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Investigation multi-target synergistic mechanism of Choerospondias axillaris in the treat of cerebral ischemia based on systems pharmacology and experimental verification

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Natural Therapy Advances 2024年第3期7卷 37-47页

作者： yang Ma Min-Chun Chen zuo-yan zhang Kang-Kang yan Yi Ding Department of Pharmacy Xi'an No.3 Hospital the affiliated Hospital of Northwest UniversityXi’an 710000China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 71000China

Background:Choerospondias axillaris(CA)is a traditional Mongolian medicine that has been proven to have a good therapeutic effect on cerebrovascular *** Ischemia(CI)is a severe and life-threatening cerebrovascular ***,the specific mechanism of action of CA in the treatment of CI is still ***:In this study,the related targets and pathways of CA in the treatment of CI were first predicted by system pharmacology and then verified by relevant ***:The results showed that 12 active ingredients and 208 targets were *** validation through protein-protein interaction(PPI)network analysis and active ingredients-target-pathway(A-T-P)network analysis has confirmed the pivotal roles of the main bioactive constituents,including quercetin,kaempferol,naringin,β-sitosterol,and gallic *** components exert their anti-ischemic effects by modulating key targets such as IL6,TNF,MAPK3,and CASP3,thereby regulating the PI3K-Akt,HIF-1,and MAPK signaling pathways,which are integral to processes like inflammation,apoptosis,and oxidative *** importantly,through experimental verification,this study confirmed our prediction that CAE significantly reduced neurological function scores,infarct volume,and the percentage of apoptosis ***:This indicates that CA acts on CI through multi-target synergistic mechanism,and this study provides theoretical basis for the clinical application of CA.

关键词： systems pharmacology Choerospondias axillaris cerebral ischemia multi-target synergistic mechanism middle cerebral artery occlusion

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Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

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Genes & Diseases 2024年第1期11卷 218-233页

作者： Zanwen zuo Zerong Zhou Yuzhou Chang yan Liu Yuping Shen Qizhang Li Lei zhang Innovative Drug R&D Center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210USA School of Agriculture and Biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and ***2 performs a critical role in the malignant biological behaviors of *** structure,regulation,and function of RRM2 and its inhibitors were ***2 gene can produce two transcripts encoding the same ***2 expression is regulated at multiple levels during the processes from transcription to ***,this gene is associated with resistance,regulated cell death,and tumor *** order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different ***,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor ***,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition Regulation Resistance RRM2

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Multi-circular formation control with reinforced transient profiles for nonholonomic vehicles:A path-following framework

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Defence Technology（防务技术） 2024年第1期31卷 278-287页

作者： Jintao zhang Xingling Shao Wendong zhang Zongyu zuo School of Instrument and Electronics North University of ChinaTaiyuan 030051China State Key Laboratory of Dynamic Measurement Technology North University of ChinaTaiyuan 030051China Seventh Research Division School of Automation Science and Electrical EngineeringBeihang UniversityBeijing 100191China

This article investigates a multi-circular path-following formation control with reinforced transient profiles for nonholonomic vehicles connected by a digraph.A multi-circular formation controller endowed with the feature of spatial-temporal decoupling is devised for a group of vehicles guided by a virtual leader evolving along an implicit path,which allows for a circumnavigation on multiple circles with an anticipant angular *** addition,notice that it typically imposes a stringent time constraint on time-sensitive enclosing scenarios,hence an improved prescribed performance control(IPPC)using novel tighter behavior boundaries is presented to enhance transient capabilities with an ensured appointed-time convergence free from any *** significant merits are that coordinated circumnavigation along different circles can be realized via executing geometric and dynamic assignments independently with modified transient ***,all variables existing in the entire system are analyzed to be *** and experimental results are provided to validate the utility of suggested solution.

关键词： Multi-circular formation Reinforced transient profiles Nonholonomic vehicles Path following

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Patient satisfaction and follow-up adherence to glaucoma case management clinic in China

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 73-81页

作者： Hao Lin Hu-Jie Lu Wen-Zhe Zhou Shu-Shu zuo yan-yan Chen Shao-Dan zhang National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina School of Ophthalmology and Optometry Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To assess glaucoma patient satisfaction and follow-up adherence in case management and identify associated predictors to improve healthcare quality and patient ***:In this cross-sectional study,a total of 119 patients completed a Patient Satisfaction Questionnaire-18 and a sociodemographic *** data was obtained from the case management ***-up adherence was defined as completing each follow-up within±30d of the scheduled time set by ophthalmologists during the study ***:Average satisfaction scored 78.65±7,with an average of 4.39±0.58 across the seven *** negatively correlated with satisfaction(P=0.008),whilst patients with follow-up duration of 2 or more years reported higher satisfaction(P=0.045).Multivariate logistics regression analysis revealed that longer follow-up durations were associated with lower follow-up adherence(OR=0.97,95%CI,0.95-1.00,P=0.044).Additionally,patients with suspected glaucoma(OR=2.72,95%CI,1.03-7.20,P=0.044)and those with an annual income over 100000 Chinese yuan demonstrated higher adherence(OR=5.57,95%CI,1.00-30.89,P=0.049).CONCLUSION:The case management model proves effective for glaucoma patients,with positive adherence *** implementation of this model can be optimized in the future based on the identified factors and extended to glaucoma patients in more hospitals.

关键词： glaucoma patient satisfaction follow-up adherence case management

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Giant reversible barocaloric effects with high thermal cycle stability in epoxybonded (MnCoGe)0.96(CuCoSn)0.04 composite

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INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS 2024年第11期31卷 2528-2534页

作者： Kuang, Yafei Tao, Kun yang, Bo Tong, Peng zhang, yan Sun, Zhigang zhang, Kewei Wang, Dunhui Hu, Jifan zuo, Liang Taiyuan Univ Sci & Technol Coll Mat Sci & Engn Taiyuan 030024 Peoples R China Taiyuan Univ Sci & Technol Shanxi Key Lab Magnet & Elect Funct Mat & Applicat Taiyuan 030024 Peoples R China Chinese Acad Sci Inst Solid State Phys Key Lab Mat Phys Hefei 230031 Peoples R China Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Minist Educ Shenyang 110819 Peoples R China Hangzhou Dianzi Univ Sch Elect & Informat Hangzhou 310018 Peoples R China

Hexagonal MnMX-based (M = Co or Ni, X = Si or Ge) alloys exhibit giant reversible barocaloric effects. However, giant volume expansion would result in the as-cast MnMX ingots fragmenting into powders, and inevitably bring the deterioration of mechanical properties and formability. Grain fragmentation can bring degradation of structural transformation entropy change during cyclic application and removal of pressure. In this paper, giant reversible barocaloric effects with high thermal cycle stability can be achieved in the epoxy bonded (MnCoGe)(0.96)(CuCoSn)(0.04) composite. Giant reversible isothermal entropy change of 43.0 J center dot kg(-1)center dot K-1 and adiabatic temperature change from barocaloric effects (Delta T-BCE) of 15.6 K can be obtained within a wide temperature span of 30 K at 360 MPa, which is mainly attributed to the integration of the change in the transition temperature driven by pressure of -101 K center dot GPa(-1) and suitable thermal hysteresis of 11.1 K. Further, the variation of reversible Delta T-BCE against the applied hydrostatic pressure reaches up to 43 K center dot GPa(-1), which is at the highest level among the other reported giant barocaloric compounds. More importantly, after 60 thermal cycles, the composite does not break and the calorimetric curves coincide well, demonstrating good thermal cycle stability.

关键词： barocaloric effects cycle stability reversible isothermal entropy change reversible adiabatic temperature change MnCoGe alloys ALLOY TRANSFORMATION EXPANSION PRESSURE

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Deep Learning in Predicting Preterm Birth:A Comparative Study of Machine Learning Algorithms

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Maternal-Fetal Medicine 2024年第3期6卷 141-146页

作者： Fangchao zhang Lingling Tong Chen Shi Rui zuo Liwei Wang yan Wang Department of Gynecology and Obstetrics Peking University Third HospitalBeijing 100191China Department of Gynecology and Obstetrics The Fourth Hospital of ShijiazhuangShijiazhuang 050010China School of Intelligence Science and Technology Peking UniversityBeijing 100871China Information Management and Big Data Center Peking University Third HospitalBeijing 100191China National Center for Healthcare Quality Management in Obstetrics Peking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Objective:To determine whether deep learning algorithms are suitable for predicting preterm ***:A retrospective study was conducted at Peking University Third Hospital from January 2018 to June *** data were divided into two parts based on the date of delivery:the first part was used for model training and validation,while real world viability was evaluated using the second *** machine learning algorithms(logistic regression,random forest,support vector machine,and transformer)were employed to predict preterm *** operating characteristic curves were plotted,and the area under the curve(AUC),sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy were ***:This research included data on 30,965 births,where 24,770 comprised the first part,and included 3164(12.77%)in the preterm birth group,with 6195 in the second part,including 795(12.83%)in the preterm birth *** differences in various factors were observed between the preterm and full-term birth *** transformer model(AUC=79.20%,sensitivity=73.67%,specificity=72.48%,PPV=28.21%,NPV=94.95%,and accuracy=72.61%in the test dataset)demonstrated superior performance relative to logistic regression(AUC=77.96%in the test dataset),support vectormachine(AUC=71.70%in the test dataset),and random forest(AUC=75.09%in the test dataset)***:This study highlights the promise of deep learning algorithms,specifically the transformer algorithm,for predicting pretermbirth.

关键词： Artificial intelligence Machine learning Preterm birth Transformer

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Phase engineering of Ni-Mn binary layered oxide cathodes for sodiumion batteries

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Journal of Energy Chemistry 2024年第4期91卷 501-511页

作者： Feifei Hong Xin Zhou Xiaohong Liu Guilin Feng Heng zhang Weifeng Fan Bin zhang Meihua zuo Wangyan Xing Ping zhang Hua yan Wei Xiang College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059SichuanChina College of Chemical Engineering Sichuan UniversityChengdu 610065SichuanChina Research Institute for Electronic Science(RIES)and Division of Information Science and Technology Graduate School of Information Science and TechnologyHokkaido UniversityN20W10SapporoHokkaido 001-0020Japan School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009JiangsuChina Yibin Libode New Materials Co. Ltd.Yibin 644200SichuanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina

Nickel-manganese binary layered oxides with high working potential and low cost are potential candidates for sodium-ion batteries,but their electrochemical properties are highly related to compositional *** composite materials with various phase structures of P3,P2/P3,P2,P2/O3,and P2/P3/O3 were synthesized by manipulating the sodium content and calcination conditions,leading to the construction of a synthetic phase diagram for Na_(x)Ni_(0.25)Mn_(0.75)O_(2)(0.45≤x≤1.1).Then,we compared the electrochemical characteristics and structural evolution during the desodiation/sodiation process of P2,P2/P3,P2/03,and P2/P3/O3-Na_(x)Ni_(0.25)Mn_(0.75)O_(2).Among them,P2/P3-Na0.75Ni0.25Mn0.75O2exhibits the best rate capability of 90.9 mA h g^(-1)at 5 C,with an initial discharge capacity of 142.62 mA h g^(-1)at 0.1 C and a capacity retention rate of 78.25%after 100 cycles at 1 C in the voltage range of 2-4.3 *** observed superior sodium storage performance of P2/P3 hybrids compared to other composite phases can be attributed to the enhanced Na^(+)transfer dynamic,reduction of the Jahn-teller effect,and improved reaction reversibility induced by the synergistic effect of P2 and P3 *** systematic research and exploration of phases in Na_(x)Ni_(0.25)Mn_(0.75)O_(2)provide new sights into high-performance nickel-manganese binary layered oxide for sodium-ion batteries.

关键词： Phase engineering Ni-Mn layered oxide Cathode Sodium-ion batteries

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Development *** in limited urban sprawl:An integrated framework for resolving the urban boundary dilemma in China

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Journal of Geographical Sciences 2024年第7期34卷 1371-1393页

作者： SONG Xiangxiang zhang zuo WANG Zhe LIU yanzhong School of Public Administration Central China Normal UniversityWuhan430079China College of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan430081China

The strategic delineation of the urban development boundary(UDB)is an effective initiative for efficient land resource allocation and for facilitating planned urban *** align with sustainable development objectives,UDB definitions have evolved to reconcile urban development with ecological *** study presents a UDB delineation framework from an integrated perspective that incorporates both demand-oriented and comprehensive ***,the urban construction land demand area was estimated based on population projections,meanwhile,the ecological red line(ERL)was delineated and integrated into the evaluation of the construction land ***,with the demand area as the simulation target and unsuitable areas as comprehensive constraints,the UDB was delineated by simulating future land use *** proposed framework was applied to Wuhan,a rapidly urbanizing city in central China,where the delineation of the UDB serves the dual purpose of managing the rapid expansion of built-up land and achieving a harmonious balance between urban development imperatives and ecological protection ***,based on the results and analysis,policy implications for the rational spatial planning of Wuhan were proposed,encompassing the spatial patterns and scientific decision-making in ecological conservation and urban *** results demonstrate that the efficacy of adopting a comprehensive perspective in delineating UDB effectively reconciles the competing needs of urban development and *** framework and the policy insights derived in this study could inform spatial planning efforts not only in Wuhan but also in other cities facing the dilemma of urban development and ecological protection.

关键词： urban development boundary(UDB) ecological red line(ERL) urban land suitability land use simulation integrated framework spatial decision-making

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Two different autorefractors for vision screening in children and adolescents

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen Lin-Jie Liu Bing Sun Dan-Dan Jiang Shu-Shu zuo yan-Hui Wang Chun-Hua zhang yan-yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and ***:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without *** data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were ***:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,***,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICC<0.10).Bland-Altman analysis revealed that SE,DS,and DC measured by the Tianle RM-9000 were significantly biased toward myopia compared with the Topcon KR-800,and the mean differences were-0.072,-0.026,-0.091 D,respectively(all P<0.01).The minimum absolute value of the difference within the 95%LoA for SE,DS,and DC was 0.63 D,0.50 D,0.62 D,respectively;all these values were in the clinically acceptable *** J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable *** can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed ***,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

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Zero-Dynamics Attacks for Multi-Agent Systems Without Velocity Measurements

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Journal of Systems Science & Complexity 2024年第5期37卷 1809-1831页

作者： GAO Jinming WANG Yijing zuo Zhiqiang zhang Wentao Tianjin Key Laboratory of Intelligent Unmanned Swarm Technology and System School of Electrical and Information Engineering Tianjin University Continental-NTU Corporate Lab School of Electrical and Electronic Engineering Nanyang Technological University

This paper studies the periodic zero-dynamics attacks(ZDAs) in multi-agent systems without velocity measurements under directed graph. Specifically, two types of attack modes are addressed,i.e., infinite number and finite number of zero-dynamics attacks. For the former case, the authors show that the consensus of the considered system cannot be guaranteed. For the latter case, the dynamic evolution of the agents is investigated and it is found that only attacking the rooted agents can destroy the consensus. Then, a sufficient condition which quantifies whether or not the consensus value is destroyed is given, revealing the relationship among parameters of system model, filter and attack ***, simulations are carried out to verify the effectiveness of the theoretical findings.

关键词： Consensus directed graph multi-agent systems zero-dynamics attacks

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