检索结果-南通市图书馆

Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis

Neural Regeneration Research 2024年第10期19卷 2281-2289页

作者： Wang Liao Jiana Wei Chongxu Liu Haoyu Luo Yuting Ruan Yingren Mai Qun Yu Zhiyu Cao Jiaxin Xu Dong Zheng zonghai sheng Xianju Zhou Jun Liu Department of Neurology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Special Medical Service Center Neuroscience CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangdongGuangdong ProvinceChina Department of Rehabilitation The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective effects on learning and memory in aged and Alzheimer's disease model mice. However, the effects of magnesium-L-threonate on the gut microbiota in Alzheimer's disease remain unknown. Previously, we reported that magnesium-L-threonate treatment improved cognition and reduced oxidative stress and inflammation in a double-transgenic line of Alzheimer's disease model mice expressing the amyloid-β precursor protein and mutant human presenilin 1(APP/PS1). Here, we performed 16S r RNA amplicon sequencing and liquid chromatography-mass spectrometry to analyze changes in the microbiome and serum metabolome following magnesium-Lthreonate exposure in a similar mouse model. Magnesium-L-threonate modulated the abundance of three genera in the gut microbiota, decreasing Allobaculum and increasing Bifidobacterium and Turicibacter. We also found that differential metabolites in the magnesiumL-threonate-regulated serum were enriched in various pathways associated with neurodegenerative diseases. The western blotting detection on intestinal tight junction proteins(zona occludens 1, occludin, and claudin-5) showed that magnesium-L-threonate repaired the intestinal barrier dysfunction of APP/PS1 mice. These findings suggest that magnesium-L-threonate may reduce the clinical manifestations of Alzheimer's disease through the microbiota-gut-brain axis in model mice, providing an experimental basis for the clinical treatment of Alzheimer's disease.

关键词： Alzheimer's disease APP/PS1 double-transgenic Alzheimer's disease mouse model inflammation intestinal barrier dysfunction magnesium-L-threonate microbiome microbiota-gut-brain axis oxidative stress serum metabolites

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magneto-mechanical effect of magnetic microhydrogel for improvement of magnetic neuro-stimulation

引用

Nano Research 2023年第5期16卷 7393-7404页

作者： Le Xue Qing Ye Linyuan Wu Dong Li Siyuan Bao Qingbo Lu Sha Liu Dongke Sun zonghai sheng Zhijun Zhang Ning Gu Jianfei Sun State Key Laboratory of Bioelectronics Jiangsu Key Laboratory of Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China School of Mechanic Engineering Southeast UniversityNanjing 211189China Department of Neurology Affiliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing 210009China Paul C.Lauterbur Research Center for Biomedical Imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Mental Health and Public Health Faculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Medicine Nanjing UniversityNanjing 210008China

Superparamagnetic iron oxide(SPIO)nanoparticles play an important role in mediating precise and effective magnetic neurostimulation and can help overcome limitations related to penetration depth and spatial resolution.However,nanoparticles readily diffuse in vivo,decreasing the spatial resolution and activation efficiency.In this study,we employed a microfluidic means to fabricate injectable microhydrogels encapsulated with SPIO nanoparticles,which significantly improved the stability of nanoparticles,increased the magnetic properties,reinforced the stimulation effectivity.The fabricated magnetic microhydrogels were highly uniform in size and sphericity,enabling minimally invasive injection into brain tissue.The long-term residency in the cortex up to 22 weeks and the safety of brain tissue were shown using a mouse model.In addition,we quantitatively determined the magneto-mechanical force yielded by only one magnetic microhydrogel using a video-based method.The force was found to be within 7–8 pN under 10 Hz magnetic stimulation by both theoretical simulation and experimental measurement.Lastly,electrophysiological measurement of brain slices showed that the magnetic microhydrogels offer significant advantages in terms of neural activation relative to dissociative SPIO nanoparticles.A universal strategy is thus offered for performing magnetic neuro-stimulation with an improved prospect for biomedical translation.

