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铜基催化剂电还原二氧化碳选择性的调控策略

化工进展 2023年第8期42卷 4043-4057页

作者：王耀刚韩子姗高嘉辰王新宇李思琪杨全红翁哲天津市先进碳与电化学储能重点实验室天津300072 国家储能技术产教融合创新平台天津300072 物质绿色创造与制造海河实验室天津300192 天津化学化工协同创新中心天津300072

在水系电解液中利用电能直接将CO_(2)还原成基础化学品为CO_(2)资源化利用提供了一种绿色可行的策略。铜是唯一能够高效地将CO_(2)还原成C^(2+)产物的金属催化剂,然而其催化产物多达16种,产物的多样性严重增加了后期产物分离的成本并大... 详细信息

在水系电解液中利用电能直接将CO_(2)还原成基础化学品为CO_(2)资源化利用提供了一种绿色可行的策略。铜是唯一能够高效地将CO_(2)还原成C^(2+)产物的金属催化剂,然而其催化产物多达16种,产物的多样性严重增加了后期产物分离的成本并大幅降低了整个电催化二氧化碳还原(eCO_(2)RR)系统的能量转换效率,是eCO_(2)RR走向工业化生产的一个重要瓶颈,因此对铜基催化剂进行合理的调控,以提高其对单一产物的选择性一直是研究的热点问题。经过30余年的发展,铜基催化剂的研究已经取得了巨大的进展,回溯近期铜基催化剂电催化CO_(2)还原领域的研究历程,本文综述了电催化二氧化碳还原的反应原理、反应路径和针对不同产物的调控策略,着重总结了提高铜基催化剂对单一产物选择性的设计策略和设计方法,最后展望了铜基催化剂面临的挑战和未来的发展方向。

关键词：电化学二氧化碳还原铜基催化剂产物选择性

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Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

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Nano Research 2025年第1期18卷 628-641页

作者： Min han zishan Chen Shiying Zhou Zunde Liao Xiangting Yi Yao He Yiling Zhong Kam W.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Functional Nano and Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(ROS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating Granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

Research on Marketing Strategies of Pinduoduo Based on SWOT Analysis

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Psychology Research 2023年第3期13卷 155-159页

作者： FU zishan han Jiatong Qingdao No.1 International School of Shandong Province QingdaoChina Nanjing University of Aeronautics and Astronautics NanjingChina

The development of the Internet has led to a dramatic increase in online shopping users.E-commerce enterprises have been rising and becoming very successful in China in recent *** an e-commerce platform established in 2015 and going public in 2018,Pinduoduo has become one of the three biggest e-commerce in China in a short period of *** attract many people’s attention,which drives people to explore the reason behind *** analysis is a model that enables us to analyze the strengths,weaknesses,opportunities,and threats of an *** this study,we use SWOT analysis model to analyze the marketing strategy of Pinduoduo,summarize the current status of Pinduoduo,and give some suggestion for itself and the other e-commerce platforms.

关键词： Pinduoduo SWOT analysis e-commerce marketing strategies

The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy

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Science China(Life Sciences) 2023年第1期66卷 81-93页

作者： han Yao Wenbin Xu Yajing Liu Zhijie Cao Jia Wen Mi Zhang Zhen Wu Xiaojun Yan zishan Jiao Zijing Zhang Jianyuan Chen Meng Zhang Wei-Guo Zhu Donglai Wang State Key Laboratory of Medical Molecular Biology&Department of Medical Genetics Institute of Basic Medical Sciences&School of Basic MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Anatomy Histology and EmbryologySchool of Basic MedicineChina Medical UniversityShenyang 110122China Department of Biochemistry and Molecular Biology Shenzhen University School of MedicineShenzhen 518060China

The oncoprotein SET is frequently overexpressed in many types of tumors and contributes to malignant initiation and progression through multiple mechanisms,including the hijacking of the tumor suppressors p53 and *** aberrant SET represents a promising strategy for cancer ***,the mechanism by which endogenous SET is regulated in cancer cells remains largely ***,we identified the tumor suppressor p53 as a key regulator that transcriptionally repressed the expression of SET in both normal and cancer *** addition,p53 stimulated PP2A phosphatase activity via p53-mediated transcriptional repression of SET,whereby SET-mediated inhibition of PP2A was ***,targeting the interaction between SET and PP2A catalytic subunit(PP2Ac)with FTY720 enhanced stress-induced p53 activation via PP2A-mediated dephosphorylation of p53 on threonine 55(Thr55).Therefore,our findings uncovered a previously unknown p53-SETPP2A regulatory feedback *** functionally potentiate this feedback loop,we designed a combined therapeutic strategy by simultaneously administrating a p53 activator and SET antagonist in cancer cells and observed a dramatic synergistic effect on tumor *** study reveals mechanistic insight into the regulation of the oncoprotein SET and raises a potential strategy for cancer therapy by stimulating the p53-SET-PP2A feedback loop.

关键词： p53 SET PP2A FTY720 feedback loop tumor suppression

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Heat Kernel Estimates on Simple Random Walks and On-Diagonal Upper Bounds

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Journal of Applied Mathematics and Physics 2024年第10期12卷 3613-3625页

作者： Runquan Zuo Yuxiao Yan zishan Zhu Liwen Yao Qihao han School of Mathematics Southeast University Nanjing China

We primarily provide several estimates for the heat kernel defined on the 2-dimensional simple random walk. Additionally, we offer an estimate for the heat kernel on high-dimensional random walks, demonstrating that the heat kernel in higher dimensions converges rapidly. We also compute the constants involved in the estimate for the 1-dimensional heat kernel. Furthermore, we discuss the general case of on-diagonal estimates for the heat kernel.

