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Type I interferon pathway in pediatric systemic lupus erythematosus

World Journal of Pediatrics 2024年第7期20卷 653-668页

作者： Yu Zhou Hong‑mei song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalBeijingChina

Background The role of type I interferon(IFN-I)signaling in systemic lupus erythematosus(SLE)has been well ***,unanswered questions remain regarding the applicability of these findings to pediatric-onset *** aim of this review is to provide an overview of the novel discoveries on IFN-I signaling in pediatric-onset *** sources A literature search was conducted in the PubMed database using the following keywords:“pediatric systemic lupus erythematosus”and“type I interferon”.Results IFN-I signaling is increased in pediatric SLE,largely due to the presence of plasmacytoid dendritic cells and pathways such as cyclic GMP-AMP synthase–stimulator of interferon genes–TANK-binding kinase 1 and Toll-like receptor(TLR)4/*** extracellular traps and oxidative DNA damage further stimulate IFN-I *** variants in IFN-I-related genes,such as IFN-regulatory factor 5 and tyrosine kinase 2,are linked to SLE susceptibility in pediatric *** addition,type I interferonopathies,characterized by sustained IFN-I activation,can mimic SLE symptoms and are thus important to *** on interferonopathies also contribute to exploring the pathogenesis of *** IFN-I activation is crucial for SLE diagnosis and *** IFNstimulated gene expression and serum IFN-α2 levels are common *** cytometry markers such as CD169 and galectin-9 are promising ***-IFN therapies,such as sifalimumab and anifrolumab,show promise in adult patients with SLE,but their efficacy in pediatric patients requires further *** kinase inhibitors are another treatment option for severe pediatric SLE *** This review presents an overview of the IFN-I pathway in pediatric *** the intricate relationship between IFN-I and pediatric SLE may help to identify potential diagnostic markers and targeted therapies,paving the way for improved patient care and outcomes.

关键词： Interferonopathies Pediatric systemic lupus erythematosus Type I interferon

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Structural and magnetic properties of micropolycrystalline cobalt thin films fabricated by direct current magnetron sputtering

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 384-394页

作者： Kerui song Zhou Li mei Fang Zhu Xiao Qian Lei School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Hunan Key Laboratory of Super-Microstructure and Ultrafast Process School of Physics and electronicsCentral South UniversityChangsha 410083China Key Laboratory of Non-Ferrous Metal Materials Science and Engineering Ministry of EducationChangsha 410083China

Pure cobalt(Co)thin films were fabricated by direct current magnetron sputtering,and the effects of sputtering power and pres-sure on the microstructure and electromagnetic properties of the films were *** the sputtering power increases from 15 to 60 W,the Co thin films transition from an amorphous to a polycrystalline state,accompanied by an increase in the intercrystal pore ***,the resistivity decreases from 276 to 99μΩ·cm,coercivity increases from 162 to 293 Oe,and in-plane magnetic aniso-tropy *** the sputtering pressure decreases from 1.6 to 0.2 Pa,grain size significantly increases,resistivity significantly de-creases,and the coercivity significantly increases(from 67 to 280 Oe),which can be attributed to the increase in defect ***-pondingly,a quantitative model for the coercivity of Co thin films was *** polycrystalline films sputtered under pressures of 0.2 and 0.4 Pa exhibit significant in-plane magnetic anisotropy,which is primarily attributable to increased microstress.

