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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Planning and construction of Xiong’an New Area(city of over 5 million people):Contributions of China’s geologists and urban geology

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China Geology 2024年第3期7卷 382-408页

作者： Bo han Zhen Ma Liang-jun Lin Hong-wei Liu Yi-hang Gao Yu-bo Xia Hai-tao Li Xu Guo Feng Ma Yu-shan Wang Ya-long Zhou Hong-qiang Li Tianjin Center China Geological Survey(North China Center of Geoscience Innovation)Ministry of Natural ResourcesTianjin 300170China Xiong’an Urban Geological Research Center China Geological SurveyMinistry of Natural ResourcesTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China China Institute of Geo-Environment Monitoring Beijing 100081China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Center for Hydrogeology and Environmental Geology China Geological SurveyMinistry of Natural ResourcesBaoding 071051China Institute of Geophysical&Geochemical Exploration Chinese Academy of Geological SciencesLangfang 065000China Chinese Academy of Geological Sciences Beijing 10037China

China established Xiong’an New Area in Hebei Province in 2017,which is planned to accommodate about 5 million people,aiming to relieve Beijing City of the functions non-essential to its role as China’s capital and to expedite the coordinated development of the Beijing-Tianjin-Hebei *** 2017 to 2021,the China Geological Survey(CGS)took the lead in multi-factor urban geological surveys involving space,resources,environments,and disasters according to the general requirements of“global vision,international standards,distinctive Chinese features,and future-oriented goals”in Xiong’an New Area,identifying the engineering geologic conditions and geologic environmental challenges of this *** achievements also include a 3D engineering geological structure model for the whole area,along with“one city proper and five clusters”,insights into the ecology and the background endowment of natural resources like land,geothermal resources,groundwater,and wetland of the area before engineering construction,a comprehensive monitoring network of resources and environments in the area,and the“Transparent Xiong’an”geological information platform that is open,shared,dynamically updated,and three-dimensionally ***’s geologists and urban geology have played a significant role in the urban planning and construction of Xiong’an New Area,providing whole-process geological solutions for urban planning,construction,operation and *** future urban construction of Xiong’an New Area will necessitate the theoretical and technical support of earth system science(ESS)from various aspects,and the purpose is to enhance the resilience of the new type of city and to provide support for the green,low-carbon,and sustainable development of this area.

关键词： Low Carbon New City Planning and construction Land Geothermal resources Groundwater Wetland Underground space Geologic disasters Site stability Natural resource Ecosystem Geological safety Transparent Xiong’an Resilient city Xiong’an New Area

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Cellular metabolism: A key player in cancer ferroptosis

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Cancer Communications 2024年第2期44卷 185-204页

作者： Xianjie Jiang Qiu Peng Mingjing Peng Linda Oyang Honghan Wang qiang Liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Public Service Platform of Tumor Organoids Technology ChangshaHunanP.R.China Department of Head and Neck Surgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Hengyang Medical School University of South ChinaHengyangHunanP.R.China

Cellular metabolism is the fundamental process by which cells maintain growth and *** produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular *** metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell *** is a recently discovered form of iron-dependent programmed cell *** inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor ***,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well ***,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this ***,we provided a detailed overview of agents used to induce cancer *** explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell *** combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.

关键词： cancer therapy cellular metabolism ferroptosis inducer ferroptosis

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新发展格局下沿边地区高质量开发开放的绩效评价与路径选择

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经济问题探索 2024年第3期 51-64页

作者：霍强韩博李龙中共云南省委党校经济学教研部昆明650111 云南省社会科学院经济研究所昆明650034 云南省发展和改革委员会社会发展处昆明650041

沿边地区是中国与周边国家推进“一带一路”倡议和周边命运共同体建设的重要支点,本文通过构建沿边省份参与国内大循环指数、链接国内国际双循环指数,运用2007—2020年数据对各沿边省份高质量开发开放进行绩效评价,结果表明:各沿边省份... 详细信息

