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Surface modified solid lipid microparticles based on homolipids and Softisan 142:preliminary characterization

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Asian Pacific Journal of Tropical Medicine 2010年第3期3卷 205-210页

作者： Nnamani PO Ibezim ec Attama AA Adikwu MU Drug Delivery Research Unit Department of PharmaceuticsFaculty of Pharmaceutical SciencesUniversity of Nigeria ICS-UNIDO International Center for High Technology and New Materials AREA Science Park Science and Technology Education Post-Basic(STEP-B) Abuja Nigeria

ObjectiveTo preliminarily investigate three different lipid matrices consisting of two natural homolipids from Capra hircus (goat fat) and Bovine Spp. (tallow fat) and one semi-synthetic lipid (Softisan? 142) separately structured with Phospholipon? 90G (P90G) as potential delivery systems for poorly water soluble drugs.MethodsThe structured lipid matrices were characterized by differential scanning calorimetry (DSC) and employed to prepare solid lipid microparticles (SLMs) by the melt homogenization method using gradient concentrations of polysorbate 80 and at different emulsification times of 2, 5 and 10 min using a Silverson mixer. The SLMs were analyzed for morphology and particle size, thermal properties, stability studies and determination of injectability.ResultsThe results showed that SLM production was optimum at 5 % of lipid matrices, 1.5 % of polysorbate 80 and emulsification time of 5 min. Increase in polysorbate 80 concentrations decreased the particle size of the SLMs. The SLMs were well formed, spherical, smooth and non-porous with particle sizes in the ranges of (13.90 ± 2.10) μm - (0.09 ± 0.01) μm for SLMs produced from the structured - tallow fat; (13.40 ± 1.30) μm - (0.10 ± 0.01) μm for the structured - goat fat and (13.40±2.00) μm - (2.10± 1.00)μm for the structured Softisan? 142 lipid matrices. DSC traces showed that Softisan? 142 was the most crystalline of all three bulk matrices due to its high enthalpy (?7.962 mW/mg) while tallow fat was the least (?5.067 mW/mg) but addition of P90G to the matrices lowered their enthalpies mostly in the structured goat fat matrices. The SLMs when stored at 4-6 ° were most stable and syringeable with 27 G needle.ConclusionsThis suggests that structured goat fat matrices with the enthalpy of ?2.813 mW/mg will mostly favour drug loading of some poorly soluble drugs more than tallow fat (?4.892 mW/mg) and Softisan? 142 (?5.501 mW/mg).

关键词： Phospholipon? 90G Solid lipid microparticle Goat fat Tallow fat Softisan? 142 Characterization

Chemical compositions,cytotoxicity and antioxidant activity of the endophytic fungus Fusarium napiforme isolated from Psidium guajava

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Studies in Fungi 2020年第1期5卷 332-352页

作者： Chutulo ec Chalannavar RK Pramod Kumar P Department of Studies&Research in Microbiology Mangalore UniversityJnana KaveriP.G.CentreChikka AluvaraKodagu-571232KarnatakaIndia Department of Biosciences Mangalore UniversityMangalagangotri-574199KarnatakaIndia Department of Biology Wolaita Sodo UniversityWolaita SodoEthiopia Department of Applied Botany Mangalore UniversityMangalagangotri-574199KarnatakaIndia Department of Biochemistry CSIR-Central Food Technological Research InstituteMysuru-570020KarnatakaIndia

The bioactive secondary metabolites from the endophytic fungus Fusarium napiforme was evaluated for the cytotoxic effect and antioxidant *** total antioxidant capacity(TAC)of the extract was determined by 2,2-diphenyl-1-picrylhydrazyl(DPPH),phosphomolybdate,and reducing power assay *** cytotoxicity of the extract was evaluated against lung adenocarcinoma(A549)cells and mouse embryo fibroblast(NIH3T3)cells by methyl thiazolyl tetrazolium(MTT)*** major composition of the crude extract was identified by the Gas Chromatography-Mass Spectrometry(GC-MS)*** of the endophyte crude extract revealed a high amount of the total flavonoid content(TFC)and total phenolic content(TPC).The extract showed high cytotoxic activity against the A549 cell line with the mean cytotoxicity of 69.74±0.49%.The extract did not show any cytotoxic effect against the NIH3T3 cell *** extract exhibited high antioxidant activity as a function of the *** a test concentration of 1 mg ml-1,the extract showed the highest inhibition against DPPH radical at 75.4607%±0.47688,ferric ion reducing power at 0.882±0.0120,and 255.434±21.404 AAE/g of the extract by phosphomolybdenum assay(PMA).There is a significant correlation between TPC and antioxidant activity at pecting the body from oxidative damages.

