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心理社会因素对孕产妇产后并发症及胎儿心理生理影响研究

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中国医药指南 2024年第12期22卷 62-65页

作者：王琼袁紫薇张正梅平凉市妇幼保健院保健部平凉744000

目的主要探讨心理社会因素对于孕产妇产后并发症及胎儿心理生理的影响。方法选择2020年11月至2022年12月收治的105例孕产妇。根据孕产妇胎心率分成正常组(n=74)与异常组(n=31);根据产后有无并发症分成有并发症组(n=22)、无并发症组(n=83... 详细信息

目的主要探讨心理社会因素对于孕产妇产后并发症及胎儿心理生理的影响。方法选择2020年11月至2022年12月收治的105例孕产妇。根据孕产妇胎心率分成正常组(n=74)与异常组(n=31);根据产后有无并发症分成有并发症组(n=22)、无并发症组(n=83)。协助孕产妇在孕早期、孕中期、孕晚期完成一般情况问卷、PHQ-9抑郁症筛查量表、生活事件量表(LES)、艾森克个性问卷(EPQ)、症状自评量表(SCL-90)问卷调查,在产后42 d内完成状态焦虑量表(SAI)、PHQ-9抑郁症筛查量表、爱丁堡产后抑郁量表(EPDS)问卷调查。结果胎心率异常组生活事件各因子得分及总值均高于正常组(P<0.05);孕产妇产前血压、胎心率与心理社会因素存在一定的关系;有并发症组的孕产妇,PHQ-9总分、SAI总分、EPDS总分均高于无并发症组(P<0.05)。结论针对孕产妇群体,心理社会因素影响孕产妇血压及胎儿预后,需加强关注。心理社会因素影响孕产妇及胎儿的健康。

关键词：心理社会因素孕产妇胎儿血压相关性

通窍脱敏方治疗变应性鼻炎疗效观察及安全性评价

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中华中医药学刊 2024年第6期42卷 236-239页

作者：马凤梅李丛丛马雷邢苗史飞飞袁子薇于向艳河北省中医院河北石家庄050011 蠡县医院河北蠡县071400 宁晋县中西医结合医院河北宁晋055550 宁晋县医院河北宁晋055550

目的探讨通窍脱敏方治疗变应性鼻炎的疗效观察及安全性评价。方法选择2021年7月—2022年7月82例河北省中医院耳鼻喉科诊断为肺气虚寒证型的变应性鼻炎患者作为研究对象,采用随机数字法平均分为观察组与对照组:对照组给予口服氯雷他定... 详细信息

目的探讨通窍脱敏方治疗变应性鼻炎的疗效观察及安全性评价。方法选择2021年7月—2022年7月82例河北省中医院耳鼻喉科诊断为肺气虚寒证型的变应性鼻炎患者作为研究对象,采用随机数字法平均分为观察组与对照组:对照组给予口服氯雷他定片治疗,观察组给予通窍脱敏方治疗。于治疗前、治疗2周及4周后比较两组中医证候积分、临床疗效差异及不良反应发生情况,并随访6个月比较两组患者的复发情况。结果观察组总有效率明显高于对照组(P0.05)。两组治疗3个月复发率比较差异无统计学意义(P>0.05);治疗后6月观察组复发率低于对照组(P<0.05)。结论通窍脱敏方治疗变应性鼻炎有更好的临床疗效,更快改善患者鼻炎症状,更好降低机体炎性反应,不仅不良反应少,且大大降低了远期复发,值得临床应用。

关键词：通窍脱敏方变应性鼻炎疗效安全性复发

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芪黄疽愈方调节ApoE^(-/-)小鼠巨噬细胞相关因子干预动脉粥样硬化形成的机制研究

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中华中医药杂志 2024年第1期39卷 376-381页

作者：武萌萌张欣苏志伟葛建立杨丽静刘学飞袁子薇张敏妹河北省中医院石家庄050011 石家庄市中医院石家庄050011

目的:探讨芪黄疽愈方调控巨噬细胞相关因子影响ApoE^(-/-)小鼠动脉粥样硬化形成的作用机制。方法:68只ApoE^(-/-)小鼠随机分为模型组(24只)、中药组(22只)、对照组(22只),另设C57BL/6小鼠25只为空白组。高脂饲料喂养构造动脉粥样硬化Apo... 详细信息

