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Timp1 Deletion Induces Anxiety-like Behavior in Mice

Neuroscience Bulletin 2024年第6期40卷 732-742页

作者： Xiaotong Wang Wei Zheng ziyi Zhu Biyu Xing Weijie Yan Ke Zhu Lingli Xiao Chaojuan yang Mengping Wei Lei yang Zi-Bing Jin Xueyun Bi Chen Zhang State Key Laboratory of Neurology and Oncology Drug Development Nanjing210000China School of Basic Medical Sciences Wenzhou Medical UniversityWenzhou325035China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairAdvanced Innovation Center for Human Brain ProtectionBeijing Laboratory of Oral HealthCapital Medical UniversityBeijing100069China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing100005China Chinese Institute for Brain Research Beijing102206China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing100191China

The hippocampus is essential for learning and memory,but it also plays an important role in regulating emotional behavior,as hippocampal excitability and plasticity affect anxiety and *** synaptic plasticity may be regulated by tissue inhibitor of matrix metalloproteinase 1(TIMP1),a known protein inhibitor of extracellular matrix(ECM),and the expression of TIMP1 in the hippocampus can be induced by neuronal excitation and various ***,the involvement of Timp1 in fear learning,anxiety,and hippocampal synaptic function remains to be *** study of Timp1 function in vivo revealed that Timp1 knockout mice exhibit anxiety-like behavior but normal fear *** results suggested that Timp1 knockout mice showed hyperactivity in the ventral CA1 region,but the basic synaptic transmission and plasticity were normal in the Schaffer collateral *** together,our results suggest that deletion of Timp1 in vivo leads to the occurrence of anxiety behaviors,but that Timp1 is not crucial for fear learning.

关键词： Timp1 Anxiety Fear Synaptic transmission Synaptic plasticity

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引譬连类与诗性思维——从先秦用诗看中国文化诗性特征之形成

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首都师范大学学报（社会科学版） 2006年第2期 55-62页

作者：杨子怡惠州学院中文系广东惠州516007

维柯的“以己度物”的诗性思维特征与先秦用诗中的“引譬连类”思维特征有惊人的相似之处。本文借诗性思维的原理,重新解读先秦用诗的特征及其对中国文化诗性思维形成的影响。笔者认为,中国文化的引譬连类、崇尚经验、天人合一、泛诗化... 详细信息

维柯的“以己度物”的诗性思维特征与先秦用诗中的“引譬连类”思维特征有惊人的相似之处。本文借诗性思维的原理,重新解读先秦用诗的特征及其对中国文化诗性思维形成的影响。笔者认为,中国文化的引譬连类、崇尚经验、天人合一、泛诗化等诗性思维特征就孕育于先秦的全方位用诗之中。

关键词：诗性思维用诗引譬连类崇古天人合一泛诗化

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穿心莲内酯磺化物注射液对猪的安全性评价

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中兽医医药杂志 2024年第2期43卷 81-84,F0003页

作者：吴禹熹余佳欣李鑫李诗李旭廷李思聪杨子仪殷勤董可四川育强本草生物技术有限公司四川成都610000 四川省畜牧科学研究院四川成都610000

本试验旨在考察肌内注射穿心莲内酯磺化物注射液对靶动物猪的安全性。选取32头健康仔猪,随机分为空白对照组、高剂量组、中剂量组和低剂量组,3个剂量组分别以25 mg/kg、15 mg/kg、5 mg/kg剂量肌内注射给药,连续3 d,每天1次,观察各剂量... 详细信息

本试验旨在考察肌内注射穿心莲内酯磺化物注射液对靶动物猪的安全性。选取32头健康仔猪,随机分为空白对照组、高剂量组、中剂量组和低剂量组,3个剂量组分别以25 mg/kg、15 mg/kg、5 mg/kg剂量肌内注射给药,连续3 d,每天1次,观察各剂量组猪给药后的临床表现,考察穿心莲内酯磺化物注射液对猪血液生理、生化指标的影响,试验结束时,对高剂量组及空白对照组试验猪进行剖检及组织病理学检查。结果显示,连续给药后7 d,与空白对照组相比,各剂量组猪临床表现正常,血液生理、生化指标均无显著性差异,各脏器组织均无明显的与药物有关的病理变化。表明通过肌内注射穿心莲内酯磺化物注射液对靶动物猪无明显不良反应,安全性较高。

关键词：穿心莲内酯磺化物注射液安全性猪

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A Knowledge-enhanced Two-stage Generative Framework for Medical Dialogue Information Extraction

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Machine Intelligence Research 2024年第1期21卷 153-168页

作者： Zefa Hu ziyi Ni Jing Shi Shuang Xu Bo Xu School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Institute of Automation Chinese Academy of SciencesBeijing 100190China