关键词： cobalt thin film magnetron sputtering microstructure electromagnetic properties

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Relationship Between Individuals’Epidemic Risk Perception Within Living Space and Subjective Well-Being:Empirical Evidence from China after the First Wave of COVID-19

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Chinese Geographical Science 2024年第2期34卷 369-382页

作者： song Jiangyu ZHOU Suhong KWAN mei-Po ZHENG Zhong School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Engineering Research Center for Public Security and Disaster Guangzhou 510275China Institute of Space and Earth Information Science the Chinese University of Hong KongHong Kong 999077China Department of Geography and Resource Management the Chinese University of Hong KongHong Kong 999077China Institute of Future Cities the Chinese University of Hong KongHong Kong 999077China Center for Territorial Spatial Planning and Real Estate Studies Beijing Normal UniversityZhuhai 519000China

It is common to observe the epidemic risk perception(ERP)and a decline in subjective well-being(SWB)in the context of public health events,such as Corona Virus Disease 2019(COVID-19).However,there have been few studies exploring the impact of individuals’ERP within living space on their SWB,especially from a geographical and daily activity perspective after the resumption of work and other activities following a wave of the *** this paper,we conducted a study with 789 participants in urban China,measuring their ERP within living space and examining its influence on their SWB using path *** results indicated that individuals’ERP within their living space had a significant negative effect on their *** density of certain types of facilities within their living space,such as bus stops,subway stations,restaurants,fast food shops,convenience shops,hospitals,and public toilets,had a significantly negative impact on their SWB,mediated by their ERP within living ***,participation in out-of-home work and other activities not only increased individuals’ERP within living space,but also strengthened its negative effect on their SWB.

关键词： subjective well-being epidemic risk perception living space the density of facilities out-of-home activities

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Mechanism and experimental study on the fruit detachment of Chinese wolfberry through reciprocating vibration

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 47-58页

作者： song mei Jinpeng Wang Zhiyu song Dunbing Tang Cheng Shen College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Nanjing Research Institute for Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014China Nanjing Forestry University Nanjing 210037China

In order to realize the efficient and high-quality mechanical picking for Chinese wolfberry,firstly,the forced reciprocating vibration picking principle of the Chinese wolfberry branch was studied,and the mechanical model of vibration picking was established based on the simplified cantilever model,and the response analysis and solution of all positions for the branch were carried *** the same time,the critical mechanical model of fruit detachment under the condition of fruit hanging on branches was established,and the theoretical values of inertia force for each component of the branch were ***,through actual measurement and finite element modeling,the natural frequency and forced vibration response simulation for each component of the branch of Chinese wolfberry terminal branch model were both studied,and the relationship between single-point periodic excitation force and high-quality fruit shedding parameters was ***,according to the conclusion of the picking model,a test bench with many groups of adjustable parameters was ***,the last branch of fruit-hanging Chinese wolf berry for Ningqi No.1 was taken as the experimental object,a four-level orthogonal experiment was designed with three factors:frequency,amplitude and entrance ***,the net picking rate,damage rate and false picking rate were taken as the evaluating indicators,referring to the comprehensive scores of the three *** was concluded that the primary and secondary relations of factors affecting the picking effect are frequency,amplitude and entrance angle,and the best operation parameters are frequency of 20 Hz,amplitude of 15 mm,and entrance angle of 45°,then,a hand-held vibration picker with setting parameters was trial-produced,and the optimal parameter combination was verified in the Chinese wolfberry planting base of the National Chinese wolfberry Engineering and Technology Research *** results showed that the net picking rate of rip

关键词： Chinese wolfberry branches reciprocating vibration inertial force orthogonal experiment

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Vanadium oxide nanospheres encapsulated in N-doped carbon nanofibers with morphology and defect dual-engineering toward advanced aqueous zinc-ion batteries

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Journal of Energy Chemistry 2024年第2期89卷 599-609,I0013页

作者： Yunfei song Laiying Jing Rutian Wang Jiaxi Cui mei Li Yunqiang Zhang School of Materials Science and Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353ShandongChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054SichuanChina

