检索结果-南通市图书馆

三点悬吊与完全单孔腹腔镜胆囊切除43例临床分析

在线全文

学校读者我要写书评

暂无评论

中华普通外科学文献（电子版） 2014年第2期8卷 32-35页

作者：温子龙薛平卢海武郑强陈凯广州医科大学第二附属医院肝胆外科 510260

目的总结43例单孔腹腔镜胆囊切除的手术经验，探讨其学习曲线及实用性推广。方法回顾性分析2010年7月至2011年12月收治43例胆囊功能障碍、有症状胆囊结石或胆囊息肉患者，甄选行单孔腹腔镜胆囊切除术（试验组），与同期行传统三孔腹腔... 详细信息

目的总结43例单孔腹腔镜胆囊切除的手术经验，探讨其学习曲线及实用性推广。方法回顾性分析2010年7月至2011年12月收治43例胆囊功能障碍、有症状胆囊结石或胆囊息肉患者，甄选行单孔腹腔镜胆囊切除术（试验组），与同期行传统三孔腹腔镜胆囊切除术49例（对照组）比较，统计分析两种术式的手术时间、患者术后并发症发生率及总住院时间。结果试验组三点悬吊法完成15例，完全单孔法完成26例，2例中转传统三孔腹腔镜胆囊切除。试验组平均手术时间为（72.8±9）min，第1例患者手术时间为96 min，随着手术经验积累，从第10例开始，平均手术时间缩短至（62.5±5）min，与对照组平均手术时间（59.4±3）min相比，差异无统计学意义（t=4.04，P=0.16）。试验组平均住院时间（3±1.1）d，对照组为（4±0.87）d，两组比较差异无统计学意义（t=3.28，P=0.17）。术后随访2~12个月，试验组1例患者出现切口液化，对照组2例患者出现伤口感染。两组患者均无切口疝，胆道损伤等并发症。结论单孔腹腔镜胆囊切除安全可行，其平均手术和住院时间与传统腔镜胆囊切除相近，但切口少，术后切口疼痛轻，美容效果好。经过10例手术可完成单孔胆囊切除学习曲线。

关键词：胆囊切除腹腔镜三点悬吊单孔

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

DC-CIK免疫治疗联合TACE介入治疗晚期肝癌的临床研究

在线全文

学校读者我要写书评

暂无评论

岭南现代临床外科 2014年第5期14卷 505-508页

作者：祖余琪薛平蒋小峰温子龙张大伟广州医科大学第二附属医院肝胆外科广州510288

目的探讨DC-CIK细胞免疫治疗联合介入治疗晚期肝癌的临床疗效。方法选择晚期原发性肝癌患者112例为研究对象,根据患者自愿情况分为TACE联合DC-CIK细胞免疫治疗组(A组,n=64)和TACE治疗组(B组,n=48),观察治疗前后血常规、肿瘤标志物、免... 详细信息

目的探讨DC-CIK细胞免疫治疗联合介入治疗晚期肝癌的临床疗效。方法选择晚期原发性肝癌患者112例为研究对象,根据患者自愿情况分为TACE联合DC-CIK细胞免疫治疗组(A组,n=64)和TACE治疗组(B组,n=48),观察治疗前后血常规、肿瘤标志物、免疫功能及治疗效果。结果 A组缓解率明显高于B组(78.12%VS 47.92%);治疗前后CD3+、CD4+、CD8+、CD19+、NK、CD3+/CD4+、CD3+/CD8+增加或减少值均高于B组;随访6个月、12个月,A组死亡病例明显低于B组(6.25%VS 16.67%,1.78%VS 12.82%),但两组18个月的死亡病例数比较没有差异。结论 TACE联合DC-CIK细胞免疫治疗一定程度上可改善免疫功能,提高近期疗效。

关键词：晚期肝癌 TACE DC-CIK 肿瘤标志物免疫功能

腹腔镜十二指肠镜联合治疗胆囊胆总管结石的两种术式临床分析

在线全文

学校读者我要写书评

暂无评论

中华普通外科学文献（电子版） 2014年第5期8卷 36-39页

作者：郑强温子龙薛平卢海武曹良启广州医科大学附属第二医院肝胆外科 510260

目的探讨腹腔镜术中联合应用十二指肠镜对接技术(LER)与十二指肠镜、腹腔镜分步处理治疗胆囊胆总管结石两种术式临床效果。方法回顾性分析自2009年1月至2010年11月收治51例胆囊合并胆总管结石患者。其中一期处理组25例实施LER进行一期处... 详细信息

