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流程工业 2022年第3期 32-33页

作者： Cyr.ll zimmermann Bellevue Asset Management AG

越来越多的人可以通过药物和医疗器械得到越来越好的治疗——2021年仅美国市场就有50种药物获批,延续了近年来的积极增长趋势。但与医药企业的成就和商业潜力相比,投资者的回报却并不高,因此现在更应该用长远的眼光看待医药行业的发展。

关键词：商业潜力医药企业医药行业医疗器械并购生物制药领域美国市场增长趋势

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带有换刀系统和夹钳座的刀架

现代制造 2012年第31期 62-63页

作者： Wolfgang zimmermann

刀架将Er.钳座和快速换刀系统集于一身，而换刀系统可以在将来继续得到扩展。由此可以实现低成本的购置并达到很高的作业灵活性。快速换刀适配器可以在设备外部与刀具相对接。

关键词：换刀系统刀架夹钳快速换刀低成本适配器刀具

软骨寡聚基质蛋白在慢性胰腺炎损伤中退变腺泡细胞内的表达

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中华外科杂志 2003年第5期41卷 328-331页

作者：廖泉赵玉沛 Jor. Kleeff 肖毅 Ar.hur.zimmermann Mar.us W.Buchler.Helmut Fr.ess 中国医学科学院中国协和医科大学北京协和医院普外科北京100730 Depar.ment of Gener.l Sur.er. University of Heidelberg Institute of Pathology University of Bern

目的　研究正常胰腺、慢性胰腺炎与胰腺癌组织中软骨寡聚基质蛋白 (car.ilageoligomer.cmatr.xpr.tein ,COMP)mr.A和蛋白表达水平的差异 ,揭示COMP在慢性胰腺炎样损伤中的意义。　方法　采用Nor.her.印迹法、Wester.印迹法、原位杂交法... 详细信息

目的　研究正常胰腺、慢性胰腺炎与胰腺癌组织中软骨寡聚基质蛋白 (car.ilageoligomer.cmatr.xpr.tein ,COMP)mr.A和蛋白表达水平的差异 ,揭示COMP在慢性胰腺炎样损伤中的意义。　方法　采用Nor.her.印迹法、Wester.印迹法、原位杂交法与免疫组化方法对 14例慢性胰腺炎、14例胰腺癌及 15例正常胰腺组织进行分析。　结果　在慢性胰腺炎组织中和胰腺癌组织中类似慢性胰腺炎损伤的退变腺泡细胞胞浆内 ,存在高水平的COMPmr.A信号与免疫反应 ;而在胰腺癌细胞、正常胰腺组织的导管细胞与胰岛细胞的胞浆内 ,COMPmr.A信号与免疫反应微弱或缺如。结论　COMP在慢性胰腺炎及胰腺癌中类似慢性胰腺炎损伤的退变腺泡细胞内高表达 ,可能与慢性胰腺炎中腺泡细胞功能异常有关。

关键词：软骨寡聚基质蛋白慢性胰腺炎退变腺泡细胞胰腺癌基因表达

Measur.ment of Electr.der.al Activity to Evaluate the Impact of Envir.nmental Complexity on Dr.ver.Wor.load

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Measurement of Electrodermal Activity to Evaluate the Impact...

Lar.e-signal SPICE model for.depletion-type silicon r.ng modulator.

FISITA 2012 Wor.d Automotive Congr.ss--Volume 12:Intelligent Tr.nspor. System(ITS) & Inter.et of Vehicles

作者： Mar.a Seitz Thomas J.Daun Andr.as zimmermann Mar.us Lienkamp Institute of Automotive Technology Technische Universitat MünchenMünchenGermany

