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Enhancing cancer immunotherapy:Nanotechnology-mediated immunotherapy overcoming immunosuppression

Acta Pharmaceutica Sinica B 2024年第9期14卷 3834-3854页

作者： Yunna Chen Qianqian Zhou zongfang jia.nuo cheng Sheng Zhang Weidong Chen Lei Wang Key Laboratory of Molecular Biology(Brain diseases) Anhui University of Chinese MedicineHefei 230012China MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials Hefei 230012China Anhui Province Key Laboratory of Chinese Medicinal Formul1 Hefei 230012China

Immunotherapy is an important cancer treatment method that offers hope for curing cancer *** immunotherapy has achieved initial success,a major obstacle to its widespread adoption is the inability to benefit the majority of *** success or failure of immunotherapy is closely linked to the tumor’s immune ***,there has been significant attention on strategies to regulate the tumor immune microenvironment in order to stimulate anti-tumor immune responses in cancer *** distinctive physical properties and design flexibility of nanomedicines have been extensively utilized to target immune cells(including tumor-associated macrophages(TAMs),T cells,myeloid-derived suppressor cells(MDSCs),and tumor-associated fibroblasts(TAFs)),offering promising advancements in cancer *** this article,we have reviewed treatment strategies aimed at targeting various immune cells to regulate the tumor immune *** focus is on cancer immunotherapy models that are based on nanomedicines,with the goal of inducing or enhancing anti-tumor immune responses to improve *** is worth noting that combining cancer immunotherapy with other treatments,such as chemotherapy,radiotherapy,and photodynamic therapy,can maximize the therapeutic ***,we have identified the challenges that nanotechnology-mediated immunotherapy needs to overcome in order to design more effective nanosystems.

关键词： Immunotherapy Nanomedicine Tumor immunosuppressive microenvironment Cancer T cells Immunogenic cell death Immune checkpoint inhibitors Extracellular matrix

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Numerical analysis of the correlation between fluid dynamic modes and hydrodynamic noise in flows around a three-dimensional circular cylinder

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Journal of Hydrodynamics 2024年第1期36卷 119-129页

作者： jia-jia Qin Ming-xin Zou Yuan Zhuang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Wuhan Second Ship Design and Research Institute Wuhan430205China

The flow around a circular cylinder for Re=1000 is characterized by flow separation and Karman vortex *** typical flow features can be captured to study the correlation between fluid fields and sound *** this paper,the three-dimensional circular cylinder is taken as the research object,and the probes of surface fluctuating pressure and far field sound pressure are arranged every 10°.The directional diagram and the coherence of fluctuating pressure and sound pressure are *** relationship between the flow mode and hydrodynamic noise is studied by using dynamic mode decomposition(DMD).The characteristics of the dipole and quadrupole sound source term of a long span cylinder are *** results show that at the angles between 30°–120°and 190°–350°,the fluctuating pressure contributes more to the generation of dipole *** quadrupole sound source shows three-dimensional effects,which is more obvious in a cylinder with large spanwise length.

关键词： Pressure coherence dynamic mode decomposition flow-sound correlation circular cylinder

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Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea

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Defence Technology（防务技术） 2024年第1期31卷 179-191页

作者： Shiyu jia cheng Wang Wenlong Xu Dong Ma Fangfang Qi State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute for Advanced Technology Shandong UniversityJinan250061China

In recent years,explosion shock wave has been considered as a signature injury of the current military *** strong shock wave is lethal to the human body,weak shock wave can cause many more lasting *** investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual *** results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not *** shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic *** overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample *** the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three *** this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are *** layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective *** the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm *** overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of s

关键词： Free-field explosion Weak shock wave mitigation Polyurea Polyurethane foam Multi-layered composites

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Propagation Properties of Shock Waves in Polyurethane Foam based on Atomistic Simulations

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Defence Technology（防务技术） 2024年第1期31卷 117-129页

作者： Zhiqiang Hu jianli Shao Shiyu jia Weidong Song cheng Wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Porous materials are widely used in the field of protection because of their excellent energy absorption *** this work,a series of polyurethane microscopic models are established and the effect of porosity on the shock waves is studied with classical molecular dynamics ***,shock Hugoniot relations for different porosities are obtained,which compare well with the experimental *** pores collapse and form local stress wave,which results in the complex multi-wave structure of the shock *** microstructure analysis shows that the local stress increases and the local velocity decreases gradually during the process of pore collapse to complete ***,it leads to stress relaxation and velocity *** shock stress peaks can be fitted with two exponential functions,and the amplitude of attenuation coefficient decreases with the increase of ***,the pore collapse under shock or non-shock are discussed by the entropy increase rate of the *** energy is dissipated mainly through the multiple interactions of the waves under *** energy is dissipated mainly by the friction between atoms under non-shock.