关键词： Heat Kernel Simple Random Walk On-Diagonal Estimate

Customized Design:from the Carbon Materials to the Start-stop System of Vehicles

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Customized Design:from the Carbon Materials to the Start-sto...

2018中国汽车工程学会年会

作者： CHEN Shuli RONG Changru han Jinlei han Yutao MI Xinyan ZhanG Kejin NI zishan China FAW Group Co.Ltd

Ultracapacitors have been used in vehicles due to their advantageous features such as high specific power,long cycle life,and wide working temperature *** this paper,based on the performance requirements of the prototype vehicle,a customized design and development from the carbon materials to the start-stop system is completed,where the combined action of the ultracapacitor and the vehicle showed improved performance.

关键词： ultracapacitors start-stop system vehicles customized design

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Ru单原子电催化固氮

科学新闻 2020年第2期 68-68页

作者：王海辉孙振宇陶亨聪 Changhyeok Choi Liang-Xin Ding Zheng Jiang zishan han Mingwen Jia Qun Fan Yunnan Gao Haihui Wang Alex W.Robertson Song Hong Yousung Jung Shizhen Liu Zhenyu Sun 华南理工大学化学与化工学院北京化工大学韩国科学技术院

文章简介在温和条件下实现固氮仍然是一个巨大的挑战。本工作报道了室温常压下钌(Ru)单原子电催化固氮,担载于氮掺杂多孔碳上的Ru单分散位点极大地促进了水溶液中N2的电化学还原,选择性地生成NH3,在-0.21 V(相对于可逆氢电极,RHE)电位... 详细信息

文章简介在温和条件下实现固氮仍然是一个巨大的挑战。本工作报道了室温常压下钌(Ru)单原子电催化固氮,担载于氮掺杂多孔碳上的Ru单分散位点极大地促进了水溶液中N2的电化学还原,选择性地生成NH3,在-0.21 V(相对于可逆氢电极,RHE)电位下获得3.665 mgNH3h-1 mg-1Ru的NH3产率。重要的一点是,引入ZrO2可显著地抑制竞争性析氢

关键词：单原子电催化

应用生物扰动实验系统(Annular Flux System)研究双壳类生物沉降作用

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青岛海洋大学学报（自然科学版） 2000年第2期30卷 270-276页

作者：张志南周宇韩洁于子山青岛海洋大学海洋生命学院青岛266003

利用不锈钢环形采泥器 ,在胶州湾潮间带沿天然断面选取典型站位 ,现场采取无扰动沉积物样品 ,应用生物扰动实验系统 (Annular Flux System) ,选用菲律宾蛤仔 (Ruditapes philippinarum)和缢蛏 (Sinonovacula constricta) ,在实验室内进... 详细信息

利用不锈钢环形采泥器 ,在胶州湾潮间带沿天然断面选取典型站位 ,现场采取无扰动沉积物样品 ,应用生物扰动实验系统 (Annular Flux System) ,选用菲律宾蛤仔 (Ruditapes philippinarum)和缢蛏 (Sinonovacula constricta) ,在实验室内进行实验。结果表明 :菲律宾蛤仔个体的生物沉降率平均为 0 .15g/ m2 · h· ind,平均净生物沉降率为自然颗粒沉降率的 3.0 5倍 ;缢蛏个体的生物沉降率平均为 0 .2 9g/ m2·h· ind,平均净生物沉降率为自然颗粒沉降率的 2 .6 3倍。

关键词：生物扰动实验系统生物沉降胶州湾双壳类

超长柔性悬挂固体充填刮板输送机异常工况表征及自主调控方法

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煤炭学报 2024年第4期49卷 2141-2151页

作者：张强张吉雄宗庭成金子山韩雨杨康张斌傅瑞华中国矿业大学矿业工程学院江苏徐州221116 中国矿业大学深部煤炭资源开采教育部重点实验室江苏徐州221116 中国矿业大学孙越崎学院江苏徐州221116 山东新巨龙能源有限责任公司山东菏泽274918 宁夏天地奔牛实业集团有限公司宁夏石嘴山753000

固体充填刮板输送机是固体充填开采技术的关键装备,其高效智能化的程度制约着固体智能充填开采技术的进步,暂难突破超大采长、大功率、高可靠性的瓶颈,运行状态受地质条件、充填工艺等主控因素影响显著,异常工况自主调控问题亟待解决。... 详细信息

固体充填刮板输送机是固体充填开采技术的关键装备,其高效智能化的程度制约着固体智能充填开采技术的进步,暂难突破超大采长、大功率、高可靠性的瓶颈,运行状态受地质条件、充填工艺等主控因素影响显著,异常工况自主调控问题亟待解决。总结了固体充填刮板输送机特征;构建了固体充填刮板输送机位姿形态与运输状态表征方法;通过分析异常工况的形成机理,选取异常工况判别指标,结合位姿与运输状态表征方法,给出了其空间位姿、牵引状态等异常工况判别准则与典型异常工况的调控路径,揭示了多工况状态下固体充填刮板输送机运载调控机制,提出了实时调控充填材料运输量、直线及水平程度组合的异常工况自主调控方法。全国首个260 m工作面长固体充填工程案例表明:通过异常工况自主调控,平均最大水平偏移距每减少100 mm,刮板链牵引力可减少85 kN,输送功率损耗可减少55 kW;平均最大垂直偏移距每减小100 mm时,输送功率损耗可减少7.2 kW;单位长度货载运量每减少100 kN/m,刮板链牵引力可减少31.9 kN,输送功率损耗可减少38.2 kW。所提出的异常工况自主调控方法可显著提升固体充填刮板输送机的输送效能,可助力实现固体智能充填开采。

关键词：固体充填刮板输送机工况表征自主调控工况判别路径解调充填开采