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Summer extreme precipitation patterns and synoptic-scale circulation precursors over the Tibetan Plateau

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Science China Earth Sciences 2024年第5期67卷 1625-1638页

作者： Zhiyuan DING Yao ha Zhong ZHONG College of meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory for Virtual Geographic Environment School of Geography ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Collaborative Innovation Center for Climate Change School of Atmospheric SciencesNanjing UniversityNanjing 210023China

In the context of global warming,the extreme summer precipitation over the Tibetan Plateau(TP)has changed *** this study,the summer(June–August)extreme precipitation on the TP was classified into three spatial types by applying the K-means clustering method to the Third Pole Region long time-series high-resolution(1/30°)precipitation dataset(TPHi Pr,1979–2020).The characteristics of the circulation anomalies and precursors corresponding to the extreme precipitation on the TP in summer during 1979–2020 were *** results showed that the summer extreme precipitation of the TP can be categorized into northwestern(NW),southeastern(SE),and southern Himalayan(HS)types based on extreme precipitation *** NW and SE types are mainly influenced by anomalous signals in the mid-to-high latitude regions upstream of them,whereas the HS type is controlled by the localized subtropical anomalous *** the 8th day before the onset of the NW type,an anomalous cyclone was observed in the western Atlantic Ocean(60°W,50°N),which triggered the west-to-east quasi-latitudinal propagation of Rossby *** the onset day of the NW type,the upper troposphere showed positive-negative-positive geopotential height anomalies along the latitudinal 40°N from the Caspian Sea,the western part of Xinjiang,to the northeastern *** entered from the Arabian Sea along the southeastern edge of the anomalous cyclone on the southwestern TP and converged in the northwestern *** to the NW type,the precursors of the SE type appeared at higher latitudes and were more *** the 8th day before the onset of the SE type,an anomalous cyclone occurred near Greenland(60°W,70°N)and excited Rossby waves propagating *** the onset day of the SE type,the upper troposphere showed negative-positive-negative geopotential height anomalies across Eurasia from the Ural mountains and the Iranian Plateau to the northern TP in the northwest-southeast directi

关键词： Tibetan Plateau Summer extreme precipitation Atmospheric circulation anomaly Precursor Teleconnection wave train

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Integrated strategies on cobalt phosphides-based electrocatalysts for efficient hydrogen evolution reaction

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Tungsten 2024年第3期6卷 488-503页

作者： Thanh Dam mai ha Huu Do Faculty of mechanical Engineering and Technology Ho Chi Minh City University of Industry and Trade VKTech Research Center NTT Hi-Tech Institute Nguyen Tat Thanh University

The development of cost-effective and durable hydrogen evolution reaction(HER) electrocatalysts plays a vital role in dealing with the issues related to carbon dioxide *** phosphide-based nanomaterials are evaluated as promising advocates for HER due to high catalytic activities,good stability,and rich *** review commences with an exploration of the synthetic pathways of CoP,including solid-phase,solution-phase along with electrochemical ***,the mechanism of hydrogen formation is expressed thoroughly,after which various integrated strategies of morphology engineering with doping,assisted highly conductive materials,and construction of heterostructure were introduced for ***,burdensome tasks and possible guidance for the advancement of CoP-based nanomaterials were discussed for hydrogen production.

关键词： Cobalt phosphides Nanomaterials Electrocatalysts Hydrogen evolution reaction

Wearable Triboelectric Nanogenerators Based on Printed Polyvinylidene Fluoride Films Incorporated with Cobalt-Based metal-Organic Framework for Self-Powered mobile Electronics

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Energy & Environmental materials 2024年第4期7卷 396-403页

作者： myeong-Hyeon Kim Sang-Joon Park Tae-Jun ha Department of Electronic materials Engineering Kwangwoon University

In this study,wearable triboelectric nanogenerators comprising bar-printed polyvinylidene fluoride (PVDF) films incorporated with cobalt-based metalorganic framework (Co-mOF) were *** enhanced output performance of the TENCs was attributed to the phase transition of PVDF from α-crystals to β-crystals,as facilitated by the incorporation of the mOF.

关键词： bar printing phase transition polyvinylidene fluoride incorporated with cobalt-based metal–organic framework self-powered mobile electronics wearable triboelectric nanogenerators

Natural Convection of a Power-Law Nanofluid in a Square Cavity with a Vertical Fin

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Fluid Dynamics & materials Processing 2024年第9期20卷 2091-2108页

作者： Amira m’hadbi mohammed El Ganaoui haïkel Ben hamed Amenallah Guizani Khalid Chtaibi LERmAB Department of Transition and Energy Efficiency ProfessionsIUT H Poincaréde LongwyUniversity of LorraineLongwy54400France LPT Center for Energy Research and Technologies(Borj Cedria2084)University of Tunis El ManarTunis1068Tunisia LTI Department of Mechanical Engineering and ProductionIUTUniversity of Picardie Jules-VerneAmiens80025France

