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Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6

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World Journal of Gastroenterology 2017年第8期23卷 1434-1442页

作者： Jun-Hui Guo Guo-Lan Xing Xin-Hui fang Hui-fang Wu Bo Zhang Jin-Zhong Yu zong-min fan Li-Dong Wang Henan Province Hospital of TCM The Second Affiliated Hospital of Henan University of Chinese Medicine Henan Key Lab For Esophageal Cancer Res The First Affiliated Hospital of Zhengzhou University Henan Province People’s Hospital The Second Affiliated Hospital of Zhengzhou University

AIM To understand the molecular mechanism of esophageal cancer development and provide molecular markers for screening high-risk populations and early diagnosis. METHODS Two-dimensional electrophoresis combined with mass spectrometry were adopted to screen differentially expressed proteins in nine cases of fetal esophageal epithelium, eight cases of esophageal cancer, and eight cases of tumor-adjacent normal esophageal epithelium collected from fetuses of different gestational age, or esophageal cancer patients from a high-risk area of esophageal cancer in China. Immunohistochemistry(avidin-biotin-horseradish peroxidase complex method) was used to detect the expression of peroxiredoxin(PRX)6 in 91 cases of esophageal cancer, tumoradjacent normal esophageal tissue, basal cell hyperplasia, dysplasia, and carcinoma in situ, as well as 65 cases of esophageal epithelium from fetuses at a gestational age of 3-9 *** After peptide mass fingerprint analysis and search of protein databases, 21 differential proteins were identified; some of which represent a protein isoform. Varying degrees of expression of PRX6 protein, which was localized mainly in the cytoplasm, were detected in adult and fetal normal esophageal tissues, precancerous lesions, and esophageal cancer. With the progression of esophageal lesions, PRX6 protein expression showed a declining trend(P < 0.05). In fetal epithelium from fetuses at gestational age 3-6 mo, PRX6 protein expression showed a declining trend with age(P < 0.05). PRX6 protein expression was significantly higher in well-differentiated esophageal cancer tissues than in poorly differentiated esophageal cancer tissues(P < 0.05).CONCLUSION Development and progression of esophageal cancer result from interactions of genetic changes(accumulation or superposition). PRX6 protein is associated with fetal esophageal development and cancer differentiation.

关键词： Fetal esophageal epithelium Esophageal squamous cell carcinoma Tumor-adjacent esophageal epithelium Proteomics

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Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, China

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World Journal of Gastroenterology 2008年第12期14卷 1828-1835页

作者： Yan-Ru Qin Li-Dong Wang zong-min fan Dora Kwong Xin-Yuan Guan Department of Clinical Oncology The FirstAffiliated Hospital of Zhengzhou University Zhengzhou 450052Henan Province China Laboratory for Cancer Research Experimental Medical Center College of Medicine ZhengzhouUniversity Zhengzhou 450052 Henan Province China Department of Clinical Oncology Queen Mary Hosptital The University of Hong Kong Room 129Professorial Block Pokfulam Road Hong Kong China

