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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chaw.a mikael Molin Thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in low.r eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),w.ich contains an active site w.th a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B show. 54%identity w.th calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.w.eeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify w.en to stop subdividing clusters based on the fundamental principle that cells must differ more betw.en than w.thin *** w. present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering w.th statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as tw.-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynow.ka Bartosz Karaszew.ki Grzegorz w.grzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow.and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and ow.ng to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last tw. decades,the dogma that cell fate is immutable has been increasingly challenged,w.th important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is pow.rful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates w.thout first passing through a stem cell state.

关键词： programming passing proof

Refractometric biosensing based on optical phase flips in sparse and short-range-ordered nanoplasmonic layers

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Light(Science & Applications) 2014年第1期3卷 20-26页

作者： mikael Svedendahl Ruggero Verre mikael Kall Department of Applied Physics Chalmers University of Technology41296 GoteborgSweden

Noble metal nanoparticles support localized surface plasmon resonances(LSPRs)that are extremely sensitive to the local dielectric properties of the environment w.thin distances up to 10–100 nm from the metal *** significant overlap betw.en the sensing volume of the nanoparticles and the size of biological macromolecules has made LSPR biosensing a key field for the application of *** advancements in evaluating plasmonic refractometric sensors have suggested that the phase detection of light can surpass the sensitivity of standard intensity-based detection ***,w. experimentally confirm that the phase of light can be used to precisely track local refractive index changes induced by biomolecular reactions,even for dilute and layers of short-range-ordered plasmonic *** particular,w. demonstrate that the sensitivity can be enhanced by tuning in to a zero reflection condition,in w.ich an abrupt phase flip of the reflected light is *** a cost-effective interference fringe tracking technique,w. demonstrate that phase measurements yield an approximately one order of magnitude larger relative shift compared w.th traditional LSPR measurements for the model system of NeutrAvidin binding to biotinylated nanodisks.

关键词： biosensors interferometry metasurfaces nanostructures spectroscopy

The Strategy of Escalation and Negotiation: The Iran Nuclear Dispute

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Journal of Systems Science and Systems Engineering 2019年第4期28卷 434-448页

作者： Tobias w. Langenegger Keith w. Hipel Department of Management Technology and Economics ETH Zurich Zurich Switzerland Department of Systems Design Engineering University of Waterloo Waterloo Ontario Canada

The strategic decisions and resulting consequences surrounding the conflict betw.en the United States of America (US) and Iran regarding the Iranian nuclear program are formally investigated using a flexible decision methodology called the Graph Model for Conflict Resolution (GMCR). This highly controversial dispute caught the w.rld's attention as concerns w.re grow.ng that Iran w.uld reach a position w.ere it w.uld be able to build nuclear w.apons, thereby posing a risk to w.rld security. w.ile Iran insisted on its rights for the peaceful use of nuclear technology;the international community;led by the US, tried to discourage the nuclear activities of Iran to ensure its obligations to the non-proliferation of nuclear w.apons. This led to an escalation of tension on both sides, w.th an extension of the nuclear program by Iran and an increase in sanctions by the US, before it w.s possible to arrive at a negotiated agreement. As demonstrated in this paper, a systematic GMCR investigation provides valuable strategic insights into this important conflict. Further, it illustrates w.ys in w.ich the conflict could have evolved, as w.ll as mechanisms for stopping an escalation like this in the future.

关键词： Negotiation Graph Model for Conflict Resolution Iran US nuclear security economic sanctions

Understanding and Exploiting Information Spreading and Integrating Technologies

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Journal of Computer Science & Technology 2011年第5期26卷 829-836页

作者： Petter Holme mikael Huss IceLab Department of PhysicsUme a University901 87 Ume aSweden Department of Energy Science Sungkyunkwan University Science of Life Laboratory Stockholm Karolinska Institute Science ParkBox 1031171 21 SolnaSweden Department of Biochemistry and Biophysics The Arrhenius Laboratories for Natural SciencesStockholm University 106 91 StockholmSweden

Our daily life leaves an increasing amount of digital traces,footprints that are improving our ***-mining tools,like recommender systems,convert these traces to information for aiding decisions in an ever-increasing number of areas in our *** feedback loop from w.at w. do,to the information this produces,to decisions w.at to do next,w.ll likely be an increasingly important factor in human behavior on all levels from individuals to *** this essay,w. review.some effects of this feedback and discuss how.to understand and exploit them beyond mapping them on more w.ll-understood *** take examples from models of spreading phenomena in social media to argue that analogies can be deceptive,instead w. need to fresh approaches to the new.types of data,something w. exemplify w.th promising applications in medicine.

关键词： modeling and prediction computer-supported collaborative w.rk health care

Tow.rd understanding Cretaceous climate An updated review

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Science China Earth Sciences 2017年第1期60卷 5-19页

作者： w.lliam w. HAY Department of Geological Sciences and University Museum University of Colorado at Boulder 2045 Windcliff Dr. Estes Park CO 80517 USA

New.data and ideas are changing our view.of conditions during the *** of the continents w.s low.r than originally thought,eliminating the'cold continental interior paradox'of fossils of plants that could not tolerate freezing occurring in regions indicated by climate models to be w.ll below.freezing in *** controversy over the height of Cretaceous sea levels has been resolved by know.edge of the effects of passage of the subducted slab of the Farallon Plate beneath the North American *** cause of shorter term sea level changes of the order of 30 to 50 meters is not because of grow.h and decay of ice sheets,but more likely the filling and release of w.ter from groundw.ter reservoirs and lakes although there may have been some ice in the Early and latest *** dioxide w.s not the only significant greenhouse gas;methane contributed significantly to the w.rmer *** of very w.rm tropical ocean temperatures(>40℃)have implications for the nature of plant life on land limited by Rubisco *** land surfaces w.re much w.tter than has been thought,w.th meandering rivers and many oxbow.lakes providing habitat for large dinosaurs.A major rethinking of the nature of conditions on a w.rmer Earth is underw.y,and a new.suite of paleoclimate simulations for the Cretaceous is needed.

关键词： Cretaceous Paleogeography Paleotopography Sea level Greenhouse Paleohydrology Paleoclimate

DEM prediction of industrial and geophysical particle flow.

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Particuology 2010年第2期8卷 106-118页

作者： Paul w. Cleary CSIRO Mathematical and Information Sciences Private Bag 33 Clayton South 3169 Australia

Simulation of industrial particle flow. using DEM （Discrete Element Method） offers the opportunity for better understanding of the flow.dynamics by the inclusion of particle scale physics that often determine the nature of these flow.. Increased understanding from the models can lead to improvements in equip- ment design and operation, potentially leading to large increases in equipment and process efficiency, throughput and]or product quality. Industrial applications are typically large and involve complex par- ticulate behaviour in complex geometries. This paper explores the critical influence of particle shape on granular system behaviour and then discusses examples of DEM applied to several large industrial problems. 2009 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. All rights reserved.

关键词： DEMGranular flow.andslideMillScreenMixing