Ernesto Fernandez-Garcia Esther Fuertes-Yebra Mario calvo Soto Angela Berlana Vicente Barrios Maria caldas Leticia Gonzalez Moreno Luisa Garcia-Buey Begoña Molina Baena Miguel Sampedro-Nuñez Maria J Beceiro c García-Monzón Águeda González-Rodríguez Servicio Aparato Digestivo Hospital Universitario La PrincesaInstituto de Investigación Sanitaria La PrincesaUniversidad Autónoma de MadridMadrid 28006Spain Unidad de Investigación Hospital Universitario Santa CristinaInstituto de Investigación Sanitaria La PrincesaMadrid 28009Spain Department of Endocrinology Department of PediatricsHospital Infantil Universitario Niño JesúsInstituto de Investigación La PrincesaMadrid 28009Spain centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición Instituto de Salud Carlos IIIMadrid 28029Spain Servicio de Endocrinología y Nutrición Hospital Universitario La PrincesaInstituto de Investigación Sanitaria La PrincesaUniversidad Autónoma de MadridMadrid 28006Spain Instituto de Investigaciones Biomédicas Sols-Morreale(IIBM) CSIC-UAMMadrid 28029Spain centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas Madrid 28029Spain

BAcKGROUND Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in these ***,their actual prevalence and pathophysiology remain to be *** To determine the prevalence of SMAs and to assess the significance of circulating myokines as biomarkers in patients with *** Skeletal muscle strength and muscle mass were measured in a cross-sectional study in a cohort of 62 patients fulfilling MASLD criteria,recruited from the outpatient clinics of a tertiary level *** degree of fibrosis and liver steatosis was studied using abdominal ultrasound and transitional *** and metabolic characteristics as well as serum levels of different myokines were also determined in the MASLD *** analysis was performed comparing results according to liver fibrosis and *** No significant differences were found in both skeletal muscle strength and skeletal muscle mass in patients with MASLD between different stages of liver ***,serum levels of fibroblast growth factor-21(FGF21)were significantly higher in patients with MASLD with advanced hepatic fibrosis(F3-F4)than in those with lower fibrosis stages(F0-F2)(197.49±198.27 pg/mL vs 95.62±83.67 pg/mL;P=0.049).In addition,patients with MASLD with severe hepatosteatosis(S3)exhibited significantly higher serum levels of irisin(1116.87±1161.86 pg/mL)than those with lower grades(S1-S2)(385.21±375.98 pg/mL;P=0.001).cONcLUSION SMAs were uncommon in the patients with MASLD *** serum levels of irisin and FGF21 were detected in patients with advanced liver steatosis and fibrosis,respectively,with potential implications as biomarkers.

关键词： Skeletal muscle alterations Myokines Metabolic dysfunction-associated steatotic liver disease Liver fibrosis Hepatosteatosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

无耗散拓扑电子学的新进展:器件与能量耗散

引用

科学通报 2025年第1期70卷 1-3页

作者：李海龙闫青江华谢心澄北京大学物理学院量子材料科学中心北京100871 复旦大学理论物理与信息科学交叉中心上海200433 复旦大学微纳电子器件与量子计算机研究院上海200433 合肥国家实验室合肥230088

晶体管,作为现代微纳电子技术的基石,是构成集成电路的基本单元,实现了复杂电路功能的微型化.晶体管通过控制电子的输运,执行各种逻辑运算和信号处理任务.然而,在执行这些功能时,传统晶体管并非完全高效和无能耗.电子在晶体管内部传输... 详细信息

晶体管,作为现代微纳电子技术的基石,是构成集成电路的基本单元,实现了复杂电路功能的微型化.晶体管通过控制电子的输运,执行各种逻辑运算和信号处理任务.然而,在执行这些功能时,传统晶体管并非完全高效和无能耗.电子在晶体管内部传输过程中,由于电阻的存在,会有一部分能量转化为热能,这种能量转化遵循焦耳定律,即电流通过导体产生的热功率与电流的平方以及导体的电阻成正比.这种以焦耳热形式释放的能量损耗,不仅降低了集成电路的能量效率,还可能导致晶体管的温度升高,进而影响电路的稳定性和可靠性,甚至限制了微纳电路性能的进一步提升.

