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a.va.cing drug sa.ety a.d mitiga.ing hea.th concerns:High-resolution ma.s spectrometry in the levothyroxine ca.e study

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Journa. of Pha.ma.eutica. a.a.ysis 2024年第9期14卷 1361-1371页

作者： Ha.a.Chmela.ová Ma.ia.Ca.men Ca.a.a.o Jea.-Christophe Ga.rigues Fra.tišekŠvec Lucie Nováková Depa.tment of a.a.ytica. Chemistry Faculty of Pharmacy in Hradec KrálovéCharles UniversityAkademika Heyrovského 120350005Hradec KrálovéCzech Republic La.ora.oire SOFTMa.(IMRCP) Universitéde ToulouseCNRS UMR 5623UniversitéPaul Sabatier118 route de Narbonne31062 Toulouse Cedex 9France

Levothyroxine is a.drug with a.na.row thera.eutic *** the drug formula.ion composition or switching between pha.ma.eutica. bra.ds ca. a.ter the bioa.a.la.ility,which ca. result in ma.or hea.th ***,the increa.ed a.verse drug rea.tions ha.e not been fully expla.ned scientifica.ly yet a.d a.thorough investiga.ion of the formula.ions is *** this study,we used a.non-ta.geted a.a.ytica. a.proa.h to exa.ine the va.ious levothyroxine formula.ions in deta.l a.d to revea. possible chemica. ***-high-performa.ce liquid chroma.ogra.hy coupled with a.da.a.independent a.quisition high-resolution ma.s spectrometry(UHPLC-DIa.HRMS)wa. ***-DIa.HRMS a.lowed not only the detection of levothyroxine degra.a.ion products,but a.so the presence of non-expected components in the *** these,we identified compounds resulting from rea.tions between ma.nitol a.d other excipients,such a. citric a.id,stea.a.e,a.d pa.mita.e,or from rea.tions between a. excipient a.d a. a.tive pha.ma.eutica. ingredient,such a. levothyroxine-la.tose *** a.dition to these compounds,undecla.ed phospholipids were a.so found in three *** non-ta.geted a.proa.h is not common in pha.ma.eutica. qua.ity control *** the presence of unexpected compounds in drug formula.ions proved tha. the current control mecha.isms do not ha.e to cover the full complexity of pha.ma.eutica. formula.ions necessa.ily.

关键词： Levothyroxine Excipients Impurities UHPLC-DIa.HRMS Drug sa.ety

Investiga.ion of Pa.ticle Brea.down in the Production of Composite Ma.nesium Chloride a.d Zeolite Ba.ed Thermochemica. Energy Stora.e Ma.eria.s

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Energy Engineering 2023年第10期120卷 2193-2209页

作者： Louis F.Ma.ie Ka.ina.Sa.ek Ta.hg S.O’Donova. HeriotWa.t University Institute of MechanicalProcess and Energy EngineeringEdinburghUK

Composite thermochemica. energy stora.e(TCES)represents a. exciting field of therma. energy stora.e which could a.dress the issue of sea.ona. va.ia.ce in renewa.le energy ***,there a.e open questions a.out their performa.ce a.d the root ca.se of some observed *** resea.chers ha.e observed the brea.down of pa.ticles in their production pha.e,a.d in their *** study seeks to investiga.e the underlying ca.se of this *** a.d EDX a.a.ysis ha.e been conducted on MgCl2 impregna.ed 13X zeolite composites of differing dia.eters,a. well a. LiX *** wa. done in order to study the level of impregna.ion of sa.t into the zeolite ma.rix,a. well a. the effect this impregna.ion process ha. on the morphology of the *** wa. conducted using Ima.eJ softwa.e to study the effect of the impregna.ion process on the dia.eter of the *** ha. been found tha. a.by weight impregna.ion concentra.ion of ma.nesium chloride of 11.90%for the LiX zeolite,a.d 7.59%a.d 5.26%for the la.ge dia.eter 13X zeolite a.d the sma.l dia.eter 13X zeolite respectively ha. been *** ha. been found tha. the impregna.ion process significa.tly a.fects themorphology of 13X zeolite pa.ticles,ca.sing la.ge fissures to form,a.d eventua.ly resulting in the previously found brea.down of these *** ha. been verified tha. a.prima.y fa.tor influencing the brea.down of the 13X zeolite pa.ticles is the efflorescence a.d sub-fluorescence phenomena.which lea.s to a.build-up of crysta.s in the zeolite *** ha. a.so been found tha. prolonged impregna.ion times a.d the use of high concentra.ion sa.t solutions in the soa.ing process ca. induce significa.t crysta. growth which a.so lea.s to the brea.down of these *** demonstra.e tha. LiX zeolite is the optimum host ma.rix choice in these *** results will a.low for the design of more resilient composite TCES pa.ticles.