Vanadium-based electrodes are regarded as attractive cathode materials in aqueous zinc ion batteries(ZIBs)caused by their high capacity and unique layered ***,it is extremely challenging to acquire high electrochemical performance owing to the limited electronic conductivity,sluggish ion kinetics,and severe volume expansion during the insertion/extraction process of Zn^(2+).Herein,a series of V_(2)O_(3)nanospheres embedded N-doped carbon nanofiber structures with various V_(2)O_(3)spherical morphologies(solid,core-shell,hollow)have been designed for the first time by an electrospinning technique followed thermal *** N-doped carbon nanofibers not only improve the electrical conductivity and the structural stability,but also provides encapsulating shells to prevent the vanadium dissolution and aggregation of V_(2)O_(3)***,the varied morphological structures of V_(2)O_(3)with abundant oxygen vacancies can alleviate the volume change and increase the Zn^(2+)***,the phase transition between V_(2)O_(3)and Zn_XV_(2)O_(5-m)·n H_(2)O in the cycling was also *** a result,the as-obtained composite delivers excellent long-term cycle stability and enhanced rate performance for coin cells,which is also confirmed through density functional theory(DFT)*** assembled into flexible ZIBs,the sample still exhibits superior electrochemical performance,which may afford new design concept for flexible cathode materials of ZIBs.

关键词： Aqueous zinc ion batteries Vanadium trioxide Oxygen vacancy Structure evolution Phase optimization

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Preparation and characterization of Rb-doped TiO_(2) powders for photocatalytic applications

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Rare Metals 2024年第2期43卷 555-561页

作者： Lu Jia Li-mei Yang Wei Wang song-Tao Huang Zheng Xu National Engineering Laboratory of Biohydrometallurgy General Research Institute for Nonferrous MetalsBeijing100088China

TiO_(2)nanoparticles doped with different concentrations of Rb were prepared by sol–gel *** crystal structures of samples were characterized by X-ray diffraction(XRD)and transmission electron microscopy(TEM).It was confirmed by the Rietveld refinement method that the as-prepared samples crystallize in anatase phase and Rb doping induces expansion and distortion of the crystal *** with the pure TiO_(2),the Rb-doped nanoparticles have smaller crystal size and better *** rate of methylene blue was used to evaluate the photocatalytic activity of Rb–TiO_(2).It indicated that doping Rb into TiO_(2)can effectively improve the photocatalytic activity of TiO_(2)and the mechanisms were discussed in *** using the sample doped with 0.20%Rb,methylene blue degraded with the fastest rate(97%within 60 min).

关键词： Rb doping TiO_(2) Photocatalysis Sol-gel

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Using NH_(2)-MIL-125(Ti)for efficient removal of Cr(Ⅵ)and Rh B from aqueous solutions:Competitive and cooperative behavior in the binary system

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Journal of Environmental Sciences 2024年第2期136卷 437-450页

作者： Lei Zheng Lixia Sun Jiangbo Qiu Junling song Luyi Zou Yue Teng Yongzhong zong Hongyan Yu School of Environmental and Civil Engineering Jiangnan UniversityWuxi 214122China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China Kunming South Water Co. Ltd.Kunming 650501China Jiangsu Key Laboratory of Anaerobic Biotechnology Jiangnan UniversityWuxi 214122China

The coexistence of inorganic and organic contaminants is a challenge for real-life water treatment ***,in this research,we used NH_2-MIL-125(Ti)to evaluate the single adsorption of hexavalent chromium(Cr(Ⅵ))or Rhodamine B(RhB)in an aqueous solution and further investigate simultaneous adsorption experiments to compare the adsorption behavior *** main influencing factors,for example,reaction time,initial concentration,reaction temperature,and pH were studied in *** all reaction systems,the pseudo-second-order kinetic and Langmuir isotherm models were well illuminated the adsorption progress of Cr(Ⅵ)and *** studies showed that the adsorption process was spontaneous and *** compared to the single system,the adsorption capacity of Cr(Ⅵ)in the binary system gradually decreased as the additive amount of RhB increased,whereas the adsorption capacity of RhB in the binary system was expanded *** the binary reaction system contained 100 mg/L Cr(Ⅵ),the removal rate of RhB increased to 97.58%.The formation of Cr(Ⅵ)-RhB and Cr(Ⅲ)-RhB complexes was the cause that provided facilitation for the adsorption of *** findings prove that the interactions during the water treatment process between contaminants may obtain additional benefits,contributing to a better adsorption capacity of co-existing contaminant.

