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Carbon nanotubes-reinforced polylactic acid/hydroxyapatite porous scaffolds for bone tissue engineering

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Frontiers of Materials Science 2024年第1期18卷 59-69页

作者： Weiwei Lan Mingbo Wang Zhenjun Lv Jun Li Fuying Chen ziwei liang Di Huang Xiaochun Wei Weiyi Chen Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Guangdong Engineering Technology Research Center of Implantable Medical Polymer Shenzhen Lando Biomaterials Co.Ltd.Shenzhen 518107China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030060China Department of Orthopaedics The Second Hospital of Shanxi Medical UniversityTaiyuan 030001China

In the field of bone defect repair,critical requirements for favorable cytocompatibility and optimal mechanical properties have propelled research efforts towards the development of composite *** this study,carbon nanotubes/polylactic acid/hydroxyapatite(CNTs/PLA/HA)scaffolds with different contents(0.5,1,1.5 and 2 wt.%)of CNTs were prepared by the thermally induced phase separation(TIPS)*** results revealed that the composite scaffolds had uniform pores with high porosities over 68%and high through *** addition of CNTs significantly enhanced the mechanical properties of resulted PLA/HA,in which the 1.5 wt.%CNTs/PLA/HA composite scaffold demonstrated the optimum mechanical behaviors with the bending elastic modulus of(868.5±12.34)MPa,the tensile elastic modulus of(209.51±12.73)MPa,and the tensile strength of(3.26±0.61)***,L929 cells on the 1.5 wt.%CNTs/PLA/HA scaffold displayed good spreading performance and favorable ***,it is expected that the 1.5 wt.%CNTs/PLA/HA scaffold has potential applications in bone tissue engineering.

关键词： CNTs/PLA/HA scaffold TIPS method mechanical property bone tissue engineering

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纳米酶在脑疾病治疗中的应用

化学进展 2024年第1期36卷 18-26页

作者：孟子楹王杰王嘉璞魏延黄棣梁紫微太原理工大学生物医学工程学院生物医学工程系纳米生物材料与再生医学研究中心太原030024 山西浙大新材料与化工研究院太原030024

近年来,作为新一代人工酶的纳米酶,凭借着优于天然酶的多酶活性、高稳定性和靶向性等特点逐步进入医学领域,又因对活性氧的调控作用而被应用于多种疾病及癌症的治疗。脑类疾病作为病死率最高的疾病之一,病理环境中存在过多的活性氧,易... 详细信息

近年来,作为新一代人工酶的纳米酶,凭借着优于天然酶的多酶活性、高稳定性和靶向性等特点逐步进入医学领域,又因对活性氧的调控作用而被应用于多种疾病及癌症的治疗。脑类疾病作为病死率最高的疾病之一,病理环境中存在过多的活性氧,易产生复杂的炎症反应。因此,将纳米酶应用于脑部环境或成为有效的脑疾病监测和治疗手段。本文综述了纳米酶应用于脑疾病治疗的原理及近年来该领域的研究现状,包括纳米酶通过调控活性氧的水平诱导癌细胞凋亡、纳米酶辅助传统抗癌疗法、纳米酶借助膜蛋白进行脑癌监测以及在创伤性脑损伤、脑卒中、大脑退行性疾病、脑型疟疾和癫痫中的应用。最后,对其应用于临床治疗所面临的问题进行了讨论。

关键词：纳米酶活性氧脑癌脑损伤阿尔茨海默病

贝伐珠单抗、呋喹替尼致高血压、肾病综合征1例

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中国医院药学杂志 2024年第15期44卷 1836-1839页

作者：梁紫微吴娜孟凡堰安顺市人民医院药剂科贵州安顺561000 安顺市人民医院肿瘤科贵州安顺561000

通过1份老年男性患者使用贝伐珠单抗、呋喹替尼引起高血压、肾病综合征的病例资料与相关文献进行回顾分析。患者使用贝伐珠单抗、呋喹替尼后出现血压升高达190/110 mmHg、大量蛋白尿(17.36 g·d^(-1)),血清白蛋白降至24.4 g·L^(-1),双... 详细信息

通过1份老年男性患者使用贝伐珠单抗、呋喹替尼引起高血压、肾病综合征的病例资料与相关文献进行回顾分析。患者使用贝伐珠单抗、呋喹替尼后出现血压升高达190/110 mmHg、大量蛋白尿(17.36 g·d^(-1)),血清白蛋白降至24.4 g·L^(-1),双下肢水肿,考虑为贝伐珠单抗、呋喹替尼所致高血压、继发性肾病综合征可能性大,经停用呋喹替尼、血液净化治疗与对症支持处理后有所好转。提示贝伐珠单抗、呋喹替尼可能会导致高血压、肾病综合征,临床使用该类药物时需警惕类似药物不良反应的发生。

