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Hydrogen sorption properties of Mg-20wt.%Fe_(23)Y_(8) composite prepared by reactive mechanical alloying

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Rare Metals 2006年第z1期25卷 247-251页

作者： LI Zhinian LIU Xiaopeng huang zuo JIANG Lijun WANG Shumao Hydrogen Material&Technology Research Institute General Research Institute for Nonferrous MetalBeijing100088China

Mg-20wt.%Fe_(23)Y_(8) composite was successfully prepared by reactive mechanical alloying(RMA).X-ray diffraction(XRD)measurement shows that the main phases of composite are MgH_(2) and *** composite exhibits excellent hydrogen abs/desorption properties and can absorb 4.36wt.%and 5.72wt.%hydrogen at 473 and 573 K in 10 min under 3.0 MPa hydrogen pressure,*** composite can desorb 5.27wt.%hydrogen at 573 K in 30 min under 0.02 MPa hydrogen *** with the pure MgH_(2),the hydrogen desorption temperature of Mg-20wt.%Fe_(23)Y_(8) composite is decreased about 40℃.It is supposed that both the catalyst effect of Fe-Y distributed in Mg substrate and the crystal defects play the main role in improving hydrogen sorption properties of Mg-20wt.%Fe_(23)Y_(8) composite.

关键词： hydrogen storage composite magnesium mechanical alloying P-C-T and Mg_(2)FeH_(6)

MODIFICATION OF EPOXY RESIN WITH POLYSILOXANE BEARING PENDANT QUATERNARY AMMONIUM GROUPS

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Chinese Journal of Polymer Science 2002年第6期20卷 537-541页

作者： zuo-xin huang Ying huang Yun-zhao Yu The State Key Laboratory of Engineering Plastics, Institute of Chemistry Chinese Academy of Sciences, Beijing 100080 China Chinese Acad Sci Inst Chem State Key Lab Engn Plast Beijing 100080 Peoples R China

Polysiloxane bearing pendant quaternary ammonium groups (PSI) was used to modify the surface properties of epoxy resins. In the cured resin, PSI formed the dispersed phase. Remarkable enrichment and gradient distribution of polysiloxane on the surface region of the epoxy resins were demonstrated by XPS analysis. The composition and properties of the surface of PSI-modified epoxy resin, which is in contact with the mold, are dependent on the material of the mold. Through the incorporation. of PSI, epoxy resins with low surface energy and low friction coefficient were obtained. Polysiloxane with lower ionic group content shows a higher degree of enrichment on the resin surface and leads to a higher contact angle against water, while the polysiloxane having optimum compatibility with the epoxy resin shows a greater effect in reducing the static friction coefficient of the resin against glass.

关键词： polysiloxane epoxy resin surface composition friction coefficient

Diagnostic workup of lymphedema

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Plastic and Aesthetic Research 2019年第10期6卷 15-23页

作者： Zheng-Yun Liang Xiao Long Nan-Ze Yu Jiu-zuo huang Department of Plastic Surgery and Reconstructive Surgery Peking Union Medical College HospitalBeijing 100005China

Lymphedema is a chronic and progressive pathological state of tissue swelling caused by congenital or acquired lymphatic ***,physical and laboratory examinations could help to diagnosis>90%lymphedema *** stage lymphedema could be challenging to *** aim of this review is to provide an objective appraisal of current diagnostic methods,such as lymphoscintigraphy,lympho-fluoroscopies,lymphangiography and *** on their respective advantages and weaknesses,and hopefully shed some lights on developing a practical diagnosis modality beneficial to early detection and clinical decision making of lymphedema.

关键词： Lymphedema diagnosis lymphoscintigraphy magnetic resonance lymphangiography indocyanine green tissue dielectric constant bioelectrical impedance spectroscopy

Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 352-360页

作者： Jun-Liang Pu zuo-Tian huang Yun-Hai Luo Tong Mou Ting-Ting Li Zhong-Tang Li Xu-Fu Wei Zhong-Jun Wu Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Anatomy Basic Medical CollegeChongqing Medical UniversityChongqing 400016China

