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Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children

Current Medical Science 2018年第4期38卷 640-647页

作者： Yu-xia TAN Hui WANG Hua LV Pei-pei LIU Shun-gang XIA Yu WANG Gao-yan WANG Ya GUO Ye-dan LIU cheng-qing YANG Li-ping chen zong-bo chen Department of Pediatrics the Affiliated Hospital of Qingdao University Qingdao 266000 China Department of Pediatrics Zibo Maternal and Child Health Hospital Zibo 255029 China Department of Clinical Laboratory the Affiliated Hospital of Qingdao University Qingdao 266003 China

This study aimed to assess the relationship of OAS2 rs739901 5＇-flanking C/A polymorphisms with the susceptibility to Enterovirus-71 （EV71） infection. We investigated 294 hand-foot-mouth disease （HFMD） Chinese children with EV71 infection （165 mild cases and 129 encephalitis cases）. The improved multiplex ligation detection reaction （iMLDR） technique was used to test the genotypes. In EV71-infected patients, the CA genotype distribution （P=0.007）, A allele frequency （OR 1.32, 95% CI 1.0-1.7, P=0.034） and CA＋AA carriage frequency （P=0.003） of OAS2 rs739901 5＇-flanking were obviously elevated as compared with controls, but there were no statistically significant differences between mild cases and encephalitis cases. In EV71-infected patients, the counts of white blood cells （P=0.034） and blood glucose concentrations （P=0.042） were raised in A carriers （CA＋AA）. Among different genotypes of encephalitis cases, the contents of cerebrospinal fluid （CSF） showed no significant differences. IFN-7 levels in EV71-infected patients were higher than those in controls （mild group vs. control group, P〈0.01; encephalitis group vs. control group, P〈0.001）. In encephalitis cases, IFN-7 levels were reduced （P〈0.05） in A carriers compared to CC genotype, however, there were no significant differences between genotypes CA and AA （ P=0.226）. These findings suggest that OAS2 rs739901 5＇-flanking C/A genetic polymorphisms involve the susceptibility to EV71 infection, and A allele might be a risk factor of the susceptibility to EV-71 infection.

关键词： enterovirus-71 infection OAS2 rs739901 C/A polymorphism

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Building the toolbox for in vivo glia-to-neuron reprogramming

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Neural Regeneration Research 2024年第6期19卷 1171-1172页

作者： Ye Xie bo chen Departments of Ophthalmology and Neuroscience Icahn School of Medicine at Mount Sinai

Unlike regenerative-competent species that possess a remarkable intrinsic capacity to replenish lost neurons and restore neurocircuits spontaneously, the central nervous system in adult mammals lacks the ability to compensate for the neuronal loss caused by neurodegenerative diseases or traumatic injuries resulting in permanent loss of functionality. Inspired by earlier discoveries that radial glia or astrocytes isolated from the postnatal cortex can generate neurons,

关键词： CONVERSION DISEASE

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Intersection theory rules symbology

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 93-104页

作者： Jiaqi chen bo Feng Lilin Yang Beijing Computational Science Research Center Beijing 100084China Zhejiang Institute of Modern Physics School of PhysicsZhejiang UniversityHangzhou 310027China Peng Huanwu Center for Fundamental Theory Hefei 230026China

We propose a novel method to determine the structure of symbols for any family of polylogarithmic Feynman integrals.Using the d log-bases and simple formulas for the leading order and next-to-leading contributions to the intersection numbers,we give a streamlined procedure to compute the entries in the coefficient matrices of canonical differential equations,including the symbol letters and the rational coefficients.We also provide a selection rule to decide whether a given matrix element must be zero.The symbol letters are deeply related to the poles of the integrands and also have interesting connections to the geometry of Newton polytopes.Our method can be applied to many cutting-edge multi-loop calculations.The simplicity of our results also hints at the possible underlying structure in perturbative quantum field theories.

