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World Journal of Clinical Cases 2022年第13期10卷 4131-4136页

作者： Ting-Ting Dan Tai-Xiang liu Yi-Lu liao zong-ze li Department of Ophthalmology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND Diffuse lamellar keratitis(DLK)is a complication of laser-assisted in situ keratomileusis(LASIK).This condition can also develop after small-incision lenticule extraction(SMILE)with a distinctive *** report the case involving a female patient with delayed onset DLK accompanied by immunoglobulin A(IgA)*** SUMMARY A 22-year-old woman was referred to our department for DLK and a decline in vision 1 mo after undergoing *** initial examination showed grade 2 DLK in the flap involving the central visual axis of the right *** was immediately administered with a large dose of a topical steroid for 30 ***,the treatment was *** vision deteriorated from 10/20 to 6/20,and DLK gradually worsened from grade 2 to ***,interface washout was performed,after which her vision *** completely disappeared 2 mo after *** months after SMILE,the patient was diagnosed with IgA nephropathy due to a 4-year history of interstitial *** DLK is a typical complication of LASIK but can also develop after *** steroid therapy was ineffective in our patient,and interface washout was *** nephropathy could be one of the factors contributing to the development of delayed DLK after SMILE.

关键词： Diffuse lamellar keratitis Small-incision lenticule extraction Immunoglobulin A nephropathy Laser-assisted in situ keratomileusis Case report

Non-invasive detection of pancreatic cancer by measuring DNA methylation of Basonuclin 1 and Septin 9 in plasma

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Chinese Medical Journal 2019年第12期132卷 1504-1506页

作者： Xiao-Bin li Jun Ma Zi-Wen liu Wen-Fei He zong-ze li Ming Cui Huang Hao Guang-Peng Zhou Lei You James Wang Xiao-liang Han Yu-Pei Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100730China BioChain (Beijing) Science & Technology Inc. Beijing 102600China

Pancreatic cancer (PC), a deadly malignancy with an overall 5-year survival rate of 5% to 15%, is ranked as the seventh leading cause of cancer death in the world in spite of its low occurrence rate.[1,2] Early detection appears to be the most effective approach to improve the overall survival of patients with PC. However, the difficulty in early detection of PC is a lack of specific symptoms and reliable biomarkers. Currently, carbohydrate antigen 19-9 (CA 19-9) is a serum biomarker that is widely used in PC detection. However, 10% of patients with PC cannot produce CA 19-9 and serum CA 19-9 is frequently absent in patients with early-stage cancer. Furthermore, CA 19-9 is often found to be elevated in benign conditions or in other cancers, making its utility limited. Therefore, it is important to identify new diagnostic biomarkers to improve PC detection.

关键词： Non-invasive detection pancreatic cancer measuring DNA methylation

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胰腺癌细胞内吉西他滨耐药机制的研究进展

世界华人消化杂志 2020年第22期28卷 1150-1161页

作者：顾宗廷李宗泽王成锋国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室/胰胃外科北京市100021

胰腺癌是人类最具致命的恶性肿瘤之一,其中胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)是最常见的组织学类型.由于PDAC早期缺乏特异的临床症状、体征及有效的筛查标志物,仅15%-20%的患者具备手术切除条件.因此,以吉西他滨(gem... 详细信息

胰腺癌是人类最具致命的恶性肿瘤之一,其中胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)是最常见的组织学类型.由于PDAC早期缺乏特异的临床症状、体征及有效的筛查标志物,仅15%-20%的患者具备手术切除条件.因此,以吉西他滨(gemcitabine,GEM)为基础的单药或联合化疗仍是目前最主要甚或唯一的治疗方案.然而,PDAC对GEM的总反应率不足20%,对GEM耐药是影响化疗疗效的最重要原因之一.目前GEM耐药的机制并不明确,可能涉及先天性和获得性两个方面,PDAC的异质性则进一步增加了其复杂性.然而,细胞内信号通路调控是实现GEM抵抗的最终途径.本文将重点对GEM在PDAC细胞内的代谢和信号通路调控的研究进展进行综述,讨论潜在的GEM化疗增敏策略,以期提高化疗有效率,改善PDAC的总体预后.

关键词：胰腺癌胰腺导管腺癌吉西他滨代谢化疗耐药

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胰腺癌细胞外吉西他滨耐药机制的研究进展

世界华人消化杂志 2021年第8期29卷 421-434页

胰腺癌是预后最差的实体恶性肿瘤,其中约90%是胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC).尽管手术切除是唯一可能治愈PDAC的手段,但术后总体生存率不容乐观.因此,以吉西他滨(gemcitabine,GEM)为基础的化疗仍是PDAC最重要的... 详细信息

胰腺癌是预后最差的实体恶性肿瘤,其中约90%是胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC).尽管手术切除是唯一可能治愈PDAC的手段,但术后总体生存率不容乐观.因此,以吉西他滨(gemcitabine,GEM)为基础的化疗仍是PDAC最重要的治疗选择之一.然而,GEM单药治疗晚期PDAC的生存期改善十分有限,其关键原因在于GEM耐药.GEM耐药的机制复杂且不明确.肿瘤微环境(tumor microenvironment,TME)中广泛而致密的纤维间质是PDAC的重要特征.越来越多的证据显示,纤维化TME不仅是肿瘤生长、扩散的积极参与者,更是诱导GEM耐药的贡献者.本文将重点从PDAC细胞外途径对GEM化疗耐药的主要细胞和分子机制研究进展进行综述,讨论潜在的GEM化疗增敏策略,以期提高化疗有效率,改善PDAC的总体预后.

