检索结果-南通市图书馆

NνDEx-100 conceptual design report

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： xi-Guang Cao Yan-Long chang Kai chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei Lang Yu-Lan Li Zhi-Jie Li tian-Yu Liang Jun Liu chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu xiang-Ming Sun xiao-xing Tang Hu-Lin wang Qian-Ming wang Le xiao Mu-Yun xiao jian-Yu xin Nu Xu Peng yang Yi-chen yang Zhen yang zong-yang Yu Dong-Liang Zhang Jun-Wei Zhang cheng-xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

The In-Flight Realtime Trigger and Localization Software of GECAM

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun Zhao Shao-Lin xiong xiang-yang wen xin-qiao Li Ce Cai Shuo xiao Qi Luo wen-xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao Yan-Qiu Zhang Yue Huang Lu Li xing wen Fei Zhang Jing Duan chen-Wei wang Dong-Li Shi Peng Zhang Qi-Bin Yi Chao-yang Li Yan-Bing Xu xiao-Hua Liang Ya-Qing Liu Da-Li Zhang xi-Lei Sun Fan Zhang Gang chen Huan-Yu wang Sheng yang xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou wang xing Zhou Yi Zhao wang-chen Xue Chao Zheng Jia-Cong Liu xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke Zhang Can chen xiong-Tao yang Dong-Jie Hou Yu-Sa wang Rui qiao xiang Ma xiao-Bo Li Ping wang xin-Ying song Li-Ming song Shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei chen jian-jian He Zhen Zhang Jin Hou Hong-Jun wang Yan-Chao Hao xiang-Yu wang zong-Yuan yang Zhi-Long wen Zhi chang Yuan-Yuan Du Rui Gao xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei yang Xue-Juan yang Shuang-Nan Zhang Chao-Yue Zhang cheng-Mo Zhang Zhi-cheng Tang cheng cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge wang Ke-ning Qi Yu-Chong wang Da-Wei qiao xiao-Shuai chen Li-Zhi Wu Meng tian Long chen Yi Wei Liao-Yuan song jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第8期67卷 2497-2523页

作者： Yuan Zeng Shuhan Zhang Yuecong Guo Yalin Cong Xu Ding Peihua Li Yunxiang Lin wenzhi Ren Hui Su Weigang Sun Liuxin Xu Guikai Zhang Shihua chen Yu chen Weiren cheng Shengqi Chu Yong Guan Jinru Han Jie Lin Hengjie Liu Zheyi Liu Pan Luo Fanchun Meng Sicong qiao zongyin song Ying wang Zhao Wu chenyu yang Meng yang Shirui yang Zi Yin Zhibin Yin Pengjun Zhang Hongyu Zhang Pingping Zheng Jia Zhou Wanlin Zhou Pengfei An He cheng Chunhai Fan xingjiu Huang Yong Lei Lina Li Mu Li Qinghua Liu Shuming Peng Li song Zhihu Sun yangchao tian Fangjun wang Lihua wang Liming wang Shiqiang Wei Aiguo Wu Chunlei xiao Xueming yang Panchao Yin Jing Zhang Mingxin Zhang Yaling wang Chunying chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science LaboratoryNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410081China State Key Laboratory of Luminescent Materials and Devices South China Advanced Institute for Soft Matter Science and TechnologySouth China University of TechnologyGuangzhou 510640China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Advanced Science Facilities Shenzhen 518107China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Acade

With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron *** further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.

关键词： large scientific facilities synchrotron radiation FEL light sources neutron sources spectroscopic analysis methods X-ray imaging techniques structural information chemical dynamics

10μm 1280×1024 HgCdTe中波红外焦平面阵列探测性能提升

在线全文

学校读者我要写书评

暂无评论

红外与毫米波学报 2024年第1期43卷 36-43页

作者：谭必松毛剑宏陈殊璇李伟伟陈世锐陈天晴杜宇彭成盼熊雄周永强余波王舒浙江珏芯微电子有限公司浙江丽水323000

对像元尺寸为10μm的1280×1024碲镉汞(HgCdTe)中波红外焦平面阵列的制备技术和性能进行了研究。通过B+注入制备小尺寸n-on-p平面结;采用高平整度HgCdTe外延材料和高精度的倒焊互连技术,实现高的电学连通率;采用多段温度填胶固化和边缘... 详细信息