沿边地区是中国与周边国家推进“一带一路”倡议和周边命运共同体建设的重要支点,本文通过构建沿边省份参与国内大循环指数、链接国内国际双循环指数,运用2007—2020年数据对各沿边省份高质量开发开放进行绩效评价,结果表明:各沿边省份参与国内大循环指数和高质量开发开放综合指数明显上升,国内大循环的主体效应已经显现;各沿边省份链接国内国际双循环指数则呈现分异特征,受到周边国家影响较为明显,西南沿边地区表现较好,西北沿边地区基本平稳,东北和北方沿边地区有所波动下降。新发展格局下应优化沿边地区高质量开发开放的路径选择,促进单一模式与多元模式的接续转换,发挥对内开发与对外开放的联动潜能,挖掘资源禀赋与科技创新的乘数效应,实现政策引导与市场主导的高效耦合,推进顶层设计与地方探索的协同一体。

关键词：新发展格局沿边地区高质量开发开放

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技术进步与就业增长并存?——基于专精特新“小巨人”企业认定政策的研究

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科学学研究 2024年第10期42卷 2055-2066,2129页

作者：韩洪灵彭瑶刘强浙江大学管理学院浙江杭州310058 浙江大学经济学院浙江杭州310058

技术创新与就业稳定对于我国经济高质量发展具有重要意义,但技术进步不可避免地会引起对潜在就业问题的担忧。以专精特新“小巨人”企业认定政策为切入点,对2015-2022年沪深A股上市公司开展准自然实验,利用双重差分法考察该政策影响企... 详细信息

技术创新与就业稳定对于我国经济高质量发展具有重要意义,但技术进步不可避免地会引起对潜在就业问题的担忧。以专精特新“小巨人”企业认定政策为切入点,对2015-2022年沪深A股上市公司开展准自然实验,利用双重差分法考察该政策影响企业劳动雇佣的效应与机理。研究发现:(1)“小巨人”认定显著增加了企业劳动雇佣规模,且结果稳健;(2)该效应在民营企业、“小巨人”企业密度更高的关键行业、竞争更激烈的行业、区域创新水平更低的地区更显著;(3)“小巨人”认定通过提高税收优惠程度、增加银行贷款、降低融资约束促进了企业劳动雇佣规模的提升;(4)“小巨人”认定通过增加企业劳动雇佣促进了企业人力资本结构优化升级与高质量发展。研究结论表明,专精特新“小巨人”的认定培育是推动企业创新与技术进步、实现就业增长的有效举措,对优化中小企业培育政策、实现稳就业保民生具有启示意义。

关键词：专精特新 “小巨人”企业企业劳动雇佣稳就业

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基于位移放大型变刚度自复位阻尼器的滞回性能研究

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建筑结构学报 2024年第8期45卷 180-191页

作者：董慧慧杨智乐杜修力韩强北京工业大学桥梁工程安全与韧性全国重点实验室北京100124

为解决传统阻尼器屈服后刚度和强度不足的问题,基于分阶段抗震设计理念,研发一种基于位移放大型变刚度自复位阻尼器(self-centering dampers based on variable stiffness and displacement amplification,SDVD),能够兼顾结构在不同变... 详细信息

为解决传统阻尼器屈服后刚度和强度不足的问题,基于分阶段抗震设计理念,研发一种基于位移放大型变刚度自复位阻尼器(self-centering dampers based on variable stiffness and displacement amplification,SDVD),能够兼顾结构在不同变形阶段的刚度和承载力需求。该阻尼器主要由子模块初始刚度模块(initial stiffness module,ISM)和变刚度模块(variable stiffness module,VSM)组成,基于阻尼器的构造,分析其子模块及整个阻尼器的工作机理;以ISM和VSM的长度和宽度为参数,设计并制作模块ISM和VSM及SDVD整体的模型试件,通过拟静力试验研究子模块及整个阻尼器的滞回性能;通过有限元模型(finite element model,FEM)研究阻尼器滞回性能的参数影响规律。研究结果表明:该阻尼器表现出拉压对称的旗帜形滞回特性,同时具有位移放大效应和变刚度特性;通过对比分析,由有限元分析得到的阻尼器滞回曲线与拟静力试验结果吻合较好;SDVD的初始刚度和强度主要由ISM提供,并且随着ISM丝束长度的减小而增加;SDVD的屈服后刚度和承载力主要由VSM提供,且随着VSM挡杆宽度的减小而增加。