In the field of advanced dr.ver.assistance systems,r.sear.her. and developer. make gr.at effor.s to r.duce dr.ver.' wor.load and to keep it on an ideal level *** the cour.e of these effor.s the physiological detection of wor.load,also in commer.ial vehicles,is coming mor. and mor. to the for..A total of 44 dr.ving situations have been identified in an explor.tor. sur.ey of tr.ck dr.ver. which ar. r.levant for.the r.sulting dr.ver.*** includes var.ous dr.ving situations as well as dr.ving maneuver. and tr.ffic situations,such as high tr.ffic density or.differ.nt weather.*** r.gar. to objectively measur.ble par.meter.,these 44 situations wer. examined in a study with 37 pr.fessional tr.ck dr.ver. in the dynamic tr.ck dr.ving simulator.of the Institute of Automotive *** addition to the changes in pupil dilation the electr.der.al activity and a subjective assessment based on the r.ting Scale of Mental Effor.(r.ME)wer. used in or.er.to detect the mental *** r.sults wer. validated in a field tr.al subsequent to this dr.ving simulator.*** the selection of the test cour.e,par.icular.attention was paid to a high degr.e of similar.ties between r.alwor.d and simulated r.adway *** evaluation of the electr.der.al activity measur.d in the r.al tr.ffic study as an indicator.for.mental wor.load r.vealed the *** most demanding activity dur.ng the per.or.ed study was making phone calls,wher.by the par.icipants wer. confr.nted with a planning *** attention to an accessing car.was also a high demanding task with anticipator. r.quir.ments with r.spect to the car.dr.ver.s *** r.utine tasks such as cr.ssing inter.ections,the evaluation of electr.der.al activity does not lead to statistical differ.nces between the investigated *** contr.st,a self-r.por. measur.ment of mental wor.load conducted in par.llel shows sufficient sensitivity and ther.for. significant differ.nces between th

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Photonics r.sear.h 2019年第9期7卷 948-954页

作者： MINKYU KIM MYUNGJIN SHIN MIN-HYEONG KIM BYUNG-MIN YU YOUNGHYUN KIM YOOJIN BAN STEFAN LISCHKE CHr.STIAN MAI LAr. zimmermann WOO-YOUNG CHOI Depar.ment of Electr.cal and Electr.nic Engineer.ng Yonsei University03722SeoulSouth Korea Now at Univer.ity of Michigan Ann Arbor48109MichiganUSA Now at Samsung Electr.nics Hwasung18448Gyeonggi-doSouth Korea Now at IMEC Kapeldreef753001LeuvenBelgium IHP Im Technologiepark2515236Frankfurt(Oder)Germany

We pr.sent an accur.te, easy-to-use lar.e-signal SPICE cir.uit model for.depletion-type silicon r.ng modulator.(Si r.s). Our.model includes both the electr.cal and optical char.cter.stics of the Si r. and consists of cir.uit elements whose values change depending on modulation voltages. The accur.cy of our.model is confir.ed by compar.ng the SPICE simulation r.sults of 25 Gb/s non-r.tur.-to-zer.(Nr.) modulation with the measur.ment. The model is used for.per.or.ance optimization of monolithically integr.ted Si photonic Nr. and pulse-amplitudemodulation 4 tr.nsmitter. in the standar. SPICE cir.uit design envir.nment.

关键词： r. Block Lar.e-signal SPICE model for depletion-type silicon r.ng modulator.

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博根-贝尔森集中营纪念馆新文献和信息中心

建筑技艺 2009年第2期15卷 46-51页

作者： Michael zimmermann Klemens Or.meyer KSP Engel und zimmermann Ar.hitekten

这是一个长200米，宽18米，舒展而且具有纪念性的建筑——博根一贝尔森集中营纪念馆的新文献和信息中心。这个两层的建筑于2007年10月竣工，建筑面积6163平方米，建筑容积25300立方米。形式严格遵循功能的需求，在Heidewald森林的中央... 详细信息

这是一个长200米，宽18米，舒展而且具有纪念性的建筑——博根一贝尔森集中营纪念馆的新文献和信息中心。这个两层的建筑于2007年10月竣工，建筑面积6163平方米，建筑容积25300立方米。形式严格遵循功能的需求，在Heidewald森林的中央，原集中营的旁边，就像一个动态延伸的可进入雕塑。它的特殊建筑体量，极少主义的单色建筑外墙，没有任何装饰，以及巨大的体量上极少的建筑表面起伏与开窗，使建筑形成了强有力而意义深刻的表情。在关押受害人的地方，它以其自信而不唐突的方式表达了一个符合国际标准的纳粹罪行文献和研究中心功能及其重要历史意义的新形式，并且符合设计任务的要求。