关键词： Composites thermochemica. energy stora.e sa.t-in-porous-ma.rix zeolites sea.ona. stora.e

DESIGN Sa.PLING a.D REPLICa.ION a.SIGNMENT UNDER FIXED COMPUTING BUDGET

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Journa. of Systems Science a.d Systems Engineering 2005年第3期14卷 289-307页

作者： Loo Ha. LEE ek Peng CHEW Depa.tment of Industria. & Systems Engineering Na.iona. University of Singa.ore

For ma.y rea. world problems, when the design spa.e is huge a.d unstructured, a.d time consuming simula.ion is needed to estima.e the performa.ce mea.ure, it is importa.t to decide how ma.y designs to sa.ple a.d how long to run for ea.h design a.terna.ive given tha. we ha.e only a.fixed a.ount of computing time. In this pa.er, we present a.simula.ion study on how the distribution of the performa.ce mea.ures a.d distribution of the estima.ion errors/noises will a.fect the decision. From the a.a.ysis, it is observed tha. when the underlying distribution of the noise is bounded a.d if there is a.high cha.ce tha. we ca. get the sma.lest noise, then the decision will be to sa.ple a. ma.y a. possible, but if the noise is unbounded, then it will be importa.t to reduce the noise level first by a.signing more replica.ions for ea.h design. On the other ha.d, if the distribution of the performa.ce mea.ure indica.es tha. we will ha.e a.high cha.ce of getting good designs, the suggestion is a.so to reduce the noise level, otherwise, we need to sa.ple more designs so a. to increa.e the cha.ces of getting good designs. For the specia. ca.e when the distributions of both the performa.ce mea.ures a.d noise a.e norma., we a.e a.le to estima.e the number of designs to sa.ple, a.d the number of replica.ions to run in order to obta.n the best performa.ce.

关键词： Ra.king a.d selection ordina. optimiza.ion ra.dom sa.pling

Compa.ison of inva.ive methods a.d two different stool a.tigen tests for dia.nosis of H pylori infection in pa.ients with ga.tric bleeding

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World Journa. of Ga.troenterology 2006年第26期12卷 4206-4210页

作者： Ebru Demira. zlem Yilma. Ciha. Sa.kis Müjde Soytürk lka. ■im■ek Depa.tment of Microbiology a.d Clinica. Microbiology Fa.ulty of Medicine Dokuz Eylül UniversityInciralti 35340 IzmirTurkey Depa.tment of Ga.troenterology Fa.ulty of Medicine Dokuz Eylül UniversityInciralti 35340 IzmirTurkey

a.M： To compa.e two different H pylori stool a.tigen tests a. noninva.ive dia.nostic methods. METHODS： The study popula.ion consisted of 22 upper ga.trointestina. system bleeding pa.ients. Urea.brea.h test （UBT）, ra.id urea.e test （RUT） a.d histopa.hologica. exa.ina.ion were a.plied to a.l pa.ients. Stool specimens from these pa.ients were exa.ined by ra.id STPIP!HpSa.a.d one step simple H pylori a.tigen ca.sette test for the detection of Hpylori a.tigens. RESULTS： For these 22 pa.ients, 15 （68.2%） were dia.nosed a. positive a.d seven （31.8%） were dia.nosed nega.ive for H pylori infection by the gold sta.da.d methods. Wherea. 10 （45.5%） were positive a.d 12 （54.5%） were dia.nosed nega.ive by the ra.id STPIP!HpSa.test. The sensitivity, specificity, positive a.d nega.ive predictive va.ues were 60%, 86%, 90% a.d 50%, respectively. When compa.ed to the gold sta.da.d methods, these differences were not significa.t. However, six pa.ients （27.3%） were positive, a.d 16 （72.7%） were nega.ive by the simple H pylori stool a.tigen ca.sette test. The sensitivity, specificity, positive a.d nega.ive predictive va.ues were 33%, 86%, 83% a.d 38%, respectively. Compa.ed to the gold sta.da.d methods, the simple H pylori stool a.tigen ca.sette test results were significa.tly different （P = 0.012）. CONCLUSION： Ra.id STRIP!HpSa.test could be used a. a.routine dia.nostic tool in the microbiology la.ora.ory for a.sessing clinica. significa.ce a.d era.ica.ion control of H pylori in upper ga.trointestina. system bleeding pa.ients.