关键词： magnetic stimulation superparamagnetic iron oxide(SPIO)nanoparticles magnetic microhydrogel long-term residency magneto-mechanical effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson’s Disease

引用

Research 2023年第3期6卷 507-519页

作者： Jing Liu Duyang Gao Dehong Hu Siyi Lan Yu Liu Hairong Zheng Zhen Yuan zonghai sheng Faculty of Health Sciences Centre for Cognitive and Brian SciencesUniversity of MacaoMacao SAR 999078P.R.China Paul C.Lauterbur Research Center for Biomedical Imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055P.R.China

Targeted therapy of Parkinson’s disease is an important challenge because of the blood–brain barrier limitation.Here,we propose a natural killer cell membrane biomimetic nanocomplex(named BLIPO-CUR)delivered via the meningeal lymphatic vessel(MLV)route to further the therapeutic efficacy of Parkinson’s disease.The membrane incorporation enables BLIPO-CUR to target the damaged neurons,thus improving their therapeutic efficacy through clearing reactive oxygen species,suppressing the aggregation ofα-synuclein,and inhibiting the spread of excessα-synuclein species.Compared with the conventional intravenous injection,this MLV administration can enhance the delivered efficiency of curcumin into the brain by~20 folds.The MLV route administration of BLIPO-CUR enhances the treatment efficacy of Parkinson’s disease in mouse models by improving their movement disorders and reversing neuron death.Our findings highlight the great potential of MLV route administration used as targeted delivery of drugs to the brain,holding a great promise for neurodegenerative disease therapy.

关键词： Targeted drugs aggregation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Indocyanine Green Nanoparticles for Theranostic Applications

引用

Nano-Micro Letters 2013年第3期5卷 145-150页

作者： zonghai sheng Dehong Hu Miaomiao Xue Meng He Ping Gong Lintao Cai Guangdong Key Laboratory of Nanomedicine CAS Key Laboratory of Health Informatics Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green(ICG) is a near infrared dye that has been approved by Food and Drug Administration(FDA) in USA for the use in indicator-dilution studies in humans. ICG nanoparticles(NPs) have attracted much attention for its potential applications in cancer theranostics. This review focuses on the preparation, application of ICG NPs for in vivo imaging(fluorescent imaging and photoacoustic imaging) and therapeutics(photothermal therapy, photodynamic therapy and photoacoustic therapy), and future directions based on recent developments in these areas. It is hoped that this review might provide new impetus to understand ICG NPs for cancer theranostics.

关键词： Indocyanine green(ICG) Nanoparticles Theranostics Cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates

引用

Research 2020年第1期2020卷 652-665页

作者： zonghai sheng Yaxi Li Dehong Hu Tianliang Min Duyang Gao Jen-Shyang Ni Pengfei Zhang Yuenan Wang Xin Liu Kai Li Hairong Zheng Ben Zhong Tang Paul C.Lauterbur Research Center for Biomedical Imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Biomedical Engineering Southern University of Science and Technology(SUSTech)Shenzhen 518055China Department of Radiation Oncology National Cancer CenterNational Clinical Research Center for CancerCancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518055China Department of Chemistry The Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina

Fluorescence probes with aggregation-induced emission(AIE)characteristics are of great importance in biomedical imaging with superior spatial and temporal resolution.However,the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical translation.Here,we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green(ICG)during a study period of 36 days to demonstrate AIE probes are nontoxic.Furthermore,through bright and nontoxic AIE probes and fluorescence imaging in the second window(NIR-II,1,000-1,700 nm),we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates,breaking the current limitation of millimeter-deep NIR-II fluorescence imaging.Our important findings,i.e.,nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates,may facilitate successful translation of AIE probes in clinical trials.

关键词： Fluorescence Probe breaking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly Sensitive MoS_2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site

引用

Nano-Micro Letters 2018年第3期10卷 115-126页

作者： Chengbo Liu Jingqin Chen Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng zonghai sheng Liang Song Research Laboratory for Biomedical Optics and Molecular Imaging Shenzhen Key Laboratory for Molecular ImagingInstitute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen College of Advanced Technology University of Chinese Academy of Sciences Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-Sen University Translational Medicine R&D Center Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS_2–ICG hybrid with indocyanine green(ICG) conjugated to the surface of MoS_2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS_2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS_2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS_2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS_2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.

