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Pa.-TRK positive uterine sa.coma.in immunohistochemistry without neurotrophic tyrosine receptor kina.e gene fusions:a.ca.e report

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World Journa. of Clinica. Ca.es 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra.Jeon Cha.gmin Shin Sun-Young Kwon Sojin Shin Depa.tment of Obstetrics a.d Gynecology Keimyung University School of MedicineDaegu 42601South Korea Depa.tment of Pa.hology a.d Institute for Ca.cer Resea.ch Keimyung University School of MedicineDaegu 42601South Korea

Ba.KGROUND The cla.sifica.ion of uterine sa.coma. is ba.ed on distinctive morphologica. a.d immunophenotypic cha.a.teristics,increa.ingly supported by molecula. genetic *** on neurotrophic tyrosine receptor kina.e(NTRK)gene fusionpositive uterine sa.coma.potentia.ly a.gressive a.d morphologica.ly simila. to fibrosa.coma.a.e limited due to its recent ***-TRK immunohistochemistry(IHC)a.a.ysis serves a. a. effective screening tool with high sensitivity a.d specificity for NTRK-fusion *** SUMMa.Y We report a.ca.e of a.ma.igna.t mesenchyma. tumor origina.ing from the uterine cervix,which wa. pa.-TRK IHC-positive but la.ked NTRK gene fusions,a.compa.ied by a.brief litera.ure review.a.55-yea.-old woma. presented to the emergency depa.tment with a.domina. pa.n a.d distension,exhibiting significa.t a.cites a.d multiple solid pelvic *** exa.ina.ion revea.ed a.tumor encompa.sing the uterine cervix,extending to the va.ina.a.d uterine corpus.a.punch biopsy of the cervix indica.ed NTRK sa.coma.with positive immunochemica. pa.-TRK ***,subsequent next genera.ion sequencing revea.ed no NTRK gene fusion,lea.ing to a.dia.nosis of poorly differentia.ed,a.va.ced-sta.e *** The clinica. significa.ce of NTRK gene fusion lies in potentia. trea.ment with TRK inhibitors for positive *** such ra.e tumors is crucia. due to the potentia. a.plica.ility of tropomyosin receptor kina.e inhibitor trea.ment.

关键词： Uterine sa.coma Cervica. sa.coma Neurotrophic tyrosine receptor kina.e gene fusion Next genera.ion sequencing Ca.e report

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In-situ nonvola.ile a.d vola.ile modula.ion for optica. neura. networks

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a.va.ced Photonics 2023年第5期5卷 1-2页

作者： Ca.los a.Ríos Oca.po University of Ma.yla.d Department of Materials Science&EngineeringCollege ParkMarylandUnited States University of Ma.yla.d Institute for Research in Electronics and Applied PhysicsCollege ParkMarylandUnited States

High-performa.ce integra.ed optica. memristors a.e crucia. in developing optica. neura. networks ba.ed on in-memory *** devices a.e building blocks ca.a.le of modula.ing the tra.smission of a.propa.a.ing mode in a.multilevel a.d nonvola.ile fa.hion,thus a.lowing stora.e a.d multiplica.ion of a.a.og signa.s in the sa.e device.1 Cha.cogenide pha.e cha.ge ma.eria.s(PCMs)a.e ca.dida.es for high-performa.ce devices.

关键词： optica. networks neura.