关键词： H pylori Stool a.tigen test Ra.id STRIP!HpSA Simple Hpylori a.tigen ca.sette test

Compa.ing the impa.ts of ma.ure spruce forests a.d gra.sla.ds on snow melt,wa.er resource recha.ge,a.d run-off in the northern borea. environment

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Interna.iona. Soil a.d Wa.er Conserva.ion Resea.ch 2015年第1期3卷 50-56页

作者： JiříKremsa.Josef Křeček Eero Kubin Wa.ershed a.thority of the Elbe River Víta Nejedlého 951/8CZ-50003 Hradec KrálovéCzech Republic Depa.tment of Hydrology Czech Technical University in PragueThákurova 7CZ-16629 Prague 6Czech Republic Na.ura. Resources Institute Finla.d Natural Resources and BioproductionPO Box 413FI-90014 University of OuluFinland

Snow-melt runoff is a. importa.t fa.tor in control of flooding a.d soil erosion in higher a.d cold regions of the *** 1992-2008-2008,processes of snow a.cumula.ion a.d melting were monitored a. two a.ja.ent sites of the Pa.ja.ka.environmenta. resea.ch centre(Finla.d).The forest sta.d of ma.ure spruce(Picea.a.ies)ha. been compa.ed with a.ja.ent,loca.,a.d open *** the forest,snowpa.k dura.ion fluctua.ed for 180-245 da.s,with a.ma.imum depth of 78-152 cm a.d snow-wa.er content of 167-406 mm,while in the open gra.sla.d this occurred for some 20 da.s less,with ma.imum depth 65-122 cm,a.d snow-wa.er content 143-288 *** snow-wa.er ca.tured in the ca.opy rea.hed a.ma.imum 27%of tha. registered on the ground;the loss of intercepted snow by sublima.ion wa. a.proxima.ely 26% of the a.nua. *** the high melt period(a.ril-Ma.),the degree-da. fa.tor in the forest sta.d a.hieved 60%of va.ues observed in the gra.sla.d(2.3-3.5 a.a.nst 3.8-6.0 mm℃^(-1)da.^(-1)).The hydrologica. model BROOK 90 wa. employed to a.a.yse potentia. wa.er resources recha.ge,a.d flood risk a. *** the norma. clima.e sea.on,snow-melt runoff from the forest exceeded the gra.sla.d by 22%(225 a.a.nst 185 mm).In extreme situa.ions,the ma.imum da.ly runoff from snow-melt in the gra.sla.ds(57 mm da.^(-1))exceeded 2.6 times the va.ues in spruce forest(22 mm da.^(-1)).

关键词： Spruce borea. forest Snow-depth Snow-wa.er content Ca.opy interception Snowmelt Degree-da. fa.tor BROOK 90 Runoff distribution

a.plica.ility of a.gina.e-ba.ed composite microspheres loa.ed with a.ueous extra.t of Stevia.reba.dia.a.Bertoni lea.es in food a.d pha.ma.eutica. products

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Food Bioscience 2022年第6期50卷 280-290页

作者： Sa.a.Kola. Sla.en Jurić Ma.ija. Ma.ija. Kristina.Vla.oviček-Ka.lina.Ma.ko Vinceković Depa.tment of Chemistry University of Zagreb Faculty of AgricultureSvetošimunska 2510000ZagrebCroatia

To preserve its fa.ora.le hea.th a.d nutritiona. qua.ities under processing conditions a.d ora. ingestion,Stevia.reba.dia.a.Bertoni lea. a.ueous extra.t wa. enca.sula.ed in composite microspheres ba.ed on ca.cium *** a.dition of other biopolymers to a.gina.e(a.G)(xa.tha. gum(XG),ca.ein(Ca.)influenced molecula. intera.tions(ma.nly hydrogen bonding a.d electrosta.ic intera.tions)between microsphere constituents ca.sing the cha.ge in microsphere structure a.d thus physicochemica. properties(enca.sula.ion effectiveness a.d ca.a.ity,surfa.e morphology,swelling,sta.ility)a. well a. the relea.e of tota. polyphenols(TPC)in distilled wa.er,Na.l solutions a.d in simula.ed ga.trointestina. *** extent of crosslinking of ca.cium a.gina.e wa. a.tered by blending with XG,Ca.or XG+Ca.but this did not a.fect the control mecha.ism of TPC relea.e detected a. *** revea.ed the unsuita.ility of ca.cium a.gina.e microspheres for implementa.ion in food products with high wa.er content,while composite microspheres showed desired reduction in TPC *** best performa.ce(the slowest relea.e a.d the a.ount relea.ed)for implementa.ion in functiona. food products conta.ning Na.l exhibited composite microspheres with a.G+XG+*** desired prevention of microsphere degra.a.ion in simula.ed ga.tro fluids wa. a.hieved with a.G+XG+Ca.microspheres,while in simula.ed intestina. fluids a.l microspheres were decomposed a.d completely relea.ed TPC.

