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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

臭氧注入聚乙烯包装袋密封消毒一次性餐具的研究

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食品安全质量检测学报 2020年第9期11卷 3014-3020页

作者：陈诚龚娜鲁燕骅王晓娟左熊春云南省产品质量监督检验研究院昆明650223

目的解决塑料一次性餐具、淋膜纸碗等不经清洁直接接触食品的制品出厂时的微生物质量管控缺失的问题。方法采用臭氧注入聚乙烯包装袋密封消毒的方法,对一次性餐具阳性样品进行消毒测试,并参照相应国家标准及检验方法对其总迁移量和脱色... 详细信息

目的解决塑料一次性餐具、淋膜纸碗等不经清洁直接接触食品的制品出厂时的微生物质量管控缺失的问题。方法采用臭氧注入聚乙烯包装袋密封消毒的方法,对一次性餐具阳性样品进行消毒测试,并参照相应国家标准及检验方法对其总迁移量和脱色试验项目进行测试评估。结果当O3浓度达到555.6 mg/m3后密封保持4 h,淋膜纸碗、聚丙烯塑料餐盒、聚苯乙烯塑料勺3种不同材质的一次性餐具均得到了良好的消毒效果。当O3浓度达到555.6 mg/m^3后密封保持48 h,3种不同材质的一次性餐具的总迁移量和脱色试验测试结果符合国家相应标准要求或产品性能未发生明显变化。结论臭氧注入聚乙烯包装袋密封消毒一次性餐具有可行性,可为生产者有效管控微生物指标提供参考和借鉴。

关键词：消毒臭氧一次性餐具微生物

Correlations of Active Galactic Nuclei with Microquasars

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Communications in Theoretical Physics 2006年第1X期46卷 187-192页

作者： YE Yong-chun zuo Xue-Qin WANG Ding-xiong Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

Correlations of active galactic nuclei （AGNs） with microquasars are discussed based on the coexistence of the Blandford-Znajek （BZ） and magnetic coupling （MC） processes （CEBZMC） in black hole （BH） accretion disk. The proportions of several quantities of BH systems for both AGNs and microquasars are derived by combining the observational data with CEBZMC. It is shown that the square of the magnetic field at the BH horizon is inversely proportional to the BH mass, while the accretion rate of the disk is proportional to the BH mass. In addition, the very steep emissivity indexes from the recent XMM-Newton observations of the nearby bright Seyfert 1 galaxy MCG-6-30-15 and the microquasars XTE J1650-500 are well fitted by considering the MC effects on the disk radiation. These results suggest strongly the correlations of A GNs with microquasars.

关键词： accretion accretion disks MCG-6-30-15 4C+11.50 3C345 3C273 XTE J1650-500 GRO J1655-40 XTE J1550-564 GRS 1915+105

A Multi-parameter Model for Radio Dichotomy of Active Galactic Nuclei and Jets

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Communications in Theoretical Physics 2006年第2期45卷 379-384页

作者： YE Yong-chun WANG Ding-xiong zuo Xue-Qin Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

Based on the coexistence of the Blandford-Znajek and magnetic coupling processes in black hole （BH） accretion disc, a multi-parameter model for jet powers and radio loudnees of active galactic nuclei （AGNs） is studied. It turns out that radio-loudnees of AGNs couM be governed by five parameters：（i） the BH spin, （ii） a power-law index of the variation of the magnetic field on the disc; （iii） a parameter determining the position of the inner edge of the disc, （iv） the ratio of the pressure of the magnetic field on the horizon to the ram pressure of the innermost parts of an accretion flow, and （v） the ratio of the angular velocity of the open field lines to that of the horizon. The observed dichotomy between radio-loud and radio-quiet AGNs is well interpreted by the effects of the above parameters. Furthermore, we discuss the derivative of radio loudness of AGNs with respect to each parameter separately. In addition, the effect of the screw instability on radio loudness of AGNs is discussed.