关键词：焦耳定律能量转化复杂电路内部传输集成电路能量效率微纳电子技术能量耗散

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three subspecies of Black-tailed Godwit share non-breeding sites in the world's largest river delta

引用

Avian Research 2025年第1期16卷 1-10页

作者： Delip K.Das Wouter M.G.Vansteelant Bingrun Zhu Shariful Islam Naim Khandakar Marco van der Velde chris J.Hassell Jesse R.conklin Pierrick Bocher Jos c.E.W.Hooijmeijer Yvonne I.Verkuil Theunis Piersma Department of Zoology Faculty of Life and Earth SciencesJagannath UniversityDhaka1100Bangladesh conservation Ecology Group Groningen Institute for Evolutionary Life SciencesUniversity of GroningenPO Box 111039700 CCGroningenthe Netherlands BirdEyes Centre for Global Ecological Change at the Faculties of Science&Engineering and Campus FryslânUniversity of GroningenZaailand 1108911 BNLeeuwardenthe Netherlands Theoretical and computational Ecology Institute for Biodiversity and Ecosystem DynamicsUniversity of AmsterdamScience Park 9041098 XHAmsterdamthe Netherlands Hunan Global Messenger Technology co. LtdChangsha410205China Behavioural&Physiological Ecology Groningen Institute for Evolutionary Life SciencesUniversity of GroningenPO Box 111039700 CCGroningenthe Netherlands Global Flyway Network PO Box 3089BroomeWA 6725Australia Littoral Environnement et Sociétés UMR LIENSs 7266 cNRS La Rochelle University2 rue Olympe de Gouges17000La RochelleFrance NIOZ Royal Netherlands Institute for Sea Research Department of Coastal SystemsPO Box 59Den Burg1790 ABTexelthe Netherlands

During the non-breeding season(September-April),Black-tailed Godwits(Limosa limosa)are commonly seen in coastal and inland wetlands of the Ganges-Brahmaputra-Meghna Delta in *** hypothesize that the Ganges-Brahmaputra-Meghna Delta,at the overlap between the central Asian and East Asian-Australasian flyways,may host three subspecies that breed in disjunct areas of temperate and northern Asia:***,***,and *** used mitochondrial DNA(mt DNA)haplotype network and biometric analysis to determine subspecies in captured individuals,and deployed GPS-GSM transmitters to verify breeding areas of individuals with subspecies *** test for differential habitat preferences,we sampled birds at two ecologically distinct habitats known to host the largest concentrations of non-breeding Black-tailed Godwits in Bangladesh:Nijhum Dweep National Park,a tidal coastal habitat with brackish water on the south-central coast,and Tanguar Haor(‘backmarsh'),a seasonal freshwater floodplain in the *** the non-breeding seasons of 2021-2022 and 2022-2023,we sampled and measured 93 Black-tailed Godwits,54 of which were equipped with GPS-GSM *** mt DNA haplotype network analysis confirmed the presence of limosa,melanuroides,and bohaii subspecies at the study ***,indeed,Black-tailed Godwits subspecies,despite having distinct breeding ranges,exhibit(partially)overlapping non-breeding ranges in *** subspecies composition differed significantly between sites,with limosa and bohaii dominating in Tanguar Haor and melanuroides in Nijhum *** the 21 individuals that were tracked to their breeding grounds,18 migrated to the expected breeding range of their respective ***,one bird with a limosa haplotype migrated to a known breeding area of bohaii,whereas two birds with melanuroides haplotypes migrated to the supposed breeding range of ***,while ecological factors at both ends of the flyways may s

关键词： Black-tailed godwits central Asian flyway Ganges-Brahmaputra-Meghna Delta GPS-GSM tracking Migration mtDNA Subspecies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

雨夜惊魂

引用

译林 2025年第1期 142-143页

作者： c.T.普拉特姜伟江苏科技大学外国语学院

天雨如注，开车的感觉犹如穿越厚厚的水幕。他稍稍松开油门。夜色深沉，又逢风狂雨骤，务必要当心，千万别发生事故，车别出故障。暴风雨之夜，人只想窝在家里。雨刮器“刺啦刺啦”地反复摩擦挡风玻璃，令人昏昏欲睡。他透过前灯微弱的...

