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Dual-Emission Carbonized Polymer Dots Combined with Metal Ions as a Single-Component Fluorescence Sensor Array for Pattern Recognition of Glycosaminoglycans

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Journal of Analysis and Testing 2023年第3期7卷 285-294页

作者： ziyang lin Wenbang Yu Rong Hu Ruixuan Hu Zihan Wei Min Zhang Jinhua Polytechnic Jinhua 321000China Rizhao Polytechnic Rizhao 276800China School of Chemistry and Molecular Engineering Shanghai Key Laboratory for Urban Ecological Processes and Eco-RestorationEast China Normal UniversityShanghai 200241China

Herein,a novel dual-emission fluorescence sensor array of carbonized polymer dots(CPDs)-Cu^(2+)has been proposed,in which CPDs were prepared by one-pot hydrothermal method and Cu^(2+)acting as a quencher was combined with CPDs by electrostatic *** negatively charged glycosaminoglycans(GAGs)bearing different hydrophilic groups showed variable binding affinities towards CPDs-Cu^(2+).Upon reacting with these GAGs,the different fluorescence response signals of CPDs-Cu^(2+)can be further differentiated by principal component analysis(PCA).The CPDs-Cu^(2+)sensor array,not only allows the identification of four similarly structured GAGs,but also realizes the discrimination of different concentrations of the same GAGs and their ***,the identification of GAGs in biological fluids can also be achieved using our proposed single-component sensor array,validating its application *** new strategy avoids multiple sensing probes,broadens the application of tongue-mimic sensor arrays and provides a viable idea for the development of single component sensing platforms.

关键词： CPDs GAGs Single-component Dual-emission Sensor array Biological fluids

NSNO:Neumann Series Neural Operator for Solving Helmholtz Equations in Inhomogeneous Medium

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Journal of Systems Science & Complexity 2024年第2期37卷 413-440页

作者： CHEN Fukai LIU ziyang lin Guochang CHEN Junqing SHI Zuoqiang Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China Yanqi Lake Beijing Institute of Mathematical Sciences and Applications Beijing 101408China

In this paper,the authors propose Neumann series neural operator(NSNO)to learn the solution operator of Helmholtz equation from inhomogeneity coefficients and source terms to *** equation is a crucial partial differential equation(PDE)with applications in various scientific and engineering ***,efficient solver of Helmholtz equation is still a big challenge especially in the case of high ***,deep learning has shown great potential in solving PDEs especially in learning solution *** by Neumann series in Helmholtz equation,the authors design a novel network architecture in which U-Net is embedded inside to capture the multiscale *** experiments show that the proposed NSNO significantly outperforms the state-of-the-art FNO with at least 60%lower relative L^(2)-error,especially in the large wavenumber case,and has 50%lower computational cost and less data ***,NSNO can be used as the surrogate model in inverse scattering *** tests show that NSNO is able to give comparable results with traditional finite difference forward solver while the computational cost is reduced tremendously.

关键词： Helmholtz equation inverse problem neumann series neural network solution operator

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基于MATLAB改进Canny算子边缘检测路径提取立交桥曲线的研究

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测绘与空间地理信息 2024年第1期47卷 32-35页

作者：李靖铭毛世华王锲林子扬姜华根西南林业大学土木工程学院云南昆明650224 西南科技大学环境资源学院四川绵阳621010 不详

针对工程项目中涉及的遥感影像图、航摄正射影像图,基于MATLAB程序设计研究改进后的Canny算子在立交桥曲线提取的应用。通过图像增强、线性与非线性处理相结合、形态学处理以及梯度倒数加权平滑针对像素点创建结构元素修改边缘检测路径... 详细信息

针对工程项目中涉及的遥感影像图、航摄正射影像图,基于MATLAB程序设计研究改进后的Canny算子在立交桥曲线提取的应用。通过图像增强、线性与非线性处理相结合、形态学处理以及梯度倒数加权平滑针对像素点创建结构元素修改边缘检测路径,较初始检测算法得到更具实用性的目标提取对象,改进的提取程序能有效滤除目标对象周围非目标提取物干扰,提取指向性显著提高。提出以像素点提取参考点范围坐标的思路,以点位中误差为基准计算提取精度,成果能满足工程中1∶1000比例尺下的生产应用,将程序封装在GUI界面中提供模块化处理和成果输出。

关键词：公路桥梁边缘检测路径 MATLAB提取梯度倒数加权 GUI界面设计

Comparison of antimony and arsenic behaviour at the river-lake junction in the middle of the Yangtze River Basin

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Journal of Environmental Sciences 2024年第2期136卷 189-200页

作者： Huiji Liu Wei Zeng ziyang Lai Mengchang He Chunye lin Wei Ouyang Xitao Liu State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

