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Correlates of resistance to gastrointestinal nematode infection in Nigerian West African dwarf sheep

Asian pacific Journal of Tropical Medicine 2012年第7期5卷 529-532页

作者： IK Idika SN Chiejina LI Mhomga pa Nnadi la Ngongeh Department of Veterinary parasitology and Entomology University of NigeriaNsukkaNigeria Department of Veterinary parasitology and Microbiology Michael Okpara University of AgricultureUmudikeNigeria Department of Animal Health and Production University of AgricultureMakurdiNigeria Department of Animal Health and Production University of NigeriaNsukkaNigeria

Objective:To investigate correlates of resistance to G1 nematode infection in Nigerian West African dwarf(WAD) ***:Thirty three sheep were randomly assigned to two groups, A(n=27) which were used for experimental infections,and B(n=6) which served as uninfected *** infected animal received weekly escalating infections with infective larvae(60% Haemonchus contortus(***) and 40%Trichostrongylus colubriformis(***) for 4 *** responses of all the infected and control sheep were assessed by faecal egg count(FEC),worm burden(Wb),packed cell volume(PCV),body weight(Bwt).and body condition score(BCS).On the basis of their individual faecal egg output,lambs in group A with epg≤1 000 on any sampling day were classified as low faecal egg count(LFEC) phenotype(n = 16),those with epg between 1 000 and 10 000 as intermediate(n=5) and lambs with epg > 10 000 as high feacal egg count(HFEC) phenotype(n=6).Results:The difference between the FEC classes was highly significant(P=0.001).The BCS and weight gained at the end of the experiment by the control and LFEC sheep was significandy higher(P≤0.05) than those of the intermediate and HFEC *** was a significant and negative correlation between the parasitological measures and the trio of BCS,PCV and Bwt of ***:The result of the study indicated that the FEC,weight gain,PCV,and BCS are correlates and potential selection crileria of G1 nematode resistant WAD sheep.

关键词： WAD sheep Phenotypic markers Resistance Resilience GI nematode

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小型质子转移反应质谱仪离子源的设计与优化

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分析试验室 2024年第6期43卷 819-827页

作者：陈蹇平王俊闻路红陈腊宁波大学宁波高等技术研究院宁波315211 宁波华仪宁创智能科技有限公司宁波315100 广州市华粤行仪器有限公司广州511400

作为一种快速、高灵敏的挥发性有机物(VOCs)检测技术,质子转移反应质谱(PTR-MS)被越来越多地应用于环境、医学、公共安全等领域。作为PTR-MS的关键部件之一,空心阴极辉光放电离子源对仪器性能具有重要影响。本文通过有限元仿真优化了空... 详细信息

作为一种快速、高灵敏的挥发性有机物(VOCs)检测技术,质子转移反应质谱(PTR-MS)被越来越多地应用于环境、医学、公共安全等领域。作为PTR-MS的关键部件之一,空心阴极辉光放电离子源对仪器性能具有重要影响。本文通过有限元仿真优化了空心阴极结构,在阴极内径为20 mm、阳极与阴极间隙为4 mm时,离子源放电效果较好。将优化后的空心阴极辉光放电离子源与便携式质谱仪联用,并测试了离子信号与放电气压和放电电流的关系。结果表明,最佳放电气压约为200 pa,最佳放电电流为9~13 m A。采用乙腈样品测试了仪器性能,系统响应时间在10 s以内,乙腈检出限约为10^(-9)(V/V),线性范围为50×10^(-9)~350×10^(-9)(V/V),线性相关系数R^(2)=0.991。利用该装置检测了苹果发酵过程中产生的VOCs随时间的变化,证明了该仪器可用于实际样品检测。

关键词：质子转移反应质谱空心阴极辉光放电离子源挥发性有机物线性离子阱有限元仿真

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Bioactive compounds of red grapes from Dao region(Portugal):Evaluation of phenolic and organic profile