天雨如注，开车的感觉犹如穿越厚厚的水幕。他稍稍松开油门。夜色深沉，又逢风狂雨骤，务必要当心，千万别发生事故，车别出故障。暴风雨之夜，人只想窝在家里。雨刮器“刺啦刺啦”地反复摩擦挡风玻璃，令人昏昏欲睡。他透过前灯微弱的光晕凝视前方。雨打汽车，听起来犹如白噪声，不由得使他想起希区柯克电影开篇的场景。透过瓢泼暴雨，他注意到路边有人影晃动。

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Evaluating Effect of Magnetic Field on Nusselt Number and Friction Factor of Fe3O4-TiO2/Water Nanofluids in Heat-Sink Using Artificial Intelligence Techniques

引用

Frontiers in Heat and Mass Transfer 2025年第1期23卷 131-162页

作者： L.S.Sundar Sérgio M.O.Tavares António M.B.Pereira Antonio c.M.Sousa centre for Mechanical Technology and Automation Department of Mechanical EngineeringUniversity of AveiroAveiro3810-131Portugal

The experimental analysis takes too much time-consuming process and requires considerable effort,while,the Artificial Neural Network(ANN)algorithms are simple,affordable,and fast,and they allow us to make a relevant analysis in establishing an appropriate relationship between the input and output *** paper deals with the use of back-propagation ANN algorithms for the experimental data of heat transfer coefficient,Nusselt number,and friction factor of water-based Fe3O4-TiO2 magnetic hybrid nanofluids in a mini heat sink under magnetic *** data considered for the ANN network is at different Reynolds numbers(239 to 1874),different volume concentrations(0%to 2.0%),and different magnetic fields(250 to 1000 G),*** types of ANN back-propagation algorithms Levenberg-Marquardt(LM),Broyden-Fletcher-Goldfarb-Shanno Quasi Newton(BFGS),and Variable Learning Rate Gradient Descent(VLGD)were used to train the heat transfer coefficient,Nusselt number,and friction factor data,*** ANOVA t-test analysis was also performed to determine the relative accuracy of the three ANN *** Nusselt number of 2.0%*** Fe3O4-TiO2 hybrid nanofluid is enhanced by 38.16%without a magnetic field,and it is further enhanced by 88.93%with the magnetic field of 1000 Gauss at a Reynolds number of 1874,with respect to the base fluid.A total of 126 datasets of heat transfer coefficient,Nusselt number,and friction factor were used as input and output *** three ANN algorithms of LM,BFGS,and VLGD,have shown good acceptance with the experimental data with root-mean-square errors of 0.34883,0.25341,and 1.0202 with correlation coefficients(R2)of 0.99954,0.9967,and 0.94501,respectively,for the Nusselt number ***,the three ANN algorithms predict root-mean-square errors of 0.001488,0.005041,and 0.006924 with correlation coefficients(R2)of 0.99982,0.99976,and 0.99486,respectively,for the friction factor *** to BFGS and VLGD algorithms,the

关键词： Artificial neural network nusselt number friction factor heat sink correlations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Finite element analysis of the effect of interlayer on interfacial stress transfer in layered graphene nanocomposites

引用

Journal of Materials Science & Technology 2019年第6期35卷 1147-1152页

作者： c.c.Roach Y.c.Lu Department of Mechanical Engineering University of Kentucky

Understanding the roles of interlayers in reinforcement efficiencies by layered graphene is very important in order to produce strong and light graphene based nanocomposites. The present paper uses the finite element method to evaluate the interfacial strain transfers and reinforcement efficiencies in layered graphene-polymer composites. Results indicate that the presence of compliant interlayers in layered graphene plays significant roles in the transfers of strain/stress from matrix to graphene and subsequently the reinforcement effectiveness of layered graphene. In general, the magnitude of shear strain transferred onto the rigid graphene decreases as the thickness of the interlayer increases. This trend becomes insignificant as the graphene becomes sufficiently large(s>25,000). The shear strain at the interface of graphene-matrix is also greatly influenced by the interlayer modulus. A stiffer interlayer would result in a higher shear strain transferred on the graphene. The performance of the interlayers is further affected by the property of the composite and the architecture of the layered graphene stack. If a composite contains more graphene phase, the efficiency of reinforcement by a layered graphene becomes improved. If a graphene stack contains more interlayers, the effectiveness of reinforcement at the edges of the graphene becomes negatively affected.