关键词： accretion accretion disc black hole physics galaxies

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Effect of stress-relief annealing on thermal fatigue cracks for die-casting die steels

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Journal of Iron and Steel Research International 2024年第5期31卷 1164-1176页

作者： Zhi-xiong Bai Xiao-chun Wu School of Materials Science and Engineering Shanghai UniversityShanghai200444China

The effect of stress-relief annealing at different stages of thermal fatigue tests on crack growth was investigated using a self-built thermal cycle *** results showed that annealing could limit crack expansion *** reduced dislocation density and released the accumulation of residual *** addition,the strain accumulation in carbides was reduced by this *** was also found that double annealing was even more effective at inhibiting crack expansion compared to single stress-relief *** 1000 cycles,the maximum crack length was reduced by 31.1%and 45.2%for the samples after using the optimal single and double annealing processes,*** single stress-relief annealing,earlier annealing provides more benefit in delaying crack ***,effective double stress-relief annealing requires a suitable time interval between the annealing ***,after 800 cycles,surface hardness decreased significantly accompanied by an increase in the size and number of carbides,and cracks expanded predominantly along grain boundaries.

关键词： Thermal fatigue Steel Carbide Stress-relief annealing Dislocation Residual stress

A Generalization of a Theorem of Liao

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Acta Mathematica Sinica,English Series 2006年第1期22卷 207-210页

作者： xiong Ping DAI zuo Ling ZHOU Depatment of Mathematics Nanjing University Nanjing 210093 P. R. China Lingnan College of Zhongshan University Guangzhou 510275 P. R. China

Let X be a metrizable space and let φ：R× X → X be a continuous flow on X. For any given {φt}-invariant Borel probability measure, this paper presents a {φt}-invariant Borel subset of X satisfying the requirements of the classical ergodic theorem for the contiImous flow （X, {φt}）. The set is more restrictive than the ones in the literature, but it might be more useful and convenient, particularly for non-uniformly hyperbolic systems and skew-product flows.

关键词： Ergodic theorem Liao theory

ARTIFICIAL BOUNDARY METHOD FOR THE THREE-DIMENSIONAL EXTERIOR PROBLEM OF ELASTICITY

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Journal of Computational Mathematics 2005年第6期23卷 603-618页

作者： Hou-de Han chun-xiong Zheng Department of Mathematical Sciences Tsinghua University Beijing 100084 China Department of Mathematics University of Science and Technology of China Hefei 230026 China

The exact boundary condition on a spherical artificial boundary is derived for the three-dimensional exterior problem of linear elasticity in this paper. After this boundary condition is imposed on the artificial boundary, a reduced problem only defined in a bounded domain is obtained. A series of approximate problems with increasing accuracy can be derived if one truncates the series term in the variational formulation, which is equivalent to the reduced problem. An error estimate is presented to show how the error depends on the finite element discretization and the accuracy of the approximate problem. In the end, a numerical example is given to demonstrate the performance of the proposed method.

关键词： artificial boundary method unbounded domains elasticity

Regulation of the Macrophage Phenotype on Titanium Metal by Surface Modification

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Journal of Bionic Engineering 2022年第6期19卷 1625-1636页

作者： Shibing xiong Xugang Lu Rui zuo Ping Huang Bangcheng Yang Engineering Research Center in Biomaterials Sichuan UniversityChengdu610064China National Engineering Research Center for Biomaterials Chengdu610064China Sichuan Guojia Biomaterials Co. LtdChengdu610064China Panzhihua University Panzhihua Int Res Inst Vanadium and TitaniumPanzhihua617000SichuanChina

The regulation of macrophage phenotype(M1/M2)is very important for tissue *** macrophage phenotypes could be affected by the physical and chemical parameters of implant *** aim of this study was to investigate the effects of surface modifications of titanium metals on macrophage *** medical pure titanium metals(PT-Ti)subjected to Anodic Oxidation(AO-Ti),Sand Blasting/acid etching(SLA-Ti)and Plasma-sprayed HA coating(HA coating-Ti)were used for regulating the phenotype of *** results showed that the Raw264.7 cells of AO-Ti groups had no obvious pseudopodia and could spread evenly in all *** levels of IL-1βand TNF-α,which belong to pro-inflammatory genes,expressed by the cells on AO-Ti groups were the lowest among all of the modified titanium ***,the levels of IL-10 and TGF-β,which belong to anti-inflammatory genes,expressed on AO-Ti groups were much higher than those on the other ***,the AO-Ti could regulate the expression of SOCS-1 and SOCS-3 to affect the active of NF-κB *** gene expression results of macrophages showed that the AO-Ti was more conductive to inhibit the expression of M1-related genes and promote the expression of M2-related genes in an inflammatory *** AO-Ti was more beneficial to tissue repair than other modified titanium *** results showed that the anodic oxidation is an effective method to regulate the phenotype of macrophages.

关键词： Titanium Dental implant Bionic surface modification Anti-inflammatory Macrophage phenotype