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Genetic analyses of ancient tea trees provide insights into the breeding history and dissemination of Chinese Assam tea(Camellia sinensis ***)

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Plant Diversity 2024年第2期46卷 229-237页

作者： Miao-Miao Li Muditha K.Meegahakumbura Moses C.Wambulwa Kevin S.Burgess Michael Möller zong-Fang Shen de-Zhu Li lian-Ming Gao CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming650201YunnanChina department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla90000Sri Lanka department of Life Sciences School of Science and ComputingSouth Eastern Kenya University170-90200KituiKenya department of Biology Columbus State UniversityUniversity System of GeorgiaColumbusGA31907-5645USA Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburghEH35LRScotlandUK Lijiang Forest Biodiversity National Observation and Research Station Kunming Institute of BotanyChinese Academy of SciencesLijiang674100YunnanChina

Chinese Assam tea(Camellia sinensis ***)is an important tea crop with a long history of cultivation in Yunnan,*** its potential value as a genetic resource,its genetic diversity and domestication/breeding history remain *** address this issue,we genotyped 469 ancient tea plant trees representing 26 *** *** populations,plus two of its wild relatives(six and three populations of *** and ***,respectively)using 16 nuclear microsatellite *** showed that Chinese Assam tea has a relatively high,but comparatively lower gene diversity(H_(S)=0.638)than the wild relative ***(H_S=0.658).Clustering in STRUCTURE indicated that Chinese Assam tea and its two wild relatives formed distinct genetic groups,with considerable interspecific *** Chinese Assam tea accessions clustered into three gene pools,corresponding well with their geographic ***,New Hybrids analysis indicated that 68.48%of ancient Chinese Assam tea plants from Xishuangbanna were genetic intermediates between the Puer and Lincang gene *** addition,10%of the ancient Chinese Assam tea individuals were found to be hybrids between Chinese Assam tea and *** results suggest that Chinese Assam tea was domesticated separately in three gene pools(Puer,Lincang and Xishuangbanna)in the Mekong River valley and that the hybrids were subsequently selected during the domestication *** the domestication history of Chinese Assam tea in southwestern Yunnan remains complex,our results will help to identify valuable genetic resources that may be useful in future tea breeding programs.

关键词： Tea plant Hybrid origin Genetic diversity Domestication history Camellia sinensis var.assamica Camellia taliensis

Efficacy comparison of fruquintinib,regorafenib monotherapy or plus programmed death-1 inhibitors for microsatellite stable metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2449-2462页

作者： Tian-Qi An Hui Qiu Quan-Bo Zhou Hong zong Shuang Hu Yu-Gui lian Rui-Hua Zhao department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina department of Hepato-Pancreato-Biliary Surgery Peking University Cancer Hospital and InstituteBeijing 100000China department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGROUND Regorafenib(R)and fruquintinib(F)are the standard third-line regimens for colorectal cancer(CRC)according to the National Comprehensive Cancer Network guidelines,but both have limited *** phase 2 trials have indicated that R or F combined with immune checkpoint inhibitors can reverse immunosuppression and achieve promising efficacy for microsatellite stable or proficient mismatch repair(MSS/pMMR)*** to the lack of studies comparing the efficacy between F,R,F plus programmed death-1(PD-1)inhibitor,and R plus PD-1 inhibitors(RP),it is still unclear whether the combination therapy is more effective than *** To provide critical evidence for selecting the appropriate drugs for MSS/pMMR metastatic CRC(mCRC)patients in clinical *** A total of 2639 CRC patients were enrolled from January 2018 to September 2022 in our hospital,and 313 MSS/pMMR mCRC patients were finally *** A total of 313 eligible patients were divided into F(n=70),R(n=67),F plus PD-1 inhibitor(FP)(n=95)and RP(n=81)*** key clinical characteristics were well balanced among the *** median progression-free survival(PFS)of the F,R,FP,and RP groups was 3.5 months,3.6 months,4.9 months,and 3.0 months,*** median overall survival(OS)was 14.6 months,15.7 months,16.7 months,and 14.1 *** FP regimen had an improved disease control rate(DCR)(P=0.044)and 6-month PFS(P=0.014)and exhibited a better trend in PFS(P=0.057)compared with F,and it was also significantly better in PFS than RP(P=0.030).RP did not confer a significant survival benefit;instead,the R group had a trend toward greater benefit with OS(P=0.080)compared with *** significant differences were observed between the R and F groups in PFS or OS(P>0.05).CONCLUSION FP is superior to F in achieving 6-month PFS and DCR,while RP is not better than *** has an improved PFS and 6-month PFS compared with RP,but F and R had similar clinical ***,FP may be a