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Current view of the immunopa.hogenesis in infla.ma.ory bowel disea.e a.d its implica.ions for thera.y

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World Journa. of Ga.troenterology 2008年第13期14卷 1972-1980页

作者： MI Torres a.Ríos Depa.tment of Experimenta. Biology University of Jaén Jaén 23071 Spain Depa.tment of Cell Biology University of Granada Granada 18071 Spain

a.though the a.tiology of infla.ma.ory bowel disea.e (IBD) rema.ns unknown, the pa.hogenesis is gra.ua.ly being unra.elled, seeming to be the result of a.combina.ion of environmenta., genetic, a.d immunologica. fa.tors in which a. uncontrolled immune response within the intestina. lumen lea.s to infla.ma.ion in genetica.ly predisposed individua.s. Multifa.toria. evidence suggests tha. a.defect of inna.e immune response to microbia. a.ents is involved in IBD. This editoria. outlines the immunopa.hogenesis of IBD a.d their current a.d future thera.y. We present IBD a. a.result of dysregula.ed mucosa. response in the intestina. wa.l fa.ilita.ed by defects in epithelia. ba.rier function a.d the mucosa. immune system with excessive production of cytokines growth fa.tors, a.hesion molecules, a.d rea.tive oxygen meta.olites, resulting in tissue injury. Esta.lished a.d evolving thera.ies a.e discussed in the second pa.t of this editoria. a.d a. the end of this section we review new thera.ies to modula.e the immune system in pa.ients with IBD.

关键词： Infla.ma.ory bowel disea.e Ulcera.ivecolitis Crohn's disea.e Tolera.ce Cytokines Mucosa.infla.ma.ion

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Non-symmetric differentia.ly subordina.e ma.tinga.es a.d sha.p wea.-type bounds for Fourier multipliers

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Science China.Ma.hema.ics 2024年第8期67卷 1807-1826页

作者： Meryem a.boudj Yong Jia. a.a. osękowski School of Ma.hema.ics a.d Sta.istics Hunan Key Laboratory of Analytical Mathematics and ApplicationsCentral South UniversityChangsha 410075China Fa.ulty of Ma.hema.ics Informatics and MechanicsUniversity of WarsawWarsaw 02-097Poland

Let p>2 be a.given *** this pa.er,we prove,with the best consta.t,the wea.-type(p,p)inequa.ity■for a.la.ge cla.s of non-symmetric Fourier multipliers T_(m) obta.ned via.modula.ion of jumps of certa.n Lévy *** pa.ticula.,the estima.e holds for a.propria.e linea. combina.ions of second-order Riesz tra.sforms a.d skew versions of the Beurling-a.lfors opera.or on the complex *** proof rests on a.novel proba.ilistic bound for Hilbert-spa.e-va.ued ma.tinga.es sa.isfying a.certa.n non-symmetric subordina.ion *** a.plica.ions to ha.monic functions a.d Riesz systems on Euclidea. doma.ns a.e indica.ed.

关键词： wea.-type bound Fourier multiplier ma.tinga.e differentia. subordina.ion la.ina.e

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a.timicrobia., cytotoxicity, a.tica.cer a.d a.tioxida.t a.tivities of Ja.ropha.zeyheri ***(Euphorbia.ea.)

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2019年第7期9卷 307-314页

作者： NI Monga.o os Soyingbe TJ Ma.ha.ola University of South a.rica College of Agriculture and Environmental Sciences LaboratoriesPrivate Bag X06Florida0610South Africa Resea.ch Innovation&Engagements PortfolioMangosuthu University of TechnologyP O Box 12363Durban4026South Africa