AIM: To characterize cytogenetic alterations in esophageal squamous cell carcinoma (ESCC) and its metastasis. METHODS: A total of 37 cases of primary ESCC and 15 pairs of primary ESCC tumors and their matched metastatic lymph nodes cases were enrolled from Linzhou, the high incidence area for ESCC in Henan, northern China. The comparative genomic hybridization (CGH) was applied to determine the chromosomal aberrations on the DNA extracted from the frozen ESCC and metastatic lymph node samples from these patients. RESULTS: CGH showed chromosomal aberrations in all the cases. In 37 cases of primary ESCC, chromosomal profile of DNA copy number was characterized by frequently detected gains at 8q (29/37, 78%), 3q (24/37, 65%), 5p (19/37, 51%); and frequently detected losses at 3p (21/37, 57%), 8p and 9q (14/37, 38%). In 15 pairs of primary ESCC tumors and their matched metastatic lymph node cases, the majority of the chromosomal aberrations in both primary tumor and metastatic lymph node lesions were consistent with the primary ESCC cases, but new candidate regions of interest were also detected. The most significant finding is the gains of chromosome 6p with a minimum high-level amplification region at 6p12-6q12 in 7 metastatic lymph nodes butonly in 2 corresponding primary tumors (P = 0.05) and 20p with a minimum high-level amplification region at 20p12 in 11 metastatic lymph nodes but only in 5 corresponding primary tumors (P < 0.05). Another interesting finding is the loss of chromosome 10p and 10q in 8 and 7 metastatic lymph nodes but only in 2 corresponding primary tumors (P < 0.05). CONCLUSION: Using the CGH technique to detect chromosomal aberrations in both the primary tumor and its metastatic lymph nodes of ESCC, gains of 8q, 3q and 5p and loss of 3p, 8p, 9q and 13q were specifically implicated in ESCC in Linzhou population. Gains of 6p and 20p and loss of 10pq may contribute to the lymph node metastasis of ESCC. These findings suggest that the gains and losse

关键词： Comparative genomic hybridization Geneticalterations Esophageal squamous cell carcinoma Metastatic lymph nodes

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Increased prognostic value of clinical–reproductive model in Chinese female patients with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2022年第13期28卷 1347-1361页

作者： Dong-Yun Zhang Jian-Wei Ku Xue-Ke Zhao Hai-Yan Zhang Xin Song Hong-fang Wu zong-min fan Rui-Hua Xu Duo You Ran Wang Ruo-Xi Zhou Li-Dong Wang State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pathology Nanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Endoscopy The Third Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Pathology The First Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Medical Oncology Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450052Henan ProvinceChina Department of Biology University of RichmondRichmondVA 23173United States

BACKGROUND In China,it has been well recognized that some female patients with esophageal squamous cell carcinoma(ESCC)have different overall survival(OS)time,even with the same tumor-node-metastasis(TNM)stage,challenging the prognostic value of the TNM system *** effective predictive model is needed to accurately evaluate the prognosis of female ESCC *** To construct a novel prognostic model with clinical and reproductive data for Chinese female patients with ESCC,and to assess the incremental prognostic value of the full model compared with the clinical model and TNM *** A new prognostic nomogram incorporating clinical and reproductive features was constructed based on univariatie and Cox proportional hazards survival analysis from a training cohort(n=175).The results were recognized using the internal(n=111)and independent external(n=85)validation *** capability of the clinical–reproductive model was evaluated by Harrell’s concordance index(C-index),Kaplan–Meier curve,time-dependent receiver operating characteristic(ROC),calibration curve and decision curve *** correlations between estrogen response and immune-related pathways and some gene markers of immune cells were analyzed using the TIMER 2.0 *** A clinical–reproductive model including incidence area,age,tumor differentiation,lymph node metastasis(N)stage,estrogen receptor alpha(ESR1)and beta(ESR2)expression,menopausal age,and pregnancy number was constructed to predict OS in female ESCC *** to the clinical model and TNM stage,the time-dependent ROC and C-index of the clinical–reproductive model showed a good discriminative ability for predicting 1-,3-,and 5-years OS in the primary training,internal and external validation *** on the optimal cut-off value of total prognostic scores,patients were classified into high-and low-risk groups with significantly different *** estrogen response was significantly associated with p53 and apop

关键词： Esophageal squamous cell carcinoma Female Nomogram Prognosis Estrogen receptor

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Electrocatalytic CO_(2)reduction to syngas

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Green Energy & Environment 2024年第7期9卷 1085-1100页

作者： Bing Chang Zhaojun min Ning Liu Nan Wang Maohong fan Jing fan Jianji Wang School of Environment Key Laboratory of Yellow River and Huai River Water Environment and Pollution ControlMinistry of EducationHenan Normal UniversityXinxiangHenan453007China School of Chemistry and Chemical Engineering Key Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Normal UniversityXinxiangHenan453007China College of Engineering and Physical Sciences and School of Energy ResourcesUniversity of WyomingLaramieWY82071USA College of Engineering Georgia Institute of TechnologyAtlantaGA30332USA