目的探讨腹腔镜术中联合应用十二指肠镜对接技术(LER)与十二指肠镜、腹腔镜分步处理治疗胆囊胆总管结石两种术式临床效果。方法回顾性分析自2009年1月至2010年11月收治51例胆囊合并胆总管结石患者。其中一期处理组25例实施LER进行一期处理,分期处理组26例实施分期处理,先行经内镜逆行性胰胆管造影+十二指肠乳头括约肌切开取出胆总管结石,5 d后行腹腔镜胆囊切除术(LC)。比较两组手术时间、胆总管结石取净率、手术成功率、术后并发症发生率、总体住院天数。结果两组胆总管结石成功取净,术中各有1例因胆囊三角严重粘连中转开腹,一期处理组与分期处理组的手术成功率96.0%vs 96.2%(χ2=0.481,P=0.509),平均手术时间为(85±20)min vs(120±18)min(t=-0.613,P<0.01),术后胰腺炎并发症发生率为4%vs 11%(χ2=5.063,P=0.020),平均住院时间分别为(5.0±1.2)d vs(11±1.6)d(Z=-6.230,P<0.01)。所有患者均未出现出血、穿孔等与十二指肠镜检操作相关的并发症。结论 LER手术一期治疗胆囊胆管结石安全、有效,与分期治疗相比,术后胰腺炎并发症发生率较低,总体住院时间大为缩短,但其推广应用,尚需待大样本临床研究和长期随访评价。

关键词：腹腔镜十二指肠镜胆囊胆总管结石

在线全文

学校读者我要写书评

暂无评论

马来海松酸衍生物手性识别能力的NMR研究

广东化工 2017年第20期44卷 4-5页

作者：吴强肖资龙王龙超文长春刘佩广西师范大学化学与药学学院广西桂林541004

以松香为原料合成马来海松酸衍生物,用作助剂制备NMR手性膦衍生化试剂,并通过测定31P NMR检验马来海松酸衍生物用于NMR手性识别的能力,结果显示,所合成的马来海松酸衍生物3可用于制备方便有效的手性衍生化试剂。

关键词：马来海松酸单乙酯 NMR 手性识别

ERCP+LC与LCBDE+LC治疗胆囊结石合并胆总管结石疗效对比研究

在线全文

学校读者我要写书评

暂无评论

中华肝脏外科手术学电子杂志 2021年第2期10卷 158-164页

作者：王伟龙温子龙郑宗敏朱文峰郑强薛平广州医科大学附属第二医院肝胆外科 510260

目的比较ERCP联合腹腔镜胆囊切除术(LC)与腹腔镜胆总管探查术(LCBDE)联合LC治疗胆囊结石合并胆总管结石疗效及安全性。方法回顾性分析2016年6月至2019年6月广州医科大学附属第二医院收治的147例胆囊结石合并胆总管结石患者临床资料。患... 详细信息

目的比较ERCP联合腹腔镜胆囊切除术(LC)与腹腔镜胆总管探查术(LCBDE)联合LC治疗胆囊结石合并胆总管结石疗效及安全性。方法回顾性分析2016年6月至2019年6月广州医科大学附属第二医院收治的147例胆囊结石合并胆总管结石患者临床资料。患者均签署知情同意书,符合医学伦理学规定。其中男77例,女70例;年龄24~65岁,中位年龄53岁。根据治疗方法不同分为ERCP+LC组和LCBDE+LC组。观察两组围手术期情况和疗效。两组住院时间、住院费用等比较采用t检验,并发症等发生率比较采用χ~2检验或Fisher确切概率法。结果 ERCP+LC组单次净石率为92%(67/73),LCBDE+LC组为92%(60/65),差异无统计学意义(χ^(2)=0.013,P>0.05)。ERCP+LC组胆总管最大直径≤8 mm者14例、>15 mm者9例,LCBDE+LC组相应为0、19例,差异有统计学意义(χ^(2)=-,6.077;P0.05)。结论 ERCP+LC和LCBDE+LC治疗胆囊结石合并胆总管结石疗效相当,两种微创术式各有优势,胆总管无扩张者首选ERCP+LC,而胆总管明显扩张、结石较大者LCBDE+LC更具优势。