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Asian pacific Journal of Tropical Biomedicine 2016年第4期6卷 315-321页

作者： Luís Rodrigues Silva Mafalda queiroz Health Sciences Research Centre Faculty of Health Sciences University of Beira Interior Department of Chemical Engineering Faculty of EngineeringUniversity of Porto Polytechnic Institute of Castelo Branco School of Health Dr.Lopes Dias laboratory of Pharmacognosy Department of ChemistryFaculty of PharmacyUniversity of Porto

Objective:To improve the knowledge on the metabolite profile of five red grapes from D?o region(Portugal),concerning to the phenolic characteristics(coloured and non-coloured phenolics) and organic acid ***:Five red grapes collected from D?o region were *** profiles of phenolic compounds and organic acids were estimated by high-performance liquid chromatography with diode-array detection and high-performance liquid chromatography with UV detector,***:Totally 24 phenolic compounds were identified,and distributed by several classes:8 anthocyanins,1 hydroxybenzoic acid,4 hydroxycinnamic acids,1 stilbene,4flavan-3-ols,6 ***,10 organic acids were detected in all *** contents of each phenolic class and organic acids amounts varied significantly among the different grape cultivars *** principal components analysis differentiates the Touriga Nacional from the other varieties due to their high contents in anthocyanins,non-coloured phenolics and organic *** Nacional is an important red grape cultivar,highly esteemed in D?o region for its ability to produce high quality ***:The results suggest that the red grapes from D?o region present a good composition in bioactive compounds,being important for the production of wines with superior quality.

关键词： Vitis vinifera Grapes Dao region Phenolics Organic acids

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甲状腺乳头状癌颈中线淋巴结分区预测对侧中央区淋巴结转移情况的价值研究

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解剖学研究 2024年第3期46卷 242-247页

作者：徐国建邹岚王威佛山市第一人民医院血管甲状腺外科广东佛山528000

目的分析甲状腺乳头状癌(PTC)患者对侧中央区淋巴结(Cont-CLNs)转移的相关因素,评估颈中线淋巴结(Mid-CLNs)分区在识别Cont-CLNs转移中的临床价值。方法选取2021年1月至2023年6月广东省佛山市第一人民医院进行甲状腺全切除术和双侧中央... 详细信息

目的分析甲状腺乳头状癌(PTC)患者对侧中央区淋巴结(Cont-CLNs)转移的相关因素,评估颈中线淋巴结(Mid-CLNs)分区在识别Cont-CLNs转移中的临床价值。方法选取2021年1月至2023年6月广东省佛山市第一人民医院进行甲状腺全切除术和双侧中央区颈淋巴清扫术(CND)治疗PTC的125例患者,组织病理学检查评估的主要因素包括:原发肿瘤最大直径、多灶性、被膜侵犯、腺外浸润、桥本氏甲状腺炎、淋巴结转移分区。组间数据比较采用单因素方差分析。利用多因素Logistic回归分析法分析Cont-CLNs转移的危险因素,计算受试者工作特征(ROC)曲线下面积,分析对侧Mid-CLNs转移对Cont-CLNs转移的预测效能。结果125例PTC患者中,107(85.60%)例患者发生Mid-CLNs转移,57.60%(72/125)的患者发生患侧Mid-CLNs转移,28.80%(36/125)的患者发生对侧Mid-CLNs转移。在单因素分析中,多灶性(P=0.004)、被膜侵犯(P=0.002)、腺外浸润(P=0.048)、对侧Mid-CLNs转移(P<0.01)和Ipis-CLNs转移(P=0.043)与Cont-CLNs转移的发生有显著相关性。而Mid-CLNs转移(P=0.422)、患侧Mid-CLNs转移(P=0.856)与Cont-CLNs转移的发生则无相关性。多因素Logistic回归分析发现,Ipis-CLNs转移(P=0.013,OR=2.065)和对侧Mid-CLNs转移(P=0.008,OR=2.072)发生越多,Cont-CLNs转移发生的概率越大。且对侧Mid-CLNs转移阳性对Cont-CLNs转移预测的AUC为0.664(95%CI=0.554~0.774,P=0.006),敏感度为76.19%,特异度为56.60%。结论对侧Mid-CLNs转移是Cont-CLNs转移的独立危险因素,且对预测Cont-CLNs转移具有较为良好的诊断价值。