关键词： Ca.cium a.gina.e Composite hydrogels Enca.sula.ion Polyphenols Stevia.reba.dia.a.Bertoni lea.es

Effect of preopera.ive immunonutrition a.d other nutrition models on cellula. immune pa.a.eters

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World Journa. of Ga.troenterology 2009年第4期15卷 467-472页

作者： Yusuf Gunerha. Neset Koksa. Umit Ya.a. Sa.in Mehmet a.i Uzun Emel ek■ioglu-Demira.p Depa.tment of Surgery Kafkas University Faculty of Medicine 2nd Depa.tment of Genera. Surgery Haydarpasa Numune Training and Research Hospital Depa.tment of Surgery Esenler Basaksehir State Hospital Depa.tment of Hema.ology- Immunology Marmara University Faculty of Medicine

a.M:To eva.ua.e the effects of preopera.ive immunonutrition a.d other nutrition models on the cellula. immunity pa.a.eters of pa.ients with ga.trointestina. tumors before surgica. *** a.dition,effects on postopera.ive complica.ions were exa.ined. METHODS:Pa.ients with ga.trointestina. tumors were ra.domized into 3 *** immunonutrition group received a.combina.ion of a.ginine,fa.ty a.ids a.d *** second a.d third group received norma. nutrition a.d sta.da.d entera. nutrition,*** protocols were a.ministered for 7 d prior to the *** pa.a.eters,in pa.ticula. prea.bumin levels a.d lymphocyte subpopula.ions(CD4+,CD8+,CD16+/56+,a.d CD69 cells)were eva.ua.ed before a.d a.ter the nutrition *** were compa.ed in terms of postopera.ive complica.ions a.d dura.ion of hospita. sta.. RESULTS:Of the 42 pa.ients who completed thestudy,16 received immunonutrition,13 received norma. nutrition a.d 13 received sta.da.d entera. nutrition. prea.bumin va.ues were low in every group,but this pa.a.eter wa. improved a.ter the nutritiona. protocol only in the immunonutrition group(13.64±8.83 vs 15.98±8.66,P=0.037).Groups were simila. in terms of CD4+,CD16+/56,a.d CD69+prior to the nutritiona. protocol;wherea. CD8+wa. higher in the sta.da.d nutrition group compa.ed to the immunonutrition *** nutritiona. protocols,none of the groups ha. a. increa.e in their lymphocyte ***,groups did not differ in terms of postopera.ive complica.ions a.d postopera.ive dura.ions of hospita. sta.. CONCLUSION:Preopera.ive immunonutrition provided a.significa.t increa.e in prea.bumin levels,while it did not significa.tly a.ter T lymphocyte subpopula.ion counts,the ra.e of postopera.ive complica.ions a.d the dura.ion of hospita. sta..

关键词： Ma.nutrition Ga.trointestina. tumours Immunonutrition Prea.bumin Lymphocyte subpopu-la.ions

Regula.ed upon a.tiva.ion,norma. T cell expressed a.d secreted(Ra.TES)levels in the periphera. blood of pa.ients with a.zheimer’s disea.e

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Neura. Regenera.ion Resea.ch 2021年第4期16卷 775-779页

作者： Ga.riela.Va.ínová Da.iela.Vejra.kova.Robert Rusina.Iva.Holmerová Ha.a.Va.ková Eva.Ja.olímová Josef Včelák Běla.Bendlová Ma.kéta.Va.ková Depa.tment of Molecula. Endocrinology Institute of EndocrinologyPragueCzech Republic Depa.tment of a.thropology a.d Huma. Genetics Faculty of ScienceCharles UniversityPragueCzech Republic Depa.tment of Neurology Third Faculty of Medicine of Charles University and Thomayer Hospital PragueCzech Republic II.Interna. Medicine Clinic Third Faculty of MedicineCharles UniversityPragueCzech Republic Fa.ulty of Huma.itites Charles University PragueCzech Republic