目的:探讨芪黄疽愈方调控巨噬细胞相关因子影响ApoE^(-/-)小鼠动脉粥样硬化形成的作用机制。方法:68只ApoE^(-/-)小鼠随机分为模型组(24只)、中药组(22只)、对照组(22只),另设C57BL/6小鼠25只为空白组。高脂饲料喂养构造动脉粥样硬化ApoE^(-/-)小鼠模型,中药组按0.2 mL/20 g体质量予芪黄疽愈方颗粒灌胃,对照组按0.2 mL/20 g体质量予阿托伐他汀钙片悬混液灌胃,空白组、模型组给予等量0.9%氯化钠溶液灌胃,连续给药12周。观察各组小鼠一般状态、体质量;主动脉HE染色、Masson染色、油红O染色,观察血管病理形态、斑块面积;血清ELISA检测巨噬细胞相关因子白细胞介素(IL)-1β、IL-4、IL-13、干扰素-γ(IFN-γ)、脂多糖(LPS)、转化生长因子-β(TGF-β)、IL-6、IL-10、IL-12表达情况;免疫荧光观察巨噬细胞表面标志物iNOS、CD206表达情况。结果:模型组、中药组、对照组小鼠精神萎靡,毛色暗淡,前期增长迅速,后逐渐减缓,其中模型组体质量显著高于其他各组(P<0.01)。HE染色、Masson染色、油红O染色病理图片显示:模型组较空白组斑块面积显著增大,胶原纤维含量明显减少,主动脉红染脂质显著增加(P<0.01),中药组、对照组较模型组斑块面积降低,胶原纤维含量明显增多,主动脉红染脂质显著减少(P<0.01)。ELISA检测结果示:模型组小鼠血清IL-1β、IFN-γ、LPS、IL-6、IL-12显著高于空白组(P<0.05),IL-4、IL-13、TGF-β、IL-10显著低于空白组(P<0.05);与模型组比较,中药组小鼠血清IL-1β、IFN-γ、LPS、IL-6、IL-12显著降低(P<0.05),IL-4、IL-13、TGF-β、IL-10的表达水平显著提高(P<0.05)。免疫荧光染色示:M1型巨噬细胞标志物iNOS在模型组阳性表达较空白组高(P<0.01),中药组表达较模型组低(P<0.05),M2型巨噬细胞标志物CD206在模型组阳性表达较中药组低(P<0.01)。结论:芪黄疽愈方可减少M1型巨噬细胞,抑制M1型巨噬细胞相关因子IL-1β、IFN-γ、LPS、IL-6、IL-12的表达;增加M2型巨噬细胞,促进M2型巨噬细胞相关因子IL-4、IL-13、TGF-β、IL-10的生成,这可能是其干预动脉粥样硬化发生发展的机制。

关键词：芪黄疽愈方动脉粥样硬化巨噬细胞炎症因子

Low-Energy Driven Ring-Opening Behavior of Benzocyclobutene Derivatives

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Chinese Journal of Chemistry 2023年第23期41卷 3238-3244页

作者： ziwei yuan Quan Sun Jinchong Xiao Pingxia Zhang Konstantin S.Levchenko Dmitry Y.Demin Wenxin Fu Laboratory of Science and Technology on High-Tech Polymer Materials Institute of ChemistryChinese Academy of SciencesBeijing100190 China College of Chemistry and Material Science Hebei UniversityBaodingHebei071002 China University of Chinese Academy of Sciences Beijing100049 China MIREA — Russian Technological University Moscow119454 Russian Federation

It's urgent to develop benzocyclobutene(BCB)-based polymers with low curing temperature for temperature-sensitive applications such as liquid crystal displays(LCDs)and flexible ***,the effect of substituents on the ring-opening behavior of BCB derivatives was *** ring-opening activation energy barriers(ΔGA)of BCB derivatives with one or two substituents on the four-membered alkyl ring were systematically calculated using the B3LYP *** mono-and di-substituted BCBs adopted the conrotatory ring-opening process,obeying the Woodward-Hoffmann's Rules upon *** mono-/di-substituted BCBs exhibited 8.2%—69%lowerΔGA compared with BCB,attributed to the electronic effects of the *** BCBs with both electron-donating and electron-withdrawing groups,e.g.,1-NH_(2)-8-NO_(2)-BCB,demonstrated the lowestΔ*** addition,BCB derivatives with amide/ester/acyloxy group modified on C1 position were synthesized as model molecules,and their ring-opening temperature can be decreased by 20℃ compared to the unsubstituted one,also consistent with our calculation *** work combined theoretical calculation methods with experimental results to provide valuable insights into the design and synthesis of BCB derivatives and next-generation BCB functional packaging materials with low ring-opening temperature.

