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Effects of L-carnitine in patients with hepatic encephalopathy

World Journal of Gastroenterology 2005年第45期11卷 7197-7202页

作者： Mariano Malaguarnera Giovanni pistone Rampello Elvira Carmelo Leotta Linda Scarpello Rampello Liborio Department of Senescence Department of Neurosciences

AIM： To evaluate the influence of Locarnitine on mental conditions and ammonia effects on patients with hepatic encephalopathy （HE）. METHODS： One hundred and fifty patients （10 patients with alcoholism, 41 patients with hepatitis virus B infection, 78 patients with hepatitis C virus infection, 21 patients with cryptogenetic cirrhosis） meeting the inclusion criteria were randomized into group A receiving a 90-d treatment with L-carnitine （2 g twice a day） or into group B receiving placebo in double blind. RESULTS： At the end of the study period, a significant decrease in NI-14 fasting serum levels was found in patients with hepatic encephalopathy （P〈0.0S） after the treatment with levocarnitine （LC）. Significant differences were also found between symbol digit modalities test and block design in patients with hepatic encephalopathy （P〈0.0S）. CONCLUSION： Results of our study suggest an important protective effect of L-carnitine against ammonia-precipitated encephalopathy in cirrhotic patients.

关键词： Hepatic encephalopathy Carnitine Cirrhosis Ammonia Treatment

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Gender specific medicine in liver diseases:a point of view

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World Journal of Gastroenterology 2014年第9期20卷 2127-2135页

作者： Marilena Durazzo Paola Belci Alessandro Collo Vanessa Prandi Erika.pistone Maria Martorana Roberto Gambino Simona Bo Department of Medical Sciences University of Turin 10126 Turin Italy

Gender medicine focuses on the patho-physiological, clinical, prevention and treatment differences in diseases that are equally represented in men and women. The purpose of gender medicine is to ensure that each individual man and woman receives the best treatment possible based on scientific evidence. The concept of “gender” includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women, including risk factors, protective/aggravating effects of sexual hormones and variances linked to genetics and corporal structures that explain biological and physiological differences between men and women. It is very important to consider all the biological, physiological, functional, psychological, social and cultural characteristics to provide patients with individualized disease management. Herein, we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies: primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis, non alcoholic fatty liver disease and alcoholic liver disease, and viral chronic hepatitis B and C. The last section addresses hemochromatosis, which is a prevalent iron overload disorder in the Caucasian population. This review aims to describe data from the literature concerning viral chronic hepatitis during pregnancy, management during pregnancy and delivery, and new effective drugs for the prevention of maternal infection transmission without significant adverse effects or complications.

关键词： Gender Liver disease Primary biliary cirrhosis Autoimmune hepatitis Viral chronic hepatitis B Viral chronic hepatitis C Non alcoholic fatty liver disease Alcoholic liver disease

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Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite

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Engineering 2017年第1期3卷 55-59页

作者： Alessandro pistone Daniela Iannazzo Claudia Espro Signorino Galvagno Anna Tampieri Monica Montesi Silvia Panseri Monica Sandri Department of Engineering University of Messina Messina 98166 Italy Institute of Science and Technology for Ceramics. National Research Council ofltaly Faenza 48018 Italy

Stem cell homing, namely the recruitment of mesenchymal stem cells （MSCs） to injured tissues, is highly effective for bone regeneration in vivo. In order to explore whether the incorporation of mimetic peptide sequences on magnesium-doped （Mg-doped） hydroxyapatite （HA） may regulate the homing of MSCs, and thus induce cell migration to a specific site, we covalently functionalized MgHA disks with two chemotactic/haptotactic factors： either the fibronectin fragment III1-C human （FF III1-C）, or the peptide sequence Gly-Arg-Gly-Asp-Ser-Pro-Lys, a fibronectin analog that is able to bind to integrin trans- membrane receptors. Preliminary biological evaluation of MSC viability, analyzed by 3-（4,5-dimethyl- thiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） test, suggested that stem cells migrate to the MgHA disks in resoonse to the grafted haototaxis stimuli.