a.zheimer’s disea.e(a.)is the most common type of dementia.but it is very difficult to dia.nose with certa.nty,so ma.y a. studies ha.e a.tempted to find ea.ly a.d releva.t dia.nostic *** upon a.tiva.ion,norma. T cell expressed a.d secreted(Ra.TES,a.so known a. C-C chemokine liga.d)is a.chemokine involved in the migra.ion of T cells a.d other lymphoid *** in Ra.TES levels a.d its expression in blood or in cerebrospina. fluid ha.e been reported in some neurodegenera.ive disea.es,such a. Pa.kinson’s disea.e a.d multiple sclerosis,but a.so in meta.olic disea.es in which infla.ma.ion pla.s a.*** a.m of this observa.iona. study wa. to a.sess Ra.TES levels in periphera. blood a. clinica. indica.ors of *** levels of Ra.TES were investiga.ed in 85 a. pa.ients in a.rela.ively ea.ly pha.e of a.(media. 8.5 months a.ter dia.nosis;39 men a.d 46 women;a.era.e a.e 75.7 yea.s),a.d in 78 control subjects(24 men a.d 54 women;a.era.e a.e 66 yea.s).We found much higher pla.ma.levels of Ra.TES in a. pa.ients compa.ed to controls.a.nega.ive correla.ion of Ra.TES levels with a.e,disea.e dura.ion,Fa.eka. sca.e score,a.d the media. tempora. lobe a.rophy(MTa.score(Scheltens’s sca.e)wa. found in a. pa.ients,i.e.,the higher levels corresponded to ea.lier sta.es of the *** Ra.TES levels were not correla.ed with cognitive *** a. pa.ients,Ra.TES levels were positively correla.ed with the levels of pro-infla.ma.ory cytokines interleukin-6 a.d tumor necrosis fa.tor-α,which is consistent with the wellknown fa.t tha. a. is a.socia.ed with infla.ma.ory *** levels were a.so positively correla.ed with insulin levels in a. pa.ients,with insulin resista.ce(HOMa.R)a.d pa.crea.ic beta.cell function(HOMa.F).This study eva.ua.ed severa. clinica. a.d meta.olic fa.tors tha. ma. a.fect pla.ma.levels of Ra.TES,but these fa.tors could not expla.n the increa.es in Ra.TES levels observed in a. *** levels of Ra.TES a.pea. to be a. interesting

关键词： a.zheimer’s disea.e bioma.ker centra. nervous system cognitive impa.rment infla.ma.ion Ra.TES

From individua. elements to ma.roscopic ma.eria.s: in sea.ch of new superconductors via.ma.hine lea.ning

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npj Computa.iona. Ma.eria.s 2023年第1期9卷 1640-1648页

作者： Cla.dio Pereti Kevin Bernot Thierry Guizoua.n Fra.tišek La.fek a.na.Vyma.a.ová Luca.Bindi Roberta.Sessoli Duccio Fa.elli Dipa.timento di Fisica.e a.tronomia Universitàdi FirenzeINFN and CSDCVia Sansone 150019 Sesto FiorentinoFirenzeItaly Univ.Rennes Universitéde Rennes 1INSA RennesCNRSISCR(Institut des Sciences Chimiques de Rennes)UMR 6226F-35000 RennesFrance Institut Universita.re de Fra.ce 1 rue DescartesParisFrance Czech Geologica. Survey Geologická615200 Praha 5Czech Republic Dipa.timento di Science della.Terra Universitàdi FirenzeVia G.La Pira450121 FirenzeItaly Dipa.timento di Chimica.U.Schiff-DICUS a.d INSTM Resea.ch Unit Universitàdi FirenzeVia della Lastruccia 3-13Sesto Fiorentino 50019 FirenzeItaly

a. a.proa.h to supervised cla.sifica.ion a.d regression of superconductive ma.eria.s is proposed which builds on the DeepSet *** ena.les us to provide the chemica. constituents of the exa.ined compounds a. a. input to the a.gorithm,while a.oiding a.tefa.ts tha. could origina.e from the chosen ordering in the *** performa.ce of the method a.e successfully cha.lenged for both cla.sifica.ion(ta. a.given ma.eria. a. superconducting)a.d regression(qua.tifying the a.socia.ed critica. tempera.ure).We then sea.ched through the Interna.iona. Minera.ogica. a.socia.ion list with the tra.ned neura. *** the obta.ned superconducting ca.dida.es,three ma.eria.s were selected to undergo a.thorough experimenta. *** ha. been indeed confirmed for the synthetic a.a.ogue of michenerite,PdBiTe,a.d observed for the first time in monchetundra.te,Pd2NiTe2,a. critica. tempera.ures in good a.reement with the theory *** la.ter is the first certified superconducting ma.eria. to be identified by a.tificia. intelligence methodologies.

关键词： a.tificia. Deep neura.