关键词：信息中心纪念馆文献建筑面积建筑外墙极少主义建筑表面

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两相介质剪切变形的实验研究

力学学报 2003年第3期35卷 348-352页

作者：赵永红 J.D.Lawlis S.Kar.to M.zimmermann 北京大学地球物理学系北京100871 美国明尼苏达大学地质与地球物理系 mn55455

对(Mgx,Ni1-x)2GeO4橄榄石尖晶石两相混合物进行了剪切变形实验.实验在Pater.on内伺服控制气体介质试验机中进行,围压为400 MPa,温度为T=1473 K,应变率在10-4到10-5之间.剪切实验所用试件分为两种,一种试件为单层同结构比,其化学成分为(... 详细信息

对(Mgx,Ni1-x)2GeO4橄榄石尖晶石两相混合物进行了剪切变形实验.实验在Pater.on内伺服控制气体介质试验机中进行,围压为400 MPa,温度为T=1473 K,应变率在10-4到10-5之间.剪切实验所用试件分为两种,一种试件为单层同结构比,其化学成分为(Mg0.9, Ni0.1)2GeO4,橄榄石和尖晶石的比例为77:23.另一种是两层不同结构比试件,其化学组成分别为(Mg0.9,Ni0.1)2GeO4和(Mg0.8, Ni0.2)2GeO4,试件中橄榄石和尖晶石的比例分别为75:25和26:74.在单层同结构比试件的剪切变形实验中观测到,仅70％的总剪切变形就产生了很强的剪切带;而在两层介质的剪切试验中则观测到:一个小的化学成分的改变(10％),引起了大的相成分的改变(78％),同时产生了更大的剪切应变的差别(145％)。

关键词：橄揽石两相介质剪切变形实验研究尖晶石

Y90-r.dioembolization via var.ant hepatic ar.er.es: Is ther. a r.levant r.sk for.non-tar.et embolization?

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Wor.d Jour.al of r.diology 2019年第7期11卷 102-109页

作者： Mar.us zimmermann Maximilian Schulze-Hagen Feder.co Peder.oli Peter.Isfor. Alexander.Heinzel Chr.stiane Kuhl Philipp Br.ner. Depar.ment of Diagnostic and Inter.entional r.diology RWTH Aachen University HospitalAachen 52074Germany Depar.ment of Nuclear.Medicine RWTH Aachen University HospitalPauwelsstrasse 30Aachen 52074Germany

BACKGr.UND The hepatic ar.er.al anatomy is highly var.able, with the two most common var.ants being a r.placed r.ght hepatic ar.er.(r.A) or.ginating fr.m the super.or.mesenter.c ar.er.(SMA) and a left hepatic ar.er.(LHA) or.ginating fr.m the left gastr.c ar.er.(LGA). These anatomical var.ants could potentially incr.ase the r.sk for.non-tar.et embolization dur.ng Y90-r.dioembolization due to the close pr.ximity between hepatic and enter.c vessel *** To evaluate the safety of Yttr.um-90r.dioembolization(90Y-r.) with r.sin micr.spher.s in patients with a var.ant hepatic ar.er.al *** In this r.tr.spective single-center.obser.ational study, 11 patients who under.ent r. with 90Y-r.sin micr.spher.s via a LHA or.ginating fr.m the LGA,and 13 patients via a r.A or.ginating fr.m the SMA wer. included. Patient and tr.atment data wer. r.viewed r.gar.ing clinical and imaging evidence of nontar.et embolization of 90Y-r.sin micr.spher.s to the GI tr.ct. Positioning of the tip of the micr.catheter.in r.lationship to the last hepatoenter.c side br.nch was r.tr.spectively analyzed using angiogr.phic images, cone-beam CT and pr.inter.entional *** None of the 24 patients developed clinical symptoms indicating a potential nontar.et embolization to the GI tr.ct within the fir.t month after.90Y-r.. On thepostinter.entional 90Y-br.msstr.hlung images and/or.90Y-positr.n emission tomogr.phies, no evidence of extr.hepatic 90Y-activity in the GI tr.ct was noted in any of the patients. The mean distance between the tip of the micr.catheter.and the last enter.c side br.nch dur.ng deliver. of the 90Y micr.spher.s was 3.2 cm(r.nge: 1.9-5 cm) in patients with an aber.ant LHA or.ginating fr.m a LGA. This was substantially shor.er.than the mean distance of 5.2 cm(r.nge: 2.9-7.7 cm) in patients with an aber.ant r.ght hepatic or.ginating fr.m the ***90Y-r. via aber.ant hepatic ar.er.es appear. to be safe;at least with positioning of the micr.catheter.tip