As typical metalloid toxic elements widely distributed in environmental media,the geochemical behaviour of antimony(Sb)and arsenic(As)affects environmental *** selected the surface waters and sediments at the river-lake junction of Dongting Lake as the research objects,analysed the concentration and chemical partitioning of Sb and As,assessed its contamination and ecological risk levels,and discussed its sources and potential influencing *** concentrations of dissolved Sb and As in surface waters were low(<5.46μg/L),and the concentrations of Sb and As in surface sediments were 2.49-22.65mg/kg and 11.10-136.34 mg/kg,*** and As in sediments were mainly enriched in the fraction of residues,but the proportion of As in bioavailability was significantly higher than that of *** the contamination level of Sb was higher than that of As,the risk assessment code(RAC)showed that the ecological risk level of As was higher than that of *** erosion and mining activities(in the midstream of Zijiang River)were the main contaminated sources of Sb,while As was affect mainly by rainwater *** contamination and ecological risk of Sb in the inlet of the Zijiang River should receive considerable attention,while those of As in the inlet of the Xiangjiang River should also be seriously *** study highlights the need for multi-index-based assessments of contamination and ecological risk and the importance of further studies on the environmental behaviour of metalloids in specific hydrological conditions,such as river-lake junctions.

关键词： Contamination Ecological risks Antimony(Sb) Arsenic(As) River-lake junction Dongting Lake

Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia

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Genes & Diseases 2024年第5期11卷 374-389页

作者： Zijun Yan Jie Xia ziyang Cao Hongyang Zhang Jinxia Wang Tienan Feng Yi Shu lin Zou Clinical Research Unit Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Institute of Pediatric Infection Immunityand Critical Care MedicineShanghai Jiao Tong University School of MedicineShanghai 200062China Center for Clinical Molecular Laboratory Medicine of Children’s Hospital of Chongqing Medical University Chongqing 400014China Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghai 200025China Bioinformatics and BioMedical Bigdata Mining Laboratory School of Big HealthGuizhou Medical UniversityGuiyangGuizhou 554300China

T-cell acute lymphoblastic leukemia(T-ALL),a heterogeneous hematological malignancy,is caused by the developmental arrest of normal T-cell *** development of targeted therapeutic regimens is impeded by poor knowledge of the stage-specific aberrances in this *** this study,we performed multi-omics integration analysis,which included mRNA expression,chromatin accessibility,and gene-dependency database analyses,to identify potential stage-specific druggable targets and repositioned drugs for this *** multi-omics integration helped identify 29 potential pathological genes for *** genes exhibited tissue-specific expression profiles and were enriched in the cell cycle,hematopoietic stem cell differentiation,and the AMPK signaling *** these,four known druggable targets(CDK6,TUBA1A,TUBB,and TYMS)showed dysregulated and stage-specific expression in malignant T cells and may serve as stage-specific targets in *** TUBA1A expression level was higher in the early T cell precursor(ETP)-ALL cells,while TUBB and TYMS were mainly highly expressed in malignant T cells arrested at the CD4 and CD8 double-positive or single-positive ***6 exhibited a U-shaped expression pattern in malignant T cells along the naıve to maturation ***,mebendazole and gemcitabine,which target TUBA1A and TYMS,respectively,exerted stage-specific inhibitory effects on T-ALL cell lines,indicating their potential stage-specific antileukemic role in ***,our findings might aid in identifying potential stage-specific druggable targets and are promising for achieving more precise therapeutic strategies for T-ALL.

关键词： Multi-omics Stage-specific druggable targets Targeted therapeutic strategies T-cell acute lymphoblastic leukemia Drug repositioning

Optical-field-induced Freeder-icksz transition of a nematic liquid crystal doped with dia-zophenyl

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Chinese Science Bulletin 2001年第8期46卷 647-649页

作者： WANG Jian LI Yu CHEN Yonglie LIANG Zhaoxi XIANG Ying lin ziyang SHI Longpei QIU Zhiren Institute of Polymer Science Zhongshan UniversityGuangzhou 510275China Department of Physics Zhongshan UniversityGuangzhou 510275China State Key Laboratory of Ultrafast Laser Spectroscopy Zhongshan UniversityGuangzhou 510275China

4[4’-(phenylazo)phenylazo]phenol was synthesized and characterized. Optical-induced Freedericksz transition of 5CB liquid crystal doped with trace diazophenyl was studied. It was observed that the doped 5CB dramatically decreased the optical field threshold, and the Freedericksz transition threshold occurred at optical intensity level of 0.3 mW/mm2 for the 12.5 μm thickness planar alignment doped 5CB, which is three orders of magnitude lower than that for the pure 5CB. This new phenomenon indicated that trans-cis isomerization of diazophenyl plays an important role in the decrease of the Freedericksz transition threshold.

关键词： 4[4’-(phenylazo)phenylazo]phenol 4-amyl-4 ’-cyanodi- phenyl Freedericksz transition nonlinear optics.

