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Efficacy of Bee Products(Anzer Honey,Pollen and Propolis)in Detection and Healing of Damage Induced by Antidiabetic Drug Vildagliptin/Metformin Hydrochloride in Healthy Human Pancreatic Cells:Cytotoxic,Genotoxic and Biochemical Studies

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Current Medical Science 2023年第6期43卷 1173-1182页

作者： ÖzlemÖzdemir zinetçöl Ömer Ertürk Department of Internal Medicine Faculty of MedicineOrdu UniversityOrdu52200Turkey Department of Molecular Biology and Genetics Faculty of Sciences and LettersOrdu UniversityOrdu52200Turkey

Background and Objective Although drugs are powerful therapeutic agents,they have a range of side *** side effects are sometimes cellular and not clinically ***/metformin hydrochloride is one of the most widely used oral antidiabetic drugs with two active *** this study,we investigated its harmful effects on the metabolic activation system in healthy human pancreatic cells“hTERT-HPNE”,and we aimed to improve these harmful effects by natural *** benefit from the healing effect,we used the unique natural products produced by the bees of the Anzer Plateau in the Eastern Black Sea Region of *** Cytotoxic and genotoxic effects of the drug were investigated by different tests,such as MTT,flow cytometry-apoptosis and comet *** honey,pollen and propolis were analyzed by gas chromatography/mass spectrometry(G/C-MS).A total of 19 compounds were detected,constituting 99.9%of the *** The decrease in cell viability at all drug concentrations was statistically significant compared to the negative control(Plly significant decrease was detected in the apoptosis caused by vildagliptin/metformin hydrochloride with the supplementation of Anzer honey,pollen and propolis in hTERT-HPNE cells(Plusion This study can contribute to other studies testing the healing properties of natural products against the side effects of oral antidiabetics in human *** particular,Anzer honey,pollen and propolis can be used as additional foods to maintain cell viability and improve heal damage and can be evaluated against side effects in other drug studies.

关键词： cell viability hTERT-HPNE Anzer bee products drug side effect diabetes mellitus

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Thermophysical Characterization and Crystallization Kinetics of Semi-Crystalline Polymers

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Journal of Modern Physics 2013年第7期4卷 28-37页

作者： Matthieu zinet Zakariaa Refaa M’hamed Boutaous Shihe Xin Patrick Bourgin Université de lyon CNRS INSA-Lyon CETHIL UMR 5008 F-69621 Villeurbanne France

Final properties and behavior of polymer parts are known to be directly linked to the thermomechanical history experienced during their processing. Their quality depends on their structure, which is the result of the interactions between the process and the polymers in terms of thermomechanical kinetics. To study the actual behavior of a polymer during its transformation, it is necessary to take into account all the thermal dependencies of their thermophysical properties. In this paper, a complete experimental thermal characterization of a semi-crystalline polymer is performed. Thermal conductivity is measured using the hot wire method. The PVT diagram is obtained by means of an isobaric piston type dilatometer. Heat capacity is characterized versus temperature by differential scanning calorimetry (DSC). A modification of the Schneider rate crystallization equations is proposed, allowing to identify in a simple way all the crystallization kinetics parameters, using only DSC measurements. Finally, a multiphysical coupled model is built in order to numerically simulate the cooling of a polypropylene plate, as in the cooling stage of the injection molding process. Calculated evolutions of temperature, crystallinity, pressure and specific volume across the plate thickness are presented and commented.

关键词： Thermophysical Characterization Heat Transfer Crystallization Kinetics Polymer Multiphysical Modeling

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Feed Signal Influence and Potential Performances of a Compact Radiation Source Based on a Helical Antenna

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Journal of Electromagnetic Analysis and Applications 2015年第7期7卷 199-208页

作者： laurent Pecastaing Marc Rivaletto Antoine de Ferron Romain Pecquois René Vézinet Jean-Christophe Diot Stéphane Tortel laboratoire SIAME Equipe Génie Electrique Université de Pau et des Pays de l’Adour Hélioparc Pau-Pyrénées Pau France Hi-Pulse 300 rue des arts et métiers Pont-de-Pany France French Alternative Energies and Atomic Energy Commission (CEA) Gramat France

In the class of emerging high power electromagnetic sources, a complete pulsed power source, named MOUNA (French acronym of “Module Oscillant Utilisant une Nouvelle Architecture”) has been developed. This device must transmit waveforms with a wide frequency band and a high figure-of-merit. To improve the overall performance of the MOUNA system while maintaining its compact size, two approaches are being explored in the paper: the replacement of the dipole antenna by a helical antenna and its feeding signal influence. Helical antenna is cylindrical shape and relatively compact. It offers relatively good gain factor and directivity. The waveform delivered to the antenna is directly related to the amplitude of the radiated electric field. Therefore, different waveforms (step pulse, Gaussian pulse, bipolar pulse and damped sinusoid) are compared to point out the feed signal influence on the radiated electric field. Switch oscillators appear to be considered as interesting resonant sources for driving an antenna. The novel radiating source consists of a primary power source, a resonant transformer, a coaxial transmission line damped oscillator (also termed as coaxial resonator), and a helical antenna. This high voltage pulsed source is very compact (volume of only 2500 cc without the antenna). Our study aims at designing the antenna (number of turns, size…) and a coaxial damped oscillator directly implemented at the output of the transformer. A CST-based simulation is proposed to predict the performances of this wideband source.

关键词： Pulse Transformer Helical Antenna Coaxial Damped Oscillator High Voltage Peaking Switch Electric Field

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