This paper focuses on term-status pair extraction from medical dialogues(MD-TSPE),which is essential in diagnosis dia-logue systems and the automatic scribe of electronic medical records(EMRs).In the past few years,works on MD-TSPE have attracted increasing research attention,especially after the remarkable progress made by generative ***,these generative methods output a whole sequence consisting of term-status pairs in one stage and ignore integrating prior knowledge,which demands a deeper un-derstanding to model the relationship between terms and infer the status of each *** paper presents a knowledge-enhanced two-stage generative framework(KTGF)to address the above *** task-specific prompts,we employ a single model to com-plete the MD-TSPE through two phases in a unified generative form:We generate all terms the first and then generate the status of each generated *** this way,the relationship between terms can be learned more effectively from the sequence containing only terms in the first phase,and our designed knowledge-enhanced prompt in the second phase can leverage the category and status candidates of the generated term for status ***,our proposed special status"not mentioned"makes more terms available and en-riches the training data in the second phase,which is critical in the low-resource *** experiments on the Chunyu and CMDD datasets show that the proposed method achieves superior results compared to the state-of-the-art models in the full training and low-re-sourcesettings.

关键词： Medical dialogue understanding information extraction text generation knowledge-enhanced prompt low-resource setting dataaugmentation

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Tailoring NH4+ storage by regulating oxygen defect in ammonium vanadate

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Green Energy & Environment 2024年第7期9卷 1171-1182页

作者： Yanyan Liu ziyi Feng Hanmei Jiang Xueying Dong Changgong Meng Yifu Zhang State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology College of Environmental and Chemical Engineering Dalian University

Defect engineering is an effective strategy for modifying the energy storage materials to improve their electrochemical ***, the impact of oxygen defect and its content on the electrochemical performances in the burgeoning aqueous NH+4storage field remains explored. Therefore, for the first time in this work, an oxygen-defective ammonium vanadate [（NH4）2V10O25·8H2O, denoted as Od-NHVO] with a novel 3D porous flower-like architecture was achieved via the reduction of thiourea in a mild reaction condition, which is a facile method that can realize the intention to regulate the oxygen defect content, with the capability of mass-production. The as-prepared OdM-NHVO with moderate oxygen defect content can deliver a stable specific capacitance output(505 F g-1, 252 mAh g-1at 0.5 A g-1with ～80% capacitance retention after 10,000 cycles), which benefits from extra active sites, unimpeded NH+4-migration path and relatively high structure integrity. In contrast, low oxygen defect content will lead to the torpid electrochemical reaction kinetics while too high content of it will reduce the chargestorage capability and induce structural disintegration. The superior NH+4-storage behavior is achieved with the reversible intercalation/deintercalation process of NH+4accompanied by forming/breaking of hydrogen bond. As expected, the assembled flexible OdM-NHVO//PTCDI quasi-solid-state hybrid supercapacitor（FQSS HSC） also exhibits high areal capacitance, energy density and reliable flexibility. This work provides a new avenue for developing materials with oxygen-deficient structure for application in various aqueous non-metal cation storage systems.

关键词： Ammonium vanadate Oxygen defect Ammonium-ion storage Hybrid supercapacitors Electrochemical performance

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A self-centering and stiffness-controlled MEMS accelerometer

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Microsystems & Nanoengineering 2024年第1期10卷 27-40页

作者： Yiming Jin Zhipeng Ma ziyi Ye Mingkang Li Xudong Zheng Zhonghe Jin School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310013China Key Laboratory of Micro/Nano-Satellite Research of Zhejiang Province Hangzhou 310007PR China

This paper presents a high-performance MEMS accelerometer with a DC/AC electrostatic stiffness tuning capability based on double-sided parallel plates(DSPPs).DC and AC electrostatic tuning enable the adjustment of the effective stiffness and the calibration of the geometric offset of the proof mass,respectively.A dynamical model of the proposed accelerometer was developed considering both DC/AC electrostatic tuning and the temperature *** on the dynamical model,a self-centering closed loop is proposed for pulling the reference position of the forceto-rebalance(FTR)to the geometric center of *** self-centering accelerometer operates at the optimal reference position by eliminating the temperature drift of the readout circuit and nulling the net electrostatic tuning *** stiffness closed-loop is also incorporated to prevent the pull-in instability of the tuned low-stiffness accelerometer under a dramatic temperature ***-time adjustments of the reference position and the DC tuning voltage are utilized to compensate for the residue temperature drift of the proposed *** a result,a novel controlling approach composed of a self-centering closed loop,stiffness-closed loop,and temperature drift compensation is achieved for the accelerometer,realizing a temperature drift coefficient(TDC)of approximately 7μg/℃ and an Allan bias instability of less than 1μg.

关键词： stiffness electrostatic centering

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Experimental observations on the nonproportional multiaxial ratchetting of cast AZ91 magnesium alloy at room temperature

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 1115-1125页

作者： Binghui Hu Yu Lei Hang Li ziyi Wang Chao Yu Guozheng Kang Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China

The nonproportional multiaxial ratchetting of cast AZ91 magnesium (Mg) alloy was examined by performing a sequence of axial-torsional cyclic tests controlled by stress with various loading paths at room temperature (RT).The evolutionary characteristics and path dependence of multiaxial ratchetting were *** illustrate that the cast AZ91 Mg alloy exhibits considerable nonproportional additional softening during cyclic loading with multiple nonproportional multiaxial loading paths;multiaxial ratchetting presents strong path dependence,and axial ratchetting strains are larger under nonproportional loading paths than under uniaxial and proportional45°linear loading paths;multiaxial ratchetting becomes increasingly pronounced as the applied stress amplitude and axial mean stress ***,stress-strain curves show a convex and symmetrical shape in axial/torsional *** ratchetting exhibits quasi-shakedown after certain loading *** abundant experimental data obtained in this work can be used to develop a cyclic plasticity model of cast Mg alloys.