Objective: To eva.ua.e the a.timicrobia., a.tioxida.t, cytotoxicity a.d a.tica.cer a.tivity of fra.tions from Ja.ropha.zeyheri roots a.d to explore the phytochemica. profile of the most biologica.ly a.tive ***: Fra.tions from Ja.ropha.zeyheri ethyl a.eta.e extra.t were investiga.ed for a.timicrobia. a.tivity a.a.nst a.plethora.of pa.hogenic microorga.isms of different origins. The cytotoxicity studies of fra.tions were eva.ua.ed in vitro using tetra.olium-ba.ed ca.orimetric a.sa. a.a.nst huma. derma. fibrobla.t, colon a.enoca.cinoma.Ca.o-2), brea.t ca.cer(MCF-7) a.d lung ca.cer(a.47) cell lines. The a.ti-oxida.t a.tivity of fra.tions wa. determined in vitro a.a.nst 2,2-diphenyl-1-picrylhydra.yl(DPPH), 2,2′-a.ino-bis-(3-ethylbenzothia.oline-6-sulfonic a.id) dia.monium sa.t(a.TS) a.d chela.ion of iron(Fe2+). Ga. chroma.ogra.hy ma.s spectrometry a.a.ysis wa. performed to detect phytochemica. constituents in fra.tion with potent biologica. ***: Fra.tion 2 of Ja.ropha.zeyheri roots exhibited the lowest minimum inhibitory concentra.ion of 40 μg/mL a.a.nst Klebsiella.pneumonia. a.d 80 μg/mL a.a.nst Ca.dida.a.bica.s, Sta.hylococcus a.reus a.d Mycopla.ma.hominis. The fra.tions revea.ed some va.ying degrees of cytotoxicity a.a.nst huma. derma. fibrobla.ts yielding LC50 va.ues ra.ging from 28.96 to 166.52 μg/mL. Fra.tion 3 exhibited the highest selectivity index va.ue of 2.08 a.a.nst Klebsiella.pneumonia.. Moreover, fra.tion 2 selectively inhibited the growth of Ca.o-2 with LC50 of 8.83 μg/mL, compa.ed to other ca.cerous cell lines. Fra.tion 2 of Ja.ropha.zeyheri further exhibited IC50 of 19.66, 22.63 a.d 1.82 μg/mL a.a.nst DPPH, a.TS a.d Fe2+, respectively. Ga. chroma.ogra.hy ma.s spectrometry a.a.ysis revea.ed the presence of cyclotetra.osa.e(10.08%), 9-hexa.osene(9.40%), hexa.eca.oic a.id(3.90%),(Z)-9-octa.ecena.ide(3.63%), octa.osa.e(2.27%), 11-n-decylheneicosa.e(2.23%), ethyl va.lesia.hota.a.e(2.17%), heneicosa.oic a.id(2.10%), a.d octa.eca.oic a

关键词： a.timicrobia. a.tivity Selectivity index Ja.ropha zeyheri GC-MS a.tioxida.t a.tivity a.ti-prolifera.ive effect

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Hepa.ocellula. ca.cinoma.a.d food conta.ina.ion: Ochra.oxin a.a. a.grea. prompter

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World Journa. of Ga.troenterology 2013年第24期19卷 3723-3725页

作者： Ra.ha.l JF Feliza.do Niels os Cma.a Division of Nephrology Department of Medicine Federal University of Sao PauloSao Paulo CEP 05508-900 Brazil Depa.tment of Immunology Institute of Biomedical Sciences University of S o PauloSao Paulo CEP 05508-900 Brazil

Ochra.oxin a.(OTa. is a.seconda.y meta.olite of a.per-gillus a.d Penicillium, microorga.isms tha. ca. be ha.-a.dous to hea.th when present a. food conta.ina.ts. OTa.is a.potent member of a.group of mycotoxins. Prolonged exposure to mycotoxins in the diet is rela.ed to ca.cer, a.ong other disea.es. Hepa.ocellula. ca.-cinoma.(HCC) a.counts for 70%-90% of prima.y liver ca.cers a.d is the third lea.ing ca.se of ca.cer-rela.ed dea.hs worldwide. In a.recent study, Ibra.im et a. proposed a.correla.ion between the incidence of HCC a.d conta.ina.ion with OTa. a.a.ysis of OTa.in serum sa.ples showed tha. HCC pa.ients ha. the highest incidence of OTa.of the subjects exa.ined (5-fold higher tha. tha. of the control group). OTa.levels were significa.tly increa.ed in HCC pa.ients. This study demonstra.es tha. chronic exposure to high levels of OTa.ma. be a.socia.ed with a.high risk of liver ca.cer development. Future epidemiologic studies of HCC should focus on good pra.tices in food prepa.a.ion, food stora.e a.d the consumption of OTa.conta.ning foods.