关键词：自复位阻尼器分阶段抗震拟静力试验位移放大效应变刚度特性滞回性能

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新型自复位变摩擦耗能支撑及其在桥墩抗震中的应用

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中国公路学报 2024年第1期37卷 66-80页

作者：董慧慧胡潇韩强杜修力北京工业大学城市与工程安全减灾教育部重点实验室北京100124 北京工业大学城市建设学部北京100124

为了减小传统摩擦耗能支撑在强震作用下的残余变形,提出一种基于形状记忆合金(SMA)板材的新型装配式自复位变摩擦耗能支撑(S-SCFB),该支撑主要包括SMA板圆环自复位系统和摩擦耗能系统。首先阐述了新型支撑的基本构造,揭示了其工作机理... 详细信息

为了减小传统摩擦耗能支撑在强震作用下的残余变形,提出一种基于形状记忆合金(SMA)板材的新型装配式自复位变摩擦耗能支撑(S-SCFB),该支撑主要包括SMA板圆环自复位系统和摩擦耗能系统。首先阐述了新型支撑的基本构造,揭示了其工作机理和自复位原理;通过开展SMA板材的材性试验研究了其力学性能,基于SMA板材的力学性能和支撑的工作机理,建立了新型支撑的简化分析模型;然后基于ABAQUS有限元软件建立了新型支撑的精细化实体有限元模型,将数值模拟结果与简化分析模型进行了对比分析,系统地研究了新型支撑的滞回性能及影响规律,同时在OpenSees软件中2次开发了新型支撑的恢复力模型;最后,基于新型支撑优良的滞回性能,将其应用到双柱式桥墩中提升桥墩的抗震韧性。研究结果表明:SMA板材本构模型呈“旗帜”型,具有承载力高,变形能力强,自恢复能力良好等优点;基于SMA板材装配的S-SCFB具有稳定的耗能能力和优良的自复位功能,卸载后无残余变形,同时建立的简化分析模型与数值模拟结果吻合较好;通过调整S-SCFB的设计参数,可有效实现调节S-SCFB滞回性能的目的,具有良好的可调节性;附加S-SCFB可以有效提高桥墩的强度和刚度,降低结构的残余位移,有效提高桥墩结构的抗震性能。

关键词：桥梁工程抗震韧性材性试验数值模拟自复位变摩擦耗能支撑形状记忆合金(SMA)板材滞回性能

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Development of international guidelines by Tuina practitioners for specific acupoints of paediatrics Tuina(2022 version)

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1044-1051页

作者： LAN Xiaoxue SUN Yanan WENG Zhiwen WANG Yue ZhanG Ying LIANG Yuanwen GU Sirui ZHOU Rong CHEN Qianji JIA Baolin BO han WANG Fangying HE qiang ZhanG Jie TAN Jiang YE Xingzhu WANG Xiyou YU Changhe CHEN Hong Department of Tuina and Pain Management the First Clinical DepartmentBeijing University of Chinese Medicine Department of Traditional Chinese Medicine Xuanwu HospitalCapital Medical University Department of Tuina and Pain Management Dongzhimen Hospital of Beijing University of Chinese Medicine Department of Encephalopathy Beijing Huairou Hospital of Traditional Chinese Medicine Yungang Community Health Service Center China Aerospace Science & Industry Corporation of 731 Hospital Department of Pediatrics China-Japan Friendship Clinical SchoolBeijing University of Chinese Medicine Department of Pediatrics the Second Clinical Medical College of Beijing University of Chinese Medicine Shenzhen Luohu Hospital of Traditional Chinese Medicine Department of Chinese Medicine Raffles Medical Group Department of Traditional Chinese Medicine Beiing Children's HospitalCapital Medicine UniversityNational Center for Children's Health Anzhen Community Health Service Center L. Ac. Ancient Healing Center Frederick Department of Tuina and Pain Management Dongzhimen HospitalBeijing University of Chinese Medicine

OBJECTIVE: To establish a standardized framework encompassing the precise locations, manipulations,functions and indications of specific acupoints in the field of paediatric Tuina. METHODS: The development of consensus involved three distinct stages. Initially, a list of paediatric Tuina specific acupoints was compiled based on an extensive literature review, which was subsequently supplemented through expert interviews. In the second stage, the Delphi method was employed to assess the significance of acupoint locations, manipulations, functions, and indications. In situations where the questionnaire survey failed to yield agreement or when the experts held reservations, the nominal group approach was utilized during the expert consensus meeting. The final version of the technical standardized material was ultimately determined during an expert consensus conference. After undergoing external peer review and evaluation, the completed draft was prepared for public dissemination RESULTS: The comprehensive list identified a total of 66 specific acupoints. The location and manipulation questionnaire consisted of 156 items based on the literature database, while the function and indication questionnaire contained 116 items. Two rounds of Delphi surveys were conducted for the location and manipulation category, and another two rounds of Delphi surveys were conducted for the function and indication category. During the experts consensus meeting The panel of experts conducted in-depth discussions on 61 questions, resulting in the formulation of technical guidelines for the locations, manipulations, functions, and indications of 64 paediatric Tuina acupoints. Subsequently, the research team compiled and edited the draft of the technical guidelines for acupoints of paediatric Tuina, which was finalized after external review and feedback. CONCLUSION: This study successfully established the recognized technical standards for practitioners of paediatric Tuina, thereby standardizi

