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Phytochemical constituents,antioxidant and antibacterial activities of methanolic extract of Ardisia elliptica

Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 569-576页

作者： Nazeh M.Al-Abd zurainee mohamed nor Marzida Mansor Asdren Zajmi Mohd Shahnaz Hasan Fadzly Azhar Mustafa Kassim Department of Parasitology Faculty of MedicineUniversity of Malaya Faculty of Medicine and Health Sciences University of Aden Department of Anesthesiology Faculty of MedicineUniversity of Malaya Department of Diagnostic and Allied Health Sciences Faculty of Health and Life SciencesManagement and Science University Department of Chemistry Faculty of ScienceUniversity of Malaya

Objective:To investigate the antioxidant,antibacterial,and chemical ingredients of Ardisia elliptica(***) methanolic ***:The plant was extracted using *** and antioxidant activities were ***:The results showed that both fruit and leaf extract of *** have significant antibacterial activities against Gram-positive and Gram-negative *** extracts showed higher content of phenolic(71 ± 0.03 GAE/mg extract dry weight),in comparison to the leaf extracts(37 ± 0.05 GAE/mg extract dry weight).Flavonoid content,and Fe2+chelating activity of fruit extracts were higher than leaf *** percentage radical inhibition of fruit extract is found to be higher(70%) than that of leaf extract(60%).LCMS results indicated that the major compounds in the fruit extract were Gingerol,Aspidin,Kampherol,and Stercuresin,while the leaf extract contained Gingerol,Aspidin,Triangularin,and Salicyl acyl ***,the results of GCMS indicated that fruit extract contained these major compounds:Vitamin E Tocopherol,5-hepylresornicol,2-Nonylmalonic acid,5-pentadecylresornicol,and ***,leaf extract of *** contained these major compounds:Alpha Amyrenol,4,4,6,6a,6b,8,8a,9,10,11,12,12 a,14,14 a,14 b octadehydro-2H-picen-3-one,and Lonasterol,4-t-Butyl-2-[4-nitrophenyl] ***:The results provide evidence that fruit and leaf of *** extracts might indeed be used as a potential source of effective natural antimicrobial and antioxidant agents in pharmaceutical and food industries.

关键词： Ardisia elliptica Antioxidant capacity Total phenol content Gas chromatography/mass spectrometry Liquid chromatography/mass spectrometry

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Prevalence of filarial parasites in domestic and stray cats in Selangor State, Malaysia

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Asian Pacific Journal of Tropical Medicine 2015年第9期8卷 693-697页

作者： Nazeh M Al-Abd zurainee mohamed nor Mustafa Kassim Marzida Mansor Abdulelah H.Al-Adhroey Romano Ngui Sinnadurai Sivanandam Department of Parasitology Faculty of Medicine University of Malaya Department of Anesthesiology Faculty of Medicine University of Malaya

Objective: To determine the prevalence of the filarial parasites, ie., Brugia malayi, Brugia pahangi(B. pahangi), Dirofilaria immitis and Dirofilaria repens(D. repens)in domestic and stray cats. Methods: A total of 170 blood sample were collected from domestic and stray cats and examined for i larial worm parasites in two localities, Pulau Carey and Bukit Gasing, Selangor State, Malaysia. Results: The overall prevalence of infection was 23.5%(40/170; 95% CI=17.4–30.6). Of this, 35%(14/40; 95% CI=22.1–50.5) and 50%(20/40; 95% CI=35.2–64.8) were positive for single B. pahangi and D. repens, respectively. The remaining of 15%(6/40; 95% CI=7.1–29.1) were positive for mixed B. pahangi and D. repens. In addition, 75% of the infected cats were domestic, and 25% were strays. No Brugia malayi and Dirofilaria immitis was detected. Eighty-four cats were captured at Pulau Carey, of which 35.7%(30/84) were infected. Among the cats determined to be infected, 93%(28/30; 95% CI=78.7–98.2) were domestic, and only 6.7%(2/30; 95% CI=19.0–21.3) were strays. Conversely, the number of infected cats was three times lower in Bukit Gasing than in Pulau Carey, and most of the cats were stray. Conclusions: B. pahangi and D. repens could be the major parasites underlying i lariasis in the study area. Adequate prophylactic plans should be administrated in the cat population in study area.