Background: Hepatic ischemia-reperfusion(I/R) injury(IRI) represents a crucial challenge in liver transplantation. Fisetin has anti-inflammatory, anti-aging and anti-oxidative properties. This study aimed to examine whether fisetin mitigates hepatic IRI and examine its underlying mechanisms. Methods: Sham or warm hepatic I/R operated mice were pretreated with fisetin(5, 10 or 20 mg/kg). Hepatic histological assessments, TUNEL assays and serum aminotransferase measurements were performed. An in vitro hypoxia/reoxygenation(H/R) model using RAW264.7 macrophages pretreated with fisetin(2.5, 5 or 10 μmol/L) was also used. Serum and cell supernatant concentrations of interleukin-1 β(IL-1 β), IL-18 and tumor necrosis factor-α(TNF-α) were determined by enzyme-linked immunosorbent assay(ELISA). Protein levels of p-GSK3 β, p-AMPK and NLR family pyrin domain-containing 3(NLRP3)-associated proteins were detected by Western blotting. Results: Compared with the I/R group, fisetin pretreatment reduced pathological liver damage, serum aminotransferase levels, serum concentrations of IL-1 β, IL-18 and TNF-α in the murine IRI model. Fisetin also reduced the expression of NLRP3 inflammasome-associated proteins(NLRP3, cleaved caspase-1, IL-1 β and IL-18) in I/R-operated liver. The experiments in vitro showed that fisetin decreased the release of IL-1 β, IL-18 and TNF-α, and reduced the expression of NLRP3 inflammasome-associated proteins in H/R-treated RAW264.7 cells. Moreover, fisetin increased the expressions of p-GSK3 β and p-AMPK in both models, indicating that its anti-inflammatory effects were dependent on GSK3 β/AMPK signaling. The antiinflammatory effects of fisetin were partially inhibited by the AMPK specific inhibitor compound C. Conclusions: Fisetin showed protective effects against hepatic IRI, countering inflammatory responses through mediating the GSK3 β/AMPK/NLRP3 inflammasome pathway.

关键词： Fisetin Hepatic ischemia-reperfusion injury GSK3βAMPK NLRP3

Application and prospect of adipose stem cell transplantation in treating lymphedema

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World Journal of Stem Cells 2020年第7期12卷 676-687页

作者： Zhu-Jun Li Elan Yang Yun-Zhu Li Zheng-Yun Liang Jiu-zuo huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Lymphedema is a chronic,debilitating and incurable disease that affects 0.13%-2%of the global *** evidence indicates that adipose-derived stem cells(ADSCs)might serve as suitable seed cells for lymphatic tissue engineering and lymphedema *** To summarize applications of ADSCs for treating lymphedema in both animal studies and clinical *** A systematic search was performed on four databases-PubMed,***,the evidence-based Cochrane Library,and OVID-using the following search string:(“lymphedema”or“lymphoedema”or“lymphangiogenesis”)and(“adipose-derived stem cells”or“adipose-derived stromal cells”or“adipose-derived regenerative cells”).A manual search was performed by skimming the references of relevant *** studies and clinical trials using adipose-derived cells for the treatment of any kind of lymphedema were *** A total of eight research articles published before November 2019 were included for this *** articles focused on animal studies and another three focused on clinical *** transplantation therapy was demonstrated to be effective against lymphedema in all *** animal studies found that coadministration of ADSCs and controlled-release vascular endothelial growth factor-C or platelet-rich plasma could improve the effectiveness of ADSC *** sequential clinical trials were conducted on breast cancer-related lymphedema patients,and all showed favorable *** ADSC-based therapy is a promising option for treating ***-scale,multicenter randomized controlled trials are needed to develop more effective and durable therapeutic strategies.

关键词： Lymphedema Adipose-derived stem cells Animal model Clinical trial Vascular endothelial growth factor-C Lymphangiogenesis

Application of adipose-derived stem cells in treating fibrosis

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World Journal of Stem Cells 2021年第11期13卷 1747-1761页

作者： Zhu-Jun Li Li-Quan Wang Yun-Zhu Li Chen-Yu Wang Jiu-zuo huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Fibrosis is the hyperactivation of fibroblasts that results in excessive accumulation of extracellular matrix,which is involved in numerous pathological changes and ***-derived stem cells(ASCs)are promising seed cells for regenerative medicine due to their bountiful source,low immunogenicity and lack of ethical *** anti-fibrosis,immunomodulation,angiogenesis and other therapeutic effects have made them suitable for treating fibrosis-related ***,we review the literature on ASCs treating fibrosis,elaborate and discuss their mechanisms of action,changes in disease environment,ways to enhance therapeutic effects,as well as current preclinical and clinical studies,in order to provide a general picture of ASCs treating fibrotic diseases.