关键词： Interlayer Layered graphene Nanocomposites Interfacial stress transfer Finite element method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analytical modeling of effect of interlayer on effective moduli of layered graphene-polymer nanocomposites

引用

Journal of Materials Science & Technology 2017年第8期33卷 827-833页

作者： c.c.Roach Y.c.Lu Department of Mechanical Engineering University of KentuckyLexingtonKY 40506-0503USA

Nanocomposites enhanced with two-dimensional, layered graphene fillers are a new class of engineering materials that exhibit superior properties and characteristics to composites with conventional ***, the roles of ＂interlayers＂ in layered graphene fillers have yet to be fully explored. This paper examines the effect of interlayers on mechanical properties of layered graphene polymer *** an effective filler, the fundamental properties（in-plane Young＇s modulus E（L1）, out-of-plane Young＇s modulus E（L2）; shear modulus G（L12）, major Poisson＇s ratio V（L12）） of the layered graphene were computed by using the Arridge＇s lamellar model. The effects of interlayers on effective moduli of layered graphene epoxy composites were examined through the Tandon-Weng model. The properties of the interlayer show noticeable impact on elastic properties of the composites, particular the out-of-plane properties（Young＇s modulus E2 and shear modulus G（12））. The interlayer spacing is seen to have much great influence on properties of the composites. As the interlayer spacing increases from 0.34 nm to 2 nm, all elastic properties of the composites have been greatly decreased.

关键词： Interlayer Layered graphene Nanocomposite Effective moduli

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Observing the evolution of graphene layers at high current density

引用

Nano Research 2016年第12期9卷 3663-3670页

作者： chun-Wei Huang Jui-Yuan chen chung-Hua chiu cheng-Lun Hsin tseung-Yuen Tseng Wen-Wei Wu Department of Materials Science and Engineering Chiao Tung University 1001 University Road Hsinchiu 30010 Taiwan China Department of Electrical Engineering Central University Chung-Li City Taoyuan 32001 Taiwan China Department of Electronics Engineering and Institute of Electronics Chiao Tung University 1001 University Road Hsinchiu 30010 Taiwan China

Graphene has demonstrated its potential in several practical applications owing to its remarkable electronic and physical properties. In this study, we successfully fabricated a suspended graphene device with a width down to 20 nm. The morphological evolution of graphene under various electric field effects was systematically examined using an in-situ transmission electron microscope （TEM）. The hourglass-shaped graphene sample instantly broke apart at 7.5 mA, indicating an impressive breakdown current density. The current-carrying capacity was calculated to be -1.6 × 10^9 ***-2, which is several orders higher than that of copper. The current-carrying capacity depended on the resistivity of graphene. In addition, atomic volume changes occurred in the multilayer graphene samples due to surface diffusion and Ostwald ripening （OR）, indicating that the breakdown mechanism is well approximated by the electric field. This study not only provides a theory to explain the breakdown behavior but also presents the effects on materials contacted with a graphene layer used as the transmission path.

关键词： graphene breakdown high current density in-situ transmissionelectron microscope (TEM) Ostwald ripening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two-plasmon-decay instability stimulated by dual laser beams in inertial confinement fusion

引用

Matter and Radiation at Extremes 2025年第1期10卷 48-56页

作者： c.-W.Lian Y.Ji R.Yan J.Li L.-F.Wang Y.-K.Ding J.Zheng Department of Modern Mechanics University of Science and Technology of ChinaHefeiAnhui 230026China collaborative Innovation center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefei 230026China Institute of Applied Physics and computational Mathematics Beijing 100088China

Two-plasmon-decay instability(TPD)poses a critical target preheating risk in direct-drive inertial confinement *** this paper,TPD collectively driven by dual laser beams consisting of a normal-incidence laser beam(Beam-N)and a large-angle-incidence laser beam(Beam-L)is investigated via particle-in-cell *** is found that significant TPD growth can develop in this regime at previously unexpected low laser intensities if the intensity of Beam-L exceeds the large-angle-incidence *** beams contribute to the growth of TPD in a“seed-amplification”manner in which the absolute instability driven by Beam-L provides the seeds that are convectively amplified by Beam-N,making TPD energetically important and causing significant pump depletion and hot-electron generation.

关键词： laser pump decay

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

引用

Science china Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan Liu Guanghui Jin Ze Li Shujie chen Xiaoshuang Dai Liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin Li Michael c Yu Jia Sun Jingxing Ou Hong chen Liwei Xie college of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern china Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the chromatin immunoprecipitation(chIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by chIP-qPcR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：