关键词： Adsorption Heavy metal ion Organic dye Simultaneous removal Mechanism studies

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Low temperature magnetism in the rare-earth perovskite GdScO3

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Chinese Physics B 2020年第5期29卷 47-51页

作者： Jie-Ming Sheng Xu-Cai Kan Han Ge Pei-Qian Yuan Lei Zhang Nan Zhao zong-mei song Yuan-Yin Yao Ji-Ning Tang Shan-Min Wang Ming-Liang Tian Xin Tong Liu-Suo Wu Department of Physics Southern University of Science and TechnologyShenzhen 518055China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Physics and Materials Science Anhui UniversityHefei 230601China High Magnetic Field Laboratory Chinese Academy of Science(CAS)Hefei 230031China

The magnetic phase diagram of rare-earth perovskite compound,GdScO3,has been investigated by magnetization and heat *** system undergoes an antiferromagnetic phase transition at TN=2.6 K,with an easy axis of magnetization along the a *** magnetization measurements show that it exists a spin-flop transition around 0.3 T for the applied field along the a *** critical magnetic field for the antiferromagnetic-to-paramagnetic transition is near 3.2 T when temperature approaches *** scaling susceptibilities,we presume this point(B=3.2 T,T=0 K)might be a fieldinduced quantum critical point and the magnetic critical fluctuations can even be felt above TN.

关键词： rare-earth perovskite magnetization spin-flop transition quantum critical point

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Sodium Sulfite as a Novel Hypoxia Revulsant Involved in Hypoxic Regulation in Escherichia coli

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Biomedical and Environmental Sciences 2024年第2期37卷 228-232页

作者： YE Qiao HUO Jia Nan LUO Yuan mei Zhu song FANG Long mei GUO Bing Qian WANG Guang Yun Laboratory of clinical medicine Air Force Medical CenterAir Force Medical UniversityBeijing 100142China

As a reducing salt,sodium sulfite could deprive oxygen in solution,which could mimic hypoxic stress in Caenorhabditis *** this study,the wildtype Escherichia coli strain MG1655 was used to examine the inhibition of so... 详细信息

关键词： hypoxic Sodium observing

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Integrated separation-electrochemical detection device based on wood column for online identification of enantiomer

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Nano Research 2024年第3期17卷 1893-1901页

作者： Junli Guo Yuanfei Xue Chenxi Zhao Junjian Zhao Zhida Gao Ye mei Yan-Yan song College of Sciences Northeastern UniversityShenyang 110004China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200062China NYU-ECNU Center for Computational Chemistry at NYU Shanghai Shanghai 200062China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Chiral chemicals have attracted significant interest in the pharmaceutical industry,yet the separation methods to get pure enantiomers from racemic mixture are still *** date,the separation of enantiomers still mainly depends on chromatography using high-cost chiral stationary ***,wood channels were used as the handheld integrated device,and enantiomer separation was simultaneously detected using an electrochemical *** this method,a chiral UIO-66(L-UIO-66)modified enantiomer separation zone and carbonized wood based online detection zone are integrated along a single wood *** on the in situ separation results from the chronoamperometry data,the wood device shows excellent separation ability for a wide range of electrochemically active enantiomers,including 3,4-dihydroxyphenylalanine,amino acids,ascorbic acid,carnitine,and penicillamine with high chirality *** unbiased molecular dynamic simulations indicate that the excellent chiral recognition and separation are attributed to the different barriers from the bound states to the dissociated state of the enantiomers in the homochiral microenvironment of the *** integrated enantiomer separation-electrochemical detection device provides a novel,easy,and low-cost platform for the separation of pure enantiomer from racemic mixture.

关键词： wood column integrated separation-detection device enantioselectivity online sensing free energy barrier

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