关键词： Filarial parasites Brugia Wuchereria Dirofilaria Cat Filariasis

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Liver cirrhosis and splenomegaly associated with Schistosoma mansoni in a Sudanese woman in Malaysia:A case report

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Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 334-336页

作者： Yamuna Rajoo Rohela Mahmud Ng Rong Xiang Sharifah F.S.Omar G Kumar Yvonne A.L Lim Arine Fadzlun Ahmad Amirah Amir zurainee mohamed nor Romano Ngui Department of Parasitology Faculty of MedicineUniversity of Malaya Department of Medicine Faculty of MedicineUniversity of Malaya Department of Biomedical Imaging Faculty of MedicineUniversity of Malaya

We report a case of a patient with Schistosoma mansoni infection who presented with liver cirrhosis and *** was diagnosed by a serological test and Kato-Katz thick smear stool *** patient was a 52-year-old woman from Sudan who came to Malaysia for a week to visit her *** patient lives in the middle of Rabak region,Sudan,a highly endemic area for schistosomiasis where her daily routine includes rearing of cows and *** site of toilet and sources of drinking water are canals and wells;both infested with *** had a long history of exposure and coming into contact with water from these canals and wells.

关键词： Schistosoma mansoni Liver cirrhosis Splenomegaly Sudanese woman

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Impact of Indoor Residual-Sprayed Deltamethrin on Different Surfaces in a Malaria Endemic Area in Balai Ringin, Sarawak

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Advances in Entomology 2014年第3期2卷 151-160页

作者： Ahmad Rohani Ismail Zamree Wan Najdah Wan Mohamad Ali Azahari Abdul Hadi Matusop Asmad zurainee mohamed nor Lee Han Lim 1Medical Entomology Unit Infectious Disease Research Center Institute for Medical Research Kuala Lumpur Malaysia Department of Parasitology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia Medical Entomology Unit Infectious Disease Research Center Institute for Medical Research Kuala Lumpur Malaysia Vector Borne Disease Control Programme Sarawak State Health Department Kuching Malaysia

Malaria control programme utilizing indoor residual spraying of chemical insecticide is only effective if a high coverage of targeted area is achieved. The effectiveness of the residual spraying, on the other hand, relies on the efficacy and residual activity of the insecticides applied, which to a certain extent are influenced by the nature of the sprayed surfaces. The bioefficacy of indoor residual-sprayed deltamethrin wettable granule (WG) formulation for the control of malaria was compared with the current dose of deltamethrin wettable powder (WP) in malaria endemic areas in Balai Ringin, Sarawak. Doses of 20 mg/m2 WP (control), 20 mg/m2 WG, 30 mg/m2 WG and 40 mg/m2 WG were sprayed separately on different surfaces namely, wooden, rough-bamboo, smooth-bamboo and brick surfaces. Residual activity of WP and WG formulations was tested against lab-bred Anopheles maculatus using WHO standard procedure. Deltamethrin at 30 mg/m2 WG exhibited the highest sustainable level of effectiveness against An. maculatus (An. maculatus mortality was between 95% - 100%) up to week 60 post-spraying when sprayed on smooth- bamboo surface. These results indicated that 30 mg/m2 WG could be an ideal concentration for controlling malaria vector effectively up to 15 months of which long-lasting residual spraying was envisaged. The usual two spraying cycles per year with 20 mg/m2 deltamethrin WP could be replaced with 30 mg/m2 deltamethrin WG since the long residual activity was achieved by employing a single spraying only.