The behavior of non-Newtonian power-law nanofluids under free convection heat transfer conditions in a cooled square enclosure equipped with a heated fin is investigated *** particular,the impact of nanofluids,composed of water and Al_(2)O_(3),TiO_(2),and Cu nanoparticles,on heat transfer enhancement is *** aim of this research is also to analyze the influence of different parameters,including the Rayleigh number(Ra=10^(4)-10^(6)),nanoparticle volume fraction(φ=0%-20%),non-Newtonian power-law indexes(n=0.6-1.4),and fin dimensions(Ar=0.3,0.5,and 0.7).Streamlines and isotherms are used to depict flow and related heat transfer *** indicate that thermal performance improves with increasing Rayleigh number,regardless of the nanoparticle type or nanofluid rheological *** suggests that the buoyancy force has a significant impact on heat transfer,particularly near the heat *** Nusselt number is more sensitive to variations in Cu nanoparticle volume fractions compared to Al₂O₃and TiO₂.moreover,the average Nusselt numbers for power-law nanofluids with n1)are greater(smaller)than for Newtonian fluids due to the decrease(increase)in viscosity with increasing(decreasing)shear rate,at the same values of Rayleigh number Ra owing to the amplification(attenuation)of the convective ***,the most substantial enhancement is observed with Cu-water shear-thinning nanofluid,where the Nusselt number increases by 136%when changing from Newtonian to shear thinning behavior and by 154.9%when adding 16%nanoparticle volume ***,an even larger increase of 57%in the average Nusselt number is obtained on increasing the fin length from 0.3 to 0.7.

关键词： Heat transfer nanofluid non-Newtonian fluid natural convection

Hydrophobic tag tethering degrader as a promising paradigm of protein degradation:Past,present and future perspectives

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Chinese Chemical Letters 2024年第8期35卷 187-200页

作者： Si ha Jiacheng Zhu Hua Xiang Guoshun Luo State Key Laboratory of Natural medicines and Department of medicinal Chemistry China Pharmaceutical UniversityNanjing 211198China

Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as the primary therapeutic paradigm targeting pathogenic ***,their efficacy heavily relies on the amino acid composition and spatial constitution of proteins,rendering them susceptible to drug resistance and failing to target undruggable *** recent years,the advent of targeted protein degradation(TPD)technology has captured substantial attention from both industry and *** an event-driven mode,TPD offers a novel approach to eliminate pathogenic proteins by promoting their degrada-tion,thus circumventing the limitations associated with traditional small molecule ***-bic tag tethering degrader(HyTTD)technology represents one such TPD approach that is currently in the burgeoning *** employ endogenous protein degradation systems to induce the degrada-tion of target proteins through the proteasome pathway,which displays significant potential for medical *** this review,we provide a comprehensive overview of the development history and the reported mechanism of action of ***,we delve into the physiological roles,structure-activity re-lationships,and medical implications of HyTTDs targeting various disease-associated ***,we propose insights into the challenges that necessitate resolution for the successful development of HyTTDs,with the ultimate goal of initiating a new age of clinical treatment leveraging the immense po-tential of HyTTDs.

关键词： Targeted protein degradation(TPD) Hydrophobic tag Degrader Hydrophobic tag tethering degrader(HyTTD) Targeted therapy

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Nature-based Natural-hazard Preparedness:A Cross Section of Categorized Examples

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Journal of Environmental & Earth Sciences 2024年第1期6卷 33-44页

作者： Kyoo-man ha Faculty of Resilience Rabdan AcademyAbu Dhabi114646UAE

Despite prevailing interests,no rigorous research has been conducted to examine the role of nature in natural-hazard *** systematic review aimed to describe how nature can reduce the impacts of natural hazards during the preparedness *** study focuses on the land,water,and air systems and on three types of stakeholders:international organizations,developed countries,and developing ***,it provides supplementary strategies,such as immediate actions,local engagement,and research and development,that the stakeholders should apply to enhance their nature-based natural-hazard *** suggest integrating costs and benefits analysis,local culture,societal challenges,and environmental justice into the implementation of nature-based ***,this review outlines the framework of nature-based natural-hazard preparedness by discussing the relationship between nature and society.

关键词： Nature-based solutions Costs and benefits Land Integration Society

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-ha Shin Hwa-Ryeon Kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

Combined Insights from Leachate Structure and microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： mingyo ha Hyo-Young JEONG Ju Hun LEE Hyun-Jung CHUNG Division of Food and Nutrition Chonnam National UniversityGwangju 61186South Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea Division of Food Science&Culinary Arts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies.

关键词： reheated convenience rice starch structure leachate multi-scale structure eating quality processing technology

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Elasto-inertial microfluidic separation of microspheres with submicron resolution at high-throughput

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microsystems & Nanoengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon Song ha Lee Jongho Shin Kicheol Song Nari Ahn Jinsoo Park Department of mechanical Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea Analytical Engineering Team Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Elasto-inertial microfluidic separation offers many advantages including high throughput and separation *** though the separation efficiency highly depends on precise control of the flow conditions,no concrete guidelines have been reported yet in elasto-inertial ***,we propose a dimensionless analysis for precise estimation of the microsphere behaviors across the interface of Newtonian and viscoelastic *** number,modified Weissenberg number,and modified elastic number are used to investigate the balance between inertial and elastic lift *** on the findings,we introduce a new dimensionless number defined as the width of the Newtonian fluid stream divided by microsphere *** proposed dimensionless analysis allows us to predict whether the microspheres migrate across the co-flow *** theoretical estimation is found to be in good agreement with the experimental results using 2.1-and 3.2-μm-diameter polystyrene microspheres in a co-flow of water and polyethylene oxide *** on the theoretical estimation,we also realize submicron separation of the microspheres with 2.1 and 2.5μm in diameter at high throughput,high purity(>95%),and high recovery rate(>97%).The applicability of the proposed method was validated by separation of platelets from similar-sized Escherichia coli(***).

关键词： solution. separation estimation