关键词： scattering amplitude Feynman integral symbology

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When smoke meets gut:deciphering the interactions between tobacco smoking and gut microbiota in disease development

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Science China(Life Sciences) 2024年第5期67卷 854-864页

作者： bo chen Guangyi Zeng Lulu Sun Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third HospitalBeijing 100191China Department of Physiology and Pathophysiology School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Women’s Reproductive Health and Fertility Promotion Peking UniversityBeijing 100191China Department of Endocrinology and Metabolism Peking University Third HospitalBeijing 100191China

Tobacco smoking is a prevalent and detrimental habit practiced worldwide,increasing the risk of various diseases,including chronic obstructive pulmonary disease(COPD),cardiovascular disease,liver disease,and cancer.Although previous research has explored the detrimental health effects of tobacco smoking,recent studies suggest that gut microbiota dysbiosis may play a critical role in these outcomes.Numerous tobacco smoke components,such as nicotine,are found in the gastrointestinal tract and interact with gut microbiota,leading to lasting impacts on host health and diseases.This review delves into the ways tobacco smoking and its various constituents influence gut microbiota composition and functionality.We also summarize recent advancements in understanding how tobacco smoking-induced gut microbiota dysbiosis affects host health.Furthermore,this review introduces a novel perspective on how changes in gut microbiota following smoking cessation may contribute to withdrawal syndrome and the degree of health improvements in smokers.

关键词： tobacco smoking gut microbiota dysbiosis nicotine smoking cessation

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Finite-time tracking control of heterogeneous multi-AUV systems with partial measurements and intermittent communication

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Science China(Information Sciences) 2024年第5期67卷 165-182页

作者： bo chen Jiangping HU Bijoy Kumar GHOSH School of Automation Engineering University of Electronic Science and Technology of China Key Laboratory of Intelligent Analysis and Decision on Complex Systems Chongqing University of Posts and Telecommunications Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Department of Mathematics and Statistics Texas Tech University

The development of a distributed trajectory-tracking control strategy that is independent of velocity measurements is critical to achieving finite-time tracking control of autonomous underwater vehicle(AUV) systems. In this study, a group of heterogeneous AUV systems with intermittent communication links is considered and a finite-time trajectory-tracking control strategy is developed. The strategy includes two observers and one controller proposed for each follower-AUV. The first observer, a hybrid finite-time observer,estimates the state of the leader, whereas the second observer, which relies only on the position measurement,is proposed to estimate the states of the follower-AUV itself. In addition, a distributed trajectory-tracking controller is designed using the states estimated by the intermittent communication network even without velocity measurements. A homogeneous technique is utilized to prove that all followers can track the leader in a finite time. Finally, the effectiveness of the developed finite-time tracking control strategy is illustrated by numerical simulations.

关键词： distributed observer finite-time tracking homogeneous technique intermittent communication multiple heterogeneous AUVs

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A Random Fusion of Mix 3D and Polar Mix to Improve Semantic Segmentation Performance in 3D Lidar Point Cloud

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 845-862页

作者： bo Liu Li Feng Yufeng chen School of Computer Science and Engineering Macao University of Science and TechnologyMacao999078China School of Computer Science and Artificial Intelligence Chaohu UniversityChaohu238000China Institute of Vehicle Information Control and Network Technology Hubei University of Automotive TechnologyShiyan442002China

This paper focuses on the effective utilization of data augmentation techniques for 3Dlidar point clouds to enhance the performance of neural network models.These point clouds,which represent spatial information through a collection of 3D coordinates,have found wide-ranging applications.Data augmentation has emerged as a potent solution to the challenges posed by limited labeled data and the need to enhance model generalization capabilities.Much of the existing research is devoted to crafting novel data augmentation methods specifically for 3D lidar point clouds.However,there has been a lack of focus on making the most of the numerous existing augmentation techniques.Addressing this deficiency,this research investigates the possibility of combining two fundamental data augmentation strategies.The paper introduces PolarMix andMix3D,two commonly employed augmentation techniques,and presents a new approach,named RandomFusion.Instead of using a fixed or predetermined combination of augmentation methods,RandomFusion randomly chooses one method from a pool of options for each instance or sample.This innovative data augmentation technique randomly augments each point in the point cloud with either PolarMix or Mix3D.The crux of this strategy is the random choice between PolarMix and Mix3Dfor the augmentation of each point within the point cloud data set.The results of the experiments conducted validate the efficacy of the RandomFusion strategy in enhancing the performance of neural network models for 3D lidar point cloud semantic segmentation tasks.This is achieved without compromising computational efficiency.By examining the potential of merging different augmentation techniques,the research contributes significantly to a more comprehensive understanding of how to utilize existing augmentation methods for 3D lidar point clouds.RandomFusion data augmentation technique offers a simple yet effective method to leverage the diversity of augmentation techniques and boost the robustness of models.The insights gained from this

关键词： 3D lidar point cloud data augmentation RandomFusion semantic segmentation

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Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 289-306页