关键词： Child Delphi technique Tuina acupoint guideline international paediatrics

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Measurement of atmospheric non-reciprocity effects for satellite-based two-way time-frequency transfer

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Photonics Research 2024年第6期12卷 1274-1282页

作者： TING ZENG QI SHEN YUAN CAO JIAN-YU GUAN MENG-ZHE LIAN JIN-JIAN han LEI HOU JIAN LU XIN-XIN PENG MIN LI WEI-YUE LIU JIN-CAI WU YONG WANG JUAN YIN JI-GANG REN HAI-FENG JIANG qiang ZhanG CHENG-ZHI PENG JIAN-WEI PAN Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Shanghai Research Center for Quantum Science and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China Hefei National Laboratory University of Science and Technology of ChinaHefei 230094China Faculty of Information Science and Engineering Ningbo UniversityNingbo 315211China Key Laboratory of Space Active Opto-Electronic Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

Future optical clock networks will require high-precision optical time-frequency transfer between satellites and ground ***,due to atmospheric turbulence,satellite motion and time delay between the satellite–ground transmission links will cause spatial and temporal variations,respectively,resulting in the breakdown of the time-of-flight reciprocity on which optical two-way time-frequency transfer is ***,we experimentally simulate the atmospheric effects by two-way spatio-temporally separated links between two stationary terminals located 113 km apart and measure the effects for optical two-way time-frequency *** experiment shows that the effect on the link instability is less than 2.3×10^(−19) at 10,000 *** indicates that when the link instability of satellite-ground optical time-frequency transfer is on the order of 10^(−19),it is not necessary to consider the atmospheric non-reciprocity effects.

关键词： breakdown transfer satellite

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针刺巨量转移平台用高推力聚磁式直线电机

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光学精密工程 2024年第9期32卷 1347-1359页

作者：刘强马宁王伟韩邦成牛萍娟北京石油化工学院精密电磁装备与先进测量技术研究所北京102617 天津工业大学电子与信息工程学院天津300387 北京航空航天大学惯性技术重点实验室北京100191

针对针刺式巨量转移平台用无铁芯直线电机推力小,边缘效应明显导致转移速度慢的问题,提出一种高推力聚磁式直线电机,利用外层V字形结构抑制漏磁效应,通过双层Halbach结构提高气隙磁密,并采用有限元法对3种方案气隙磁密和漏磁磁通进行比... 详细信息

针对针刺式巨量转移平台用无铁芯直线电机推力小,边缘效应明显导致转移速度慢的问题,提出一种高推力聚磁式直线电机,利用外层V字形结构抑制漏磁效应,通过双层Halbach结构提高气隙磁密,并采用有限元法对3种方案气隙磁密和漏磁磁通进行比较分析。V形双层Halbach方案的气隙磁密和漏磁磁通分别为0.6 T和0.05 T,与单层梯形方案相比气隙磁密提高了17.6%,与双层Halbach方案相比漏磁磁通降低了71.4%。利用等效磁化电流法对电机磁场进行区域分割,采用分割补偿法建立矩形边界条件,建立了直线电机磁路数学模型,得到了影响电机推力线性度的关键结构参数,并基于有限元法对形状及结构参数进行优化。结果表明,优化后气隙的最大磁密和最小磁密分别0.67 T和0.47 T,x向和y向磁密变化率分别为25%和29.8%,推力仿真计算结果为278 N,推力波动率为2.1%,空载加速度为10 m/s^(2),理论芯片转移速度可达50颗/秒。根据优化结果研制了一台直线电机用于巨量转移平台,测试结果与优化结果一致,本研究对提高巨量转移平台转移效率具有重要意义。

关键词：直线电机针刺式巨量转移聚磁有限元法空间应用

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