关键词： Polyurethane foam Shock wave Attenuation Atomistic simulation

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The configuration of Au^(δ+)-ZrO_(2)^(δ−)species induced activation enhances electrocatalytic CO_(2)to formate conversion

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Nano Research 2024年第7期17卷 6006-6015页

作者： Yongjian jia Yadi Zhang Mengque Lin Yangyang cheng Yanjie Xu National Engineering Research Center for Technology and Equipment of Environmental Deposition Lanzhou Jiaotong UniversityLanzhou 730070China Key Lab of Opt-Electronic Technology and Intelligent Control of Ministry of Education Lanzhou Jiaotong UniversityLanzhou 730070China School of Environmental Engineering and Chemistry Luoyang Institute of Science and TechnologyLuoyang 471023China

Electrochemical CO_(2)conversion into value-added chemicals is a promising technology to solve the greenhouse effect and recycle chemical ***,the electrochemical CO_(2)reduction reaction(e-CO_(2)RR)is seriously compromised by weak CO_(2)adsorption and a rough CO_(2)activation process based on the chemical inertness of the CO_(2)molecule and the formed fragile metal–C/O *** this paper,we designed and fabricated Au particles embedded in ZrO_(2).The configuration of Au particles being of positive charge and ZrO_(2)with negative charge is induced and generated by metal–support interactions(MSIs).As a result,Au/ZrO_(2)@C presents a big difference in the CO_(2)conversion compared with the known work,affording a formate yield of 112.5μmol·cm^(−2)·h^(−1)at−1.1 V *** hydrogen electrode(RHE),and a max formate Faradaic efficiency of up to 94.1%at−0.9 V *** superior performance was attributed to the activated Au–ZrO_(2)interface to form the Au^(δ+)*** insitu Fourier transform infrared(FTIR)spectroscopy and theoretical calculations show that the MSIs configuration can be inclined to the*OCO intermediate generation on Au^(δ+)species activating CO_(2)molecules and then accelerate the formation of the*OCHO intermediate in e-CO_(2)RR,thereby favoring the CO_(2)conversion to formate.

关键词： electrochemical CO_(2)reduction reaction(e-CO_(2)RR) Au_(δ+)species formic acid *OCHO intermediate metal-support interactions

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Polymorphic cerium-based Prussian blue derivatives with in situ growing CNT/Co heterojunctions for enhanced microwave absorption via polarization and magnetization

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Nano Research 2024年第3期17卷 2050-2060页

作者： Jixi Zhou Xinmeng Huang Di Lan Yuhang cheng Fengyi Xue Chenyu jia Guanglei Wu Zirui jia Institute of Materials for Energy and Environment State Key Laboratory of Bio-fibers and Eco-textilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China

In this paper,the structure evolution of cerium cobaltohexanoate(Ce[Co(CN)6],Ce-Co Prussian blue analog(PBA))has been realized by solvent catalysis at room *** hexagonal bipyramidal microcrystals of Ce-Co PBA can be gradually transformed into dendrites by different proportions of ethanol(EtOH)and *** the same time,the porous dendrites CeO_(2)/Co@carbon nanotub(CNT)with oxygen-rich vacancies(OVs)can be obtained by annealing Ce-Co PBA at 700℃.The microstructure study shows that carbon nanotubes will be catalyzed after annealing at high temperature,and the cobalt metal particles encapsulated in carbon nanotubes will be anchored in the matrix,regulating the impedance matching and multi-polarization suppression of the material,and its unique structure,vacancies,and strong interface effect make the material exhibit excellent electromagnetic wave(EMW)absorption *** the matching thickness is 2.5 mm,the minimum reflection loss(RLmin)of the composite is-51.68 dB,and the effective absorption bandwidth(RL<-10 dB)is 7.76 *** results show that the prepared CeO_(2)/Co@CNT composite has excellent EMW absorption *** is expected to be a candidate material for EMW absorption.

关键词： Ce-Co Prussian blue analog(PBA) carbon nanotubes(CNTs) CeO_(2)/Co@CNT solvent catalysis electromagnetic wave absorption

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Inner-shell ionization cross sections of atoms by positron impact

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Communications in Theoretical Physics 2024年第6期76卷 142-147页

作者： Yuan-cheng Wang jia Ma Li-Guang jiao Stephan Fritzsche College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China Helmholtz-Institut Jena D-07743 JenaGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH D-64291 DarmstadtGermany College of Science Shenyang Aerospace UniversityShenyang 110136China College of Physics Jilin UniversityChangchun 130012China Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena07743 JenaGermany

The relativistic binary-encounter-Bethe model with Wannier-type threshold law is employed to obtain the inner-shell ionization cross sections of multi-electron atoms(Ni,Cu,Y,Ag,Au,Yb,Ta,and Pb)for positron impact energies from the thresholds up to 105ke *** is good agreement between the present calculations and the experimental *** constant in the acceleration term derived from the Wannier law is determined to be 0.2 and 0.5 for the K-and L-shells,respectively.