While carbon dioxide(CO_(2))is a major greenhouse gas,it is also an important C1 *** the trend of energy conservation and emission reduction,electrocatalytic reduction has become a very promising strategy for CO_(2)utilization because it can convert CO_(2)directly to high-valued chemicals and fuels under mild *** particular,the product CO and by-product H_(2)can be combined into syngas by an electrocatalytic CO_(2)reduction reaction(CO_(2)RR)in an aqueous *** molar ratios of CO and H_(2)may be used to produce essential bulk chemicals or liquid fuels such as methanol,alkanes,and olefins through thermochemical catalysis,Fischer-Tropsch synthesis,microbial fermentation,and other *** work discusses the latest strategies in controlling the molar ratio of CO/H_(2)and improving the yield of CO_(2)*** challenges of electrocatalytic syngas production are analyzed from an industrial application perspective,and the possible measures to overcome them are proposed in terms of new catalyst design,electrolyte innovation,flow reactor optimization,anodic reaction coupling,and operando technique application.

关键词： Electrocatalysis CO_(2)reduction Syngas Electrolyte Electrolyzer

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Experimental and numerical study regarding H-steel all-bolted connection steel frame with composite wall boards

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 427-443页

作者： fan min Guo Hongchao Li Shen Wang Zhenshan Wang Huaqiang School of Civil Engineering and Architecture Xi’an University of TechnologyXi’an 710048China State Key Laboratory Base of Eco-Hydraulic Engineering in Arid Area Xi’an University of TechnologyXi’an 710048China

H-steel all-bolted connection steel frame structures with heat preservation and decoration composite wall boards were investigated and the seismic performances of three scaled specimens were *** failure modes,hysteresis curves,bearing capacity,ductility,energy dissipation capacity,stiffness degradation and strain distribution were *** calculation method of structural theoretical internal force was *** results showed that the overall structural seismic performance was better,and the structural ductility met the demands of elastic-plastic inter-story drift angle for seismic *** H-steel weak-axis connection structure obtained better energy dissipation capacity,and its bearing capacity and stiffness were slightly different from the strong-axis *** heat preservation and decoration performance of composite wallboard and the all-bolted connection of the steel frame realized prefabrication during the whole construction *** plastic hinge of the steel beam can be moved outwards because of the L-angles,which effectively avoids stress concentration in joint areas and expands the plastic hinge *** errors between the theoretical structural capacity calculated by the plastic analysis method and the test results were within 2.44%.In addition,structural failure mechanisms and bearing capacities were verified by the finite element(FE)analysis,and the effects of the main parameters on the structures were *** FE verification results were the same as in the *** research results provide theoretical support and technical guidance for the application of thermal insulation and decorative composite wall panels in H-shaped steel all-bolted steel frames.

关键词： composite wall boards all-bolted steel frame H-steel low-cyclic loading failure modes

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Truth telling for patients with esophageal squamous cell carcinoma in Henan,China

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Cancer Biology & Medicine 2017年第1期14卷 83-89页

作者： Lian-Qun Zhang Pei-Nan Chen Hai-Ling Wang Li Sun Xue-Ke Zhao Xin Song min-Jie Wu Tang-Juan Zhang Ling-Fen Ji Wei-Li Han zong-min fan Yuan Yuan Hai-Jun Yang Jian-Po Wang Fu-You Zhou Yi-Jun Qi Li-Dong Wang Anyang Tumor Hospital Anyang 455000China Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052China The Second Affiliated Hospital of Zhengzhou University Zhengzhou 450014China The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou 450008China Key Laboratory of Cellular and Molecular Immunology College of MedicineHenan UniversityKaifeng 475004China

