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Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang Wen He Yong-Hao Gui Quan Lu Yong yin Jian-Hua Zhang Xiao-Yan Dong ying-Wen Wang ying-zi Ye Hong Xu Jia-Yu Wang Bing Shen Dan-Ping Gu Li-Bo Wang yi Wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of Life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina Department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Nursing Children's Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang Hospital Development Center ShanghaiChina Center for Medical Quality Control Management of Shanghai ShanghaiChina Department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory

智能网联卡车编队领航车驾驶人驾驶能力需求综述

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中国公路学报 2024年第2期37卷 219-238页

作者：伍毅平赵子龙倪鹏北京工业大学城市建设学部北京100124 北京市高级别自动驾驶示范区工作办公室北京100176

智能网联卡车编队在减少人力成本、节省燃料消耗、提高运输效率等方面具有较大优势,是未来货物运输发展的新趋势。领航车驾驶人作为在智能化和网联化背景下出现的新兴角色,对于保障智能网联卡车编队安全平稳运行至关重要。通过对大量文... 详细信息

智能网联卡车编队在减少人力成本、节省燃料消耗、提高运输效率等方面具有较大优势,是未来货物运输发展的新趋势。领航车驾驶人作为在智能化和网联化背景下出现的新兴角色,对于保障智能网联卡车编队安全平稳运行至关重要。通过对大量文献、标准规范以及企业调研结果的系统梳理,综述了智能网联卡车编队领航车驾驶人驾驶能力需求研究现状。首先,介绍了卡车编队系统架构、自动化分级标准和驾驶模式等智能网联卡车编队概况。然后,归纳了卡车编队行驶场景的组成要素种类,总结了超出车辆设计运行范围的边界场景,以此为基础分析了各边界场景下领航车驾驶人的能力需求。其次,论述了卡车编队不同功能对应领航车驾驶人的作用和职责。最后,以传统卡车驾驶人和自动驾驶卡车安全员的基本驾驶能力需求为基准,结合边界场景和编队功能对应的特殊驾驶能力需求,汇总获得卡车编队领航车驾驶人在理论知识、实操技能和生心理状态方面的需求,并对比分析了不同驾驶阶段下驾驶人能力需求差异。综述结果有助于更加科学合理地开展智能网联卡车编队领航车驾驶人的遴选、培训和考核。

关键词：交通工程智能网联综述卡车编队领航车驾驶人驾驶能力

跨文化人工智能体的伦理设计何以可能?——基于设计师伦理责任意识的培养

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自然辩证法研究 2024年第7期40卷 99-106页

作者：王亮马紫依西安交通大学马克思主义学院西安710049

面对当今文化多样化的社会现实,人工智能体的伦理设计已不再只遵循一种文化传统,而必须兼顾多种文化传统。设计师在跨文化人工智能伦理设计中扮演关键角色,可从外部约束和内在修养两方面培养他们的伦理意识:外部约束包括建立跨文化伦理... 详细信息

面对当今文化多样化的社会现实,人工智能体的伦理设计已不再只遵循一种文化传统,而必须兼顾多种文化传统。设计师在跨文化人工智能伦理设计中扮演关键角色,可从外部约束和内在修养两方面培养他们的伦理意识:外部约束包括建立跨文化伦理原则、采用文化适应性“誓言”等方式,强化设计师的伦理责任;内在修养则涉及提升设计师的文化理解力、道德敏感性和“道德想象力”等,增强他们的跨文化视野和伦理自觉。此外,儒家伦理的丰富资源也为设计师的跨文化道德能力培养提供理论支持。重视设计师跨文化伦理责任意识的培养,不仅有助于突出人类在AI系统开发中的重要性,而且是缩小人工智能伦理理论与实践差距的有效路径。

关键词：跨文化人工智能体伦理设计设计师

Janus hydrogel/electrospun-membrane dressing enhancing wound healing in rats

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Biomedical Engineering Communications 2024年第2期3卷 17-25页

作者： zi-Rui Zhu Jia-Na Huang Jin-Ze Li Hao Cao Zhao-yi Lin Yan Li School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument Sun Yat-sen UniversityGuangzhou 510006China