关键词： flavonoids GC-MS analysis lung adenocarcinoma cells mouse embryo fibroblast cells MTT assay phenolics

Parenting preschoolers with autism: Socioeconomic influences on wellbeing and sense of competence

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World Journal of Psychiatry 2019年第2期9卷 30-46页

作者： Nisha E Mathew Karen L O Burton Anne Schierbeek Rudi ?rn?ec Amelia Walter Valsamma Eapen School of Psychiatry University of New South Wales Vrije Universiteit Amsterdam Academic Unit of Child Psychiatry South West Sydney and Ingham Institute South West Sydney Local Health District Liverpool Hospital ICAMHSMental Health Centre (Level L1)

BACKGROUND Previous research suggests that parents raising a child with autism experience higher levels of psychological distress than parents of typically developing children and parents of children with other developmental disorders. Little is known, however, about the intersection between the effects of socioeconomic status(SES) on the wellbeing and sense of parental competency of parents of preschoolers with autism and how it relates to child symptom *** To examine the relationship between their child's symptom severity, SES, as measured by neighbourhood advantage and occupational status, on the psychological wellbeing and perceived parenting competence among parents of preschoolers with *** Parents of 117 preschool-aged children with a diagnosis of autism spectrum disorder(ASD), 107 mothers and 54 fathers, completed questionnaires about their child's symptoms of ASD and functioning, their own perceptions of their wellbeing and parental competence on entry to an early intervention program in Sydney, Australia. Parents also provided demographic information pertaining to their occupation, level of education attained and address(postcode). All children were also assessed for their severity of symptoms using the Autism Diagnostic Observation Schedule. The Australian Socioeconomic Index of occupationalstatus as a measure of familial SES and the Index of Relative Socio-economic Advantage and Disadvantage as a measure of neighbourhood advantage were used to examine the impact of SES on parental sense of competence and *** Compared to normative populations, both mothers and fathers in our sample reported significantly higher levels of parenting sense of efficacy but lower levels of interest in the parenting role. Mothers also displayed higher levels of satisfaction. Both mothers and fathers displayed higher levels of depression than normative populations with mothers also reporting greater levels of stress and anxiety. Child symptom sev

关键词： Wellbeing Parenting competency Autism Autism spectrum disorder Parent Mother Father Socioeconomic status

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用排队论来改进空军医疗后送阶梯工作

国外医学（军事医学分册） 1992年第3期9卷 117-118页

作者： Б.,ec 肖力

单段塞,水气交替及混合式CO2注气工艺的数...

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油气田开发工程译丛 1992年第10期 2-8页

作者：罗景琪 Lin,ec

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住院医生经验与医疗费用和质量的关系

国外医学（卫生经济分册） 1991年第2期8卷 18-20页

作者： Rich ec 丁卫群

住院医生缺乏经验被认为是教学医院医疗费用增多的一个原因,但尚无确定的证据。本文以St Paul-Ramsey医学中心(教学医院)的大样本内科住院病人为对象,研究了住院医生经验与医疗费用和质量的关系。对21679例出院病人的多元线性回归分析表... 详细信息

住院医生缺乏经验被认为是教学医院医疗费用增多的一个原因,但尚无确定的证据。本文以St Paul-Ramsey医学中心(教学医院)的大样本内科住院病人为对象,研究了住院医生经验与医疗费用和质量的关系。对21679例出院病人的多元线性回归分析表明,住院医生经验的增加与住院时间和住院总费用的减少显著相关。逻辑回归分析表明,住院医生经验与住院医疗质量无显著相关。研究结果提出,对缺乏经验的住院医生的培训可能是导致教学医院在竞争条件下效率偏低的一个重要原因.