关键词： Benzocyclobutene Thermosets Monomers Low curing temperature Activation energy barrier Electronic effect Captodative effect

Patent-based technological developments and surfactants application of lithium-ion batteries fire-extinguishing agent

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Journal of Energy Chemistry 2024年第1期88卷 39-63,I0002页

作者： Jianqi Zhang Tao Fan Shuai yuan Chongye Chang Kuo Wang ziwei Song Xinming Qian State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100084China Industrial Safety Research Institute China Academy of Safety Science and TechnologyBeijing 100012China Fire Engineering Department China People’s Police UniversityLangfang 065000HebeiChina

While newer,more efficient Lithium-ion batteries(LIBs)and extinguishing agents have been developed to reduce the occurrence of thermal runaway accidents,there is still a scarcity of research focused on the application of surfactants in different LIBs extinguishing agents,particularly in terms of patented *** aim of this review paper is to provide an overview of the technological progress of LIBs and LIBs extinguishing agents in terms of patents in Korea,Japan,Europe,the United States,China,*** initial part of this review paper is sort out LIBs technology development in different *** addition,to compare LIBs extinguishing agent progress and challenges of liquid,solid,combination of multiple,and *** subsequent section of this review focuses on an in-depth analysis dedicated to the efficiency and challenges faced by the surfactants corresponding design principles of LIBs extinguishing agents,such as nonionic and anionic surfactants.A total of 451,760 LIBs-related patent and 20 LIBs-fire-extinguishing agent-related patent were included in the *** extinguishing effect,cooling performance,and anti-recombustion on different agents have been *** a comprehensive comparison of these agents,this review suggests that temperature-sensitive hydrogel extinguishing agent is ideal for the effective control of LIBs *** progress and challenges of surfactants have been extensively examined,focusing on key factors such as surface activity,thermal stability,foaming properties,environmental friendliness,and electrical ***,it is crucial to emphasize that the selection of a suitable surfactant must align with the extinguishing strategy of the extinguishing agent for optimal firefighting effectiveness.

关键词： LIBs Fire-extinguishing agent Surfactants Patent

Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy

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Bioactive Materials 2022年第10期7卷 232-248页

作者： Bin Wang Maoping Tang ziwei yuan Zhongyu Li Bin Hu Xin Bai Jinxian Chu Xiaoyang Xu Xue-Qing Zhang Engineering Research Center of Cell&Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong University800 Dongchuan RoadShanghai200240PR China Department of Chemical and Materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

Immunotherapy is emerging as a powerful tool for combating many human ***,the application of this life-saving treatment in serious brain diseases,including glioma,is greatly *** major obstacle is the lack of effective technologies for transporting therapeutic agents across the blood-brain barrier(BBB)and achieving targeted delivery to specific cells once across the ***,an iron storage protein,traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1(TfR1)overexpressed on BBB endothelial ***,we developed bioengineered ferritin nanoparticles as drug delivery carriers that enable the targeted delivery of a small-molecule immunomodulator to achieve enhanced immunotherapeutic efficacy in an orthotopic glioma-bearing mouse *** fused different glioma-targeting moieties on self-assembled ferritin nanoparticles via genetic engineering,and RGE fusion protein nanoparticles(RGE-HFn NPs)were identified as the best ***,RGE-HFn NPs encapsulating a stimulator of interferon genes(STING)agonist(SR717@RGE-HFn NPs)maintained stable self-assembled structure and targeting properties even after traversing the *** the glioma-bearing mouse model,SR717@RGE-HFn NPs elicited a potent local innate immune response in the tumor microenvironment,resulting in significant tumor growth inhibition and prolonged ***,this biomimetic brain delivery platform offers new opportunities to overcome the BBB and provides a promising approach for brain drug delivery and immunotherapy in patients with glioma.

关键词： Blood brain barrier Bioengineered protein nanoparticles Dual-targeting property STING agonist Glioma-targeted immunotherapy

Nitric oxide removal from flue gas coupled with the Fe^(Ⅱ)EDTA regeneration by ultraviolet irradiation

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Chinese Journal of Chemical Engineering 2024年第4期68卷 133-143页

作者： yuan Xu ziwei Liu Ying Dai Jinbo Ouyang Zhuyao Li Yuling Zhu Jianhua Ding Feiqiang He School of Chemistry and Materials Science East China University of TechnologyNanchang 330013China

During wet complexation denitrification of flue gas,Fe^(Ⅱ)EDTA regeneration,also known as reducing Fe^(Ⅱ)EDTA and Fe^(Ⅱ)EDTA-nitric oxide(NO)to Fe^(Ⅱ)EDTA,is *** this paper,ultraviolet(UV)light was used for the first time to reduce Fe^(Ⅱ)*** experimental result demonstrated that Fe^(Ⅱ)EDTA-NO reduction rate increased with UV power increasing,elevated temperature,and initial Fe^(Ⅱ)EDTA-NO concentration ***^(Ⅱ)EDTA-NO reduction rate increased first and then decreased as pH value increased(2.0-10.0).Fe^(Ⅱ)EDTA-NO reduction with UV irradiation presented a first order reaction with respect to Fe^(Ⅱ)*** with other Fe^(Ⅱ)EDTA regeneration methods,Fe^(Ⅱ)EDTA regeneration with UV show more superiority through comprehensive consideration of regeneration rate and ***,NO absorption experiment by Fe^(Ⅱ)EDTA solution with UV irradiation confirmed that UV can significantly promote the NO removal performance of Fe^(Ⅱ)*** oxygen concentration(3%(vol))and acidic environment(pH=4)was favorable for NO *** UV power increasing as well as temperature decreasing,NO removal efficiency *** addition,the mechanism research indicates that NO from flue gas is mostly converted to NO_(2)-,NO_(3)-,NH_(4)^(+),N_(2),and N_(2)O with Fe^(Ⅱ)EDTA absorption liquid with UV *** strengthens NO removal in Fe^(Ⅱ)EDTA absorption liquid by forming a synergistic effect of ***,compared with NO removal methods with Fe^(Ⅱ)EDTA,Fe^(Ⅱ)EDTA combined UV system shows prominent technology advantage in terms of economy and secondary pollution.