Background:Excessive exudate secreted from chronic wounds often leads to overhydration and *** a variety of dressings are currently available in clinical applications,they frequently fail to provide multifunction to promote chronic wound *** dressings with a Janus structure,featuring distinct properties on each side,are potential to improve wound ***:Composite dressings with a Janus structure were fabricated,comprising freeze-dried polycaprolactone(PCL)electrospun membrane and alginate-based *** PCL fibrous membrane provided air permeability,while the hydrogel loaded with Deferoxamine,composed of alginate and poly(N-isopropylacrylamide)(PNIPAM),exhibited hygroscopic *** inclusion of PNIPAM imparted ***:The hydrogel(thickness of 2.778±0.082 mm)exhibited a robust adhesion to the fiber membrane(thickness of 0.261±0.041 mm).For ANDC(Alginate-PNIPAM hydrogel with Deferoxamine/PCL membrane)samples,the water vapor transmission rate(WVTR)was measured to be 3364.80±23.23 g∙m−2∙day−1 and the swelling ratio at 2 h was determined to be 1179±125%.The thermo-responsivity of ANDC samples manifested in an increased swelling rate,escalating from 797±189%at 37°C to 1132±147%at 4°*** elastic modulus was assessed for lyophilized and rehydrated ANDC *** theωof the rheometer rotor was decreased from 10 rad/s to 0.1 rad/s,the lyophilized dressing exhibited a decrease from 2.65±0.01 MPa to 1.80±0.90 MPa,while the rehydrated dressing demonstrated an increase from 133.65±55.68 Pa to 264.23±141.71 *** pro-healing properties of the dressings were evaluated using full-thickness skin defect model on SD rats,and a circular wound of diameter 10 mm healed completely by day ***:The dressings not only protected the wound and absorbed excess exudate,but also demonstrated nondestructive peelability upon cooling,providing a novel approach for accelerating wound healing and management.

关键词： Janus structure composite dressing wound healing

Exploring the molecular mechanism of Suoquan pill in the treatment of diabetic kidney disease based on network pharmacology,molecular docking,in vitro experiment

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Traditional Medicine Research 2024年第11期9卷 27-37页

作者： zi-Jie Yan Yu Kang Shu-Man Liu Fang-Yu Wang Man Xiao yi-Qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Graduate School Heilongjiang Academy of Traditional Chinese MedicineHarbin 150001China Department of Pharmacology College of PharmacyHainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:Diabetic kidney disease(DKD)is a microvascular complication of diabetes mellitus and is the main cause of end-stage renal *** pills(SQP)has a variety of pharmacological activities and multiple therapeutic effects,and it is used clinically as a basic formula for the treatment of ***:Public databases were used to identify SQP compounds and the potential targets of SQP and DKD.A drug-component-therapeutic target network was ***-protein interaction network analysis,Gene Ontology functional analysis,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were used to analyse the potential molecular mechanisms of SQP based on common targets of drugs and *** docking simulations were conducted to confirm the binding abity of the core compounds to key *** efficacy and predicted molecular mechanisms of SQP were validated using cell counting kit-8 assay,flow cytometry,and western blotting with HK-2 cells as a ***:Network pharmacology analysis showed that 26 compounds and 207 potential targets of SQP were involved in the treatment of DKD;boldine,denudatin B,pinocembrin,kaempferoid,and quercetin were considered core compounds,and epidermal growth factor receptor(EGFR)and proto-oncogene,non-receptor tyrosine kinase(SRC)were considered key *** Ontology enrichment analysis indicated that protein phosphorylation and negative regulation of apoptotic processes are important biological processes in the treatment of DKD by *** docking confirmed the excellent binding abilities of boldine,denudatin B,kaempferide,and quercetin to EGFR and *** results of in vitro experiments showed that treatment with an ethanolic extract of SQP significantly protected HK-2 cells from high glucose-induced cell *** addition,the SQP ethanol extract inhibited the phosphorylation of EGFR and SRC,suppressed the apoptosis rate,and regulated apoptosis-related proteins in HK-2 cells under hig

关键词： traditional Chinese medicine diabetic kidney disease Suoquan pill network analysis molecular docking

美国污泥调查(NSSS)概况、数据分析与启示

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中国给水排水 2024年第8期40卷 54-56,57-59页

作者：王涛王子逸中国机械科学研究总院环保技术与装备研究所北京100044 机科发展科技股份有限公司北京100044 机械工业有机固废生物处理与资源化利用工程研究中心北京100044