关键词： Component Indoor Residual-Sprayed Deltamethrin Wettable Granule An. maculatus

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Nocturnal man biting habits of mosquito species in Serian, Sarawak, Malaysia

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Advances in Entomology 2013年第2期1卷 42-49页

作者： Ahmad Rohani Ismail Zamree Wan Najdah Wan Mohamad Ali Azahari Abdul Hadi Matusop Asmad David Lubim zurainee mohamed nor Lee Han Lim Medical Entomology Unit Infectious Disease Research Center Institute for Medical Research Kuala Lumpur Malaysia

Knowledge of the composition and biting habits of mosquito associated with endemic areas is important in establishing sound vector control programmes and understanding the epidemiology of vector borne diseases. The biting activity cycle of several mosquito species in Serian, Sarawak was observed and described. Collections were carried out indoors and outdoors for 12 hours from 6.00 pm to 6.00 am using human landing catch techniques. A total of 7271 mosquitoes comprising 27 species belonging to sixgenera were collected. Mansonia bonneae (23.6%) was the predominant species caught in the study areas followed by Culex vishnui (22.3%), Culex pseudovishnui (19.6%) and Culex tritaenorhynchus (13.7%). A high rate of human biting activity by Ma. bonneae was detected during November but the activity was low during *** biting activity of *** was found higher outdoor compared to indoorand peaked at 7.00 pm-8.00 *** also exhibited similar biting activity peak while Anopheles letiferex-hibited biting activity peaked at 12.00 am-1.00 *** showed biting patterns which were almost similar between indoor and outdoor activity and could be considered active throughout the 12 hour period.

关键词： Mosquitoes Biting Nocturnal Outdoor Indoor

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Insecticide susceptibility status and resistance mechanism of Anopheles cracens Sallum and Peyton and Anopheles maculatus Theobald(Family: Culicidae) from knowlesi malaria endemic areas in Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2019年第2期12卷 79-86页

作者： Ahmad Rohani Abdul Rahman Aidil Azahary Ke-Xin Yu mohamed nor zurainee Wan Mohamad Ali Wan Najdah Han Lim Lee Medical Entomology Unit Institute for Medical Research(Malaysia) Department of Parasitology University of Malaya Faculty of Health and Life Sciences Management and Science University(Malaysia)

Objective: To assess the insecticide susceptibility status of Anopheles cracens(***) and Anopheles maculatus(***) from knowlesi malaria endemic areas in Peninsular Malaysia towards DDT, malathion and deltamethrin and to determine the resistance mechanism ***: Adult and larval mosquitos were collected for *** status of Anopheles was determined using the standard WHO adult bioassay, larval bioassay and biochemical enzyme ***: WHO adult bioassay results indicated *** collected from Kampung Sungai Ular, Pahang was resistant towards 4% DDT, while *** collected from Kampung Sokor, Kelantan and Kampung Sungai Lui, Selangor exhibited resistance towards 4% ***, the enzyme activity profiles varied according to strains and *** resistance ratio of larval bioassay, showed that all strains and species tested were susceptible to malathion and ***: Since only a few anopheline strains exhibited low level of insecticide resistance towards malathion, DDT and *** insecticides are still considered effective for vector control program towards *** and ***.

关键词： Insecticide susceptibility Vector control WHO adult bioassay Biochemical enzyme assay

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Insecticide resistance status of Aedes aegypti and Aedes albopictus in Malaysia(2010 to 2022):A review

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Asian Pacific Journal of Tropical Medicine 2023年第10期16卷 434-445页

作者： Sabar Nurul-Nastasea Ke-Xin Yu Ahmad Rohani mohamed nor zurainee Tengku Idzzan Nadzirah Tengku-Idris Roza Dianita Masse Rezki Sabrina Wan Mohamad Ali Wan Najdah School of Graduate Studies Management and Science UniversitySeksyen 1340100Shah AlamSelangorMalaysia Faculty of Health and Life Sciences Management and Science UniversitySeksyen 1340100 Shah AlamSelangorMalaysia Medical Entomology Unit Institute for Medical ResearchNational Institute of HealthMinistry of Health MalaysiaPersiaran Setia MurniSetia Alam40170 Shah AlamSelangorMalaysia Department of Parasitology Faculty of MedicineUniversity of Malaya50603Kuala LumpurMalaysia School of Biology Faculty of Applied SciencesUniversiti Teknologi MARA40450Shah AlamSelangorMalaysia School of Pharmaceutical Sciences Universiti Sains Malaysia11800GelugorPenangMalaysia