关键词： positron scattering ionization cross section binary-encounter-Bethe model

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Unique electromagnetic wave absorber for three-dimensional framework engineering with copious heterostructures

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Journal of Materials Science & Technology 2024年第3期170卷 129-139页

作者： Liyuan Yu Qianqian Zhu Zhiqiang Guo Yuhang cheng Zirui jia Guanglei Wu Institute of Materials for Energy and Environment State Key Laboratory of Bio-fibers and Eco-textilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China

In order to obtain high-performance electromagnetic wave absorbers,the adjustment of structure and components is *** on the above requirements,this system forms a three-dimensional frame structure consisting of MXene and transition metal oxides(TMOs)through efficient electrostatic *** three-dimensional network structure has rich heterojunction structures,which can cause a large amount of interface polarization and conduction losses in incident electromagnetic *** structures cause multiple reflections and scattering of electromagnetic waves,which is also an important reason for further increasing electromagnetic wave *** the doping ratio is 1:1,the system has the best impedance matching,the maximum effective absorption bandwidth(EAB max)can reach 5.12 GHz at 1.7 mm,and the minimum reflection loss(RL_(min))is-50.30 dB at 1.8 *** provides a reference for the subsequent formation of 2D-MXene materials into 3D materials.

关键词： MXene Three-dimensional frame Heterojunction structure Conduction loss Electromagnetic wave absorption

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Insights into Formation and Li-Storage Mechanisms of Hierarchical Accordion-Shape Orthorhombic CuNb_(2)O_(6) toward Lithium-Ion Capacitors as an Anode-Active Material

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Energy & Environmental Materials 2024年第2期7卷 287-298页

作者： Chao cheng Yunsheng Yan Minyu jia Yang Liu Linrui Hou Changzhou Yuan School of Material Science and Engineering University of JinanJinan 250022China

The orthorhombic CuNb_(2)O_(6)(O-CNO)is established as a competitive anode for lithium-ion capacitors(LICs)owing to its attractive compositional/structural ***,the high-temperature synthesis(>900℃)and controversial charge-storage mechanism always limit its ***,we develop a low-temperature strategy to fabricate a nano-blocks-constructed hierarchical accordional O-CNO framework by employing multilayered Nb_(2)CT_(x)as the niobium *** intrinsic stress-induced formation/transformation mechanism of the monoclinic CuNb_(2)O_(6)to O-CNO is tentatively put ***,the integrated phase conversion and solid solution lithium-storage mechanism is reasonably unveiled with comprehensive in(ex)situ *** to its unique structural merits and lithium-storage process,the resulted O-CNO anode is endowed with a large capacity of 150.3 mAh g^(-1)at 2.0 A g^(-1),along with long-duration cycling ***,the constructed O-CNO-based LICs exhibit a high energy(138.9 Wh kg^(-1))and power(4.0 kW kg^(-1))densities with a modest cycling stability(15.8%capacity degradation after 3000 consecutive cycles).More meaningfully,the in-depth insights into the formation and charge-storage process here can promote the extensive development of binary metal Nb-based oxides for advanced LICs.

关键词： high-rate anodes lithium-ion capacitors lithium-storage mechanisms orthorhombic CuNb_(2)O_(6) phase transform

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Optimization of the co-closing law of guide vanes and blades for bulb turbines based on CFD

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Journal of Hydrodynamics 2024年第2期36卷 363-377页

作者： Hui Liu Yun-fa Lin Yong-guang cheng Song Xue Mao-jia Tang jian Zhang jia-yi Fan State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China Dongfang Electric Machinery Co. Ltd.Deyang618000China

The load rejection transient process of bulb turbine units is critical to safety of hydropower stations,and determining appropriate closing laws of guide vanes(GVs)and runner blades(RBs)for this process is of *** this study,we proposed a procedure to optimize the co-closing law of GVs and RBs by using computational fluid dynamics(CFD),combined with the design of experiment(DOE)method,approximation model,and genetic optimization *** sensitivity of closing law parameters on the histories of head,speed,and thrust was analyzed,and a two-stage GVs’closing law associating with a linear RBs’closing law was *** results show that GVs dominate the transient characteristics by controlling the change of *** GVs’first-stage closing speed while shortening first-stage closing time can not only significantly reduce the maximum rotational speed but also suppress the water hammer pressure;slowing GVs’second-stage closing speed is conducive to controlling the maximum reverse axial *** directly affect the runner *** RBs’closing speed can further reduce the rotational speed and the maximum reverse axial *** safety margin of each control parameter,flow patterns,and pressure pulsations of a practical hydropower station were all improved after optimization,demonstrating the effectiveness of this method.

关键词： Bulb turbine load rejection transient process double regulation closing law optimization computational fluid dynamics(CFD)

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