关键词：胰腺癌胰腺导管腺癌吉西他滨肿瘤微环境化疗耐药

Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis

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World Journal of Gastroenterology 2025年第2期31卷 13-26页

作者： ze-Long Zheng Qing-Fan Zheng li-Qiang Wang Yi liu Department of Gastroenterology(Endoscopy Center) China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human *** adequate bowel preparation can improve the results of colonoscopy,it may interfere with the gut *** preparation for colonoscopy can lead to transient changes in the gut microbiota,potentially affecting an individual’s health,especially in vulnerable populations,such as patients with inflammatory bowel ***,measures such as oral pro-biotics may ameliorate these adverse *** focused on the bowel prepa-ration-induced changes in the gut microbiota and host health status,hypothesized the factors influencing these changes,and attempted to identify measures that may reduce dysbiosis,thereby providing more information for individualized bowel preparation for colonoscopy in the future.

关键词： Bowel preparation Colonoscopy Microbiota Inflammatory bowel disease Probiotics

小鼠CD45^-/CD31^+肺侧群细胞诱导分化的研究

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中国现代医学杂志 2017年第6期27卷 17-22页

作者：张明杰李宗泽徐杨梁迅锦州医科大学生物化学与分子生物学教研室辽宁锦州121000

目的探讨在体外诱导分化肺侧群细胞(SP)的特性。方法取小鼠肺组织,流式细胞术分选小鼠白细胞分化抗原(CD)45^-/CD31^+肺SP;免疫荧光检测分选肺SP三磷酸腺苷结合转运蛋白G超家族成员2(ABCG2)的表达;逆转录聚合酶链反应(RT-PCR)检测肺SP中... 详细信息

目的探讨在体外诱导分化肺侧群细胞(SP)的特性。方法取小鼠肺组织,流式细胞术分选小鼠白细胞分化抗原(CD)45^-/CD31^+肺SP;免疫荧光检测分选肺SP三磷酸腺苷结合转运蛋白G超家族成员2(ABCG2)的表达;逆转录聚合酶链反应(RT-PCR)检测肺SP中ABCG2、酪氨酸激酶2(Tie2)及血管性血友病因子(vWF)的表达。细胞体外分化诱导14 d后,免疫荧光检测细胞vWF的表达;RT-PCR检测分化诱导前后细胞中ABCG2和vWF的表达。结果流式细胞术成功分选出CD45^-/CD31^+肺SP细胞,免疫荧光检测其表达ABCG2;RT-PCR检测SP表达ABCG2和Tie2,不表达vWF。主群细胞表达vWF;分化诱导前的肺SP表达ABCG2;分化诱导后的肺SP表达vWF。结论 CD45^-/CD31^+肺SP是血管内皮细胞的祖细胞,具有干细胞分化特性。在体外培养可分化为血管内皮细胞。

关键词：侧群细胞血管内皮细胞三磷酸腺苷结合转运蛋白G超家族成员2 ATP-binding cassette sub-family G member 2

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预应力混凝土斜拉桥施工控制新进展

同济大学学报（自然科学版） 2001年第1期29卷 99-103页

作者：陈德伟许俊周宗泽李国志同济大学桥梁工程系上海200092

在预应力混凝土斜拉桥的施工中几何线形和结构内力的控制非常重要 ,据此介绍近年来我国在这一方面的新进展 ,应用现代工程控制理论中自适应控制的思想形成控制系统 ,其中主要在结构参数辨识和现浇主梁底模标高的实时修正等关键技术上有... 详细信息

在预应力混凝土斜拉桥的施工中几何线形和结构内力的控制非常重要 ,据此介绍近年来我国在这一方面的新进展 ,应用现代工程控制理论中自适应控制的思想形成控制系统 ,其中主要在结构参数辨识和现浇主梁底模标高的实时修正等关键技术上有了突破 ,并经过几座大跨预应力混凝土斜拉桥的实践取得了成功的经验 .

关键词：拉索力预应力混凝土斜拉桥施工控制几何线形结构内力自适应施工控制参数识别

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-ze li Wen-li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第01期 118-133页

作者： ze-Le Chen Qiang-Qiang li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

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Structural refinement of 00Cr13Ni5Mo2 supermartensitic stainless steel during single-stage intercritical tempering

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International Journal of Minerals,Metallurgy and Materials 2014年第3期21卷 279-288页

作者： Da-kun Xu Yong-chang liu zong-qing Ma Hui-jun li ze-sheng Yan State Key Laboratory of Hydraulic Engineering Simulation and Safety School of Material Science and Engineering Tianjin University

The 00Cr13Ni5Mo2 supermartensitic stainless steel was first tempered at 570-730°C for 2 h to observe the microstructure and hardness changes. The tempering temperature was set to 600, 650, and 700°C, which is below, equal to, and above the austenite transformation start temperature, respectively, for each holding period to investigate the effects of tempering time on the structure and properties of the steel. The microstructure of the specimens was examined by optical microscopy and transmission electronic microscopy, and the phase composition was detected by X-ray diffraction. As expected, lath refinement was observed in the steel tempered at 700°C, and the refinement degree significantly depended on the tempering time. Contrary to normal steel softening by tempering, the hardness performance of the steel was significantly enhanced primarily because of the refinement of martensite laths after single-stage intercritical tempering. It is believed that the reverse transformation of martensite（α′） to austenite（γ） is responsible for the refinement.

关键词： stainless steel tempering retained austenite phase transitions