This review aimed to determine the prevalence of the insecticide resistance status of the field-collected Aedes(Ae.)aegypti and *** in Malaysia from 2010 to 2022 towards carbamates,organochlorines,organophosphates and *** and environmental controls were summarized with an emphasis on the mosquito vector control strategies in *** information in this review was extracted from several databases such as PubMed(MEDLINE),Science Direct and Scopus by using keywords including“insecticide resistance”,“carbamate resistance”,“organochlorine resistance”,“organophosphate resistance”,“pyrethroid resistance”,“Aedes”and“Malaysia”,between January 2022 and December *** of resistant *** and *** in Malaysia was mapped using QGIS *** resistance in both *** and *** is widespread in Malaysia,although the rates vary by *** most notable was the steep increase in permethrin resistance of *** in Selangor,Malaysia,over the past *** also displayed moderate resistance to permethrin,though not as widespread as *** in Selangor,but showed sign of resistance in Sarawak,East *** towards four main classes of insecticides have been widely documented in *** extensive resistance towards permethrin in Malaysia which is one of the current insecticides used in Malaysia suggested that policies supporting the widespread use of permethrin fogging needs further evaluation.

关键词： Aedes Pyrethroids Insecticide resistance Malaysia Vector control

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Spatial distribution and structure of benthic polychaete communities of Essaouira intertidal rocky shores(Atlantic coast of Morocco)

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Journal of Oceanology and Limnology 2020年第1期38卷 143-155页

作者： CHOUIKH nor-eddine GILLET Patrick LANGSTON WJ CHEGGOUR mohamed MAAROUF Abdelmalek MOUABAD Abdelfattah Laboratory“Aliments Environnement et santé”Faculty of Sciences and TechnicsB.P.549Cadi Ayyad UniversityMarrakech 40000Morocco Mer Molécules Santé Department of Biology EnvironmentFaculty of Sciences UCOAngers 49008France Marine Biological Association the LaboratoryCitadel HillPlymouth PL12PBUnited Kingdom Department of Biology Ecole Normale SupérieureB.P.2400Cadi Ayyad UniversityMarrakech 40000Morocco

Polychaetes are one of the most important groups ofmacrobenthic organisms in coastal and marine environments,in terms of diversity and abundance,and play an important role in the functioning of *** study aims to describe the structure and spatial distribution ofpolychaete communities along Essaouira's rocky shoreline(Atlantic coast of Morocco)in relation to the major environmental variables such as granulometry,salinity,temperature,pH,and intertidal *** sites from these intertidal rocky shores were sampled using a quadrat method during the summer 2016.A total of 4435 individuals belonging to 34 taxa were *** the families,Sabellaridae(24%)and Nereididae(23%)were ranked first in terms of abundance of *** alveolata(24%)and Perinereis cultrifera(13%)were the dominant ***(H')values varied from 2.28 to ***'s index(J')varied between 0.62 and *** was essentially due to the low dominance of few *** analysis was used to characterise Essaouira's rocky shores on the basis of benthic polychaete *** analysis confirmed the presence of three distinct *** to canonical correspondence analysis,the structure and distribution of faunal assemblages of benthic polychaetes was mainly related to topographical complexity,water temperature,hydrodynamic conditions and *** conclude that these rocky shores show typically high benthic polychaete diversity compared to the taxonomic list of other rocky *** addition,these results constitute a baseline data for the development of a sustainable network for long-term monitoring of benthic polychaete community changes due to ecological factor influences and anthropogenic activity impacts.

