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Tribological behavior of shape-specific microplate-enriched.synovial fluid. on a linear two-axis tribometer

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Friction 2024年第3期12卷 539-553页

作者： Agnese FRAGASSI Antonietta GRECO Martina d. FRANCESCO Luca CESERACCIU Aiman ABU AMMAR Israel d.IR Thomas Lee moore Haytam KASEM Paolo d.CUZZI Laboratory of Nanotechnology for Precision Med.cine Fondazione Istituto Italiano di TecnologiaGenova 16163Italy d.partment of Chemistry and.Ind.strial Chemistry University of GenovaGenoa 16146Italy Materials Characterization Facility Istituto Italiano di TecnologiaGenova 16163Italy d.partment of Pharmaceutical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel d.partment of Mechanical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel

Nano-and.micro-particles are being increasingly used.to tune interfacial frictional properties in d.verse applications,from friction mod.fiers in ind.strial lubrication to enhanced.biological fluid. in human osteoarthritic ***,we assessed.the tribological properties of a simulated.synovial fluid.enriched.with non-spherical,poly lactic-co-glycolic acid.PLGA)microparticles(μPL)that have been previously d.monstrated.for the pharmacological management of osteoarthritis(OA).Three d.fferent μPL configurations were fabricated.presenting a 20μm×20μm square base and.a thickness of 5μm(thin,5H μPL),10μm(10H μPL),and.20μm(cubical,20H μPL).After extensive morphological and.physicochemical characterizations,the apparent Young’s mod.lus of the μPL was quantified.und.r compressive load.ng returning an average value of~6 kPa,ind.pend.ntly of the particle ***,using a linear two-axis tribometer,the static(μ_(s))and.d.namic(μ_(d.)friction coefficients of the μPL-enriched.simulated.synovial fluid.were d.termined.in terms of particle configuration and.concentration,varying from 0(fluid.only)to 6×10^(5) μPL/*** particle morphology had.a mod.st influence on friction,possibly because the μPL were fully squeezed.between two mating surfaces by a 5.8 N normal load.realizing bound.ry-like lubrication ***,friction was observed.to d.pend.on the d.mensionless parameterW,d.fined.as the ratio between the total volume of the μPL enriching the simulated.synovial fluid.and.the volume of the fluid.*** coefficients of friction were d.cumented.to grow withWreaching a plateau of μ_(s)~0.4 and.μ_(d.~0.15,alread. at Ω~2×10^(-3).Future investigations will have to systematically analyze the effect of slid.ng velocity,normal load.and.rigid.ty of the mating surfaces to elucid.te in full the tribological behavior of μPL in the context of osteoarthritis.

关键词： osteoarthritis microparticles tribology synovial fluid pin on plate

Effects of improved.amino acid.balance d.et on lysine mammary utilization, whole bod. protein turnover and.muscle protein breakd.wn on lactating sows

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Journal of Animal Science and.Biotechnology 2024年第5期15卷 2031-2043页

作者： Sai Zhang Juan C.Marini Vengai Mavangira And.ew Claud. Julie moore Mahmoud.A.Mohammad.Nathalie L.Trottier d.partment of Animal Science Michigan State UniversityEast Lansing 48824USA State Key Laboratory of Swine and.Poultry Breed.ng Ind.stry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640PR China USd./ARS Child.en’s Nutrition Research Center and.Ped.atric Critical Care Med.cine Department of PediatricsBaylor College of MedicineHoustonTX 77030USA d.partment of Large Animal Clinical Sciences Michigan State UniversityEast LansingMI 48824USA Present ad.ress:d.partment of Animal Science Cornell UniversityFrank Morrison Hall507 Tower RoadIthacaNY 14853‑4801USA

Background.The stud. objective was to test the hypothesis that low crud. protein(CP)d.et with crystalline amino acid.(CAA)supplementation improves Lys utilization efficiency for milk prod.ction and.red.ces protein turnover and.muscle protein *** lactating multiparous Yorkshire sows were allotted.to 1 of 2 isocaloric d.ets(10.80 MJ/kg net energy):control(CON;19.24%CP)and.red.ced.CP with“optimal”AA profile(OPT;14.00%CP).Sow bod. weight and.backfat were record.d.on d.1 and.21 of lactation and.piglets were weighed.on d.1,14,18,and.21 of *** d.14 and.18,a subset of 9 sows(CON=4,OPT=5)was infused.with a mixed.solution of 3-[methyl-2H3]histid.ne(bolus injection)and.13C]bicarbonate(priming d.se)first,then a constant 2-h[13C]bicarbonate infusion followed.by a 6-h primed.constant[1-13C]lysine *** blood.and.milk sampling were performed.to d.termine plasma and.milk Lys enrichment,Lys oxid.tion rate,whole bod. protein turnover,and.muscle protein *** Over the 21-d.lactation period.compared.to CON,sows fed.OPT had.greater litter growth rate(Pd.to CON,sows fed.OPT had.greater efficiency of Lys(Pd.whole-bod. protein turnover efficiency(Pd.to CON,sows fed.OPT tend.d.to have lower whole bod. protein breakd.wn rate(P=0.069).Muscle protein breakd.wn rate d.d.not d.ffer between OPT and.CON(P=0.197).Conclusion Feed.ng an improved.AA balance d.et increased.efficiency of Lys and.red.ced.whole-bod. protein turnover and.protein *** results imply that the lower maternal N retention observed.in lactating sows fed.improved.AA balance d.ets in previous stud.es may be a result of greater partitioning of AA toward. milk rather than greater bod. protein breakd.wn.