关键词：甲状腺乳头状癌颈淋巴结分区甲状腺全切除术相关性

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MYC and gastric adenocarcinoma carcinogenesis

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World Journal of Gastroenterology 2008年第39期14卷 5962-5968页

作者： Danielle queiroz Calcagno Mariana Ferreira Leal paulo Pimentel Assumpo Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano Human Cytogenetics laboratory Biology Science InstituteFederal University of ParáBelém PA 66075-900Brazil Genetics Division Department of Morphology and GeneticsFederal University of So PauloSo Paulo SP 04023-900Brazil Joo de Barros Barreto University Hospital Federal University of ParáBelém PA 66073-000Brazil

MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. In the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinoma carcinogenesis, including its association with Helicobacterpylori （Hpylon] and clinical applications.

关键词： MYC Gastric adenocarcinoma Gastric preneoplastic lesions Gastric carcinogenesis Helicobacter pylori

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Branch retinal vein thrombosis and visual loss probably associated with pegylated interferon therapy of chronic hepatitis C

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World Journal of Gastroenterology 2006年第28期12卷 4602-4603页

作者： Luciana Lofego Gonalves Alberto queiroz Farias patrícia Lofego Gonalves Elbio Antonio D'Amico Flair José Carrilho Santa Casa de Misericórdia de Vitória Espírito Santoand University of Sao Paulo School of MedicineBrazil University of Sao paulo School of Medicine Brazil Federal University of Espírito Santo School of Medicine Brazil

Ophthalmological complications with interferon therapy are usually mild and reversible, not requiring the withdrawal of the treatment. We report a case of a patient who had visual loss probably associated with interferon therapy. Chronic hepatitis C virus infection （genotype la） was diagnosed in a 33-year old asymptomatic man. His past medical history was unremarkable and previous routine ophthalmologic check-up was normal. Pegylated interferon alpha and ribavirin were started. Three weeks later he reported painless reduction of vision. Ophthalmologic examination showed extensive intraretinal hemorrhages and cottonwool spots, associated with inferior branch retinal vein thrombosis. Antiviral therapy was immediately discontinued, but one year later he persists with severely decreased visual acuity. This case illustrates the possibility of unpredictable and severe complications during pegylated interferon therapy.

关键词： Hepatitis C Interferon Visual loss

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Identification of <i>JAK2</i>(V617F) Mutation in Myeloproliferative Neoplasms by Using Allele Specific Polymerase Chain Reaction (AS-PCR)

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American Journal of Molecular Biology 2020年第4期10卷 273-282页

作者： Khin la Pyae Tun Aung Zaw latt Win pa pa Naing San San Htwe Yamin Ko Ko Win Win Mar San Yu Hlaing Wai Wai Han Sein Win Department of Medical Research Yangon Myanmar Department of Clinical Haematology Yangon General Hospital Ministry of Health and Sports Nay Pyi Taw Myanmar