关键词： MoS2–ICG hybrid Orthotopic brain glioma Photoacoustic imaging Molecular imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

近红外二区荧光金纳米团簇用于生物医学光子学:进展与挑战

引用

中国激光 2024年第3期51卷 116-126页

作者：李丝雨田方正高笃阳胡德红郑海荣盛宗海居胜红东南大学智能影像与介入医学国家级重点实验室培育建设点江苏南京210009 中国科学院深圳先进技术研究院生物医学与健康工程研究所劳伯特生物医学成像研究中心医学成像科学与技术系统重点实验室广东深圳518055

近红外二区(NIR-Ⅱ)金纳米团簇(Au NCs)具有明亮的多色荧光、良好的生物相容性和可肾脏清除的特性,已成为当前生物医学光子学领域中备受关注的纳米材料。首先介绍了NIR-ⅡAu NCs的合成方法,讨论了其面临的低产率和缺乏规模化制备的问题... 详细信息

近红外二区(NIR-Ⅱ)金纳米团簇(Au NCs)具有明亮的多色荧光、良好的生物相容性和可肾脏清除的特性,已成为当前生物医学光子学领域中备受关注的纳米材料。首先介绍了NIR-ⅡAu NCs的合成方法,讨论了其面临的低产率和缺乏规模化制备的问题。其次,介绍了NIR-ⅡAu NCs的表面调控技术,讨论了调控团簇表面结构、组成和形态的方法,以及增大发光波长和提高荧光量子产率的方法。然后,总结了NIR-ⅡAu NCs在血管成像、淋巴管和淋巴结成像、肿瘤成像以及成像引导治疗等方面的最新研究进展。最后,讨论了NIR-ⅡAu NCs在生物医学光子学领域中面临的机遇与挑战。

关键词：生物光学金纳米团簇近红外二区荧光生物医学光子学生物成像成像引导治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Activatable Small-Molecule Photoacoustic Probes that Cross the Blood–Brain Barrier for Visualization of Copper（II） in Mice with Alzheimer’s Disease

Activatable Small-Molecule Photoacoustic Probes that Cross t...

引用

第十一届全国化学生物学学术会议

作者： Shichao Wang zonghai sheng Hairong Zheng Xuanjun Zhang Cancer Centre and Centre of Reproduction Development and AgingFaculty of Health SciencesUniversity of Macau Paul C. Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of Sciences

Copper enrichment in the brain is highly related to Alzheimer’s disease（AD） pathogenesis, but in vivo tracing of Cu2+ in the brain by imaging techniques is still a great challenge. In this work, we developed a series of activatable photoacoustic（PA） probes with low molecular weights（less than 438 Da）, RPS1–RPS4, which can specifically chelate with Cu2+ to form radicals with turn-on PA signals in the near-infrared（NIR） region. Introducing the electron-donating group N,N-dimethylaniline into the probe was found to significantly enhance the radical stability and PA intensity. The best probe in the series, RPS1, showed a fast response（within seconds） to Cu2+ with high selectivity and a low PA detection limit of 90.9 nM. Owing to the low molecular weight and amphiphilic structure, RPS1 could effectively cross the blood–brain barrier（BBB） and thus allowed us, for the first time, to visualize Cu2+ in vivo via PA imaging in the brains of AD mice.

关键词： Alzheimer’s disease blood brain barrier copper photoacoustic probe

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

近红外二区荧光可视化超声联合吲哚菁绿微泡开放血脑屏障增强脑胶质瘤光热治疗

引用

Science Bulletin 2022年第22期67卷 2316-2326页

作者：梁思敏胡德红黎国锋高笃阳李飞郑海荣潘敏盛宗海 Department of Ultrasonography Shenzhen Hospital(Futian)of Guangzhou University of Chinese MedicineShenzhen 518034China Paul C.Lauterbur Research Center for Biomedical Imaging CAS Key Laboratory of Health InformaticsShenzhen Key Laboratory of Ultrasound Imaging and TherapyInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Biomedical Engineering Guangdong Medical UniversityDongguan 523808China

聚焦超声开放血脑屏障是增强胶质母细胞瘤治疗的关键,然而,缺乏一种高时空分辨率的体内成像方法用于原位同步监测血脑屏障开放过程.本文报道了使用吲哚菁绿掺杂的微泡(MBs-ICG)可视化聚焦超声开放血脑屏障和增强对抗胶质母细胞瘤的光热... 详细信息