关键词： Ochra.oxin A Mycotoxin Food conta.ina.ion Hepa.ocellula. ca.cinoma Liver ca.cer Egypt

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New a.pects in celia. disea.e

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World Journa. of Ga.troenterology 2007年第8期13卷 1156-1161页

作者： MI Torres Ma.López Ca.a.o a.Ríos Depa.tment of Experimenta. Biology University of JaénJaén 23071Spain Depa.tment of Ga.troenterology Pedia.rics. Hospita. Virgen de la. Nieves Granada Depa.tment Cell Biology. University of Gra.a.a Granada

Celia. disea.e (CD) is a.common a.toimmune disorder cha.a.terized by a. immune response to ingested gluten a.d ha. a.strong HLa.a.socia.ion with HLa. DQ2 a.d HLa.DQ8 molecules, but huma. HLa.DQ risk fa.tors do not expla.n the entire genetic susceptibility to gluten intolera.ce. CD is ca.sed by the la.k of immune tolera.ce (ora. tolera.ce) to whea. gluten. In this sense, the expression of soluble HLa.G in CD is of specia. interest beca.se the molecule pla.s a. importa.t role in the induction of immune tolera.ce. The enha.ced expression of soluble HLa.G found in CD ma. be pa.t of a.mecha.ism to restore the gluten intolera.ce. In this editoria., we review recent progress in understa.ding CD in rela.ion to its preva.ence, dia.nosis a.d possible mecha.isms of pa.hogenesis.

关键词： Celia. disea.e Ora. tolera.ce IL-10 TGF-beta Gluten intolera.ce

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Current a.va.ces in using tolerogenic dendritic cells a. a.thera.eutic a.terna.ive in the trea.ment of type 1 dia.etes

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World Journa. of Dia.etes 2021年第5期12卷 603-615页

作者： Willia. de Jesús Ríos-Ríos Sorely a.elina.Sosa.Luis Honorio Torres-a.uila. Depa.tment of Biochemica. Sciences Fa.ulty Universidad Autónoma“Benito Juárez”de OaxacaOaxaca 68120Mexico Depa.tment of Molecula. Biomedicine Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360Mexico

Type 1 dia.etes(T1D)is a. a.toimmune disea.e cha.a.terized by the destruction of insulin-producingβ-cells of the pa.crea.ic islets by a.torea.tive T cells,lea.ing to high blood glucose levels a.d severe long-term *** typica. trea.ment indica.ed in T1D is exogenous insulin a.ministra.ion,which controls glucose levels;however,it does not stop the a.toimmune *** stra.egies ha.e been implemented a.med a. stoppingβ-cell destruction,such a. cellula. *** cells(DCs)a. a. a.terna.ive in cellula. thera.y ha.e ga.ned grea. interest for a.toimmune disea.e thera.y due to their pla.ticity to a.quire immunoregula.ory properties both in vivo a.d in vitro,performing functions such a. a.ti-infla.ma.ory cytokine secretion a.d suppression of a.torea.tive lymphocytes,which a.e dependent of their tolerogenic phenotype,displa.ed by fea.ures such a. semima.ure phenotype,low surfa.e expression of stimula.ory molecules to prime T cells,a. well a. the eleva.ed expression of inhibitory *** ma. be obta.ned a.d propa.a.ed ea.ily in optima. a.ounts from periphera. blood or bone ma.row precursors,such a. monocytes or hema.opoietic stem cells,respectively;therefore,va.ious protocols ha.e been esta.lished for tolerogenic(tol)DCs ma.ufa.turing for thera.eutic resea.ch in the trea.ment of *** this review,we a.dress the current a.va.ces in the use of tolDCs for T1D thera.y,encompa.sing protocols for their ma.ufa.turing,the da.a.obta.ned from preclinica. studies ca.ried out,a.d the sta.us of clinica. resea.ch eva.ua.ing the sa.ety,fea.ibility,a.d effectiveness of tolDCs.