关键词： Colorectal cancer Fruquintinib Regorafenib Programmed death-1 inhibitor Real-world

Revisiting thermal comfort and thermal sensation

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Building Simulation 2024年第2期17卷 185-188页

作者： Zhiwei lian department of Architecture Shanghai Jiao Tong UniversityShanghai200240China

The thermal environment is closely intertwined with comfort,health,efficiency,and building energy *** Comfort stands as a crucial concept for evaluating the thermal environment,yet the prevailing evaluation metric is Thermal *** correspondence between genuine Thermal Comfort and Thermal Sensation is influenced by a variety of environmental factors.

关键词： thermal Comfort prevailing

Modeling and Simulation of Lithium Vacuum Evaporation Process Using COMSOL Multiphysics

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Journal of Thermal Science 2024年第1期33卷 86-100页

作者： lian Xuexin ZHONG Dawen Beijing Key Laboratory of Passive Nuclear Power Safety and Technology North China Electric Power UniversityBeijing 102206China

Based on the COMSOL Multiphysics simulation software,this study carried out modeling and numerical simulation for the evaporation process of liquid metal lithium in the vacuum free molecular flow *** motion of lithium atoms in the evaporation process was analyzed through a succession of *** on the available experimental values of the saturated vapor pressure of liquid metal lithium,the relationship between saturated vapor pressure and temperature of liquid lithium in the range of 600 K-900 K was obtained.A two-dimensional symmetric model(3.5 mm×20 mm) was established to simulate the transient evaporation process of liquid lithium at wall temperatures of 750 K,780 K,800 K,810 K,825 K,and 850 K,*** effects of temperature,the evaporation coefficient,back pressure,and length-to-diameter ratio on the evaporation process were studied;the variation trends and reasons of the molecular flux and the pressure during the evaporation process were *** the same time,the evaporation process under variable wall temperature conditions was *** research made the evaporation process of liquid lithium in vacuum molecular flow clearer,and provided theoretical support for the space reactor and nuclear fusion related fields.

关键词： free molecular flow saturated vapor pressure vacuum evaporation liquid lithium metal

Uncertainty Principles on Clifford Modules

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2537-2570页

作者： Pan lian School of Mathematical Sciences Tianjin Normal University

In this paper, we derive the optimal Cauchy–Schwarz inequalities on a class of Hilbert and Krein modules over a Clifford algebra, which heavily depend on the Clifford algebraic *** obtained inequalities further lead to very general uncertainty inequalities on these modules. Some new phenomena arise, due to the non-commutative nature, the Clifford-valued inner products and the Krein geometry. Taking into account applications, special attention is given to the Dirac operator and the Howe dual pair Pin(m) × osp(1|2). Moreover, it is surprisingly to find that the recent highly nontrivial uncertainty relation for triple observables is indeed a direct consequence of our Cauchy–Schwarz inequality. This new observation leads to refined uncertainty relations in terms of the Wigner–Yanase–Dyson skew information for mixed states and other generalizations. These show that the obtained uncertainty inequalities on Clifford modules can be considered as new uncertainty relations for multiple observables.

关键词： 30G35 81P45 Clifford algebra Fischer decomposition Krein space uncertainty principle Wigner–Yanase–Dyson skew information

deepSI:A Sensitive-Driven Testing Samples Generation Method of Whitebox CNN Model for Edge Computing

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Tsinghua Science and Technology 2024年第3期29卷 784-794页

作者： Zhichao lian Fengjun Tian School of Cyber Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

In recent years,deep Learning(DL)technique has been widely used in Internet of Things(IoT)and Industrial Internet of Things(IIoT)for edge computing,and achieved good *** more and more studies have shown the vulnerability of neural ***,it is important to test the robustness and vulnerability of neural *** specifically,inspired by layer-wise relevance propagation and neural network verification,we propose a novel measurement of sensitive neurons and important neurons,and propose a novel neuron coverage criterion for robustness *** on the novel criterion,we design a novel testing sample generation method,named deepSI,which involves definitions of sensitive neurons and important ***,we construct sensitive-decision paths of the neural network through selecting sensitive neurons and important ***,we verify our idea by setting up several experiments,then results show our proposed method achieves superior performances.