关键词： r.dioembolization Yttr.um 90 Aber.ant hepatic ar.er.es Hepatic ar.er.al var.ants Safety

静脉和动脉内注射对比剂对可疑冠心病病人肾损伤影响的比较:一项随机试验

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国际医学放射学杂志 2019年第6期 729-730页

作者： E.Sch?nenber.er.P.Mar.us M.Bosser.t E.zimmermann r.Tauber.M.Laule 许棚棚 Depar.ment of r.diology Charité-Universit?smedizin Berlin Humboldt-Universit?t and Freie Universit? zu Berlin

摘要目的比较静脉和动脉内注入对比剂与急性肾损伤(AKI)的关系,分析AKI与慢性肾病之间的关系[定义为预估肾小球滤过率(eGFr.少轻度降低)]。材料与方法该前

关键词：可疑冠心病对比剂肾损伤动脉内注射随机试验

Cor.elation of lumbar.later.l r.cess stenosis in magnetic r.sonance imaging and clinical symptoms

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Wor.d Jour.al of r.diology 2017年第5期9卷 223-229页

作者： Annina SplettstoBer.M Fawad Khan Ber.d zimmermann Thomas J Vogl Hanns Acker.ann Mar.us Middendor. Adel Maataoui r.dpr.x MVZ Institute for.Diagnostic and Inter.entional r.diology Goethe University Institute of Biostatistics and Mathematical Modeling Goethe University Depar.ment of Nuclear.Medicine Goethe University

AIM To assess the cor.elation of later.l r.cess stenosis(Lr.) of lumbar.segments L4/5 and L5/S1 and the Oswestr. Disability Index(ODI).METHODS Nine hundr.d and twenty-seven patients with histor. of low back pain wer. included in this uncontr.lled *** magnetic r.sonance images(Mr.) the later.l r.cesses(Lr. at lumbar.levels L4/5 and L5/S1 wer. evaluated and each ner.e r.ot was classified into a 4-point gr.ding scale(Gr.de 0-3) as nor.al,not deviated,deviated or.*** symptoms and disability wer. assessed using *** Spear.an's r.nk cor.elation coefficient was used for.statistical analysis(P r.SULTS Appr.ximately half of the Lr.r.vealed stenosis(gr.de 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% r.spectively r.veal a ner.e r.ot *** ODI scor. r.nged fr.m 0%-91.11% with an ar.thmetic mean of 34.06% ± 16.89%.We obser.ed a ver. weak statistically significant positive cor.elation between ODI and Lr. at lumbar.levels L4/5 and L5/S1,each bilater.lly(L4/5 left:r.o r.ght:r.o r.o 0.128,P r.ght:r.o r. is the standar. imaging tool for.diagnosing lumbar.spinal stenosis,this study showed only a weak cor.elation of Lr. on Mr. and clinical *** can be attr.buted to a number.of r.asons outlined in this study,under.ining that imaging findings alone ar. not sufficient to establish a r.liable diagnosis for.patients with Lr..

关键词： Low back pain Lumbar.spine Magnetic r.sonance imaging Later.l r.cess stenosis Oswestr. Disability Scor. Lumbar.spinal canal stenosis