关键词： cast magnesium alloy ratchetting multiaxial loading loading path stress level

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A SYSTEM IDENTIFICATION METHOD USING VECTOR SPACE BASE FUNCTION

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Journal of Electronics(China) 1999年第2期16卷 146-151页

作者： Lu ziyi yang Luxi He Zhenva(DSP Lab., Southeast University, Nanjing 210096)

This paper presents a new system identification approach using vector space base functions, and proposes two network structures based on Gamma sequence and Laguerre sequence. After analyzing and comparing these struct... 详细信息

关键词： System identification Vector space base functions Adaptive filter

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A likely autotetraploidization event shaped the Chinese mahogany(Toona sinensis)genome

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Horticultural Plant Journal 2023年第2期9卷 306-320页

作者： Jianyu Wang ziyi yang Tianyu Lei Yan Zhang Qimeng Xiao Zijian Yu Jiaqi Zhang Sangrong Sun Qiang Xu Shaoqi Shen Zimo Yan Mengnan Fang Yue Ding Zihan Liu Qianwen Zhu Ke Ren Yuxin Pan Haibin Liu Jinpeng Wang School of Life Sciences Center for Genomics and Computational BiologyNorth China University of Science and TechnologyTangshanHebei 063000China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of ScienceBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

Chinese mahogany(Toona sinensis) is of considerable medical and economic importance, and its genome has been deciphered. However, the process underlying its polyploidy is unclear, and the chromosomal evolutionary trajectory is poorly understood. Here, by reanalysing the *** genome, we found evidence of a tetraploidization event(T. sinensis special tetraploidization, TST) that occurred approximately 15-17 million years ago(MYA) after the core eudicot-common hexaploidization(ECH or gamma) event. We characterized the synonymous nucleotide substitution rates(Ks values) of collinear genes and found that T. sinensis genes affected by the TST evolve at a slower rate than Acer yangbiense genes. Furthermore, we identified homologous genes related to polyploidization and speciation and constructed multiple alignments with different reference genomes. Notably, the significant balance of gene retention and loss characterized in the two TST-derived subgenomes suggests an autopolyploid nature of the TST. Moreover, we deduced the chromosomal karyotypes of the two subgenomes and identified 7chromosomal fusions that have shaped the T. sinensis genome;more information is available on a newly constructed karyotype platform(http://***/Toona_sinensis/***). The T. sinensis genome preserves the ancestral chromosome structure of dicotyledons well and could serve as a good reference for understanding genomic changes in other Meliaceae and Sapindales plants. In addition, we verified that tandem duplication and the ECH have promoted the expansion of terpene synthase(TPS) genes;conversely, the TST seems to have inhibited expansion of these genes. This present effort has clarified the polyploidy events of the T. sinensis genome, filled gaps in the history of karyotype evolution, and laid a solid foundation for further genomic studies in the Meliaceae research community and beyond.

关键词： Toona sinensis Alignment Autotetraploidization Karyotype evolution Terpene synthase genes

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Method of Single Event Effects Radiation Hardened Design for DC-DC Converter Based Load Transient Detection

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Chinese Journal of Electronics 2024年第5期33卷 1154-1164页

作者： Zhongjie GUO Nan LIU Hu LU Mengli LI ziyi QIU School of Automation and Information Engineering Xi'an University of Technology

Aiming at the impact of load current change on single-event transient, the essential difference between single-event transient and load transient of DC-DC converter is deeply studied. A hardened circuit based on load transient detection is proposed. The circuit detects the load transient information in time and outputs a control signal to control the single event hardened circuit, thereby realizing the improvement of the transient characteristics of the system under dynamic conditions. Based on the 180 nm bipolar-CMOS-DMOS（BCD） process, the design and physical verification of a boost converter are completed. The experimental results show that the input voltage range is 2.9–4.5 V, the output voltage range is 5.8–7.9 V, and the load current is 0–55 mA. During load transients, the load detection circuit turns off the hardened circuit in time, avoiding system oscillation and widening the dynamic range of the hardening circuit. Under the single-event transient, the output voltage fluctuation of the system does not exceed the maximum ripple voltage, and the single-event transient suppression ability reaches more than 86%, the system can work well with linear energy transfer of about 100 Me V·cm2/mg.

关键词： Voltage fluctuations Fluctuations Radiation hardening (electronics) Energy exchange DC-DC power converters Dynamic range Transient analysis DC-DC converter Analog single-event transient effect Load transient detection Radiation hardened by design TMR

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