作者： chen Qiu Yu-Kai Xiang Xuan-bo Da Hong-Lei Zhang Xiang-Yu Kong Nian-zong Hou cheng Zhang Fu-Zhou Tian Yu-Long Yang Center of Gallbladder Disease Shanghai East HospitalInstitute of Gallstone DiseaseSchool of MedicineTongji UniversityShanghai 200092China General Surgery Center Chengdu Military General HospitalChengdu 610083Sichuan ProvinceChina

BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface barrier.Notably,these enzymes play a significant role in the development of diverse tumors.AIM To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression Omnibus.The study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and PLA2G12B.Gene Set Enrichment Analysis was utilized to pinpoint associated pathways.Moreover,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was evaluated.RESULTS PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy individuals.Elevated expression of PLA2G2A was correlated with poorer overall survival in CCA patients.Additionally,the study delineated pathways and miRNAs associated with these genes.CONCLUSION Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for CCA.The increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.

关键词： PLA2G2A PLA2G12B Diagnostic Prognostic biomarkers cholangiocarcinoma

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The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

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Neural Regeneration Research 2024年第1期19卷 22-28页

作者： Caiyun Liu Haixin Yu Zhengchao Li Shulian chen Xiaoyin Li Xuyi chen bo chen School of Acupuncture&Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupucture Science Tianjin University of Traditional Chinese MedicineTianjinChina Characteristic Medical Center of Chinese People’s Armed Police Force TianjinChina Binhai New Area Hospital of TCM TianjinChina Fourth Teaching Hospital of Tianjin University of TCM TianjinChina

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury.However,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord injury.Artificial hibernation is a futureoriented disruptive technology for human life support.It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold stimulation.Thus,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology.This review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation technology.It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection.These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central protection.It also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine systems.This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation.At present,artificial hibernation technology is not mature,and research fa ces various challenges.Neve rtheless,the effort is wo rthwhile for the future development of medicine.

关键词： artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor

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Left bundle branch area pacing combined with implantable cardioverter-defibrillator treatment for heart failure after myocardial infarction

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Journal of Geriatric Cardiology 2024年第5期21卷 577-582页

作者： Bing-chen GUO Jian XU Yan-zong LIU Guo-Qing DU bo YU Shu-Feng LI Wen-Juan DU Department of Cardiology the 2nd Affiliated Hospital of Harbin Medical UniversityHarbinChina The Key Laboratory of Myocardial Ischemia Chinese Ministry of EducationHarbinChina Department of Ultrasonography Guangdong Provincial People's HospitalGuangzhouGuangdongChina

Left bundle branch area pacing(LBBAP)has emerged as a new physiological pa-cing mode.Previous studies have confir-med the feasibility and efficacy of LBBAP for cardi-ac resynchronization therapy(CRT)in heart failure(HF)patients with left bundle branch block(LBBB)and a narrower QRS duration(QRSd)to have a higher percentage of super responders,and lower pacing thresholds than biventricular pacing(BiVP).

关键词： pacing branch bundle

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A resonant high-pressure microsensor based on a composite pressure-sensitive mechanism of diaphragm bending and volume compression

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Microsystems & Nanoengineering 2024年第2期10卷 57-66页

作者： Pan Qian zongze Yu Jie Yu Yulan Lu bo Xie Jian chen Deyong chen Junbo Wang The State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing100190China The School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing100049China

In this paper,a composite pressure-sensitive mechanism combining diaphragm bending and volume compression was developed for resonant pressure microsensors to achieve high-pressure measurements with excellent accuracy.The composite mechanism was explained,and the sensor structure was designed based on theoretical analysis and finite element simulation.An all-silicon resonant high-pressure microsensor with multiple miniaturized cavities and dual resonators was developed,where dual resonators positioned in two resonant cavities with suitably different widths are used to perform opposite characteristics in pressure and the same characteristics at different temperatures,which can improve pressure sensitivities and realize temperature self-compensation by differential frequency output.The microsensor was fabricated by microfabrication,and the experimental results showed that the sensor had an accuracy of±0.015%full scale(FS)in a pressure range of 0.1~100 MPa and a temperature range of−10~50℃.The pressure sensitivity of the differential frequency was 261.10 Hz/MPa(~2523 ppm/MPa)at a temperature of 20℃,and the temperature sensitivities of the dual resonators were−1.54 Hz/℃(~−14.5 ppm/℃)and−1.57 Hz/℃(~−15.6 ppm/℃)at a pressure of 2 MPa.The differential output had an outstanding stability within±0.02 Hz under constant temperature and pressure.Thus,this research provides a convenient solution for high-pressure measurements because of its advantages,namely,large range,excellent accuracy and stability.

关键词： stability. resonant bending

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