美国污泥调查(NSSS)是美国污泥法规标准制定和修订的技术数据基础,介绍了NSSS的背景与目的以及流程与方法,概述了美国四次全国范围的污泥调查概况以及NSSS1988、NSSS2001、NSSS2006三次调查结论;从法规制定与技术支持体系构架、动态指... 详细信息

美国污泥调查(NSSS)是美国污泥法规标准制定和修订的技术数据基础,介绍了NSSS的背景与目的以及流程与方法,概述了美国四次全国范围的污泥调查概况以及NSSS1988、NSSS2001、NSSS2006三次调查结论;从法规制定与技术支持体系构架、动态指标体系、调查方式方法、关注新污染物四个方面,总结了对我国污泥事业发展的启示,指出我国从未开展与NSSS类似的全国范围污泥调查,为更好地开展污泥管理工作,有必要加强此方面的调查研究。

关键词：美国污泥调查污泥重金属新污染物

Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： zi-Yuan Zou Tian-yi Ren Jia-Qi Li Ting-ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-Zhe Lin Yuan-Yang Wang Xiao-Zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

大兴安岭林草交错带植被NDVI时空演变及定量归因

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环境科学 2024年第1期45卷 248-261页

作者：石淞李文曲琛杨子仪东北林业大学园林学院哈尔滨150040

探究植被动态变化并识别其驱动因素对区域生态环境恢复与可持续发展具有重要意义.基于2000~2020年MODIS NDVI数据与同期气象、DEM和土地利用类型等数据,运用Sen+Mann-Kendall趋势分析与Hurst指数法,深入解析大兴安岭林草交错带植被时空... 详细信息

探究植被动态变化并识别其驱动因素对区域生态环境恢复与可持续发展具有重要意义.基于2000~2020年MODIS NDVI数据与同期气象、DEM和土地利用类型等数据,运用Sen+Mann-Kendall趋势分析与Hurst指数法,深入解析大兴安岭林草交错带植被时空变化特征,预测其未来演变规律,并引入地理探测器模型,定量揭示全域及不同自然地理分区尺度下,各探测因子及其交互作用对植被空间分异的影响程度和作用机制.结果表明:(1)时空演变上,2000~2020年大兴安岭林草交错带NDVI时空异质性明显,时间上以0.002 a^(-1)(P<0.05)的速率波动增长并于2011年发生上升突变;空间上呈“自西南向东北递增”分布格局,21年间NDVI等级转移以“中植被覆盖→中高植被覆盖”为主,植被改善区域面积远大于退化区域面积.(2)趋势预测上,大兴安岭林草交错带NDVI未来变化趋势主要为持续改善,占比37%,但以弱持续居多.(3)驱动机制上,风速、蒸发和相对湿度对全域NDVI空间分异的影响最为显著,21年间自然因素的影响呈削减态势,而人为因素的影响愈发增强,在不同植被区、气候区、土壤区和地貌区中,NDVI空间分异的主控驱动因子差异性较大;不同空间尺度下各因子间协同效应均表现为双因子增强或非线性增强关系,较单因子作用有明显提升.研究有助于明晰北方寒区林草交错带生态脆弱成因,为不同环境条件下制定植被资源差异化保护与管理方案提供科学支撑.

关键词：林草交错带归一化植被指数(NDVI) 时空演变驱动因子地理探测器

Holographic Schwinger effect in spinning black hole backgrounds

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Chinese Physics C 2024年第1期48卷 165-172页

作者：蔡镒泽张自强 School of Mathematics and Physics China University of GeosciencesWuhan 430074China

We perform a potential analysis for the holographic Schwinger effect in spinning Myers-Perry black *** compute the potential between the produced pair by evaluating the classical action of a string attached on a probe D3-brane at an intermediate position in the AdS *** find that increasing the angular momentum reduces the potential barrier,thus enhancing the Schwinger effect,consistent with previous findings obtained via the local Lorentz *** particular,these effects are more visible for the particle pair lying in the transversal plane compared with that along the longitudinal *** addition,we discuss how the Schwinger effect changes with the shear viscosity to entropy density ratio at strong coupling under the influence of angular momentum.

关键词： AdS/CFT gauge/gravity duality holographic Schwinger effect