对像元尺寸为10μm的1280×1024碲镉汞(HgCdTe)中波红外焦平面阵列的制备技术和性能进行了研究。通过B+注入制备小尺寸n-on-p平面结;采用高平整度HgCdTe外延材料和高精度的倒焊互连技术,实现高的电学连通率;采用多段温度填胶固化和边缘刻蚀工艺减轻HgCdTe器件和读出集成电路(ROICs)之间的热失配,从而降低焦平面器件失效率。在85 K焦平面工作温度下,研制探测器的光谱响应范围为3.67μm至4.88μm,有效像元率高达99.95%,并且探测器组件像元的平均噪声等效温差(NETD)和暗电流密度的平均值分别小于16 mK和2.1×10^(-8)A/cm^(2)。与像元尺寸为15μm的探测器相比,10μm的1280×1024中波红外探测器可获取更加精细的图像,具有更远的识别距离。目前,该技术已成功转移到浙江珏芯微电子有限公司(ZJM)的HgCdTe红外探测器产线。

关键词：红外探测器碲镉汞 1 K×1 K红外焦平面阵列 n-on-p

Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1-induced inflammation

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第44期27卷 7669-7686页

作者： chang-Ju Zhu Wan-Guang yang De-jian Li Yao-Dong song San-yang chen qiao-Fang wang Yan-Na Liu Yan Zhang Bo cheng Zhong-Wei Wu zong-Chao Cui Henan Medical Key Laboratory of Emergency and Trauma Research The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Acute lung injury(ALI)is a common and life-threatening complication of severe acute pancreatitis(SAP).There are currently limited effective treatment options for SAP and associated ***(Cal),a bioactive constituent extracted from the medicinal herb Radix Astragali exhibits potent anti-inflammatory properties,but its effect on SAP and associated ALI has yet to be *** To identify the roles of Cal in SAP-ALI and the underlying *** SAP was induced via two intraperitoneal injections of L-arg(4 g/kg)and Cal(25 or 50 mg/kg)were injected 1 h prior to the first L-arg *** were sacrificed 72 h after the induction of SAP and associated ALI was examined histologically and *** in vitro model of lipopolysaccharide(LPS)-induced ALI was established using A549 *** analysis and western blot were evaluated in *** docking analyses were conducted to examine the interaction of Cal with *** Cal treatment substantially reduced the serum amylase levels and alleviated histopathological injury associated with SAP and *** infiltration and lung tissue levels of neutrophil mediator myeloperoxidase were reduced in line with protective effects of Cal against ALI in *** treatment also attenuated the serum levels and mRNA expression of pro-inflammatory cytokines tumor necrosis factor-α,interleukin-6,IL-1β,HMGB1 and chemokine(CXC motif)ligand 1 in lung *** and western blot analyses showed that Cal treatment markedly suppressed the expression of HMGB1 and phosphorylated nuclear factor-kappa B(NF-κB)p65 in lung tissues and an in vitro model of LPSinduced ALI in A549 cells suggesting a role for HGMB1 in the pathogenesis of ***,molecular docking analysis provided evidence for the direct interaction of Cal with *** Cal protects mice against L-arg-induced SAP and associated ALI by attenuating local and systemic neutrophil infiltration a

关键词： Severe acute pancreatitis Acute lung injury Calycosin Mouse model Highmobility group box 1 Nuclear factor-kappa B

CEPC Technical Design Report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun chang Yue chang Zhe chang xinyuan chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen tianlu chen Wei chen xiang chen xiaoyu chen xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

雌激素通过受体介导的通路影响大鼠心脏心钠素表达

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华内分泌代谢杂志 2006年第2期22卷 169-173页

作者：田宗文杨晓宁宋健王乔陈锡昌程邦昌武汉大学医学院人体解剖学与组织胚胎学系 430071 武汉大学人民医院心胸外科

目的研究雌激素对卵巢切除大鼠心脏雌激素受体(ER)α和β的调控及对血压、心率、心肌细胞心钠素(ANP)基因表达、合成和释放的影响。方法成年雌性Wistar大鼠随机分成5组假手术组,卵巢切除组和卵巢切除不同剂量17β-雌二醇组(80、800、800... 详细信息