Myeloproliferative neoplasms (MPNs) are a group of clonal haematopoietic stem cell disorders characterized by the proliferation of one or more myeloid cell lineages. According to WHO classification, the Janus associated kinase 2 (JAK2) V617F mutation is one of the major diagnostic criteria in BCR-ABL1 negative myeloproliferative neoplasms. The aim of this study is to detect the JAK2 (V617F) mutation in patients with myeloproliferative neoplasms to get accurate diagnosis and proper management. A total of 90 clinically diagnosed MPN patients attending to Department of Clinical Haematology, Yangon General Hospital were enrolled in this study. The mean age was 53.4 ± 14 years which ranged from 16 to 81 years old and male and female ratio was 2.4:1. The identification of JAK2 (V617F) point mutation was found to be positive in 44/90 MPN patients (48.9%). According to MPN subtypes, the JAK2 mutation positivity was found in 19 out of 46 polycythemia vera patients (41.3%), 17 out of 25 essential thrombocythemia patients (68%), 8 out of 15 primary myelofibrosis patients (53.3%), 0 of 4 others myeloproliferative neoplasms (0%). Confirmation of each of nine JAK2 mutation positive and negative samples was done by Sanger sequencing. The arterial or venous thrombotic attack was found in 32/44 JAK2 mutation positive cases (72.7%) and 12/44 JAK2 mutation negative cases (27.3%). The association between thrombotic attack and presence of JAK2 mutation was statistically significance with p = 0.000. The diagnosis of myeloproliferative neoplasms mainly relies on the molecular genetics according to WHO classification. The Allele specific PCR reaction is sensitive, simple test and relatively cost-effective. Therefore, the identification of JAK2 (V617F) somatic point mutation by AS-PCR should be implemented as

关键词： Myeloproliferative Neoplasms JAK2 (V617F) Allele-Specific PCR

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Malignancy and mortality in a population-based cohort of patients with coeliac disease or ‘gluten sensitivity’

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World Journal of Gastroenterology 2007年第1期13卷 146-151页

作者： la Anderson SA McMillan RGP Watson P Monaghan AT Gavin C Fox LJ Murray Queen's University Belfast Centre for Clinical and Population Sciences Belfast United Kingdom Royal Group of Hospitals Regional Immunology Service Belfast United Kingdom Royal Group of Hospitals Institute of Clinical Science Belfast United Kingdom. Queen's University Belfast Northern Ireland Cancer Registry Belfast United Kingdom

AIM: To determine the risk of malignancy and mortality in patients with a positive endomysial or anti-gliadin an- tibody test in Northern Ireland. METHODS: A population-based retrospective cohort study design was used. laboratory test results used in the diagnosis of coeliac disease were obtained from the Regional Immunology laboratory, cancer statistics from the Northern Ireland Cancer Registry and mortal- ity statistics from the General Registrar Office, Northern Ireland. Age standardized incidence ratios of malignant neoplasms and standardized mortality ratios of all-cause and cause-specific mortality were calculated. RESULTS: A total of 13 338 people had an endomysial antibody and/or an anti-gliadin antibody test in Northern Ireland between 1993 and 1996. There were 490 pa- tients who tested positive for endomysial antibodies and they were assumed to have coeliac disease. There were 1133 patients who tested positive for anti-gliadin anti- bodies and they were defined as gluten sensitive. Ma- lignant neoplasms were not significantly associated with coeliac disease; however, all-cause mortality was signifi- cantly increased following diagnosis. The standardized incidence and mortality ratios for non-Hodgkin’s lym- phoma were increased in coeliac disease patients but did not reach statistical significance. Lung and breast cancer incidence were significantly lower and all-cause mortal-ity, mortality from malignant neoplasms, non-Hodgkin’s lymphoma and digestive system disorders were signifi- cantly higher in gluten sensitive patients compared to the Northern Ireland population. CONCLUSION: patients with coeliac disease or gluten sensitivity had higher mortality rates than the Northern Ireland population. This association persists more than one year after diagnosis in patients testing positive for anti-gliadin antibodies. Breast cancer is significantly re- duced in the cohort of patients with gluten sensitivity.