关键词： Mg-doped hydroxyapatite Mesenchymal stem cells Chemotactic/haptotactic factorsBone tissue engineering

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法学院与技术——我们现在何处并将驶向何方

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法学教育研究 2016年第2期15卷 258-279,408页

作者： [美]米歇尔·皮斯托周亚玲(译) 邱昭继(校) 美国维拉诺瓦大学法学院西北政法大学西北政法大学刑事法学院

在法学院面临诸多困境的背景下,技术提供了一种具有吸引力的促使法律教育更有效和实际的可能性,并将在未来的法律教育中发挥越来越大的作用。在未来,越来越多的管理者将鼓励和奖励法律教育创新,越来越多的法学教授将与技术合作达到创新... 详细信息

在法学院面临诸多困境的背景下,技术提供了一种具有吸引力的促使法律教育更有效和实际的可能性,并将在未来的法律教育中发挥越来越大的作用。在未来,越来越多的管理者将鼓励和奖励法律教育创新,越来越多的法学教授将与技术合作达到创新。教育实验的文化可能以这种方式扎根,创新被看重不仅是因为他们眼前教学价值,同时也是因为他们将会塑造和影响未来实验的途径。

关键词：法学院技术法律教育创新

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忠奸人

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作者： (美)约瑟夫·D. 皮斯通(Joseph D. pistone)，(美)理查德·伍德利(Richard Woodley)

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我在黑手党的秘密生涯

我在黑手党的秘密生涯

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1996年

作者：（美）约瑟夫·皮斯托尼（Joseph D.pistone）（美）理查德·伍德雷（Richard Woodley）古绪满王文华译

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Study of the production of Λ_b^0 band ~0 hadrons in pp collisions and first measurement of the Λ_b^0→J/ψpK^- branching fraction

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Chinese Physics C 2016年第1期40卷 1-16页