目的研究雌激素对卵巢切除大鼠心脏雌激素受体(ER)α和β的调控及对血压、心率、心肌细胞心钠素(ANP)基因表达、合成和释放的影响。方法成年雌性Wistar大鼠随机分成5组假手术组,卵巢切除组和卵巢切除不同剂量17β-雌二醇组(80、800、8000ng·g-1·d-1)。测量大鼠收缩期血压(SBP)、心率;采用半定量RT-PCR和Western印迹方法,探讨不同剂量的17β-雌二醇对卵巢切除大鼠心脏ERα和ERβmRNA、ER蛋白质的表达调控及对ANPmRNA表达的影响;放射免疫方法测定血浆和心房组织ANP含量。结果超生理剂量的17β-雌二醇能降低卵巢切除大鼠SBP,减慢心率;成年雌性大鼠心脏ERαmRNA高于ERβmRNA的表达水平,而心房ERαmRNA表达又明显超过心室;卵巢切除减少心房ERαmRNA和蛋白质的表达,下调ANPmRNA,使心房组织和血浆ANP含量明显降低[(121±19)ng/mg组织vs(184±12)ng/mg组织,(196±21)ng/Lvs(288±36)ng/L,P<0.01];生理剂量17β-雌二醇能逆转上述改变。随剂量增加,17β-雌二醇的这种作用在一定程度上呈剂量依赖性关系。但卵巢切除和17β-雌二醇替代并不影响心脏ERβmRNA、心室ERαmRNA表达。结论超生理剂量雌激素可降低卵巢切除大鼠SBP,心率;ERα的高水平表达说明ERα是雌激素对心脏调控的优势受体;雌激素对心脏作用的主要靶部位是心房;雌激素促进心房肌细胞ANPmRNA的表达、合成和释放,通过受体依赖的ANP介导的通路发挥作用。

关键词：雌激素类受体雌激素卵巢切除术心钠素心脏

雌激素对大鼠心脏雌激素受体α和β表达的影响

在线全文

学校读者我要写书评

暂无评论

解剖学报 2005年第4期36卷 412-416,427页

作者：田宗文宋健王乔杨晓宁陈锡昌程邦昌武汉大学医学院人体解剖学与组织胚胎学系武汉430071 武汉大学医学院人民医院外科武汉430060

目的研究雌激素受体(ER)α和β在新生、成年和卵巢切除大鼠心脏的表达.方法采用半定量逆转录聚合酶链反应(RT-PCR)和Western blot方法,分析新生和成年大鼠心脏各部的ERα和β mRNA及ER蛋白质的表达,探讨不同剂量的17β-雌二醇对卵巢切... 详细信息

目的研究雌激素受体(ER)α和β在新生、成年和卵巢切除大鼠心脏的表达.方法采用半定量逆转录聚合酶链反应(RT-PCR)和Western blot方法,分析新生和成年大鼠心脏各部的ERα和β mRNA及ER蛋白质的表达,探讨不同剂量的17β-雌二醇对卵巢切除大鼠心脏ERα和β mRNA、ER蛋白质的表达调控及对心房、心室重量和它们与体重比变化的影响.结果ERα mRNA在新生大鼠心脏各部表达较低,而成年大鼠心脏各部ERαmRNA的转录水平提高3～20倍,这种差别体现在ERα蛋白质的表达水平不同.反之新生大鼠心脏ERβ mRNA表达水平较高,而成年大鼠心脏ERβmRNA的表达降低2～7倍.卵巢切除减少成年大鼠心房ERα mRNA和蛋白质的表达,减轻心房重量及心房/体重比;17β-雌二醇替代却能反转这些改变,同时随着血浆17β-雌二醇水平的增高,这种影响在一定程度上呈剂量依赖关系.卵巢切除和17β-雌二醇替代并不改变心脏和心室/体重比,也不影响ERβmRNA的表达.结论雌激素受体α和β在新生和成年大鼠心脏的表达存在差别,ERβ可能在大鼠心脏的发育过程中起重要作用,ERα是雌激素对成年大鼠心脏调控的优势受体;雌激素的主要靶器官是心房,且通过其受体的介导促进心房肌细胞的增生.

关键词：雌激素雌激素受体卵巢切除半定量逆转录聚合酶链反应免疫印迹杂交心脏