关键词：贝伐珠单抗呋喹替尼高血压肾病综合征抗VEGF抑制剂

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Recent advances in bifunctional catalysts for zinc-air batteries:Synthesis and potential mechanisms

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Science China(Technological Sciences) 2022年第10期65卷 2221-2245页

作者： ZHAO LinWei GU TengTeng liang ziwei LIU Jun School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510641China

Zinc-air batteries(ZABs) are considered promising candidates for next-generation clean and sustainable energy storage devices because of their low cost, safety, environment-friendliness, and high specific energy density. However, owing to its poor chargedischarge capacity and low efficiency, its practical application remains challenging. The main obstacles are the intrinsic slow reaction kinetics on the air cathode, including the oxygen reduction reaction(ORR) during discharging and oxygen evolution reaction(OER) during recharging. Therefore, a reasonable design of bifunctional ORR/OER electrocatalysts with high activity and stability is the key to the development of ZABs. In this review, the recent advances in bifunctional ORR/OER electrocatalysts as air cathodes in ZABs are discussed from three perspectives: metal-organic framework-based catalysts, metal-free carbon catalysts, and metal-based catalysts. In particular, the synthesis, electrocatalytic activity, and potential mechanism of bifunctional catalysts in ZABs are discussed. In recent years, research on bifunctional catalysts has intensified, and the performance of these catalysts has significantly improved. However, most of the experimental products have complex preparation processes and high costs;therefore, the industrialization of these experimental products remains difficult. This review offers prospects for the optimal design of high-activity rechargeable ZAB bifunctional air cathodes.

关键词： zinc-air batteries air cathode bifunctional electrocatalysts non-noble metal catalyst

Metal-organic frameworks based single-atom catalysts for advanced fuel cells and rechargeable batteries

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Journal of Energy Chemistry 2023年第5期80卷 501-534,I0012页

作者： Yifei Wu Peng Hu Fengping Xiao Xiaoting Yu Wenqi Yang Minqi liang ziwei liang Aixin Zhu College of Chemistry and Chemical Engineering Yunnan Normal UniversityKunming 650500YunnanChind School of Energy and Environment Science Yunnan Normal UniversityKunming 650500.YunnanChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China School of Environment and Chemical Engineering Zhaoqing UniversityZhaoqing 526061GuangdongChina

The next-generation energy storage systems such as fuel cells,metal-air batteries,and alkali metal(Li,Na)-chalcogen(S,Se)batteries have received increasing attention owing to their high energy density and low ***,one of the main obstacles of these systems is the poor reaction kinetics in the involved chemical ***,it is essential to incorporate suitable and efficient catalysts into the *** years,single-atom catalysts(SACs)are emerging as a frontier in catalysis due to their maximum atom efficiency and unique reaction *** SACs fabrication,metal-organic frameworks(MOFs)have been confirmed as promising templates or precursors due to their high metal loadings,structural adjustability,porosity,and tailorable catalytic *** this review,we summarize effective strategies for fabricating SACs by MOFs with corresponding advanced characterization techniques and illustrate the key role of MOFs-based SACs in these batteries by explaining their reaction mechanisms and ***,current applications,prospects,and opportunities for MOFs-based SACs in energy storage systems are discussed.

关键词： Metal-organic frameworks Single-atom catalysts Rechargeable batteries Electrocatalysts Coordination configuration

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钛植入物表面抗菌涂层的研究进展

生物医学工程学杂志 2024年第1期41卷 191-198页

作者：贺旭宏郭柴琼刘轩妤王玉辉梁紫微连小洁胡银春黄棣(综述) 魏延(审校) 太原理工大学生物医学工程学院生物医学工程系纳米生物材料与再生医学研究中心太原030024 太原理工大学生物医学工程研究所太原030024

近年来,钛及钛合金等骨植入材料以其卓越的机械性能和良好的生物相容性广泛应用于生物医学领域。然而在临床实践中,细菌在材料表面的黏附以及术后感染问题可能导致植入失败。根据抗菌机制,本文从抗细菌黏附、接触杀菌和光控杀菌等方面... 详细信息

近年来,钛及钛合金等骨植入材料以其卓越的机械性能和良好的生物相容性广泛应用于生物医学领域。然而在临床实践中,细菌在材料表面的黏附以及术后感染问题可能导致植入失败。根据抗菌机制,本文从抗细菌黏附、接触杀菌和光控杀菌等方面详细阐述了钛植入物的抗菌表面设计。通过采用不同技术对钛或基于钛的合金植入物进行表面修饰,抑制细菌黏附并促进骨整合,将扩大多功能钛基植入物在骨科领域的应用范围。

关键词：钛植入物生物相容性抗菌能力金属离子抗菌

Double-crosslinked PNIPAM-based hydrogel dressings with adjustable adhesion and contractility