Objective: This study aims to investigate the truth-telling status and the relevant factors of esophageal squamous cell carcinoma(ESCC) patients in Henan, ***: A cross-sectional study from April to June 2015 using questionnaires was given to 301 family members of hospitalized ESCC patients based in three affiliated hospitals of Zhengzhou University(i.e., The First Hospital, The Second Hospital, and Tumor Hospital) and Anyang Tumor ***: Among the 41.9%(126/301) hospitalized ESCC patients who knew of their true diagnoses, only 4.0% patients were informed by their corresponding responsible doctors, 39.7% by their family members, and 56.3% by themselves. Univariate analyses showed that disclosure of confirmed ESCC diagnosis to patients was correlated with gender, family history of cancer(FHC), education level, vocation, hospital administrative level, and attitudes of family members(P < 0.05). Furthermore,multivariate analysis indicated that attitude of family members was the most important and an independent factor for diagnosis disclosure. Those patients with a negative FHC, under-education, manual occupation, advanced stages, and hospitalized in municipal hospitals exhibited a low rate of truth ***: Truth telling for ESCC patients in Henan is not prevalent and may be improved through consultation with family members, particularly for patients with a negative FHC, poor education, manual occupation, and advanced stages.

关键词： Truth telling esophageal squamous cell carcinoma diagnosis

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Hybrid Dynamic Variables-Dependent Event-Triggered Fuzzy Model Predictive Control

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 723-733页

作者： Xiongbo Wan Chaoling Zhang fan Wei Chuan-Ke Zhang min Wu IEEE the School of Automation China University of Geosciencesthe Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systemsand the Engineering Research Center of Intelligent Technology for Geo-ExplorationMinistry of EducationWuhan 430074China

This article focuses on dynamic event-triggered mechanism(DETM)-based model predictive control(MPC) for T-S fuzzy systems.A hybrid dynamic variables-dependent DETM is carefully devised,which includes a multiplicative dynamic variable and an additive dynamic *** addressed DETM-based fuzzy MPC issue is described as a “min-max” optimization problem(OP).To facilitate the co-design of the MPC controller and the weighting matrix of the DETM,an auxiliary OP is proposed based on a new Lyapunov function and a new robust positive invariant(RPI) set that contain the membership functions and the hybrid dynamic variables.A dynamic event-triggered fuzzy MPC algorithm is developed accordingly,whose recursive feasibility is analysed by employing the RPI *** the designed controller,the involved fuzzy system is ensured to be asymptotically *** examples show that the new DETM and DETM-based MPC algorithm have the advantages of reducing resource consumption while yielding the anticipated performance.

关键词： Dynamic event-triggered mechanism(DETM) hybrid dynamic variables model predictive control(MPC) robust positive invariant(RPI)set T-S fuzzy systems

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Alleviated photoinhibition on nitrification in the Indian Sector of the Southern Ocean

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Acta Oceanologica Sinica 2024年第7期43卷 52-69页

作者： Lingfang fan min Chen Zifei Yang minfang Zheng Yusheng Qiu College of Ocean and Earth Sciences Xiamen UniversityXiamen 361102China

Nitrification,a central process in the marine nitrogen cycle,produces regenerated nitrate in the euphotic zone and emits N_(2)O,a potent greenhouse gas as a *** regulatory mechanisms of nitrification in the Southern Ocean,which is a critical region for CO_(2)sequestration and radiative benefits,remain poorly ***,we investigated the in situ and dark nitrification rates in the upper 500 m and conducted substrate kinetics experiments across the Indian Sector in the Cosmonaut and Cooperation seas in the late austral *** findings indicate that light inhibition of nitrification decreases exponentially with depth,exhibiting a light threshold of 0.53%photosynthetically active radiation.A positive relationship between dark nitrification and apparent oxygen utilization suggests a dependence on substrate availability from primary ***,an increased NH_(4)^(+) supply can act as a buffer against photo-inhibitory ***,substrate affinity(α)increases with depth and transitions from light to dark,decreases with increasing ambient NH_(4)^(+)and exhibits a latitudinal distribution,reflecting substrate utilization *** also reveal that upwelling in Circumpolar Deep Water(CDW)stimulates nitrification through the introduction of potentially higher iron and deep diverse nitrifying microorganisms with higherα.We conclude that although light is the primary limiting factor for nitrification in summer,coupling between substrate availability and CDW upwelling can overcome this limitation,thereby alleviating photoinhibition by up to 45%±5.3%.