关键词： Adipose-derived stem cells Fibrosis Immunomodulation Modification Therapeutic effect Clinical trials

“惊人的奇妙科学”——笛卡尔形而上学思想的发端

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哲学研究 2021年第7期 110-118页

作者：黄作华南师范大学哲学与社会发展学院

一般认为,笛卡尔的形而上学思想产生于1628—1629年前后,其主要依据是后来遗失的《形而上学小论文》。通过聚焦笛卡尔在1619年的伟大发现即"惊人的奇妙科学"理论,并对照同时期的三个文本(《来自奥林匹亚》、《指导精神的规则》的前四个... 详细信息

一般认为,笛卡尔的形而上学思想产生于1628—1629年前后,其主要依据是后来遗失的《形而上学小论文》。通过聚焦笛卡尔在1619年的伟大发现即"惊人的奇妙科学"理论,并对照同时期的三个文本(《来自奥林匹亚》、《指导精神的规则》的前四个规则和《谈谈方法》的前三部分),本文力图揭示出:从"全新科学"到"惊人的奇妙科学",笛卡尔走出了数学的一般性范畴,并尝试构建一种可以作为物理学基础的、非数学性的普遍科学理论,由此展现了其形而上学思想的萌芽。

关键词：全新科学惊人的奇妙科学普遍的马特西斯元-数学

思之受动性及其局限--从笛卡尔的“Videre Videor”谈起

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哲学研究 2023年第12期 91-101,125页

作者：黄作华南师范大学哲学与社会发展学院哲学系

法国现象学家米歇尔·亨利创造性地解读了笛卡尔在第二沉思中谜一般的表述--“videre videor”(“在我看来我看到”),用“自身感受”理论突出了感知的根本维度;马礼荣则通过吾身(合一或肉)现象学进一步彰显了这一原初感知的价值,由此,... 详细信息

法国现象学家米歇尔·亨利创造性地解读了笛卡尔在第二沉思中谜一般的表述--“videre videor”(“在我看来我看到”),用“自身感受”理论突出了感知的根本维度;马礼荣则通过吾身(合一或肉)现象学进一步彰显了这一原初感知的价值,由此,他们都主张把“我思”的确定性还原到这种感受性。通过分析《指导精神的规则》《第一哲学沉思集》《哲学原理》和《灵魂的感受》中的相关文本,梳理笛卡尔“思维活动”(cogitatio)概念的由来和发展,可发现笛卡尔在感受性问题上确实推进得非常彻底,即他主张所有思维活动都可以是受动的。但是,单独的感受性或受动性一面有其局限,无法决定“我思”的明见性和确定性;相反,带有亚里士多德主义色彩的行动理智和受动理智相结合的理论框架,会更适合解读“我思”之确定性。

关键词：最初的看起来原初的感知思维活动受动性

死去的父亲作为法则——拉康对弗洛伊德的批评及其对策

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哲学动态 2024年第9期 85-95页

作者：黄作华南师范大学哲学与社会发展学院

弗洛伊德在《图腾与禁忌》中提出的象征父亲理论是基于死去的父亲,这是因为他把父亲图腾化、禁忌化、崇拜化,进而达到理想化,即理想的父亲能够代表法则。拉康批评这一理想性,认为父亲的理想形象并非弗洛伊德本人的理论构想,而是出自神... 详细信息

弗洛伊德在《图腾与禁忌》中提出的象征父亲理论是基于死去的父亲,这是因为他把父亲图腾化、禁忌化、崇拜化,进而达到理想化,即理想的父亲能够代表法则。拉康批评这一理想性,认为父亲的理想形象并非弗洛伊德本人的理论构想,而是出自神经症患者的幻想。针对这一以理想性为基础的父亲理论和现代社会父亲形象的衰落状况,拉康提出了自己的理论对策,那就是欲望与法则的共生观:一方面,拉康运用能指这一结构利器来武装欲望问题,破除了纯粹享乐与法则之间的神经症患者式的假想性对立,破除了通过否定(即禁忌)确立起来的法则的理想性,力图探索父亲的真正作用与功能(借助“父亲的姓名”理论);另一方面,受到圣·保罗用恩典代替法则做法的启示,拉康认为欲望和法则在原初意义上不但不是对立的,反而还是相伴的、共生的,因为有了父亲的爱,欲望欲求法则,法则勾勒欲望的轨迹。

关键词：拉康弗洛伊德法则欲望