关键词： neuron sensitivity Layer-wise Relevance Propagation(LRP) neural network verification deeplearning testing

Contrasting physical mechanisms of yellowfin tuna fluctuations between the western and eastern Indian Ocean

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Journal of Oceanology and Limnology 2024年第3期42卷 960-971页

作者： Peng lian Le GAO Key Laboratory of Ocean Observation and Forecasting and Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Laboratory for Ocean Dynamics and Climate Laoshan LaboratoryQingdao 266061China

As an economically critical pelagic migratory species,yellowfin tuna(Thunnus albacores,YFT)is very sensible to physical and environmental conditions,such as sea surface temperature(SST),ocean heat content(OHC),and the mixed layer depth(MLD).We investigated the impact of SST,OHC,and MLD on fluctuations of YFT catch in the western/eastern Indian Ocean using the long time series of 63-year environmental and YFT *** found that the impact of SST on YFT was heavily overestimated in the past,and MLD plays a more critical role in the YFT catch *** the MLD deepens(>34.8 m),SST was more influential in predicting the catches of YFT than OHC in the western Indian Ocean,and OHC was more critical to YFT than SST in the eastern Indian ***,when the MLD shallows(decrease of YFT in the eastern Indian *** above findings clarified a non-stationary relationship between the environmental factors and catches of YFT and provided new insights into variations in YFT abundance.

关键词： yellowfin tuna Indian Ocean sea surface temperature(SST) ocean heat content(OHC) mixed layer depth(MLD) hiatus

Impacts of central-Pacific El Niño and physical drivers on eastern Pacific bigeye tuna

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Journal of Oceanology and Limnology 2024年第3期42卷 972-987页

Bigeye tuna Thunnus obesus is an important migratory species that forages deeply,and El Niño events highly influence its distribution in the eastern Pacific *** sea surface temperature is widely recognized as the main factor affecting bigeye tuna(BET)distribution during El Niño events,the roles of different types of El Niño and subsurface oceanic signals,such as ocean heat content and mixed layer depth,remain *** conducted A spatial-temporal analysis to investigate the relationship among BET distribution,El Niño events,and the underlying oceanic signals to address this knowledge *** used monthly purse seine fisheries data of BET in the eastern tropical Pacific Ocean(ETPO)from 1994 to 2012 and extracted the central-Pacific El Niño(CPEN)indices based on Niño 3 and Niño ***,we employed Explainable Artificial Intelligence(XAI)models to identify the main patterns and feature importance of the six environmental variables and used information flow analysis to determine the causality between the selected factors and BET ***,we analyzed Argo datasets to calculate the vertical,horizontal,and zonal mean temperature differences during CPEN and normal years to clarify the oceanic thermodynamic structure differences between the two types of *** findings reveal that BET distribution during the CPEN years is mainly driven by advection feedback of subsurface warmer thermal signals and vertically warmer habitats in the CPEN domain area,especially in high-yield fishing *** high frequency of CPEN events will likely lead to the westward shift of fisheries centers.

关键词： bigeye tuna central-Pacific El Niño(CPEN) ocean heat content Argo explainable artificial intelligence(XAI) information flow

Cultivating the uncultured:Harnessing the“sandwich agar plate”approach to isolate heme-dependent bacteria from marine sediment

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mLife 2024年第1期3卷 143-155页

作者： Jing Zhang Qi-Yun liang Da-Shuai Mu Fengbai lian Ya Gong Mengqi Ye Guan-Jun Chen Yuqi Ye zong-Jun Du State Key Laboratory of Microbial Techlogy Insttute of Micrbial TchnoogyShandong UniversityQingdaoChina Marine College Shandong UniverstyWeihaiChina Shandong University-Weihai Research Institute of Industrial Technology WeihaiChina

In the classical microbial isolation technique,the isolation process inevitably destroys all microbial interactions and thus makes it difficult to culture the many microorganisms that rely on these interactions for *** this study,we designed a simple coculture technique named the“sandwich agar plate method,”which maintains microbial interactions throughout the isolation and pure culture *** total yield of uncultured species in sandwich agar plates based on eight helper strains was almost 10-fold that of the control *** uncultured species displayed commensal *** study found that heme was the growth-promoting factor of some marine commensal *** genomic analysis revealed that heme auxotrophies were common in various biotopes and prevalent in many uncultured microbial ***,our study supported that the survival strategies of heme auxotrophy in different habitats varied *** findings highlight that cocultivation based on the“sandwich agar plate method”could be developed and used to isolate more uncultured bacteria.

关键词： cultivation growth factors heme sandwich agar plate uncultured bacteria