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Regenerative Biomaterials 2023年第1期10卷 1496-1511页

作者： Yu Cao Longfei Wang Xiumei Zhang Yi Lu Yan Wei ziwei liang Yinchun Hu Di Huang Department of Biomedical Engineering Research Center for Nano-Biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Rapid post-wound closure is necessary to avoid wound infection and promote scar-free healing when skin trauma *** this study,new types of hydrogel dressings with adjustable contractility were fabricated based on N-isopropyl acrylamide/sodium alginate/graphene oxide(P/SA/GO).Then,the chitosan(CS)solution was used as a bridging polymer to achieve tissue adhesion to the *** results show that the hydrogel based on poly(N-isopropyl acrylamide)(PNIPAM)not only has the ability to self-shrink but also can adjust the rate of shrinkage through near-infrared thermal *** the same time,high adhesion strength(7.86±1.22 kPa)between the tissue and the dressing is achieved through the introduction of bridging polymers(CS),and the coating area of the bridging polymer can be adjusted to achieve regional *** mouse total skin defects experiments have shown that sutures-free wound closure in the early stages of wound healing could be obtained by adjusting the material ***,the dressings can promote scar-free wound healing by reducing inflammatory cell infiltration and collagen *** results indicate that double-crosslinked PNIPAM-based hydrogel dressings with adjustable adhesion and contractility proposed in this study provide a candidate material for achieving trackless wound healing.

关键词： hydrogel dressings temperature-sensitive adjustable adhesion adjustable contractility scar-free healing

Progress in cancer therapy with functionalized Fe_(3)O_(4) nanomaterials

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Frontiers of Materials Science 2023年第3期17卷 57-70页

作者： Yuhui Wang Xuanyu Liu Shilong Ma Xuhong He Chaiqiong Guo ziwei liang Yinchun Hu Yan Wei Xiaojie Lian Di Huang Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringShanxi Key Laboratory of Materials Strength&Structural ImpactTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Malignant neoplasms represent a significant global health *** address the need for accurate diagnosis and effective treatment,research is underway to develop therapeutic *** oxide nanoparticles(NPs),specifically Fe_(3)O_(4) NPs have been extensively studied as potential therapeutic agents for cancer due to their unique properties including magnetic targeting,favorable biocompatibility,high magnetic response sensitivity,prolonged in vivo circulation time,stable performance,and high *** ability to be integrated with magnetic hyperthermia,photodynamic therapy,and photothermal therapy has resulted in the widespread use of Fe_(3)O_(4) NPs in cancer diagnosis and treatment,making them a popular choice for such *** methods can be employed to synthesize magnetic Fe_(3)O_(4) NPs,which can then be surface-modified with biocompatible materials or active targeting *** systems can be created by combining Fe_(3)O_(4) NPs with *** combining various therapeutic approaches,more effective biomedical materials can be *** paper discusses the synthesis of Fe_(3)O_(4) NPs and the latest research advances in Fe_(3)O_(4)-based nanotherapeutic platforms,as well as their applications in the biomedical field.

关键词： Fe_(3)O_(4)NPs cancer treatment magnetic targeting magnetic thermotherapy

Self-assembled aerogel sheet electrodes of thermocells for low-grade heat harvest

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Science China Chemistry 2024年第5期67卷 1672-1679页

作者： ziwei Mo Shouhao Wei Daibin Xie Kaihua Zhu Hongxiong Li Xin Lu Lirong liang Chunyu Du Zhuoxin Liu Guangming Chen College of Materials Science and Engineering Shenzhen UniversityShenzhen 518055China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

Efficiently harvesting low-grade heat is crucial for sustainable energy management. Thermocells(TECs), inducing heat-toelectricity conversion via the thermogalvanic effect, have thus drawn tremendous attention in recent years. This study introduces a self-assembly approach for fabricating aerogel sheet electrodes(ASEs) tailored for TECs. The crafted ASEs retain a remarkable porous architecture with approximately 95% porosity, even with their slimmed-down thickness. Results reveal that the electrode composition has minimal influence on the thermopower of TECs. Notably, the porous ASE with tunned composition demonstrates an optimal effective surface area for the thermogalvanic effect, resulting in enhanced output current density. This balances the desirable traits of electrode compactness with abundant redox active sites, positioning it favorably against conventional bulky electrode designs. The TECs utilizing the optimized ASE achieve a peak output power of 22.10 μW cm^(-2)under a temperature difference of 30 K. Furthermore, a tubular TEC device is readily assembled and specially designed for harvesting heat energy from hot fluids. These findings underscore the potential of composite electrodes in the realm of low-grade heat harvest, paving the way for broader applications in sustainable energy solutions.

关键词： thermocells low-grade heat harvest energy conversion composite electrodes

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