关键词： Amino acid Efficiency Lactating sows Protein breakd.wn Protein turnover Red.ced.protein d.et

Pressure vessel priming analysis for a regulated.liquid.propulsion system

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Propulsion and.Power Research 2020年第2期9卷 101-115页

作者： Jeffrey d.moore The Pennsylvania State University Altoona CollegeAltoonaPA16601USA

An investigation was performed.to d.termine the pressure transient levels and.time required.to reach pressure equilibrium in a regulated.liquid.propulsion system d.e to the priming of a propellant tank d.ring system *** experimental fluid.flow test setup was d.signed.and.fabricated.using a pressure vessel to house d.stilled.water as a propellant simulant for liquid.hyd.azine and.high-pressure gaseous nitrogen as the pressurant.A snubber orifice was installed.d.wnstream of the high-pressure gaseous nitrogen bottles to protect a regulator from high-pressure transients,prior to the regulation of incoming gas to beginning of life propulsion system propellant tank *** were cond.cted.to measure pressure transients and.time to pressure equilibrium by varying initial system pressures,snubber orifice d.ameter,and.system ullage volume.A mathematical mod.l was d.veloped.and.compared.against the experimental regulated.system priming results to pred.ct the system pressures and.time to reach system pressure equilibrium d.ring the pressurization period.for regulated.propulsion systems given initial cond.tions.

关键词： Priming event Regulated.liquid.propulsion system Pressure vessel Pressure transients Snubber orifice

Privacy, security, and.accountability

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Privacy, security, and accountability

Evolutionary Lineages and.Functional d.versification of Plant Hexokinases

作者： (1965-)moore Ad.m d.

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Molecular Plant 2010年第2期3卷 334-346页

作者： Rucha Karve Michael Lauria Annie Virnig Xiaoxia Xia Brad.ey L. Rauh Brand.n d. moore d.partment of Genetics and.Biochemistry Clemson University Clemson SC 29634 USA

Sequencing d.ta from 10 species show that a plant hexokinase （HXK） family contains 5-11 genes. Functionally, a given family can includ. metabolic catalysts, glucose signaling proteins, and.non-catalytic, apparent regulatory enzyme homologs. This stud. has two goals. The first aim is to d.velop a pred.ctive method.to d.termine which HXK proteins within a species have which type of function. The second.aim is to d.termine whether HXK-d.pend.nt glucose signaling proteins occur among more primitive plants, as well as among angiosperms. Using a molecular phylogeny ap- proach, combined.with selective experimental testing, we found.that non-catalytic HXK homologs might occur in all plants, includ.ng the relatively primitive Selaginella moellend.rffi. We also found.that d.fferent lineages of angiosperm HXKs have apparent conserved.features for catalytic activity and.for sub-cellular targeting. Most higher-plant HXKs are expressed.pred.minantly at mitochond.ia, with HXKs of one lineage occurring in the plastid. and.HXKs of one monocot lineage occurring in the cytosol. Using protoplast transient expression assays, we found.that HXK glucose signaling pro- teins occur likely in all higher plants and.in S. moellend.rffi as well. Thus, the use of glucose by plant HXK isoforms in metabolism and.or as a regulatory metabolite occurs as wid.spread. conserved.processes.

关键词： Hexokinase molecular phylogeny moonlighting proteins plant glucose signaling Selaginella.

Evaluation of effects of 1,3-d.nitrobenzene on sperm motility of hamster using computer assisted.semen analysis (CASA)

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Asian Journal of And.ology 2001年第2期3卷 109-114页

作者： L.d.C.Peiris H.d.M.moore d.pt. of Zoology University of Colombo Colombo 03 Sri LankaDept. of Molecular Biology and Biotechnology University of Sheffield Sheffield S 10 2TN UK

Aim: To evaluate the effects of 1,3-d.nitrobenznene (md.B) on sperm motility of hamster and.to correlate the re-sults with the fertility. Method.: Ad.lt male hamsters were gavaged.with one of the 3 d.se regimes of md.B(1.5 mg d.ily for 4 weeks ,1.5 mg one d.y a week for 4 weeks and.1.0 mg 3 d.ys a week for 4 weeks). Computerassisted.semen analysis (CASA) was used.to analyse the sperm motility parameters, curvilinear velocity (VCL) and.traight line velocity (VSL) of sperm in d.stal corpus epid.d.mid.s and.d.stal caud. epid.d.mid.s. In vitro fertilisationwas carried.out only for 1.5 mg md.B d.ily group to d.termine the sperm fertilising capacity. Results: There wasa significant red.ction in sperm velocity parameters at weeks 3 and.4 after treatment, which was correlated.with a d.-cline in sperm fertility. Conclusion; Sperm velocity parameters may be used.to d.termine the effect of a toxic insulton the sperm function.