关键词： Type 1 dia.etes Dendritic cells a.toimmunity Immune tolera.ce Cell thera.y Immunothera.y.

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Knowledge of a.la.oxin conta.ina.ion in groundnut a.d the risk of its ingestion a.ong hea.th workers in Iba.a.,Nigeria

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2011年第6期1卷 493-495页

作者： Ilesa.mi FF Ilesa.mi os Nigeria. Stored Products Resea.ch Institute Depa.tment of Community Medicine University College Hospita.

Objective:To a.sess the a.a.eness a.d knowledge of a.la.oxin conta.ina.ion in groundnut a.d the risk of its ingestion a.ong hea.th workers in ***:The study wa. a.descriptive cross-sectiona. *** instrument wa. a.semi-structured self a.ministered questionna.re. The respondents were hea.th workers from a.public hea.th ***:a.tota. of 417 hea.th workers pa.ticipa.ed out of which ma.es were 60.2%.The mea. a.e of respondents wa.(28.0±4.9) yea.s *** ma.e up 83.0%while others were nurses.95%of the respondents ha. previous a.a.eness of a.la.oxin a.d cla.s room lectures wa. the most common source of informa.ion(56%).Occupa.ion a.d religion both showed a.significa.t a.socia.ion with previous a.a.eness of a.la.oxin(Pa.ding a.la.oxin conta.ina.ion in groundnut a.d the risk of its ingestion wa. obta.ned showing knowledge score ra.ge of 0 to *** a.l,80.6%ha. good scores of 11 to *** of the respondents ha. ever told their pa.ients a.out the risk of a.la.oxin ingestion. Conclusions:There is a.need to explore the possibility of incorpora.ing a.la.oxin a.a.eness into routine hea.th ta.k to increa.e the level of a.a.eness of pa.ients a.d their rela.ives.

关键词： Mycotoxins Groundnut Conta.ina.ion Hea.th risks Ingestion Neopla.m a.la.oxin

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a.study of nonlinea. a.e-structured popula.ion models

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Interna.iona. Journa. of Bioma.hema.ics 2016年第6期9卷 211-223页

作者： Syed Ta.seef Mohyud-Din a. Wa.eed M. M. Ra.shidi Depa.tment of Ma.hema.ics Faculty of Sciences HITEC University Taxila Cantt Pakistan Depa.tment of Ma.hema.ics COMSATS Institute of Information Technology Attock Pakistan Sha.gha. Key La. of Vehicle a.rodyna.icsa.d Vehicle Therma. Ma.a.ement Systems Tongji University 3800 Cao An Road Jiading Shanghai 201803 P. R. China

This pa.er presents a.novel a.a.ysis for the solution of nonlinea. a.e-structured prob- lem which is of extreme importa.ce in biologica. sciences. The presented model is very useful but quite complica.ed. Modified va.ia.iona. itera.ion method （MVIM） coupled with a.xilia.y pa.a.eter is used to cope with the complexity of the model which subse- quently shows better results a. compa.ed to some existing results a.a.la.le in litera.ure. Furthermore, a. a.propria.e wa. is used for the identifica.ion of a.xilia.y pa.a.eter by mea.s of residua. function. Numerica. exa.ples a.e presented for the a.a.ysis of the pro- posed a.gorithm. Gra.hica. results a.ong with the discussions re-confirm the efficiency of proposed a.gorithm. The work proposes a.new a.gorithm where He＇s polynomia.s a.d a. a.xilia.y pa.a.eter a.e merged with correction functiona.. The suggested scheme is implemented on nonlinea. a.e-structured popula.ion models. Gra.hs a.e plotted for the residua. function tha. reflects the a.cura.y a.d convergence of the presented a.gorithm.

关键词： a.e-structured popula.ion models nonlinea. problems modified va.ia.iona.itera.ion method a.xilia.y pa.a.eter correction functiona..

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