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西班牙图书出版业转型探索与启示

出版发行研究 2023年第1期 80-86,56页

作者：沈悦孙露铭林子洋上海师范大学旅游学院上海外国语大学上海全球治理与区域国别研究院

西班牙图书出版业伴随着全球化以及欧盟文化政策改良的步伐,经历了萌芽发展、恢复发展、民主扩张、市场整合、技术转型、多元融合等六个阶段。同时,通过搭建立体营销渠道、优化图书出版模式、完善图书贸易规制、调适经营环境等策略,提... 详细信息

西班牙图书出版业伴随着全球化以及欧盟文化政策改良的步伐,经历了萌芽发展、恢复发展、民主扩张、市场整合、技术转型、多元融合等六个阶段。同时,通过搭建立体营销渠道、优化图书出版模式、完善图书贸易规制、调适经营环境等策略,提升其市场竞争力。西班牙图书出版业所面临的机遇和挑战与中国图书出版业的现实境况较为相似,对未来我国图书出版业的转型探索具有一定的借鉴价值。

关键词：西班牙出版图书出版数字出版数字创新欧盟

硅烷化介孔硼硅酸盐生物玻璃微球对PMMA骨水泥生物活性和力学性能的影响

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无机材料学报 2023年第8期38卷 971-977页

作者：倪晓诗林子扬秦沐严叶松王德平同济大学材料科学与工程学院上海201804

聚甲基丙烯酸甲酯(PMMA)骨水泥因具有良好的力学性能、适宜的凝固时间和低毒性等优点而在骨科手术中作为可注射型人工骨修复材料受到广泛的应用。然而,其生物惰性可能导致假体长期植入后产生无菌性松动。本研究采用模板法制备了介孔硼... 详细信息

聚甲基丙烯酸甲酯(PMMA)骨水泥因具有良好的力学性能、适宜的凝固时间和低毒性等优点而在骨科手术中作为可注射型人工骨修复材料受到广泛的应用。然而,其生物惰性可能导致假体长期植入后产生无菌性松动。本研究采用模板法制备了介孔硼硅酸盐生物玻璃微球(MBGS),并用硅烷偶联剂γ-甲基丙烯酰氧基丙基三甲氧基硅烷(γ-MPS)对其进行改性,制备了MBGSSI。再将硅烷化介孔硼硅酸盐生物玻璃微球(MBGSSI)与聚甲基丙烯酸甲酯(PMMA)骨水泥复合,制备了一种具有良好生物活性和力学性能的复合骨水泥。实验结果表明,由于γ-MPS与MBGS的结合主要发生在介孔微球的近表面,MBGSSI比MBGS具有更大的比表面积和更小的孔容积。与MBGS/PMMA复合骨水泥相比,γ-MPS可以改善复合材料中无机相和有机相之间的结合,因此MBGSSI/PMMA复合骨水泥的力学性能得到了改善,符合ISO 5833:2002对丙烯酸类骨水泥的力学性能要求。此外,在SBF溶液中浸泡42 d后,MBGS/PMMA和MBGSSI/PMMA复合骨水泥的表面均生成了羟基磷灰石(HA),证明复合骨水泥具有良好的生物活性。因此,MBGSSI/PMMA复合骨水泥是一种潜在的骨修复材料。

关键词：生物玻璃硅烷化 PMMA骨水泥生物活性力学性能

人工湿地-电活性菌藻膜技术处理养猪废水中试试验

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农业工程学报 2023年第4期39卷 180-187页

作者：倪智力匡彬林梓杨周丽琳汪涛郏建波五邑大学生物科技与大健康学院江门529020 江门职业技术学院经济管理系江门529020

人工湿地由于具有运行成本低、维护简单等优点而被广泛应用于养殖废水处理。然而,人工湿地技术普遍存在污染物去除效率受温度影响大等问题。在该研究中,通过构建电活性菌藻生物膜来强化人工湿地系统,对养猪废水进行了自然温度下的处理... 详细信息

人工湿地由于具有运行成本低、维护简单等优点而被广泛应用于养殖废水处理。然而,人工湿地技术普遍存在污染物去除效率受温度影响大等问题。在该研究中,通过构建电活性菌藻生物膜来强化人工湿地系统,对养猪废水进行了自然温度下的处理效能与微生物群落研究,在室外开展了18个月试验,结果表明:电活性菌藻生物膜强化组在夏季化学需氧量、氨氮、硝态氮、总氮、总磷、亚硝态氮的去除率分别达到98.26%、97.96%、85.45%、95.07%、94.64%和85.45%。在冬季化学需氧量、氨氮、硝态氮、总氮、总磷、亚硝态氮的去除率分别达到96.10%、91.56%、75.29%、89.94%、92.12%和83.15%。具有良好低温适应性。强化组冬季化学需氧量、氨氮、硝态氮、总氮、总磷、亚硝态氮的出水浓度均满足《禽畜养殖业污染物排放标准》(GB18596—2001)。相比未构建电活性菌藻生物膜的对照组,以上污染物去除率均分别提高。电活性菌藻膜在冬夏季节的优势微生物均为Cyanobium、Shewanella、Azoarcus,群落结构稳定性高,有利于促进冬季污染物去除率,为提高系统污水处理可靠性提供了保障。

关键词：厌氧人工湿地禽畜养殖生物膜冬季