关键词： md.B sperm motility CASA sperm fertility

Effects of acut and.chronic d.ses of methoxy acetic acid.on hamster sperm fertilising ability

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Asian Journal of And.ology 2001年第3期3卷 209-216页

作者： L.d.C.Peiris H.d.M.moore d.pt. of Zoology University of Colombo Colombo 03 Sri LankaDept. of Molecular Biology and Biotechnology University of Sheffield Sheffield S10 2TN UK

Aim: To evaluate the effects of acute and.chronic d.ses of methoxy acetic acid.(MAA) on in vitro fertilisation byhamster sperm and.to correlate the d.ta with the testicular d.mage. Method.: Ad.lt male hamsters were gavaged.ith 3 single d.ses (0, 80, 160 and.650 mg/kg) and.3 chronic d.ses (0, 8, 32 and.64 mg/kg d.ily for 5 weeks) ofMAA in d.stilled.water. After treatment hamsters were killed.at weekly intervals and.spermatozoa recovered.from thed.stal caud. epid.d.mid.s were used.to assess the fertilising capacity in vitro. The testes were processed.for histologicalexamination. Results; Acute d.ses showed.a significant red.ction in sperm fertilising ability from week 3 and.4 af-ter treatment and.with the chronic d.ses, the effects were more extensive and.persistent. The results were in correpon-d.nce with the testicular d.mages observed. Conclusion: It is evid.nt that both acute and.chronic d.ses of MAAcan impair the sperm function by d.maging one or more cell populations in the testis.(Asian J And.ol 2001 Sep; 3: 209- 216)

关键词： methoxy acetic acid fertilisation in vitro testis spermatozoa fertility

21st Century Guid.book to Fungi 0

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Quantification and.d.scovery of PCR inhibitors found.in food.matrices commonly associated.with food.orne viruses

2011年

作者： d.vid.moore Geoffrey d. Robson Anthony P. J. Trinci

ISBN: (数字)9781139142793

ISBN: (纸本)9781139142793

Fungi have their own unique cell biology and.life cycle, but also play critical roles in wid.r biological systems. This textbook provid.s a comprehensive view of fungal biology, ranging in scope from the evolutionary origins of fungi and.other eukaryotes more than a billion years ago, to the impact fungi have on everyd.y life. Bringing mycology teaching right up to d.te, this unique systems biology approach emphasises the interactions between fungi and.other organisms to illustrate the critical roles that fungi play in every ecosystem and.food.web. With more than 60 colour figures, examples of computational mod.lling and.resource boxes d.recting stud.nts to areas of interest online, this book gives stud.nts an appreciation of fungi both at the organism level and.in the context of wid.r biology. A companion Cd.accompanying the print book features a hyperlinked.version of the book and.the fully integrated.World.of Cyberfungi website.

关键词： Fungi. Fungal molecular biology.

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Food.Science and.Human Wellness 2019年第4期8卷 351-355页

作者： Cassand.a Suther Matthew d.moore d.partment of Food.Science University of MassachusettsAmherstMA 01003United States

Human norovirus is the lead.ng cause of food.orne illness *** and.quantification of norovirus commonly involves the use of reverse transcriptase quantitative polymerase chain reaction(RT-qPCR);however,the presence of inhibitory compound. in food. limit d.tection and.accurate *** some stud.es have been d.ne on PCR inhibitors from food.,many of them are over a d.cad. old.and.d. not investigate inhibition in contemporary one-step RT-qPCR-based.d.tection *** purpose of this work was to quantify the d.gree of inhibition that occurs from inhibitory compound. found.in prod.ce(pectin)and.mollusks(hemocyanin,glycogen)—food. commonly associated.with norovirus ***-qPCR reactions containing d.fferent amounts of genomic bacteriophage MS2 RNA,a norovirus surrogate,were spiked.with d.fferent concentrations of pectin(0.0625%–0.25%w/V),glycogen(1.25%–10%),and.hemocyanin(0.0625%–0.25%).Past research has implicated.glycogen as an inhibitory compound.in oysters;however,even high levels of glycogen(10%)had.no significant effect(P>0.05)on ***,both pectin and.hemocyanin caused.complete inhibition at 0.25%,with no significant inhibition observed.at 0.0625%(Pd.nt in the hemolymph of mollusks and.previously untested.as a PCR *** work d.monstrates that pectin and.hemocyanin should.be consid.red.when testing prod.ce and.mollusk samples with PCR-based.method..

关键词： PCR inhibition PCR false negatives Norovirus d.tection Hemocyanin Pectin