关键词： nitrification light inhibition substrate affinity circumpolar deep water(CDW)upwelling the Southern Ocean

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An advanced 2D/3D g-C_(3)N_(4)/TiO_(2)@MnO_(2) multifunctional membrane for sunlight-driven sustainable water purification

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Nano Research 2024年第4期17卷 2368-2380页

作者： fan Yu Chunjia Luo Xiaohan Niu min Chao Pengfei Zhang Luke Yan Polymer Materials&Engineering Department School of Materials Science&EngineeringChang’an UniversityXi’an 710064China Key Laboratory of Road Construction Technology and Equipment MOEChang’an UniversityXi’an 710064China School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an 710064China

Graphitic carbon nitride(g-C_(3)N_(4))nanosheets have attracted widespread interest in the construction of advanced separation ***,dense stacking and a single functionality have limited the membrane ***,an advanced two-/three-dimensional(2D/3D)g-C_(3)N_(4)/TiO_(2)@MnO_(2) membrane is constructed by intercalating 3D TiO_(2)@MnO_(2) nanostructures into g-C_(3)N_(4) *** 3D flower-like nanostructures broaden the transport channels of the composite *** membrane can effectively separate five oil-in-water(O/W)emulsions,with a maximum flux of 3265.67±15.01 L·m^(-2)·h^(-1)·bar^(-1) and a maximum efficiency of 99.69%±0.45%for toluene-in-water emulsion(T/W).Meanwhile,the TiO_(2)@MnO_(2) acts as an excellent electron acceptor and provides positive spatial separation of electrons–holes(e^(-)–h^(+)).The formation of 2D/3D heterojunctions allows the material with wider light absorption and smaller bandgap(2.10 eV).These photoelectric properties give the membrane good degradation of three different pollutants,with about 100%degradation for methylene blue(MB)and malachite green(MG).The photocatalytic antibacterial efficiency of the membrane is also about 100%.After cyclic experiment,the membrane maintains its original separation and photocatalytic *** remarkable multifunctional and self-cleaning properties of the g-C_(3)N_(4) based membrane represent its potential value for complex wastewater treatment.

关键词： graphitic carbon nitride(g-C_(3)N_(4))based membrane three-dimensional(3D)nanostructures self-cleaning multifunction

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Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high-and low-incidence areas

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Cancer Biology & Medicine 2017年第1期14卷 60-65页

作者： Lian-Qun Zhang Xin Song Xue-Ke Zhao Jia Huang Peng Zhang Lu-Wen Wang Hui Meng Jian-Wei Ku Guo-Qiang Kong Tao Jiang Xin-min Li Xiao-Long Lv Teng Ma Guo Yuan min-Jie Wu Shou-Jia Hu Shuang Lv Tang-Juan Zhang Ling-Fen Ji zong-min fan Neng-Chao Wang Yao-Wen Zhang Fu-You Zhou Li-Dong Wang Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052China Anyang Tumor Hospital Anyang 455000China Cancer Research Center Xinxiang Medical UniversityXinxiang 453003China

Objective: This study aimed to determine if gastric cardia adenocarcinoma(GCA) risk was associated with the lys(A or *2) allele at the rs671(glu504lys) polymorphism within the aldehyde dehydrogenase 2(ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma(ESCC).Methods: We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and lowincidence areas for both GCA and ESCC in China. Taq Man allele discrimination assay was used to genotype the rs671 polymorphism. χ~2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA,and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different ***: Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population(P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in highincidence areas for both GCA and ESCC was lower than that in low-incidence areas(P<0.001).Conclusions: Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China.

关键词： Gastric cardia adenocarcinoma rs671 ALDH2

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