聚焦超声开放血脑屏障是增强胶质母细胞瘤治疗的关键,然而,缺乏一种高时空分辨率的体内成像方法用于原位同步监测血脑屏障开放过程.本文报道了使用吲哚菁绿掺杂的微泡(MBs-ICG)可视化聚焦超声开放血脑屏障和增强对抗胶质母细胞瘤的光热治疗方法.结果显示, MBs-ICG具有明亮的近红外二区荧光,超声造影成像和超声响应特性.利用其互补的成像特性, MBs-ICG可实现脑血管的高分辨率(~168.9μm)近红外二区荧光成像、大穿透深度(~7 mm)超声造影成像.通过近红外二区荧光成像, MBs-ICG联合聚焦超声可原位同步可视化血脑屏障开放,信噪比为6.2±1.2.此外,在聚焦超声辐照下, MBs-ICG转化为脂质ICG纳米颗粒,并在10 min内迅速进入肿瘤组织,成功用于增强原位胶质母细胞瘤小鼠的光热治疗.多功能MBs-ICG为监测血脑屏障开放和增强胶质母细胞瘤治疗提供了一种新的范式.

关键词：吲哚菁绿光热治疗胶质母细胞瘤血脑屏障聚焦超声荧光成像近红外脑胶质瘤

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

超顺磁氧化铁纳米微粒促进大鼠骨髓间充质干细胞向软骨细胞分化

引用

南方医科大学学报 2017年第5期37卷 652-658页

作者：蒋方肖继杰陆苑婷李葳段宇雯盛宗海李绍林南方医科大学第三附属医院影像科广东广州510630 中国科学院深圳先进技术研究院广东深圳518055 中山大学第五附属医院放射科广东珠海519000

目的探讨超顺磁氧化铁(SPIO)纳米微粒对SD大鼠骨髓间充质干细胞(BMSCs)成软骨分化的影响并探讨背后可能的机制。方法体外培养SD大鼠BMSCs,Caspase-8比色测定工具包(CCK8法)检测SPIO(1和5μg/m L)对BMSCs细胞毒性;SPIO(1和5μg/m L)与成... 详细信息

目的探讨超顺磁氧化铁(SPIO)纳米微粒对SD大鼠骨髓间充质干细胞(BMSCs)成软骨分化的影响并探讨背后可能的机制。方法体外培养SD大鼠BMSCs,Caspase-8比色测定工具包(CCK8法)检测SPIO(1和5μg/m L)对BMSCs细胞毒性;SPIO(1和5μg/m L)与成软骨培养基混合培养9 d,普鲁士蓝染色和自发荧光检测验证SPIO与BMSCs结合情况;荧光定量聚合酶链反应检测成软骨相关因子mRNA的表达量,如:二型胶原α2、聚集蛋白聚糖、基质金属蛋白酶13;体外行阿利新蓝染色及二型胶原α2免疫荧光染色检测BMSCs成软骨量;Western blot检测软骨标记蛋白二型胶原α2,聚集蛋白聚糖和基质金属蛋白酶13表达量以及Ihh/PTHr P信号通路蛋白Ihh、PTHr P表达量明确机制。结果体外CCK8法检测提示SPIO(1和5μg/m L)对BMSCs细胞活性无影响,差异无统计学意义(P>0.05);荧光定量聚合酶链反应检测二型胶原α2和聚集蛋白聚糖的mRNA表达提示,和对照组(单纯加入溶剂)相比,1μg/m L SPIO的mRNA量明显增加,5μg/m L SPIO的mRNA量大于1μg/m L SPIO,基质金属蛋白酶13的mRNA表达出现浓度依赖抑制,和对照组相比1μg/m L SPIO表达减少,5μg/m L SPIO的mRNA量小于1μg/m L SPIO;体外阿利新蓝染色和二型胶原α2免疫荧光染色提示阳性细胞随着SPIO浓度增加而增加,且均大于对照组(P<0.05);蛋白免疫印迹提示二型胶原α2和聚集蛋白聚糖蛋白表达随SPIO升高而升高,且均大于对照组,但基质金属蛋白酶13表达量随SPIO升高而降低,且均小于对照组,Ihh和PTHr P蛋白表达量随SPIO浓度增加而升高,且均大于对照组(P<0.05)。SPIO促进Ihh/PTHr P信号通路,除CCK8法检测结果外均出现浓度依赖性。结论超顺磁氧化铁纳米微粒在体外实验促进BMSCs向软骨细胞分化,并上调Ihh/PTHr P信号通路,为治疗软骨退变相关疾病提供可能的治疗手段。

关键词：超顺磁氧化铁骨髓间充质干细胞成软骨分化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：