关键词： Fe^(II)EDTA Ultraviolet Flue gas Nitric oxide Regeneration Absorption

COPD急性加重期患者出院1个月内非计划性再入院的危险因素调查及护理对策

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护理实践与研究 2024年第5期21卷 713-719页

作者：李素华杨琼马东艳袁紫薇邵娥芬邓敏康云昆明医科大学第一附属医院云南省昆明市650000

目的探讨慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者出院1个月内非计划性再入院的危险因素及其护理对策。方法选择医院2020年3月—2022年3月收治的AECOPD患者120例为研究对... 详细信息

目的探讨慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者出院1个月内非计划性再入院的危险因素及其护理对策。方法选择医院2020年3月—2022年3月收治的AECOPD患者120例为研究对象,收集患者性别、年龄、吸烟史等一般资料,了解患者基础疾病情况、呼吸困难评分(mMRC)、空腹外周静脉血等实验室指标。以患者出院1个月内非计划性再入院为终点,通过单因素分析、多因素Logistic回归分析筛选1个月内非计划性再入院的影响因素,据此确定护理对策。结果AECOPD患者出院1个月内非计划性再入院23例,单因素分析结果显示,血清C反应蛋白(CRP)、FEF75预计值、FEV1实际值、血清白蛋白(ALB)、气流受限严重程度(GOLD)分级、中性粒细胞与淋巴细胞比(NLR)、呼吸困难评分(mMRC)、血小板与淋巴细胞比(PLR)水平、二氧化碳分压(PaCO_(2))、肺康复锻炼依从性是AECOPD患者出院1个月内非计划性再入院的影响因素(P<0.05)。多因素Logistic回归分析结果显示,FEF75预计值、CRP、ALB、NLR、FEV1实际值和肺康复锻炼依从性是AECOPD患者出院1个月内非计划性再入院的影响因素(P<0.05)。结论针对CRP、PLR、FEF75水平升高和ALB水平、FEV1实际值下降,肺康复锻炼依从性差的AECOPD患者,医院应采取针对性防控措施,提高护理服务质量,减少AECOPD患者非计划性再入院率。

关键词：慢性阻塞性肺疾病再入院率影响因素呼吸困难肺康复

Channel estimation-based time-frequency neural network for post-equalization in underwater visible light communication

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Chinese Optics Letters 2024年第6期22卷 116-122页

作者： Haoyu Zhang Li Yao Chaoxu Chen yuan Wei Chao Shen Jianyang Shi Junwen Zhang ziwei Li Nan Chi Key Laboratory for Information Science of Electromagnetic Waves(MoE) Department of Communication Science and EngineeringSchool of Information Science and TechnologyFudan UniversityShanghai 200433China Shanghai CIC of LEO Satellite Communication Technology Fudan UniversityShanghai 200433China Shanghai ERC of LEO Satellite Communication and Application Fudan UniversityShanghai 200433China

This Letter proposes a post-equalizer for underwater visible light communication(UVLC) systems that combines channel estimation and joint time-frequency analysis, named channel-estimation-based bandpass variable-order time-frequency network(CBV-TFNet). By utilizing a bandpass variable-order loss function with communication prior knowledge, CBVTFNet enhances communication performance and training stability. It enables lightweight implementation and faster convergence through a channel estimation-based mask. The superior performance of the proposed equalization method over Volterra and deep neural network(DNN)-based methods has been studied experimentally. Using bit-power loading discrete multitone (DMT) modulation, the proposed method achieves a transmission bitrate of 4.956 Gbps through a 1.2 m underwater channel utilizing only 38.15% of real multiplication calculations compared to the DNN equalizer and achieving a bitrate gain of440 Mbps and a significantly larger dynamic range over the LMS-Volterra equalizer. Results highlight CBV-TFNet's potential for future post-equalization in UVLC systems.

关键词： underwater visible light communication channel estimation post-equalizer neural network