关键词：胆囊结石病胆总管结石胆囊切除术腹腔镜胰胆管造影术内窥镜逆行腹腔镜胆总管探查术

超声联合腹腔镜射频消融术对肝癌患者免疫功能的影响

在线全文

学校读者我要写书评

暂无评论

临床医学工程 2012年第10期19卷 1637-1640页

作者：薛平郑超曹良启卢海武郑强温子龙广州医学院第二附属医院肝胆外科广东广州510260

目的观察肝癌患者经超声联合腹腔镜射频消融(laparoscopic radiofrequency ablation,LRFA)治疗前后外周血免疫指标的变化情况,评价腹腔镜射频消融治疗对机体免疫功能的影响。方法选取2011年3月至2012年3月本科室收治的肝癌患者62例,分... 详细信息

目的观察肝癌患者经超声联合腹腔镜射频消融(laparoscopic radiofrequency ablation,LRFA)治疗前后外周血免疫指标的变化情况,评价腹腔镜射频消融治疗对机体免疫功能的影响。方法选取2011年3月至2012年3月本科室收治的肝癌患者62例,分为三组,A组为腹腔镜联合超声引导射频消融组(22例)、B组为经肝动脉化疗栓塞组(TACE组)(20例)、C组为外科手术组(20例),射频消融组采用超声引导联合腹腔镜射频消融治疗,手术组行肝癌根治术,20例健康献血员作为正常对照组。采用流式细胞术检测LRFA组治疗前后以及三组患者治疗前后同时相外周血中淋巴细胞亚群(CD3+、CD4+、CD8+、NK、CD19+)细胞的比例变化。结果 A、B、C三组患者治疗前外周血CD3+、CD4+数目、CD4+/CD8+比值、NK细胞数目明显低于正常对照组(PTACE>外科手术。

关键词：原发性肝癌腹腔镜射频免疫功能

Behavior and Functional Study of Myeloid Leukocytes in the Epimorphic Regeneration of Larval Tail Fin in zebrafish

在线全文

学校读者我要写书评

暂无评论

Behavior and Functional Study of Myeloid Leukocytes in the E...

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

2012全国发育生物学大会

作者： Bo Yan~1,LiLi~(2*) zilong wen~(1*) 1 State Key Laboratory of molecular Neuroscience,Department of Biochemistry,the Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong,P.R.China 2 State Key Laboratory Breeding Base of Eco-Enviroments and Bio-Resources of the Three Gorges Area,School of life science,Southwest University,Chongqing,400715,China

Macrophages and neutrophils are the pivotal immune phagocytes that enter the wound after tissue injury to remove the cell debris and invaded microorganisms,and facilitate the regrowth of injured *** advantage of the regeneration abilities of zebrafish and the newly generated Tg(corola:eGFP/lyz:Dsred) zebrafish line with labeling of both myeloid lineages,we assessed the behaviors and functions of neutrophils and macrophages during tail fin *** imaging showed that within 6 hours post amputation(hpa)-the inflammatory stage,neutrophils with high mobility were the primary cells scavenging apoptotic bodies and small cell debris,although they had limited phagocytic capacity and quickly underwent *** of interleukin factor could inhibit the directional migration of neutrophils but not macrophages to the wound region,suggesting different molecules responded to the distinct behaviors of both cell types during this *** 6 hpa onwards-the resolution and regeneration stage,macrophages became the dominant scavengers, efficiently resolving inflammation and facilitating tissue remodeling and *** of macrophages but not neutrophils impaired the regeneration,resulting in the formation of large vacuoles in the regenerated fins. Conclusions:Our study documents the differing behaviors and functions of macrophages and neutrophils during tissue *** the future,we will explore the detailed mechanisms used by both cell types in the whole process

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen wen Zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave