Investigation multi-target synergistic mechanism of Choerospondias axillaris in the treat of cerebral ischemia based on systems pharmacology and experimental verification
作者机构：Department of PharmacyXi'an No.3 Hospital the affiliated Hospital of Northwest UniversityXi’an 710000China Department of PharmacyXijing HospitalFourth Military Medical UniversityXi’an 71000China
出 版 物：《Natural Therapy Advances》
年 卷 期：2024年第7卷第3期
页 面：37-47页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the National Natural Science Foundation of China,specifically through grants(No.82274313 82074321)
主 题：systems pharmacology Choerospondias axillaris cerebral ischemia multi-target synergistic mechanism middle cerebral artery occlusion
摘 要：Background:Choerospondias axillaris(CA)is a traditional Mongolian medicine that has been proven to have a good therapeutic effect on cerebrovascular *** Ischemia(CI)is a severe and life-threatening cerebrovascular ***,the specific mechanism of action of CA in the treatment of CI is still ***:In this study,the related targets and pathways of CA in the treatment of CI were first predicted by system pharmacology and then verified by relevant ***:The results showed that 12 active ingredients and 208 targets were *** validation through protein-protein interaction(PPI)network analysis and active ingredients-target-pathway(A-T-P)network analysis has confirmed the pivotal roles of the main bioactive constituents,including quercetin,kaempferol,naringin,β-sitosterol,and gallic *** components exert their anti-ischemic effects by modulating key targets such as IL6,TNF,MAPK3,and CASP3,thereby regulating the PI3K-Akt,HIF-1,and MAPK signaling pathways,which are integral to processes like inflammation,apoptosis,and oxidative *** importantly,through experimental verification,this study confirmed our prediction that CAE significantly reduced neurological function scores,infarct volume,and the percentage of apoptosis ***:This indicates that CA acts on CI through multi-target synergistic mechanism,and this study provides theoretical basis for the clinical application of CA.
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