关键词： polychaetes taxonomic diversity Essaouira rocky shore faunal assemblage

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The protective effects of procyanidin C-1 on bisphenol A-induced testicular dysfunction in aged mice

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Food Science and Human Wellness 2022年第4期11卷 965-974页

作者： Mastura Abd Malek Razif Dasiman nor-Ashikin mohamed Noor Khan Sofee mohamed-Akhlak Mohd-Hafi zi Mahmud Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam Campus42300 Puncak AlamSelangorMalaysia

The number and quality of sperm are decreased due to bisphenol A(BPA) exposure, an endocrine-disrupting chemical on the male reproductive system, especially in advanced paternal age(APA). Procyanidin C-1(PCY-1), an antioxidant from grape seed(Vitis vinifera L.), has demonstrated anti-viral, anti-melanogenic and immunostimulatory effects. Therefore, this study aims to determine the effects of PCY-1 intervention on sperm parameters, testis morphological changes, serum testosterone, oestradiol, and luteinizing hormone(LH) concentrations and the expression of apoptotic(Bax and Bcl-2) and mitochondria-related(Mfn1 and Opa1) genes in BPA-exposed aged mice. Results revealed that PCY-1 intervention improves aged male fertility in BPA-exposed conditions by decreasing abnormal sperms percentage and increasing spermatogenic cell diameter and epithelial height. PCY-1 also decreased oestradiol, and increased LH and testosterone levels. The gene expression of Bax was significantly down-regulated by PCY-1 intervention. In contrast, Bcl-2 was substantially up-regulated. Expression of Mfn1 and Opa1 genes were also significantly up-regulated in the PCY intervention group. Hence, it is demonstrated that PCY-1 was able to mitigate the adverse effects of BPA on reproductive parameters of aged mice. Collectively, we postulated that PCY-1 has a potential role in protecting the ageing male reproductive system against the damaging impacts of BPA.

关键词： Apoptosis Bisphenol A Procyanidin Mitochondrial dynamics Testis

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Fenofibrate for the prevention of progression of non-proliferative diabetic retinopathy:review,consensus recommendations and guidance for clinical practice

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2001-2008页

作者： nor Fariza Ngah nor Asiah Muhamad Roslin Azni Abdul Aziz Shelina Oli mohamed nor Azita Ahmad Tarmizi Azian Adnan Zalifah Zakiah Asnir Zanariah Hussein Hui Foo Siew Masni mohamed Noor Aliza Lodz Vijayamala Valayatham Institute for Clinical Research National Institutes of HealthSetia AlamSelangor 40790Malaysia Hospital Shah Alam Selangor 40000Malaysia Sector for Evidence-Based Healthcare National Institutes of HealthSetia AlamSelangor 40790Malaysia Hospital Kuala Lumpur Wilayah Persekutuan Kuala Lumpur 50586Malaysia Hospital Selayang Selangor 68100Malaysia Hospital Ampang Selangor 68000Malaysia Hospital Putrajaya Wilayah Persekutuan Putrajaya 62250Malaysia Institute for Public Health National Institutes of HealthSetia AlamSelangor 40790Malaysia

The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific *** evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in patients with cardiovascular risk,and pre-existing mild-to-moderate *** has also been found to reduce maculopathy,and the need for laser treatment in these *** these benefits of fenofibrate,a group of experts from the fields of endocrinology and ophthalmology convened in May 2017,to discuss on the the mechanism of action,and clinical efficacy of fenofibrate in *** findings from key clinical studies on fenofibrate in DR were reviewed by the experts,and consensus statements were derived to define the role of fenofibrate in the prevention and treatment of *** statements were rated based on the GRADE *** algorithm was also developed for the screening and treatment of DR in patients with type 2 diabetes(T2D),and the place of fenofibrate was defined in the *** expert recommendations,and the algorithm provided in this review will serve as a guide to the clinicians to reconsider the adjunctive use of fenofibrate for preventing the progression of DR in selected T2D patients.

关键词： diabetic retinopathy fenofibrate consensus recommendations

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