关键词：医生经验医疗费用医疗质量

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心脏磁共振评估肾素-血管紧张素-醛固酮系统的心血管相互作用：动脉粥样硬化的多种族研究

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中华高血压杂志(中英文) 2024年第6期 600-600页

作者： Varadarajan V Marques MD Venkatesh BA Allison M Ostovaneh MR Yoneyama K Donekal S Shah RV Murthy VL Wu CO Tracy RP Ouyang P Rochitte ec Bluemke DA Lima JAC 袁源练桂丽

小型研究已描述了肾素-血管紧张素-醛固酮系统在心血管系统中的作用。该研究旨在探讨醛固酮和血浆肾素活性（plasma renin activity,PRA）与心血管结构和功能的关系。方法：研究者评估在2003-2005年进行醛固酮和PRA检测，并在2010年接...

小型研究已描述了肾素-血管紧张素-醛固酮系统在心血管系统中的作用。该研究旨在探讨醛固酮和血浆肾素活性（plasma renin activity,PRA）与心血管结构和功能的关系。方法：研究者评估在2003-2005年进行醛固酮和PRA检测，并在2010年接受心脏磁共振检查的动脉粥样硬化多种族研究参与者的随机样本。排除服用血管紧张素转换酶抑制药或血管紧张素受体阻滞药的参与者。结果：醛固酮组615例，平均年龄（61.6±8.9）岁；肾素组580例，平均年龄（61.5±8.8）岁，两组女性占比均约50%。

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共用阿片类和苯二氮类药物与药物过量之间的关系:一项回顾性分析

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中国疼痛医学杂志 2018年第6期24卷 407-408页

作者： Sun ec Dixit A Humphreys K 李楠琦中山大学附属第一医院麻醉科

目标确定同时使用苯二氮类药物和阿片类药物的趋势,确定这些趋势对阿片类药物过量导致的住院和急诊就诊的影响,提出修改建议。参与者:在研究期间,18~64岁的私人投保人连续参加医疗和药房福利健康计划的病人,并且至少接受过一张阿片类... 详细信息

目标确定同时使用苯二氮类药物和阿片类药物的趋势,确定这些趋势对阿片类药物过量导致的住院和急诊就诊的影响,提出修改建议。参与者:在研究期间,18~64岁的私人投保人连续参加医疗和药房福利健康计划的病人,并且至少接受过一张阿片类药物的处方。干预:同时使用苯二氮类药物/阿片类药物,定义为每种药物处方所涵盖的时间段内至少有一天重叠。主要观察结局指标:使用苯二氮类药物的阿片类药物使用者的年度百分比;每年发生的急诊就诊和阿片类药物过量住院事件。结果:阿片类药物使用者中在2001年使用苯二氮卓类药物的有9%,2013年增加到17%(相对增加80%)。这种增加主要是间断性阿片类药物使用者的增加,而非长期的阿片类药物使用者。与未使用苯二氮卓类药物的阿片类药物使用者相比,同时使用这两种药物与急诊室留观或阿片类药物过量住院相关的风险增加(校正比值比2.14,95%置信区间2.05-2.24;P<0.001)。间断性阿片类药物使用者的急诊室或住院病人阿片类药物过量的校正比值比为1.42(1.33-1.51;P<0.001),长期阿片类药物使用者为1.81(1.67-1.96;P<0.001)。如果这种关联是因果关系,那么消除同时使用两种药物的情况可以减少阿片类药物使用和阿片类药物过量住院病人因急诊就诊的风险,估计有15%(95%置信区间14-16)。结论:从2001年到2013年,在美国大量私人保险病人样本中,苯二氮类药物和阿片类药物的并用显着增加,并且导致总体人群阿片类药物过量使用的风险。

关键词：苯二氮卓类药物阿片类药物药物过量住院病人药物处方置信区间使用者急诊室

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Association of body mass index with knee cartilage damage

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中华物理医学与康复杂志 2018年第2期 86-86页

作者： Keng A Sayre ec Guermazi A

BACKGROUND AND OBJecTIVE As body mass index(BMI)is a well-established risk factor for the development of symptomatic cartilage damage and osteoarthritis(OA),this study was designed to understand the prevalence of cartilage damage in subjects without knee pain,and its relationship to *** This cross-sectional study included randomly selected,community dwelling adults,40 to 79 years of age,who had had no complaints of knee pain over the past *** subjects underwent MRI of the knee,with MR cartilage graded on a Disler scale of zero to

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