作者： O.Kochebina M.Kolpin I.Komarov R.F.Koopman P.Koppenburg M.Kozeiha L.Kravchuk K.Kreplin M.Kreps G.Krocker P.Krokovny F.Kruse W.Krzemien W.Kucewicz M.Kucharczyk V.Kudryavtsev A.K.Kuonen K.Kurek T.Kvaratskheliya D.Lacarrere G.Lafferty A.Lai D.Lambert G.Lanffanchi C.Langenbruch B.Langhans T.Latham C.Lazzeroni R.Le Gac J.van Leerdam J.-P.Lees R.Lefevre A.Leflat J.Lefrancois E.Lemos Cid O.Leroy T.Lesiak B.Leverington Y.Li T.Likhomanenko M.Liles R.Lindner C.Linn F.Lionetto B.Liu X.Liu D.Loh I.Longstaff J.H.Lopes D.Lucchesi M.Lucio Martinez H.Luo A.Lupato E.Luppi O.Lupton A.Lusiani F.Machefert F.Maciuc O.Maev K.Maguire S.Malde A.Malinin G.Manca G.Mancinelli P.Manning A.Mapelli J.Maratas J.F.Marchand U.Marconi C.Marin Benito P.Marino J.Marks G.Martellottil M.Martin M.Martinelli D.Martinez Santos F.Martinez Vidal D.Martins Tostes A.Massafferri R.Matev A.Mathad Z.Mathe C.Matteuzzi A.Mauri B.Maurin A.Mazurov M.McCann J.McCarthy A.McNab R.McNulty B.Meadows F.Meier M.Meissner D.Melnychuk M.Merk E Michielin D.A.Milanes M.-N.Minard D.S.Mitzel J.Molina Rodrigue I.A.Monroy S.Monteil M.Morandin P.Morawski A.Morda M.J.Morello J.Moron A.B.Morris R.Mountain F.Muheim D.Miiller J.Muller K.Muller V.Muller M.Mussini B.Muster P.Naik T.Nakada R.Nandakumar A.Nandi I.Nasteva M.Needham N.Neri S.Neubert N.Neufeld M.Neuner A.D.Nguyen T.D.Nguyen C.Nguyen-Mau V.Niess R.Niet N.Nikitin T.Nikodem D.Ninci A.Novoselov D.P.O'Hanlon A.Oblakowska-Mucha V.Obraztsov S.Ogilvy O.Okhrimenko R.Oldeman C.J.G.Onderwater B.Osorio Rodrigues J.M.Otalora Goicochea A.Otto P.Owen A.Oyanguren A.Palano F.Palombo M.Palutan J.Panman A.Papanestis M.Pappagallo L.L.Pappalardo C.Pappenheimer C.Parkes G.Passaleva G.D.Patel M.Patel C.Patrignani A.Pearce A.Pellegrino G.Penso M.Pepe Altarelli S.Perazzini P.Perret L.Pescatore K.Petridis A.Petrolini M.Petruzzo E.Picatoste Olloqui B.Pietrzyk T:.Pilar D.Pinci a.pistone A.Piucci S.Playfer M.Plo Casasus T.Poikela F.Polci A.Poluektov I.Polyakov E.Polycarpo A.Popov D.Popov B.Popovici C.Potterat E.Price J.D.Price J.Prisciandaro A.Pritchard Centro Brasileiro de Pesquisas Ffsicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina LAPP Universite Savoie Mont-BlancCNRS/IN2P3Annecy-Le-VieuxFrance Clermont Universite Universite Blaise PascalCNRS/IN2P3LPCclermont-FerrandFrance CPPM Aix-Marseille UniversitYCNRS/IN2P3MarseilleFrance LAL Universite Paris-SudCNRS/IN2P3OrsayFrance LPNHE Universite Pierre et Marie CurieUniversite Paris DiderotCNRS/IN2P3ParisFrance Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-lnstitut fur Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland Sezione INFN di Bari BariItaly Sezione INFN di Bologna BolognaItaly Sezione INFN di Cagliari CagliariItaly Sezione INFN di Ferrara FerraraItaly Sezione INFN di Firenze FirenzeItaly Laboratori Nazionali dell'INFN di Prascati FrascatiItaly Sezione INFN di Genova GenovaItaly Sezione INFN di Milnno Bicocca MilunoItaly Sezione INFN di Milano MilanoItaly Sezione INFN di Padova PadovaItaly Sezione INFN di Pisa PisaItaly Sezione INFN di Roma Tor Vergata RomaItaly Sezione INFN di Roma La Sapienza RomaItaly Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences Krak6wPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakowPoland National Center for Nuclear Research(NCBJ) WarsawPoland Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest-MagureleRomania Petersburg Nuclear Physics Institute(PNPI) GatchinaRussia Institute of Theoretical and Experimental Physics(ITEP) MoscowRussia Institute of Nuclear Physics Moscow State University(SINP MSU)MoscowRussia Institute for Nuclear Research of the Russian Academy of Sciences(INR RAN) MoscowRussia Budker Institute of Nuclear Physics(SB RAS)and Novosibirsk State University No

The product of the ∧0/b （-B/0） differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-（-B/0→ J/ψ-K＊（892）0）is measured as a function of the beauty hadron transverse momentum, PT, and rapidity, y. The kinematic region of the measurements is pT〈20 GeV/c and 2.0 〈g〈*** measurements use a data sample corresponding to an integrated luminosity of 3fb-1 collected by the LHCb detector in pp collisions at centre-of-mass energies √s=7 TeV in 2011 and √s=8 TeV in 2012. Based on previous LHCb results of the fragmentation fraction ratio,f∧0/b/fd,the branching fraction of the decay ∧0/b→ J/ψ pK-is measured to be B（∧0/b→ J/ψ pK-）=（3.17±0.04±0.07±0.34＋0.45/-0.28）×10-4,where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay -B/0 →J/ψ-K＊（892）0,and the fourth is due to the knowledge of f∧0/b/*** sum of the asymmetries in the production and decay between ∧0/b and ∧0/bis also measured as a function of PT and *** previously published branching fraction of ∧0/b→ J/ψ pπ-,relative to that of ∧0/b→ J/ψ pK-,is updated. The branching fractions of ∧0/b→P＋c（→ J/ψp）K-are determined.

关键词： production cross-section branching fraction b hadrons proton-proton collisions

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