MYC and gastric adenocarcinoma carcinogenesis

作     者：Danielle Queiroz Calcagno Mariana Ferreira Leal Paulo Pimentel Assumpo Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano 

作者机构：Human Cytogenetics LaboratoryBiology Science InstituteFederal University of ParáBelém PA 66075-900Brazil Genetics DivisionDepartment of Morphology and GeneticsFederal University of So PauloSo Paulo SP 04023-900Brazil Joo de Barros Barreto University HospitalFederal University of ParáBelém PA 66073-000Brazil 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第39期

页      面：5962-5968页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq,DQC,MACS and RRB) Fundao de Amparo à Pesquisa do Estado de So Paulo (FAPESP,MFL) 

主　　题：胃癌 肿瘤形成 病理机制 治疗方法 

摘      要：MYC is an oncogene involved in cell cycle regulation,cell growth arrest,cell adhesion,metabolism,ribosome biogenesis,protein synthesis,and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. In the present review,we focus on the deregulation of the MYC oncogene in gastric adenocarcinoma carcinogenesis,including its association with Helicobacter pylori (H pylori) and clinical applications.