关键词： Coeliac disease Cancer Mortality Gluten sensitivity

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Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children

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World Journal of Gastroenterology 2012年第40期18卷 5729-5733页

作者： Salvatore Leonardi Andrea Domenico Praticò Elena Lionetti Massimo Spina Giovanna Vitaliti Mario la Rosa Department of Pediatrics University of Catania

AIM： To compare intradermal （ID） and intramuscular （IM） booster doses, which have been used in healthy and high risk subjects, such as healthcare workers, haemodialysis patients, human immunodeficiency virus patients, and renal transplant recipients unresponsive to initial hepatitis B vaccination, in celiac individuals. METHODS： We conducted our study on 58 celiac pa- tients, vaccinated in the first year of life, whose blood analysis had showed the absence of protective hepati- tis B virus （HBV） antibodies. All patients had received the last vaccine injection at least one year before study enrolment and they had been on a gluten free diet for at least 1 year. In all patients we randomly performed an HBV vaccine booster dose by ID or IM route. Thirty celiac patients were revaccinated with recombinant hepatitis B vaccine （Engerix B） 2 μg by the ID route, while 28 celiac patients were revaccinated with Engerix B 10 μg by the IM route. Four weeks after every boost- er dose, the anti-hepatitis B surface （HBs） antibody titer was measured by an enzyme-linked immune- adsorbent assay. We performed a maximum of three booster doses in patients with no anti-HBs antibodies after the first or the second vaccine dose. The cut off value for a negative anti-HBs antibody titer was 10 IU/*** with values between 10 and 100 IU/L were considered ＂low responders＂ while patients with an antibody titer higher than 1000 IU/L were considered ＂high responders＂. RESULTS： No significant difference in age, gender, du- ration of illness, and years of gluten intake was found between the two groups. We found a high percent- age of ＂responders＂ after the first booster dose （ID = 76.7%, IM = 78.6%） and a greater increase after the third dose （ID = 90%, IM = 96.4%） of vaccine in both groups. Mloreover we found a significantly higher num- ber of high responders （with an anti-HBs antibody titer 〉 1000 IU/L） in the ID （40%） than in the IM （7.1%） group, and this difference was evident after the firs

关键词： Hepatitis B virus Non responders Intradermal route Intramuscular route Celiac disease

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Fat grafting in autologous breast reconstruction:applications,outcomes,safety,and complications

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Plastic and Aesthetic Research 2023年第1期10卷 485-500页

作者： Bahaa Shaaban David Guerrero Carolyn De la Cruz lauren Kokai Department of Plastic Surgery University of PittsburghPittsburghPA 15213USA University of Pittsburgh Medical Center PittsburghPA 15213USA Department of Bioengineering University of PittsburghPittsburghPA 15213USA McGowan Institute for Regenerative Medicine PittsburghPA 15213USA

Autologous fat grafting is an important surgical technique in aesthetic and reconstructive *** grafting for breast reconstruction is now an established procedure for adding volume and improving cutaneous pliability;it can be used independently to replace more invasive flap procedures or implants,or as an adjunct for smaller volume *** breadth of applications in the breast necessitates diversity in technique and approach,and while there is no universally agreed-upon protocol,basic principles have guided the evolution of some commonly adopted ***,fat grafting outcomes are highly favorable but dependent on patient and procedure factors,requiring learned patient selection and expertise in recipient site *** complications from fat grafting,such as fat necrosis and the development of nodules,are particularly troublesome for post-oncologic patients,requiring considerable pre-surgical consultation for patient education and managing *** addition to volume and contour augmentation,fat grafting has additional beneficial effects that have recently drawn increased attention including pain reduction from implant capsular contracture or postmastectomy pain syndrome,improved skin quality and reduced fibrosis following radiation,and possible anti-tumorigenic *** developments in clinical fat grafting research that are promising include the use of adipose progenitor cells admixed with lipoaspirate for improved volume retention or alternative biologics such as platelet-rich ***,research towards safe and effective regenerative medicine approaches is actively underway,with the ultimate goal of achieving predictable and increased graft retention,reducing the number of required surgical procedures and enabling on-table results to reflect procedure outcomes.

关键词： Fat grafting fat transfer autologous breast reconstruction implant reconstruction lipo-injection breast augmentation graft survival skin expansion mastectomy post-mastectomy pain breast fibrosis capsular contracture

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